Abstract: There is provided a heart rate detection device including a sensing unit for sensing emergent light from subcutaneous tissues illuminated by a single light source of multiple light colors to output multiple light detection signals associated with multiple wavelengths. The heart rate detection device further includes a processor uses the multiple light detection signals associated with the multiple wavelengths to cancel motion artifact to obtain a clean heart rate signal.

Abstract: Systems and methods are described to determine joint center of rotation during a procedure. Joint center measurements may be useful to determine other clinically relevant measurements and/or to assist with replacement surgery.

Abstract: An apparatus and method is provided for intraoperative tissue stimulation during port-based surgery. The apparatus includes an access port and electrical terminals attached to the access port for tissue stimulation. In an alternative embodiment, the apparatus may include an access port, with or without electrical terminals attached to the access port for tissue stimulation, and electrocorticography sensors attached to the access port. The method includes inserting an access port into a tissue, applying an electrical potential to the tissue using electrical terminals attached to the access port, and measuring consequent neural activity using electrocorticography sensors attached to the access port.

Abstract: A method of generating a 3D ultrasound image includes acquiring a 3D volumetric data set corresponding to a 3D imaging volume of an ultrasound probe in a 3D detection volume; acquiring a position of the ultrasound probe with respect to the 3D detection volume; acquiring a position of an interventional medical device with respect to the 3D detection volume; determining a position of the interventional medical device relative to the 3D imaging volume of the ultrasound probe; determining an interventional medical device-aligned plane that intersects with a longitudinal axis of the interventional medical device; extracting a texture slice from the 3D imaging volume for a corresponding interventional medical device-aligned plane positional and rotational orientation; mapping the texture slice onto the interventional medical device-aligned plane; and rendering the interventional medical device-aligned plane as a 3D ultrasound image and displaying the rendered 3D ultrasound image on a display screen.

Abstract: The invention is a device, system, and method for providing an initial assessment of potential heart valve disease and recommending and/or providing follow-up assessments for heart valve disease. The invention includes a simple ECHO device which uses ultrasonic signals to detect and determine maximum blood flow velocities, and compares the maximum blood flow velocities to set thresholds to determine if it is appropriate for the patient to be subjected to additional and more detailed assessments for heart valve disease.

Abstract: Human and animal biofilms and pathogens are treated with extracorporeal acoustic pressure shock waves at a location of prosthesis or implant in a body.

Abstract: The present disclosure provides a device for carrying out magnetic resonance imaging compatible optogenetics; and methods for using the device.

Abstract: The disclosure herein provides methods, systems, and devices for virtually staining biological tissue for enhanced visualization without use of an actual dye or tag by detecting how each pixel of an unstained tissue image changes in waveform after staining with a certain dye(s) and/or tag(s) or other transformation under a certain electromagnetic radiation source, developing a virtual staining transform based on such detection, and applying such virtual staining transform to an unstained biological tissue to virtually stain the tissue.

Abstract: Cystic lesions can be treated by electroporation. For example, this document describes methods and devices for endoscopic ultrasound-guided ablation of cystic lesions using a needle for electroporation.

Abstract: A medical device includes a flexible elongate instrument, an actuator for inserting and retracting the instrument, and a control unit configured to determine at least one of a force being exerted by the actuator or an amount of force applied at a proximal end of the instrument. The control unit is configured to determine a force exerted by the instrument on tissue of a patient based on a shape of the instrument and at least one of the force exerted by the actuator or the force applied at the proximal end. A method of operating a medical device includes: determining a shape of a flexible elongate instrument and at least one of a first force exerted by an actuator or a second force applied to a proximal end; and determining a third force, exerted on tissue, based on the shape and at least one of the first or second forces.

Abstract: Apparatus, including a probe having an insertion tube and a section connected to the insertion tube. A camera is attached to the section and a magnetic field sensor coil, having a first coil axis of symmetry, is also attached with the first axis parallel to a camera direction of view. Another magnetic field sensor coil, which has a second coil axis of symmetry, is attached to the insertion tube with the second axis perpendicular to the camera direction of view. A processor receives signals generated by the coils and in response to signals received at a first time, identifies an initial orientation of an initial image produced by the camera. In response to signals received at a second, subsequent, time, the processor identifies a subsequent orientation of a subsequent image and rotates the subsequent image on a display so as to reorient the subsequent image to the initial orientation.

Abstract: A fractionated photoacoustic flow cytometry (PAFC) system and methods for the in vivo detection of target objects in biofluidic systems (e.g., blood, lymph, urine, or cerebrospinal fluid) of a living organism is described. The fractionated system includes a fractionated laser system, a fractionated optical system, a fractionated acoustic system, and combinations thereof. The fractionated laser system includes at least one laser or laser array for pulsing a target object within the circulatory vessel with fractionated focused laser beams. The fractionated optical system separates one or several laser beams into multiple beams in a spatial configuration on the skin above the circulatory vessel of the living organism. The fractionated acoustic system includes multiple focused ultrasound transducers for receiving photoacoustic signals emitted by the target object in response to the fractionated laser beams.

Abstract: An OCT (Optical Coherence Tomography) handheld device is provided comprising: a housing configured for handheld OCT scanning during a surgical procedure, the housing comprising an OCT scanning end and a proximal end opposite the OCT scanning end; an OCT scanning device inside the housing, the OCT scanning device configured for one or more of OCT polarized scanning and Doppler OCT scanning from the OCT scanning end, the OCT scanning device further configured to receive and convey OCT light between the proximal end and an OCT analysing system; and a tip extending from the OCT scanning end, the tip being removably attached to the OCT scanning end, the tip configured to receive and collect the OCT light therethrough. The OCT handheld device is configured to be removably draped around the tip, for use in the surgical procedure.

Abstract: A medical probe includes a tubular distal end section, which is configured to be inserted into a cavity of a patient, and includes (a) a visually guiding object disposed over a perimeter of the distal end section, and (b) a magnetic field sensor including two sensor coils aligned non-parallel with each other, the sensor attached to the distal end section, and having: (i) a first axis of symmetry, of one of the coils, which is aligned perpendicular to a central longitudinal axis of the distal end section, and (ii) a second axis of symmetry, of the remaining coil, which is aligned perpendicular to the central longitudinal axis of the distal end section and not parallel to the first axis of symmetry.

Abstract: A system and method for locating a medical device within a body uses wireless technology to transmit the information obtained from the sensors to a mobile device or other computing system. A software application on the mobile device or computing system can be used to display the information, wherein the user can control the display without needing to contact any items that are not sterile.

Abstract: An electromagnetic tomography system for gathering measurement data pertaining to a human head includes an image chamber unit, a control system, and a housing. The image chamber unit includes an antenna assembly defining a horizontally-oriented imaging chamber and including an array of antennas arranged around the imaging chamber. The antennas include at least some transmitting antennas and some receiving antennas. The control system causes the transmitting antennas to transmit a low power electromagnetic field that is received by the receiving antennas after passing through a patient's head in the imaging chamber. A data tensor is produced that may be inversed to reconstruct a 3D distribution of dielectric properties within the head and to create an image. The housing at least partially contains the antenna assembly and has a front entry opening into the imaging chamber. The head is inserted horizontally through the front entry opening and into the imaging chamber.

Abstract: An ultrasonic probe for acquiring an ultrasonic image is provided. The ultrasonic probe includes a transducer generating an ultrasonic signal and including a lens provided to transmit the ultrasonic signal to the outside, a case accommodating the transducer and having an opening at one side so that the lens is brought into contact with an external target object, and a buffer member provided along a circumference of the transducer to protect the transducer from external impact and disposed between the case and the transducer.

Abstract: Techniques, systems, and devices are disclosed for ultrasound diagnostics using spread spectrum, coherent, frequency- and/or phase-coded waveforms.

Abstract: A surgical robot system includes a surgical robot, a robot arm connected to such surgical robot, and an end-effector connected to the robot arm. A registration fixture is used in conjunction with various registration systems in the surgical robot system. Such registration systems likewise include a detachable base in the form of a detachable dynamic reference base, along with an associated mount, the dynamic reference base and mount having certain features which permit the dynamic reference base to be selectively attached, detached, and reattached at different phases of an operation, whether pre-operative or intra-operative, and such successive attachments are done without the dynamic reference base, and tracking markers associated therewith, losing registration. Related methods allow for the more efficient and effective performance of operations by virtue of the dynamic reference base maintaining its registration during attachments and reattachments.

Abstract: Methods and systems for alignment of a subject for medical imaging are disclosed, and involve providing a reference image of an anatomical region of the subject, the anatomical region comprising a target tissue, processing the reference image to generate an alignment reference image, displaying the alignment reference image concurrently with real-time video of the anatomical region, and aligning the real-time video with the alignment reference image to overlay the real-time video with the alignment reference image. Following such alignment, the subject may be imaged using, for example, fluorescence imaging, wherein the fluorescence imaging may be performed by an image acquisition assembly aligned in accordance with the alignment.