Abstract: A self dosing skin composition and method releases sun blocking agent or other active ingredient onto the skin of a user as a function of exposure to at least one environmental condition over time. The environmental condition is preferably exposure to sun light, in particular, harmful UV radiation. The composition includes a medium adapted to be spread onto the skin of a user and a reservoir defining at least one wall for containing at least one sun blocking or other agent. The reservoir is dispersed in the medium and the wall is designed and/or selected to deteriorate over time with exposure to the environmental condition or conditions, for releasing the agent into the medium and onto the skin. At least one agent is provided in the reservoir.

Abstract: A viscous hydrogel composition, for use in a topical treatment of a skin condition involving dry or inflammed skin, comprising an antimicrobially active nitroimidazole drug, a water miscible alkylene glycol, a bydroxyalkyl cellulose gelling agent and water, buffered to have a physiologically acceptable pH and a method of making the same.

Abstract: Disclosed is a process for preparing water-in-oil type emulsion cosmetic compositions containing L-ascorbic acid. The use of 2-hydroxypropyl cyclodextrin and a water-in-oil type emulsion allow L-ascorbic acid itself to be preserved for a lengthy period of time with high functional maintenance. Even after being stored for a significant period of time, the water-in-oil type emulsion cosmetic compositions do not exhibit discoloration nor give out offensive odor nor show the separation of cosmetic ingredients. In addition, the cosmetic compositions keep L-ascorbic acid high in the effective whitening activity, such as melanin reduction and inhibitory activity against tyrosinase.

Abstract: Use of ascorbic acid derivatives of the formula I where the variables independently of one another have the following meanings: R1 is hydrogen, C1-C20-acyl, C1-Cl2-alkoxycarbonyl, C1-C12-alkyl, R2 is hydrogen, C1-C20-acyl, C1-Cl2-alkoxycarbonyl, C1-C12-alkyl, where R1 and R2, together with the oxygen atoms to which they are bonded and the carbon atoms bonded to the oxygen atoms, can form an unsubstituted or substituted heterocycle, R3 is hydrogen or a cation selected from the group consisting of NH4+, alkali metal and alkaline earth metal cations, R4 is C1-C12-alkoxycarbonyl, for cosmetic and pharmaceutical preparations is described.

Abstract: The present invention relates to a deodorant composition, in particular a cosmetic composition, comprising, as odor-absorbing agent, at least one water-soluble zinc salt, and preferably zinc pyrrolidonecarboxylate, to the use of the composition for the manufacture of cosmetic products intended for human topical application, in particular deodorants, to a process for treating human axillary smells, and to the use of a water-soluble zinc salt as, preferably sole, an odor-absorbing agent in a deodorant composition. The composition is particularly intended for formulations comprising an aqueous phase: aqueous lotions, emulsions and preferably water-in-silicone emulsions.

Abstract: By combining dihydroxyacetone as the active skin coloring agent in combination found with a blend of dispersion polymers and polyester polymers, an easily employed, self-tanning formulation is realized which produces a long lasting, naturally appearing coloring of the skin without any orange pigmentation being produced. In addition, tan colored skin produced by the present invention maintains the desired color for extended periods of time. In the present invention, the dispersion polymers stabilize the dihydroxyacetone as well as provide a thickening agent for the composition. In addition, the present invention also incorporates an oil soluble polyester polymer in combination with the other ingredients which achieves a formulation which provides a slow release of the active ingredient.

Abstract: Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.

Abstract: Photoaging skin care preparations and methods of treating wrinkled skin are described. The photoaging skin care preparations contain at least one triterpenoid derivative which is a substituted form of ursolinic, oleanolic, or betulic acid. The photoaging skin care preparations inhibit photoaging and prevent and ameliorate wrinkled skin. The methods of treating wrinkled skin involve applying an effective amount of the skin care preparation to the wrinkled skin.

Abstract: A method and composition for treating hypertrophic scars so as to reduce the size and approve the appearance of scars comprises applying to the scar a composition comprising a film-forming carrier such as a Collodion which contains one or more active ingredients such as a topical steroid, silicone gel and vitamin E. Novel compositions using the Collodion film-forming carrier are also useful to treat a variety of adverse skin disorders.

Abstract: An endless belt in which a fibrous material is dispersed in a substantially uniform manner all over an endless elastic body layer is provided. A non-woven tape is impregnated with a polyurethane elastomer material liquid and wound and layered on a supporting belt, and then, after curing the polyurethane elastomer material liquid to form an elastic body, it is removed from supporting belt.

Abstract: The use of acetyl L-carnitine and its pharmacologically acceptable salts is disclosed for producing a composition suitable for controlling mood disorders mainly in young individuals who are not affected by permanent pathological CNS disturbances.

Abstract: Pharmaceutical composition comprising (S)-N-ethyl-3-[1-dimethylamino)ethyl]-N-methyl-phenyl-carbamate in free base or acid addition salt form and an anti-oxidant. Said pharmaceutical compositions may be delivered to a patient using a transdermal delivery device.

Abstract: A cosmetic or dermatological composition, comprising: an aqueous phase dispersed in an oily phase with a silicone emulsifying agent, wherein the viscosity of the composition, measured with a Rheomat 180 viscometer at a shear rate of 200 s−1 and at 25° C., ranges from 3 Pa.s (30 poises) to 20 Pa.

Abstract: Germicidal composition for incorporation into polymeric materials molded to form germicidally protected conveyor components used for food handling. Germicidally protected conveyor components are also provided.

Abstract: The invention relates to anhydrous compositions that are useful as UV-light screens for mammalian skin. Such compositions comprise octocrylene, octyldodecyl neopentanoate, and a C1-C4 alcohol vehicle. The invention also relates to methods of inhibiting or preventing UV light-induced skin damage by administering an effective amount of such a composition to the skin of a mammal in need of such inhibition or protection.

Abstract: The present invention relates to an isosorbide dinitrate-containing patch, in which an adhesive layer comprising an adhesive composition is formed on a flexible support, and the adhesive composition consists of an acrylic-based adhesive (A), a polyvinyl acetate-based adhesive (B), a plasticizing component (C) and isosorbide dinitrate (D), and satisfies the following weight ratios (1) through (3) of each of the components: (1) A:B=70:30 to 10:90, (2) the weight ratio of the component C based on the adhesive composition is 10 to 40% by weight, and (3) the weight ratio of the component D based on the adhesive composition is 20 to 35% by weight. Provided is a patch excellent in percutaneous absorption, handleability, resistance to skin irritation, sustained release, adhesivity, etc.

Abstract: Pharmaceutical composition comprising (S)-N-ethyl-3-[1-dimethylamino)ethyl]-N-methyl-phenyl-carbamate in free base or acid addition salt form and an antioxidant. Said pharmaceutical compositions may be delivered to a patient using a transdermal delivery device.

Abstract: Methods of treating diseases of ocular tissues expressing the nuclear receptor PPAR&ggr;, by inhibiting the inflammatory response, the neovascularization and angiogenesis, and programmed cell death (apoptosis) in these target tissues, comprising administering to a human or animal in need of treatment an effective amount of a compound that modifies the activity of PPAR&ggr;, or pharmaceutically acceptable salts and solvates thereof.

Abstract: An improved method of treatment for anxiety and/or depression provides a quicker and more robust anxiolytic/antidepressant activity to a patient suffering from depression. The method comprises the concurrent administration of effective doses of certain azapirones, such as buspirone, given in a manner that suppresses formation of the 1-(2-pyrimidinyl)piperazine metabolite; and a 5-HT1A autosomal receptor antagonist, such as pindolol.

Abstract: The invention includes a patch and method for transdermal delivery of bupropion base. In the method of this invention, a patient is administered a bupropion base in an amount effective to alleviate withdrawal symptoms and to prevent or reduce craving of nicotine in said patient. Alternatively, an effective amount of bupropion base is delivered to alleviate depression in a patient or to treat obesity. A transdermal patch includes a bupropion base. The bupropion base can be mixed with an acceptable pharmaceutical carrier.