Abstract: A method and system for registering a pre-operative 3D medical image volume of a target organ to intra-operative ultrasound images is disclosed. An intra-operative 3D B-mode ultrasound volume and an intra-operative 3D ultrasound elastography volume are acquired. Patient-specific boundary conditions for a biomechanical tissue model of a target organ are determined using the intra-operative 3D B-mode volume. Patient-specific material properties for the biomechanical tissue model of the target organ are determined using the 3D ultrasound elastography volume. The target organ in the pre-operative 3D medical image volume is deformed using the biomechanical tissue model with the patient-specific material properties with the deformation of the target organ in the pre-operative 3D medical image volume constrained by the patient-specific boundary conditions.

Abstract: A position is determined for each fiducial marker of a plurality of fiducial markers in an image volume. Based on the determined positions, a position and orientation of the registration fixture with respect to the anatomical feature is determined. A position is determined for each tracked marker of a first plurality of tracked markers on the registration fixture and a second plurality of tracked markers on the robot arm in a tracking data frame. Based on the determined positions of tracked markers, a position and orientation of the registration fixture and the robot arm of a surgical robot with respect to the tracking space are determined.

Abstract: Disclosed embodiments provide an apparatus and method for imaging breast tissue of a subject, wherein a subject is positioned on a structure so that at least a portion of the subject's body is supported by the structure, magnetic resonance imaging is performed on the portion of the subject's body using an MRI system including a plurality of MRI coils positioned in proximity to the structure, wherein, while the portion of the subject's body is positioned upon the structure, breast tissue of the subject's body is compressed in the proximity of plurality of MRI coils.

Abstract: A method and a system for producing images of a subject, such as the heart of a human being. The method may comprise acquiring ultrasound images of the subject with a catheter comprising a position sensor. The method may also comprise capturing a plurality of 4D surface registration points in the acquired ultrasound images corresponding to points on the subject. The method may also comprise registering, in space and time, a high-resolution 4D model of the subject with the plurality of 4D surface registration points. The method may also comprise displaying high resolution, real-time images of the subject during a medical procedure based on the registration of the high resolution 4D model to the 4D surface registration points. Embodiments of the present invention are especially useful in left atrium ablation procedures.

Abstract: A fusion-imaging method for radiofrequency ablation is provided, including: obtaining preoperative volume image of an individual; reconstructing a virtual three-dimensional model of a target area of the individual according to the preoperative volume image; creating a global reference frame by a tracking device and registering the virtual three-dimensional model to the global reference frame; obtaining an ultrasound image of the target area by using an ultrasonic probe and tracking the ultrasonic probe by the tracking device in order to register the ultrasonic image to the global reference frame; capturing a virtual corresponding image corresponding to a portion of the virtual three-dimensional model along a plane of the ultrasonic image; and overlapping the ultrasonic image and the virtual corresponding image and simultaneously displaying the overlapping image and a virtual radiofrequency ablation probe model.

Abstract: Systems and methods are disclosed for assessing the severity of plaque and/or stenotic lesions using contrast distribution predictions and measurements.

Abstract: A contactless system for measuring and continuously monitoring arterial blood pressure includes a light source configured to illuminate light having at least one predetermined wavelength at a predetermined area of a human subject having an artery therein. A detector responsive to reflected light from the predetermined area to continuously acquire images of the artery in the predetermined area. A processor processes the images and determines when an image at a proximal location of the predetermined area is darker indicating transition of a pulse wave into the artery at the proximal location and at a proximal time and when an image at a distal location of the predetermined area is darker indicating transition of the pulse wave into the artery at a distal location at a distal time to contactlessly and continuously calculate the arterial blood pressure for each cardiac cycle of the human subject.

Abstract: A magnetic resonant imaging (MRI) review workstation includes a control processor, and a display integrated or otherwise operatively coupled with the control processor, wherein the control processor is configured to receive and analyze magnetic resonant imaging information pertaining to an imaged volume of tissue, and to cause to be displayed on the display output information that reflects or is otherwise indicative of an absorption rate of a contrast agent in the volume of tissue.

Abstract: An image capturing apparatus for a breast examination in which a breakthrough mammary gland density can be adduced. A mammary gland density is calculated by recognizing a distribution of mammary gland tissues of a subject according to a distribution of radioactive pharmaceuticals distributed in a breast. An imaged image of the distribution of the radioactive pharmaceuticals is one type of function image, and represents activity in the subject. Therefore, it is possible to calculate the mammary gland density based on a mammary gland tissue of which the activity is active (an active mammary gland tissue) in the mammary gland tissues.

Abstract: A system for robotic surgery makes use of an end-effector which has been configured so that any selected one of a group of surgical tools may be selectively connected to such end-effector. The end-effector makes use of a tool-insert locking mechanism which secures a selected one of the surgical tools at not only a respective, predetermined height and angle of orientation, but also at a rotational position relative to an anatomical feature of the patient. The tool-insert locking mechanism may include interchangeable inserts to interconnect multiple tools to the same end-effector. In this way, different robotic operations may be accomplished with less reconfiguration of the end-effector. The end-effector may also include a tool stop which has a sensor associated with a moveable stop mechanism which may be positioned to selectively inhibit tool insertion or end-effector movement.

Abstract: A non-invasive, transcutaneous, real-time viral detection device that is configured for self-administration, e.g., at a user's home. In one embodiment, and after positioning the device relative to the human body part (e.g., the user's finger), light sources in the device are activated (excited), and resulting data captured. In particular, a set of Raman spectra are collected from a configured set of emitters and detectors in the device and delivered to a nearby receiver, preferably wirelessly. The receiver filters and de-convolves the Raman spectra producing a data set representative of the constituent elements in the user's tissue of interest. The data set is applied against a statistical classifier, e.g., a neural network that has been trained to recognize and distinguish the absence or presence of viral components, e.g., C-19, or its associated blood-borne acute phase reactants.

Abstract: The present invention relates to devices and methods for measuring vascular deficiency using Doppler ultrasound detection. Embodiments can be used to monitor the condition of surgical tissue flaps or other conditions in which obstruction in the vascular system can impact patient health. The systems can include a Doppler ultrasound probe, a color probe, a temperature probe, and/or other suitable probes to measure blood volume and perfusion status of a tissue region. The systems and methods can be used to monitor flaps after flap transplant surgeries. The systems and methods can automatedly assess tissue condition and alert the patient or medical staff if the condition has fallen below a threshold indicating occlusion of a blood vessel. One or more additional sensors can be integrated into a probe to measure vascular conditions and a metric can be computed based on sensed data.

Abstract: Embodiments of the present disclosure provide methods, apparatuses, devices and systems for measuring vital signs in human and animals by interrogating electromagnetic signals reflected from tissues in a human or animal subject. Probes may transmit radio frequency electromagnetic waves into a living body and generate signals responsively to the waves that are scattered from within the body. Such embodiments may be suitable for wearable devices as well as for use by medical practitioners.

Abstract: Disclosed is an electronic apparatus comprising a mounting portion to which one of a plurality of optical heads is selectively mountable; a communicator configured to communicate with an external apparatus; an optical module (optical unit) configured to transmit light, which is reflected from a user's body and passed through the optical head mounted to the mounting portion, to the external apparatus; and a controller configured to obtain identification information about the optical head mounted to the mounting portion when one of the plurality of optical heads is mounted to the mounting portion, and control the communicator to transmit the identification information to the external apparatus. Thus, a desired optical head is mounted as necessary to capture an image of a user's body part, analyze the captured image, and provide analysis information to a user.

Abstract: A method of visualizing spinal nerves includes receiving a 3D image volume depicting a spinal cord and a plurality of spinal nerves. For each spinal nerve, a 2D spinal nerve image is generated by defining a surface within the 3D volume comprising the spinal nerve. The surface is curved such that it passes through the spinal cord while encompassing the spinal nerve. Then, the 2D spinal nerve images are generated based on voxels on the surface included in the 3D volume. A visualization of the 2D spinal images is presented in a graphical user interface that allows each 2D spinal image to be viewed simultaneously.

Abstract: Solid-state ultrasound imaging devices, systems, and methods are provided. Some embodiments of the present disclosure are particularly directed to compact and efficient ultrasound transducer scanner formed from a substantially cylindrical semiconductor substrate. In some embodiments, an intravascular ultrasound (IVUS) device includes: an ultrasound scanner assembly disposed at a distal portion of the flexible elongate member, the ultrasound scanner assembly including a semiconductor substrate having a plurality of transistors formed thereupon. The semiconductor substrate is curved to have a substantially cylindrical form when the ultrasound scanner assembly is in a rolled form, and the plurality of transistors are arranged in a cylindrical arrangement when the ultrasound scanner assembly is in the rolled form.

Abstract: There is provided a heart rate detection device including a sensing unit for sensing emergent light from subcutaneous tissues illuminated by a single light source of multiple light colors to output multiple light detection signals associated with multiple wavelengths. The heart rate detection device further includes a processor uses the multiple light detection signals associated with the multiple wavelengths to cancel motion artifact to obtain a clean heart rate signal.

Abstract: An ultrasound-enabled invasive medical device and a method of manufacturing the ultrasound-enabled invasive medical device. The ultrasound-enabled invasive medical device includes an invasive medical device, an electrical trace deposited either directly on the surface of the invasive medical device or onto an insulating layer covering at least a portion of the surface of the invasive medical device, where the electrical trace is deposited during an additive manufacturing process. The ultrasound-enabled invasive medical device includes an ultrasound transducer assembly attached to the invasive medical device and electrically connected to the electrical trace, and a transducer support structure attached to the invasive medical device, where the transducer support structure defines a nest that is adapted to receive the ultrasound transducer assembly.

Abstract: In certain aspects, the invention relates to processes for using renally excretable optical agents to detect one or more tissues of the renal system of a surgical patient. In certain aspects, the invention relates to a kit including a biocompatible composition containing one or more optical agents and instructions for using the optical agent(s) in a process of the present invention.

Abstract: A device for detection of internal bleeding in a patient's body is provided. An optical interface for transmitting IR light through an area of a skin of a patient and to collect IR light from the area of the skin, is provided. In some embodiments the optical interface includes one or more delivery components and one or more collection components. The delivery component includes a plurality of first optical channels configured to transmit the IR light through a plurality of respective first sub-areas on the area of the skin, into an internal layer of the body. The collection component includes a plurality of second optical channels, configured to collect IR light from a plurality of respective second sub-areas on the area of the skin.