Patents Examined by Mark W. Noel
  • Patent number: 4732978
    Abstract: There are disclosed compounds having the formula ##STR1## wherein X is CR or N when n=1; orX is O, S, NR or CR when n=0;R is hydrogen or lower alkyl;Y is --CH.sub.2 --, --S--, --O-- or ##STR2## and A is ##STR3## Z is CH or N; R.sup.1 is halo or trifluoromethyl;R.sup.2 is hydrogen or halo;R.sup.3 is hydrogen or halo;with the proviso that when A is naphthyl, Y is --O-- and n=0, X is other than S; and their use in the treatment of inflammatory conditions and in the treatment of leukotriene-medicated naso-bronchial obstructive passageway conditions.
    Type: Grant
    Filed: September 12, 1986
    Date of Patent: March 22, 1988
    Assignee: American Home Products Corporation
    Inventors: Anthony F. Kreft, Kenneth L. Kees, John H. Musser, James J. Bicksler, Winifred P. Howse
  • Patent number: 4728647
    Abstract: Compounds of formula: ##STR1## in which V and W are H, halogen, alkyl (1-4C) or alkoxy (1-4C), amino, or acylamino,Z is phenyl, optionally substituted, thienyl, or pyridyl,R.sub.1 is alkyl (1-6C), alkoxyalkyl, cycloalkyl (3-6C), phenyl, phenylalkyl, or cycloalkylalkyl,R.sub.2 is alkyl (1-6C), alkoxyalkyl, cycloalkyl (3-6C), phenyl, phenylalkyl, cycloalkylalkyl, or morpholino, andNR.sub.1 R.sub.2 can also be pyrrolidino, optionally substituted piperidino, optionally substituted morpholino, thiomorpholino, optionally substituted piperazino, or an optionally substituted piperazinone, are useful as anxiolytic agents.
    Type: Grant
    Filed: May 28, 1986
    Date of Patent: March 1, 1988
    Assignee: Rhone-Poulenc Sante
    Inventors: Jesus Benavides, Marie-Christine Dubroeucq, Gerard Le Fur, Christian Renault
  • Patent number: 4727158
    Abstract: 5-tert-Octyl-2-(2-hydroxy-3,5-di-alpha-cumylphenyl)-2H-benzotriazole and related 2H-benzotriazoles substituted on the 5-position of the benzo ring by a higher alkyl group such as tert-octyl or dodecyl exhibit outstanding efficacy in protecting organic substrates from light-induced deterioration as well as good resistance to loss by volatilization or exudation during the high temperature processing of stabilized compositions. The above-named compounds exhibit good solubility in common organic solvents, and exhibit very high extinction coefficients.
    Type: Grant
    Filed: September 3, 1985
    Date of Patent: February 23, 1988
    Assignee: Ciba-Geigy Corporation
    Inventors: Raymond Seltzer, Roland A. E. Winter
  • Patent number: 4716159
    Abstract: The present invention is directed to pyridazino[4,3-c]isoquinolines of Formula I ##STR1## wherein R represents methyl, phenyl or substituted phenyl groups, R.sub.1 represents inter alia amino or substituted amino, alkoxy or cycloalkoxy groups, having pharmacological activity, to process for preparing them and to the pharmaceutical compositions containing them. The compounds of the invention possess anti-anxiety activity.
    Type: Grant
    Filed: July 30, 1986
    Date of Patent: December 29, 1987
    Assignee: Gruppo Lepetit, S.p.A.
    Inventor: Emilio Toja
  • Patent number: 4714698
    Abstract: The invention relates to new compounds of general formula ##STR1## wherein R.sub.1 represents an alkyl group,R.sub.2 represents a hydrogen atom, an alkyl group optionally substituted (except at the .alpha. carbon atom) by a hydroxy group, or represents a cycloalkyl group or an allyl, phenyl or benzyl group,R.sub.3 represents an allyl group, an alkyl group optionally substituted (except at the .alpha. carbon atom) by a hydroxy group, or represents a cycloalkyl group orR.sub.2 and R.sub.3 together with the nitrogen atom between them represent a straight-chained alkyleneimino group,the acid addition salts thereof, particularly the acid addition salts thereof with physiologically acceptable inorganic or organic acids which have valuable pharmacological properties, particularly a metastasis-inhibiting effect based on their selective tumour-PDE inhibiting effect, and pharmaceutical compositions containing these compounds or the physiologically acceptable acid addition salts thereof.
    Type: Grant
    Filed: June 17, 1985
    Date of Patent: December 22, 1987
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Josef Roch, Armin Heckel, Josef Nickl, Erich Muller, Berthold Narr, Rainer Zimmermann, Johannes Weisenberger
  • Patent number: 4713454
    Abstract: (6R)-Tetrahydro-L-biopterin of the following formula: ##STR1## is prepared by catalytically reducing L-erythrobiopterin or an acyl derivative thereof in the presence of an amine, at pH 10-13 and with a platinum-base catalyst and when one or more acyl groups still remain, then removing the acyl groups. (6R)-Tetrahydro-L-biopterin is effective for the treatment of certain serious neuroses and malignant hyperphenylalaniemia. The present invention has succeeded in preparing (6R)-tetrahydro-L-biopterin at a high asymmetric ration R/S and moreover with a high yield. Since the process of this invention makes use of an amine as a base, the process is free from admixture of any inorganic salt and can hence provide high-purity crystals with ease.
    Type: Grant
    Filed: January 23, 1986
    Date of Patent: December 15, 1987
    Assignees: Shiratori Pharmaceutical Co., Ltd., Suntory Limited
    Inventors: Hideaki Sakai, Tadashi Kanai
  • Patent number: 4709041
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen or a hydroxy-protecting group are disclosed. The compounds are versatile intermediates which can be derivatized by reaction of the formyl group to provide a wide variety of ultraviolet-absorbing substituted 2-(2-hydroxyphenyl)-2H-benzotriazoles.
    Type: Grant
    Filed: August 25, 1986
    Date of Patent: November 24, 1987
    Assignee: Polaroid Corporation
    Inventor: Avinash C. Mehta