Abstract: Thermostable Cas9 nucleases. The present invention relates to the field of genetic engineering and more particularly to nucleic acid editing and genome modification. The present invention provides an isolated Cas protein or polypeptide fragment thereof having an amino acid sequence of SEQ ID NO: 1 or a sequence of at least 77% identity therewith. The Cas protein or polypeptide is capable of binding, cleaving, marking or modifying a double stranded target polynucleotide at a temperature in the range 20° C. and 100° C. inclusive. The invention further provides isolated nucleic acid molecules encoding the Cas9 nucleases, expression vectors and host cells. The invention also provides PAM sequences recognized by the Cas protein or polypeptide, The Cas9 nucleases disclosed herein provide novel tools for genetic engineering in general, in particular at elevated temperatures and are of particular value in the genetic manipulation of thermophilic organisms; particularly microorganisms.

Abstract: Provided is an improved estimation and identification device that estimates the position of a plurality of identification targets and identifies the plurality of identification targets.

Abstract: An approach for blockchain transaction processing using generative cryptograms for bi-lateral and Multi-lateral transactions may be provided. The approach may include, the use of decentralization ledger storage, negating the need of repetitive storage while preserving the need for data redundancy. A generative cryptogram may provide verification of processed blocks and file handles or storage address schemes of the ledger storage. The approach creates a cryptogram which is added to transaction processing, post processing and commits to the ledger. In the approach, the cryptogram is the only version of storage pointer and is utilized in subsequent transaction processing without the need for extensive compute and latest cryptogram is all that would be needed for transaction processing.

Abstract: An optical transmission apparatus (1_1) according to the present invention includes a first transmission unit (11_1) that transmits a first optical transmission signal (21_1), a second transmission unit (11_2) that transmits a second optical transmission signal (21_2), and an output unit that outputs, when the first optical transmission signal (21_1) and the second optical transmission signal (21_2) share a set of information, both the first optical transmission signal (21_1) and the second optical transmission signal (21_2) to a first path (26_1) and outputs, when the first optical transmission signal (21_1) and the second optical transmission signal (21_2) do not share the set of information, one of the first optical transmission signal (21_1) and the second optical transmission signal (21_2) to a second path (26_2).

Abstract: In an example embodiment, an optical communication system includes an implantable optical transmitter and an external optical receiver. The transmitter includes a housing having one or more drivers, plural light emitting sources, and an optical element arranged therein. Each driver converts a digital data signal into modulation signals to drive the sources. Each source generates a light beam in response to a corresponding modulation signal, each light beam contributing to form a single optical signal. The optical element directs the light beams to exit the housing such that a peak position of light intensity of each light beam is separated from a corresponding peak position of light intensity of an adjacent light beam by at least a first distance and less than a second distance. The optical receiver includes at least one photodiode that detects light generated by the sources and generates a reconstructed data signal.

Abstract: A fault detection apparatus includes: a transmitter that transmits a first optical signal through an optical transmission line; a receiver that receives, in response to the transmission of the first optical signal, a second optical signal from the line, and measures the reception level of the second optical signal; and a control unit that specifies a section where the second optical signal corresponding to the first optical signal was generated, calculates an optical level corresponding to a loss in said section on the basis of the reception level, determines that a first fault has occurred in the section when the optical level in the section has changed from a first reference level by a first threshold or more, sets a second reference level and a second threshold after occurrence of the first fault, and determines occurrence of a second fault.

Abstract: Described implementations obtain credential information including an encrypted digital identity (ID). The encrypted digital ID may include a public component of a credential and identity data. Furthermore, the credential information may include cryptographically obfuscated data based on the identity data and a private component of the credential. A proof is obtained that includes proof data. The proof data may confirm that the credential information was correctly generated. Verification of the proof data, and confirmation that the cryptographically obfuscated data is not associated in a collection of cryptographically obfuscated data, cause a computer-implemented service to issue a pseudonym. The pseudonym is usable to generate a relationship associated with a computer-implemented service.

Abstract: Described herein is the use sodium (E)-2-(4-((3-(4-fluorophenyl)-3-(4-(3-morpholinoprop-1-yn-1-yl)phenyl)allyl)oxy)-2-methylphenoxy)acetate in the preparation of pharmaceutical compositions for the treatment of diseases or conditions that would benefit by administration with a PPAR? agonist compound.

Abstract: A coupling mechanism for connecting a replaceable shaving cartridge of a shaving device to a handle of the shaving device includes a first connector, a second connector, and a locking member. The first connector of the replaceable shaving cartridge is adapted to move along an axial direction. The second connector of the handle is adapted to move along a substantially arc-shaped path with respect to the handle when at least one connector of the first connector and the second connector is pushed against the other connector. The second connector is adapted to mechanically engage with the first connector in the course of its motion so as to reach an engaged position with the first connector. The locking member of the handle is adapted to lock the second connector when the latter is in the engaged position with the first connector.

Abstract: A method for protecting sensitive data from being exposed in graph embedding vectors. In some embodiments, a method may include generating first graph embedding vectors from an original graph and generating a proxy graph from the first graph embedding vectors. The proxy graph may include a plurality of proxy nodes and proxy edges connecting the proxy nodes. The proxy nodes may include one or more attributes of the original nodes that are included in the first graph embedding vectors. Second graph embedding vectors may then be generated by encoding the proxy graph and a reconstructed graph may be generated from the second graph embedding vectors. Finally, the reconstructed graph may be compared to the original graph and if a threshold level of similarity is met, a security action may be performed to protect sensitive data from being exposed.

Abstract: Compositions and methods for binding to a target sequence of interest are provided. The compositions find use in cleaving or modifying a target sequence of interest, visualization of a target sequence of interest, and modifying the expression of a sequence of interest. Compositions comprise RNA-guided nuclease polypeptides, CRISPR RNAs, trans-activating CRISPR RNAs, guide RNAs, and nucleic acid molecules encoding the same. Vectors and host cells comprising the nucleic acid molecules are also provided. Further provided are CRISPR systems for binding a target sequence of interest, wherein the CRISPR system comprises an RNA-guided nuclease polypeptide and one or more guide RNAs.

Abstract: A packet-filtering system configured to filter packets in accordance with packet-filtering rules may receive data indicating network-threat indicators and may configure the packet-filtering rules to cause the packet-filtering system to identify packets comprising unencrypted data, and packets comprising encrypted data. A portion of the unencrypted data may correspond to one or more of the network-threat indicators, and the packet-filtering rules may be configured to cause the packet-filtering system to determine, based on the portion of the unencrypted data, that the packets comprising encrypted data correspond to the one or more network-threat indicators.

Abstract: A photonics-electronics convergence switch with which, even if an optical network system is built by combining a plurality of packet switches, the amount of processing in the packet switches does not increase, the optical network system operates with low electric power consumption, and this enables wide-range optical communication between the nodes of a communication origin and of a communication partner, includes a network processor that is an electronic circuit configured to control the functions of the packet switch, a plurality of optical transmitter-receivers having photoelectric conversion functions, and a plurality of optical switches.

Abstract: Embodiments include a bar for a chain saw that is equipped with one or more oil channels that run along the length of the bar. Each oil channel receives oil at a first end, which exits the oil channel at an oil exit aperture at a second end of the channel. The oil exit aperture of one of the channels is positioned along the side of a bar groove, through which runs the saw chain, proximate to the cutting area of the bar to lubricate the saw chain just prior to the cutting area. A second channel may have an oil exit aperture proximate to the nose of the bar, to lubricate a sprocket wheel in the nose of the bar.

Abstract: An isolator includes a first core, a second core, a nonreciprocal member, and a magnetic body. The first core and the second core extend in a first direction and are positioned side by side with a cladding therebetween in a second direction that intersects the first direction. The nonreciprocal member is in contact with at least a part of the second core while being positioned side by side with the second core in the second direction. In a magnetic field generated by the magnetic body in a portion where the nonreciprocal member is positioned, a component in a third direction perpendicular to the first direction and the second direction is greater than any component other than the component in the third direction.

Abstract: Systems and techniques provide activity monitoring and selective obfuscation of various fields or categories of information included in traffic between servers providing services and end-user devices accessing such services. The selective obfuscation may account for a user's role and one or more levels of authorization or permission assigned to such a role. More generally, the disclosed techniques provide the ability to selectively restrict end-user access to data included in server responses, such that desired portions of the data are not accessible while other portions of the data are still accessible. An administrator tool may configure the permissions and rules used to decide whether traffic to or from a particular server or service should be selectively obfuscated; and if so, how that traffic should be selectively obfuscated.

Abstract: The present disclosure provides gene edited modified immune cells or precursors thereof (e.g., gene edited modified T cells) comprising an exogenous T cell receptor (TCR) and/or a chimeric antigen receptor (CAR) having specificity for a target antigen, and an insertion and/or deletion in one or more endogenous gene loci, wherein the endogenous gene loci encode regulators of T cell function, thereby resulting in immune cells having enhanced function. Compositions and methods of treatment are also provided. The present invention provides methods of screening for TCR- or CAR-T cells with enhanced immune function (e.g., T cell efficacy, T cell memory, and/or T cell persistence).

Abstract: A computer-implemented method, computer program product and computing system for: obtaining first system-defined platform information concerning a first security-relevant subsystem within a computing platform; obtaining at least a second system-defined platform information concerning at least a second security-relevant subsystem within the computing platform; combining the first system-defined platform information and the at least a second system-defined platform information to form system-defined consolidated platform information; and generating a security profile based, at least in part, upon the system-defined consolidated platform information.

Abstract: An electronic device may include an antenna that conveys wireless signals at frequencies greater than 100 GHz. The antenna may include a radiating element coupled to a uni-travelling-carrier photodiode (UTC PD). An optical path may illuminate the UTC PD using a first optical local oscillator (LO) signal and a second optical LO signal. An optical phase shift may be applied to the first optical LO signal. A Mach-Zehnder modulator (MZM) may be interposed on the optical path. During signal transmission, the MZM may modulate wireless data onto the second optical LO signal while control circuitry applies a first bias voltage to the UTC PD. During signal reception, the control circuitry may apply a second bias voltage to the UTC PD that configures the UTC PD to convert received wireless signals into intermediate frequency signals and/or optical signals.

Abstract: This invention relates to a method for the enzymatic synthesis of oligosaccharides, preferably human milk oligosaccharides (HMOs) The method comprises the enzymatic transfer of a glycosyl moiety and subsequent removal of by-products, such as lactose, by nanofiltration using a membrane comprising an active polyamide layer.