Abstract: This invention relates to unsymmetrical mono-3-nitro bis-naphthalimides of formula ##STR1## including (R,R)-2-{2-[2-((2-(1,3-dioxo-1H-benz[de]isoquinolin-2-(3H)-yl)-propylamino ))ethylamino]-1-methylethyl}-5-nitro-1H-benz[de]isoquinolin-1,3-(2H)-dione, processes for their preparation, pharmaceutical compositions containing them, and methods of using them to treat cancer, particularly solid tumor carcinomas, in mammals.
Type:
Grant
Filed:
February 11, 1993
Date of Patent:
December 27, 1994
Assignee:
The Du Pont Merck Pharmaceutical Company
Inventors:
Robert F. Kaltenbach, III, Jung-Hui Sun, Robert J. Cherney, Steven P. Seitz
Abstract: Disclosed are a dye having a structural formula (I): ##STR1## where n is form 1 to 15, and a solution containing the dye. The dye is highly stable and has a characteristic color hue, and it is insoluble in water. The dye is expected to be useful in various fields of coating materials, dyes, cosmetics and food additives.
Abstract: Dyed raw cellulose can be bleached in a bleaching and after-treatment bath containing, in addition to usual stabilizers, cationic-monomeric and/or polymeric compounds and, if desired, nonionic surfactants. Bleaching is carried out with the aid of aqueous-hydrogen peroxide. The stabilizers that can be used and the cationic compounds are defined in the specification. Nonionic tensides, if their co-use is desired, are those of the class polyglycolethers.
Type:
Grant
Filed:
September 3, 1992
Date of Patent:
December 13, 1994
Assignee:
Bayer Aktiengesellschaft
Inventors:
Volker Kahle, Klaus Kackstadter, Karl-Heinz Passon, Martin Riegels, Klaus Walz
Abstract: A liquid alkali composition for use in fiber reactive dyeing of cotton and cotton blended fabrics or the like. The liquid alkali is a water-based solution of an alkali metal hydroxide and an alkali metal silicate. Preferably the composition is an aqueous mixture of potassium hydroxide and sodium silicate. In the most preferred embodiment the composition includes 35 wt % potassium hydroxide at a 45 wt % concentration, 25 wt % sodium silicate at 50.degree. Baume, 5 wt % of a borate, and the balance water. The resulting solution has a high enough pH to achieve reaction between the dye and fiber but is sufficiently buffered to achieve this reaction slowly so that the fiber reactive dyes fix in a level, uniform fashion.
Abstract: The present invention relates to a phosphatidyl chromanol derivative having the formula: ##STR1## wherein R.sub.1 and R.sub.2 represent a hydrogen atom, or a saturated or unsaturated fatty acid residue of 2-24 carbon numbers, n is an integer of 1-5 and X is a monovalent cation; a process for synthesizing the phosphatidyl chromanol derivative of the formula (3) which comprises reacting a phospholipid with a chroman derivative of the formula: ##STR2## wherein n is an integer of 1-5 using a phospholipase D and an antioxidant/emulsifier containing the compound of the formula (3).
Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: R.sub.1 is --CH.sub.3 or --CH.sub.2 CH.sub.3 unsubstituted or substituted by 1 to 3 fluorines;X is O or S(O).sub.s where s=0 to 2;R.sub.2 is C.sub.4 -C.sub.6 cyclic alkyl, optionally substituted by one to three methyl groups or one ethyl group; --CH.sub.2 -cyclopentyl, --CH.sub.2 -cyclopropyl, 3-tetrahydrofuranyl, C.sub.1-7 alkyl, CH.sub.3 or CH.sub.2 CH.sub.3 substituted by one to three fluorines;--(CH.sub.2).sub.n COO(CH.sub.2).sub.g CH.sub.3, or (CH.sub.2).sub.n O(CH.sub.2).sub.g CH.sub.3, wherein n is 2 to 4 and g is 0 to 2;R.sub.3 represents a moiety of formula (a); ##STR2## wherein R.sub.4 and R.sub.5 each represent hydrogen or R.sub.4 and R.sub.5 together represent a bond;B represents >C.dbd.O, >C.dbd.S or >CH--R.sub.6 wherein R.sub.6 represents H, OH, C.sub.1-6 alkoxy or C.sub.
Abstract: A modified alkali metal or ammonium huminate being made from molecules of the group consisting of ##STR1## wherein R.sub.1, R.sub.3 and R.sub.4 are individually hydrogen or --OH, R.sub.2 is ##STR2## or --CH.sub.2 -- and R.sub.5 and R.sub.6 are individually selected from the group consisting of hydrogen, --OH and --OCH.sub.3, with the proviso that R.sub.4, R.sub.5 and R.sub.6 are not all hydrogen at the same time and their preparation and their medical uses.
Abstract: Derivatives and analogues of 2-deoxy-2,3-didehydro-N-acetyl neuraminic acid, pharmaceutical formulations thereof, methods for their preparation .and their use in the treatment of viral infections, in particular influenza, are described.
Type:
Grant
Filed:
November 10, 1992
Date of Patent:
November 1, 1994
Assignee:
Biota Scientific Management Pty Ltd
Inventors:
Laurence M. von Izstein, Wen-Yang Wu, Tho V. Phan, Basil Danylec, Betty Jin
Abstract: A method for upgrading a petroleum material comprises charging the material into a vessel having a cylindrical wall, then heating the cylindrical wall. The petroleum material adjacent the wall is heated to a temperature sufficient to form a layer of carbon on the wall, and volatile material generated at the wall during the carbon formation passes through the bulk of the petroleum material thermally cracking it to form smaller molecules and simultaneously desulfurizing same.
Abstract: The invention relates to a catalyst comprising a rare metal of Group VIII of the Periodic Table of Elements which has been deposited on an inert support and which has been used to dehalogenate .alpha.-halogenated carboxylic acids in the presence of hydrogen, and a rare metal of Group VIII of the Periodic Table of Elements which has been deposited on an inert support and which is such that the granulometry of b) is very much lower than that of a) to form a homogeneous mixture as a result of the action of currents of .alpha.-halogenated carboxylic acid and hydrogen.It is particularly useful for regenerating palladium catalysts used in the purification of crude monochloroacetic acid.
Type:
Grant
Filed:
October 16, 1992
Date of Patent:
October 18, 1994
Assignee:
Societe Elf Atochem S.A.
Inventors:
Yves Correia, Dominique Jourdain, Joseph Nowocien, Alexandre Salerno
Abstract: The invention relates to a process for the manufacture of 1,1,1,2-tetrafluorochloroethane and of pentafluoroethane.The process which consists of gas phase catalytic fluorination of at least one pentahaloethane of formula C.sub.2 HX.sub.2-n F.sub.3+n in which X denotes a chlorine or bromine atom and n the number 0 or 1, by hydrofluoric acid, is characterized in that a catalyst is employed consisting of a catalytic quantity of chromium in an oxidation state equal to or greater than 3 and of an activated charcoal as support.The selectivity for 1,1,1,2-tetrafluorochloroethane and pentafluoroethane reaches approximately 95% and even more.
Type:
Grant
Filed:
May 24, 1993
Date of Patent:
October 11, 1994
Assignee:
Societe Atochem
Inventors:
Bernard Cheminal, Eric Lacroix, Andre Lantz
Abstract: The synthesis and the biological evaluation of a series of basic ethers of 2-benzyl-3-arylbenzofurans as antitumor agents is described. These compounds bind significantly to the antiestrogen-binding sites but only poorly to the estrogen receptor sites and are cytotoxic to tumor cells. Some of these compounds also significantly inhibited de novo cholesterol biosynthesis in an estrogen receptor negative lymphoma cell line rich in antiestrogen-binding sites.
Abstract: In an etherification process that uses an FCC effluent as a source of isoolefins, the buildup of nitriles in an alcohol-containing stream that is recycled to the etherification zone is prevented by dragging at least a portion of the methanol-containing stream to the FCC reaction zone. As a result, the etherification catalyst deactivation rate is reduced.
Abstract: Avermectin derivatives are disclosed which incorporate two fluorine atoms at the 4' monosaccharide position, the 4" disaccharide position or the 23 position. Avermectin aglycone derivatives are also disclosed which incorporate two fluorine atoms at position 13 or 23. These difluoro avermectin analogs are derived from corresponding ketones and enones which in turn are prepared by chemical modification of naturally occurring avermectins. These compounds are used as antiparisitic, insecticidal and antihelmintic agents in humans and animals and compositions containing such compounds as the active ingredient thereof are also disclosed.
Type:
Grant
Filed:
June 10, 1993
Date of Patent:
September 27, 1994
Assignee:
Merck & Co., Inc.
Inventors:
Peter T. Meinke, Helmut Mrozik, Michael H. Fisher
Abstract: Process for pharmaceutical grade high purity hyodeoxycholic acid preparation starting from swine bile, consisting in the treatment of swine bile with sodium hydroxide, isolation of hyodeoxycholic, chenodeoxycholic and hyocholic acids by precipiation of their zinc salts and subsequent selective precipitation of the hyodeoxycholic acid magnesium salt, from which the acid is freed by acidification and then crystallized.
Abstract: A method and system for removing hydrogen sulfide from a continuous aqueous phase-containing fluid without forming a sulfur sludge. Oil is either initially present in the fluid or added thereto.
Type:
Grant
Filed:
November 10, 1992
Date of Patent:
September 13, 1994
Assignee:
Union Oil Company of California
Inventors:
Christohper R. Culver, Clifford D. Juengst
Abstract: In a fuel cell comprising a pair of gas-diffusion electrodes provided with a porous catalyst layer and an acidic electrolyte layer held by the pair of gas-diffusion electrodes, a cathode which constitutes itself one of the pair of gas-diffusion electrodes comprises a heat-resistant and acid-resistant carrier particles and a noble metal catalysts carried on the carrier particles, the surface of the carrier particles and the catalysts being coated with a proton-conductive thin film exhibiting the ability to dissolve and diffuse oxygen and offering resistance to heat and acids or at least the surface of the noble metal catalysts being coated with a thin film which is a polymer network retaining a proton-conductive substance capable of dissolving and diffusing oxygen and resisting heat and acids therein.
Abstract: Disclosed are the improvements of a process for the preparation of 1,3-butylene glycol, in which the generation of by-products can be decreased, resulting in being capable of producing 1,3-butylene glycol having high quality (e.g. an odorless, so-called "cosmetic grade") at a high-yield.
Abstract: A method for reducing the cold water bleed propensity of acid and premetallized acid dyed cationic dyeable nylon fibers which comprises treating such fibers with sulfonated anionic polymers, useful as nylon fixing agents, and cationic amine based polymers, useful as cotton fixing agents.
Abstract: A process flow sequence for the reduction of polymer fouling while maintaining efficient production levels wherein a dual pressure, dual column configuration is used to effect the reduction in polymer fouling. The dual pressure, dual column configuration of the invention uses a high pressure and a separate low pressure to isolate the desired fractions while effecting a reduction in the production of fouling polymers.
Type:
Grant
Filed:
September 24, 1992
Date of Patent:
August 30, 1994
Assignee:
Exxon Chemical Patents Inc.
Inventors:
Sheri R. Snider, David A. Bamford, Rimas V. Vebeliunas, Roy T. Halle, Robert D. Strack