Abstract: A process for rectificatively separating a liquid which comprises acrylic acid, methacrylic acid or a mixture thereof, and additionally comprises low molecular weight aldehydes and acetone.
Type:
Grant
Filed:
April 10, 2006
Date of Patent:
January 29, 2008
Assignee:
BASF Aktiengesellschaft
Inventors:
Gunter Lipowsky, Klaus Joachim Mueller-Engel
Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
Type:
Grant
Filed:
June 3, 2005
Date of Patent:
January 29, 2008
Assignee:
XenoPort, Inc.
Inventors:
Jia-Ning Xiang, Mark A. Gallop, Cindy X. Zhou, Mark Nguyen, Xuedong Dai, Jianhua Li, Kenneth C. Cundy
Abstract: The present invention relates to sulfanilide derivatives of formula (I), in which R1 and R2 are optionally substituted aryl and heteroaryl groups and the other variables are as defined in the claims, for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such sulfanilide derivatives. Said derivatives are useful in the treatment and/or prevention of preterm labor, premature birth, dysmenorrhea, inappropriate secretion of vasopressin, congestive heart failure, arterial hypertension, liver cirrhosis, nephrotic syndrome and ocular hypertension. In particular, the present invention is related to sulfanilide derivatives displaying a substantial modulatory, in particular antagonistic activity, of the oxytocin and/or vasopressin receptor.
Type:
Grant
Filed:
October 15, 2001
Date of Patent:
December 25, 2007
Assignee:
Laboratoires Serono SA
Inventors:
Anna Quattropani, Matthias Schwarz, Catherine Joran-Lebrun, Dennis Church, Alexander Scheer
Abstract: Novel positive-working photoresist compositions are disclosed. The monomers of the base resin of the resist contain diamondoid-containing pendant groups higher than adamantane in the polymantane series; for example, diamantane, triamantane, tetramantane, pentamantane, hexamantane, etc. The diamondoid-containing pendant group may have hydrophilic-enhancing substituents such as a hydroxyl group, and may contain a lactone group. Advantages of the present compositions include enhanced resolution, sensitivity, and adhesion to the substrate.
Type:
Grant
Filed:
November 4, 2005
Date of Patent:
December 4, 2007
Assignee:
Chevron U.S.A. Inc.
Inventors:
Shenggao Liu, Jeremy E. Dahl, Robert M. Carlson
Abstract: A process is provided for producing an enriched carboxylic acid compositions produced by contacting composition comprising a carboxylic acid with an enrichment feed in an enrichment zone to form an enriched carboxylic acid composition. This invention also relates to a process and the resulting compositions for removing catalyst from a carboxylic acid composition to produce a post catalyst removal composition.
Type:
Grant
Filed:
March 1, 2006
Date of Patent:
December 4, 2007
Assignee:
Eastman Chemical Company
Inventors:
Philip Edward Gibson, Kenny Randolph Parker
Abstract: The present invention provides a process for preparing crystalline parahydroxybenzoic acid anhydride, comprising the step of precipitating and isolating parahydroxybenzoic acid in an aqueous solvent at a temperature equal to or above the transition temperature of parahydroxybenzoic acid.
Abstract: A method and integrated system are provided for purifying and delivering a metal carbonyl precursor utilized to process a substrate. The method includes providing the metal carbonyl precursor containing un-reacted metal carbonyl precursor and metal-containing impurities in a metal precursor vaporization chamber containing a precursor collection plate, evacuating the metal precursor vaporization chamber, pressurizing the metal precursor vaporization chamber with a CO-containing gas, vaporizing the un-reacted metal carbonyl precursor, and condensing the vaporized un-reacted metal carbonyl precursor as a purified metal carbonyl precursor on the precursor collection plate. The method may further include vaporizing the purified metal carbonyl precursor, and delivering a process gas containing the vapor of the purified metal carbonyl precursor by flowing a gas containing CO through the metal precursor vaporization chamber to a deposition system configured to expose a substrate to the process gas.
Abstract: The present invention relates to catalytic compositions for esterification, transestrification and polycondensation reactions, a process for the catalysis of said reactions employing such catalytic compositions and polyesters for resins obtainable by this process.
Type:
Grant
Filed:
November 25, 2003
Date of Patent:
November 20, 2007
Assignee:
Chemtura Organometalics GmbH
Inventors:
Jens Röder, Andrea Kapries, Liane Franke, Oliver Schumacher, Johannes Canisius
Abstract: This invention is directed to compounds of the following formula (I): wherein R is either: wherein R1 and R2 are as defined in the specification; the use of these compounds for treating inflammatory disorders; and pharmaceutical compositions comprising a therapeutically effective amount of the above-defined compounds.
Type:
Grant
Filed:
November 6, 2006
Date of Patent:
November 13, 2007
Assignee:
Teva Pharmacaetical Industries Ltd.
Inventors:
Yaacov Herzig, David Lerner, Jeffrey Sterling
Abstract: The present invention is an improvement upon the process for the production of 1,3-propanediol wherein an aqueous solution of 3-hydroxy propanal is formed, catalyst, if any, used in said formation is removed from the solution, sodium hydroxide is added to the solution to neutralize any acid therein such that the pH is at least about 5, the neutralized aqueous solution is subjected to hydrogenation to produce a crude 1,3-propanediol mixture which is distilled to produce 1,3-propanediol, water, and reactive heavy components. The improvement on this process comprises replacing the sodium hydroxide with a hydroxide selected from the group consisting of ammonium hydroxide, alkali metal hydroxides other than sodium hydroxide, and alkaline earth metal hydroxides to reduce the viscosity of the reactive heavy components.
Type:
Grant
Filed:
October 1, 2003
Date of Patent:
October 2, 2007
Assignee:
Shell Oil Company
Inventors:
John Frederick Knifton, Talmadge Gail James, Paul Richard Weider, Joseph Broun Powell, Edward Lewis Nielsen, Glenn Charles Komplin
Abstract: A method for producing sequenced reaction products comprising performing, in one pot, a first reaction at a lower temperature followed by a second reaction at a higher temperature in the presence of a catalyst system comprising a proazaphosphatrane in combination with a palladium compound is provided. In one embodiment, the first reaction is a double amination reaction and the second reaction is an arylation. Use of one pot and a single catalyst system for each set of sequential reactions is efficient and economical. Novel N,N-diarylaminostyrenes and N,N-diarylaminostilbenes are produced according to the methods described herein.
Type:
Grant
Filed:
April 5, 2005
Date of Patent:
October 2, 2007
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
Nandakumar Mecheril Valsan, John G. Verkade
Abstract: Compounds of formula (I): wherein: Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring; X represents O, S, NR5 or CR6 R7; Y represents CHOH, CHSH, NOR8, CNR8 or CNOR8; Z represents a bond, CR10R11, O, S, SO, SO2, NR10, OCR10R11, CR10R11 O or Z, R4 and Q together form an optionally substituted fused tricyclic group; R1, R1?, R3 and R3? each independently represents H, C1-6 alkyl or C1-4 alkylaryl; R2 represents CO2R8, CONR5OR9 or NR5COR9; R4 represents optionally substituted 5- or 6-membered aryl or heteroaryl; R5 represents H or C1-3 alkyl; R6 and R7 each independently represents H, C1-3 alkyl or halo; R8 represents H or C1-2 alkyl; R9 represents H or C1-3 alkyl; R10 and R11 each independently represents H, C1-6 alkyl or C1-4 alkylaryl; and physiologically functional derivatives thereof, processes for their preparation, pharmaceutical formulations containing them and their use as inhibitors of matrix metalloproteinase enzymes (MMPs) are described.
Type:
Grant
Filed:
June 1, 2004
Date of Patent:
July 31, 2007
Assignee:
Glaxo Group Limited
Inventors:
Simon Gaines, Ian Peter Holmes, Stephen Paul Watson