Patents Examined by Mohammad Y. Meah
  • host cell having improved cellulolytic activity and enzymatic compounds produced with same
    Patent number: 11254956
    Abstract: The invention relates to a host cell, preferably a Myceliophthora thermophila cell, which presents a lower expression and/or secretion of non-contributory cellulolytic enzymes, preferably where the non-contributory cellulolytic enzyme is endoglucanase 6 comprising SEQ ID NO: 2, thereby promoting the presence of contributory cellulolytic enzymes in the enzymatic cocktail synthesised by said host cell. The invention also relates to the use of said host cells and the enzymatic cocktails synthesised by said host cells for the production of fermentable sugars of biomass and a method for producing bioproducts, preferably bioethanol, comprising the use of said host cell or the composition according to the invention.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: February 22, 2022
    Assignee: ABENGOA BIOENERGÍA NUEVAS TECHNOLOGÍAS, S.A.
    Inventors: Bruno Díez García, Noelia Valbuena Crespo, Francisco Reyes Sosa, Antonio Javier Moreno Pérez, Dolores Pérez Gómez, Ana Isabel Platero Gómez, Lucía Martín Pérez, Sandra Gavaldá Martín, Laura Viñas De La Cruz, Laura Sánchez Zamorano, Consolación Álvarez Núñez, María De Los Ángeles Bermúdez Alcántara, Javier Rocha Martín, Laura Ledesma García, Ricardo Arjona Antolín, Juan Luis Ramos Martín
  • Processes for recovering products from a corn fermentation mash
    Patent number: 11248197
    Abstract: Processes and systems for recovering products from a corn fermentation mash. In one example, a process for recovering products from a corn fermentation mash can include separating ethanol from a fermentation mash to produce a whole stillage. The fermentation mash can be derived from a ground corn product milled from a plurality of corn pieces. The plurality of corn pieces can include whole corn kernels, fragmented corn kernels, size-reduced corn kernels, milled corn kernels, or a mixture thereof. Greater than 25 wt % of the ground corn product can have a particle size of greater than 105 ?m and greater than 80 wt % of the ground corn product can have a particle size of 425 ?m or less, as measured according to AOAC 965.22-1966. The process can also include separating the whole stillage to produce a fiber rich portion and a filtrate.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: February 15, 2022
    Assignee: POET GRAIN (OCTANE), LLC
    Inventor: Jason Bootsma
  • Gene involved in synthesis of cyclic peptide compound, method for producing cyclic peptide compound using the same, and transformant comprising the same
    Patent number: 11230726
    Abstract: This invention is intended to identify a gene cluster involved in biosynthesis of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species and to establish a system for synthesizing such cyclic peptide compound. The gene is composed of a first module to a tenth module and encodes a protein having activity of synthesizing a nonribosomal peptide constituting a basic peptide backbone of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: January 25, 2022
    Assignees: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, TOHOKU UNIVERSITY, KUMIAI CHEMICAL INDUSTRY CO., LTD.
    Inventors: Takashi Kubo, Masayuki Machida, Maiko Umemura, Keietsu Abe, Akira Yoshimi, Tomonori Fujioka, Shigenari Yamaguchi, Kiyoshi Kawai
  • Method for enzymatic preparation of R-3 aminobutyric acid
    Patent number: 11220701
    Abstract: An R-3-aminobutyric acid preparation method with high efficiency and high stereoselectivity. The method comprises using aspartase with stereoisomerization catalytic activity derived from Escherichia coli to efficiently convert butenoic acid into R-3-aminobutyric acid. After only 24 h of reaction, the conversion rate is as high as ?98%, and the ee value is ?99.9%. The conversion efficiency is greatly improved, the reaction time is shortened, and the production costs are reduced. The method features a high yield, a high conversion rate, low costs, a short production cycle, a simple process, ease of enlargement, suitability for mass production and the like.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: January 11, 2022
    Assignee: ABIOCHEM BIOTECHNOLOGY CO., LTD.
    Inventors: Chuanmin Sun, Zhanbing Cheng, Jianghua Jiao, Shaonan Ding, Zhenhua Tian
  • Alkane oxidation by modified hydroxylases
    Patent number: 11214817
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: January 4, 2022
    Assignee: California Institute of Technology
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M. Y. Chen
  • Methods and kits for detection of coenzyme Q10
    Patent number: 11209422
    Abstract: The invention provides methods for rapid and quantitative extraction and detection of coenzyme Q10 in a sample readily adaptable to high throughput screening methods. The invention further provides reagents and kits for practicing the methods of the invention.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: December 28, 2021
    Assignee: Berg LLC
    Inventors: Shen Luan, Niven Rajin Narain, Rangaprasad Sarangarajan, Nikunj Narendra Tanna
  • Protecting group chemistry for clean, reductant-free dyeing
    Patent number: 11203774
    Abstract: The present disclosure relates to the biosynthesis of indigoid dye precursors and their conversion to indigoid dyes. Specifically, the present disclosure relates to methods of using polypeptides to produce indigoid dye precursors from indole feed compounds, and the use of the indigoid dye precursors to produce indigoid dyes.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: December 21, 2021
    Assignee: The Regents of the University of California
    Inventors: John Eugene Dueber, Zachary Nicholas Russ, Tammy Melody Hsu, Terry Don Johnson, Jr., Bernardo Cervantes, Ramya Lakshmi Prathuri, Shyam Pravin Bhakta, Arthur Muir Fong, III, Luke Nathaniel Latimer
  • Engineered phenylalanine ammonia lyase polypeptides
    Patent number: 11198861
    Abstract: The present invention provides engineered phenylalanine ammonia lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia lyase (PAL) polypeptides. Methods for producing PAL enzymes are also provided. In some embodiments, the engineered PAL polypeptides are optimized to provide enhanced catalytic activities that are useful under industrial process conditions for the production of pharmaceutical compounds.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: December 14, 2021
    Assignee: Codexis, Inc.
    Inventors: Scott J. Novick, Ravi David Garcia, Charlene Ching, Nikki Dellas, David Entwistle, Vesna Mitchell
  • Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system
    Patent number: 11193157
    Abstract: The present disclosure relates to the use of an amino acid dehydrogenase in combination with a cofactor regenerating system comprising a ketoreductase. In particular embodiments, the process can be used to prepare L-tert-leucine using a leucine dehydrogenase.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: December 7, 2021
    Assignee: Codexis, Inc.
    Inventors: Fabien Louis Cabirol, Steven J. Collier, Thomas Daussmann, Naga K. Modukuru
  • Mutant pore
    Patent number: 11186868
    Abstract: The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterisation using CsgG.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: November 30, 2021
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Lakmal Jayasinghe, Elizabeth Jayne Wallace
  • Yeast strain having improved capability for fermenting xylose in the presence of acetic acid
    Patent number: 11186814
    Abstract: The invention relates to a method for selecting a yeast strain having improved capability for fermenting a pentose, advantageously xylose, in the presence of organic acid, advantageously acetic acid, in non-dissociated form, in which at least one yeast strain that is capable of fermenting said pentose is consecutively cultured in the following two media: a first growth medium comprising said pentose as the only carbon source and said organic acid in non-dissociated form; a second growth medium comprising another carbon source as the only carbon source, advantageously glucose, free of said organic acid in non-dissociated form, the consecutive culture in at least said two growth media being repeated at least twice, in the presence of rising concentrations of organic acid in non-dissociated form.
    Type: Grant
    Filed: February 18, 2020
    Date of Patent: November 30, 2021
    Assignee: LESAFFRE et COMPAGNIE
    Inventors: Jean-Michel Bavouzet, Thomas Desfougeres, Georges Pignede, Jennifer Techel
  • Increased production of ginsenosides through yeast cell organelle improvement
    Patent number: 11186616
    Abstract: Provided are a recombinant yeast having improved ability to produce ginsenoside, which is prepared by overexpressing INO2 and INO4 or deleting OPT1 in a yeast having ability to produce ginsenoside, a method of preparing the yeast, and a method of producing ginsenoside by using the yeast.
    Type: Grant
    Filed: September 21, 2020
    Date of Patent: November 30, 2021
    Assignee: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Ju Young Lee, In Seung Jang, Seohyun Kim, Sun-Chang Kim, Suk Chea Jung, Jong Geon Jegal
  • Biosynthesis of products from 1-carbon compounds
    Patent number: 11186834
    Abstract: An engineered microbe that contains a designed platform for the conversion of one-carbon substrates to chemical products is described. The designed platform embodies a new metabolic architecture that consolidates carbon fixation, central metabolism, and product synthesis into a single pathway. This is made possible by the key finding that 2-hydroxyacyl-CoA lyase, an enzyme in the ?-oxidation pathway, is capable of catalyzing the C—C bond formation between formyl-CoA and aldehydes of different chain lengths, allowing for the elongation of the carbon backbone of said aldehyde by one-carbon units. These novel microbes present an opportunity for the production of chemicals from single-carbon feedstocks such as carbon dioxide, carbon monoxide, formate, formaldehyde, methanol or methane.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: November 30, 2021
    Inventors: Ramon Gonzalez, Alexander Chou, James Clomburg
  • Transformed fungus having enhanced ergothioneine productivity and method for producing ergothioneine
    Patent number: 11186855
    Abstract: The purpose of the present invention is to provide an organism having an ergothioneine productivity that is capable of easily producing ergothioneine within a short period of time at a high yield, as compared with a conventional technology, and, therefore, enables ergothioneine production on an industrial scale. This purpose can be achieved by a transformed fungus into which a gene encoding enzyme (1) or genes encoding enzymes (1) and (2) have been inserted and in which the inserted gene(s) are overexpressed. (1) an enzyme catalyzing a reaction of synthesizing hercynyl cysteine sulfoxide from histidine and cysteine in the presence of S-adenosyl methionine, iron (II) and oxygen. (2) An enzyme catalyzing a reaction of synthesizing ergothioneine from hercynyl cysteine sulfoxide using pyridoxal 5?-phosphate as a coenzyme.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: November 30, 2021
    Assignee: KIKKOMAN CORPORATION
    Inventors: Seiichi Hara, Keiko Kurosawa, Keiichi Ichikawa
  • Mixtures and compositions comprising strains or metabolites thereof and other biopesticides
    Patent number: 11185078
    Abstract: The present invention relates to novel mixtures comprising, as active components, at least one isolated bacterial strain, which is a member of the genus Paenibacillus, or a cell-free extract thereof or at least one metabolite thereof, and at least one other biopesticide. The present invention also relates to compositions comprising at least one of such bacterial strains, whole culture broth or a cell-free extract or a fraction thereof or at least one metabolite thereof, and at least one other biopesticide. The present invention also relates to a method of controlling or suppressing plant pathogens or preventing plant pathogen infections by applying such composition. The present invention also relates to mixtures of fusaricidins which are pesticidal metabolites produced by the abovementioned strains, and other biopesticides.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: November 30, 2021
    Assignee: BASF SE
    Inventors: Isabella Siepe, Thorsten Jabs, Burghard Liebmann, Annette Schuster
  • Organisms for the production of 1,3-butanediol
    Patent number: 11180780
    Abstract: A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: November 23, 2021
    Assignee: Genomatica, Inc.
    Inventors: Anthony P. Burgard, Mark J. Burk, Robin E. Osterhout, Priti Pharkya
  • GH10 xylanase, GH62 arabinofuranosidase, milling process and other application
    Patent number: 11180786
    Abstract: The present invention provides an improved process of treating crop kernels to provide a starch product of high quality suitable for conversion of starch into mono- and oligosaccharides, ethanol, sweeteners. The present invention also provides polypeptides having GH10 xylanase activity, polypeptides having GH62 arabinofuranosidase activity and the uses thereof.
    Type: Grant
    Filed: November 24, 2017
    Date of Patent: November 23, 2021
    Assignee: Novozymes A/S
    Inventors: Yi Cao, Yu Zhang, Bernardo Vidal, Jr., Randall Scott Deinhammer, Mary Ann Stringer, Ye Liu, Purna Venkatesh, Cui Liu
  • Genetically modified acetogenic cell
    Patent number: 11174496
    Abstract: There is provided an acetogenic microbial cell which is capable of producing at least one higher alcohol from a carbon source, wherein the acetogenic microbial cell is genetically modified to comprise an increased expression relative to its wild type cell of at least one enzyme, E8, a butyryl-CoA:acetate CoA transferase (cat3). There is also provided a method and use of the cell to produce higher alcohols.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: November 16, 2021
    Assignee: Evonik Operations GmbH
    Inventors: Thomas Haas, Thomas Bülter, Anja Hecker
  • D-psicose 3-epimerase and method for preparing D-psicose using the same
    Patent number: 11174475
    Abstract: Provided are a novel D-psicose 3-epimerase and a method for preparing psicose using the same.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: November 16, 2021
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Su Jin Kim, Young Mi Lee, Yang Hee Kim, Seong Bo Kim, Seung Won Park, Seong Jun Cho
  • Enzymatic production of D-allulose
    Patent number: 11168342
    Abstract: The current disclosure provides a process for enzymatically converting a saccharide into allulose. The invention also relates to a process for preparing allulose where the process involves converting fructose 6-phosphate (F6P) to allulose 6-phosphate (A6P), catalyzed by allulose 6-phosphate 3-epimerase (A6PE), and converting the A6P to allulose, catalyzed by allulose 6-phosphate phosphatase (A6PP).
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: November 9, 2021
    Assignee: BONUMOSE, INC.
    Inventors: Daniel Joseph Wichelecki, Edwin O. Rogers