Abstract: The present invention is directed to a medicinal composition, and more particularly, to a composition of chlorhexidine to treat lesions, particularly lesions caused by cold sores and herpes. The composition comprises chlorhexidine as the active ingredient. The composition also comprises a component for pain relief and a component for anti-inflammation. These three components, which act efficaciously in concert, are then combined with a suitable emollient or vehicle to form a topical formulation effective to treat the symptoms of cold sores and herpes. The composition may be formulated as an over-the-counter (OTC) topical formulation.

Abstract: A 12-bromo-2,16-dioxa-9,9,18,18-tetramethylpentacyclo[7.7.5.01,21.03,8.010,15]henicosa3(8),10,12,14-tetraene-7,20-dione compound, its synthesis, and its use as an antimicrobial agent.

Abstract: This invention relates to dentifrice compositions comprising stannous fluoride and a silica abrasive having a N2 BET surface area of less than 50 m2/g and an Einlehner hardness of from 4 to 11, as well as to methods of using these compositions.

Abstract: A product for providing a customized color shade sunscreen product to match a skin tone of a subject is provided. The product comprises a color dose formulation, an instruction and optionally a sunscreen. The color dose formulation has high concentration of pigments and is suitable for being mixed with a sunscreen to prepare a customized color shade sunscreen product. Also is a method of preparing a customized color shade sunscreen product to match a skin tone of a subject. Such method comprises mixing a selected color dose formulation with a sunscreen. The color dose formulations may be selected from six color shade compositions that offer color shades suitable for all skin tones. The customized color shade sunscreen product may provide a sensorial benefit such as dry touch, good spreadability, no white residues, oil control and UV protection and visible light.

Abstract: A natural hair oil treatment product and methods of producing the hair oil and using the oil. The hair oil includes multiple vegetable oils and natural products that are combined in a multi-step process, with the products providing therapy and/or treatment for the hair and scalp.

Abstract: The present disclosure provides a composition for promoting hair growth including camellia kaempferol glycoside as an active ingredient. The composition for promoting hair growth according to an aspect of the present disclosure can promote hair growth by promoting the proliferation of hair follicle cells without side effects. In addition, the composition for promoting hair growth can promote hair growth and prevent hair loss by inhibiting the apoptosis of outer root sheath cells. Such a composition for promoting hair growth can be used as an external application to the skin, and can be used as a food, cosmetics or pharmaceutical composition.

Abstract: The present disclosure provides topical compositions of rofecoxib and methods of making said compositions. The present disclosure also provides methods of using topical compositions of rofecoxib to treat inflammation.

Abstract: The present invention relates to an extrudable photocrosslinkable hydrogel comprising a biochemically modified extracellular matrix (ECM) with an electroconductive nanomaterial embedded; a photoinitiator and a solvent, the method for its preparation starting from decellularized extracellular matrices (dECMs) and its applications for preparing electroconductive scaffolds, electroconductive extrudable hydrogels for in situ defect-filling, conductive grafts, in situ or in vitro printed tissues or organs, adhesives for different tissues, or bone adhesives.

Abstract: Nanoparticles including tacrolimus, and a method for providing nanoparticles including tacrolimus as well as to nanoparticles including tacrolimus that are obtainable by said method. Also relates to the nanoparticles including tacrolimus for use as a medicament. Further relates to a mucoadhesive buccal film containing the nanoparticles including tacrolimus and the mucoadhesive buccal film for use as a medicament, especially in pediatric patients.

Abstract: This disclosure provides a dry powder formulation of free amino acids with an acceptable and even good taste profile.

Abstract: A method of manufacturing a clay skin care mask comprising: admixing a lipid blend, polyglutamic acid, pomegranate sterol, barley extract, wheat germ oil, linoleic acid, Montamorillonite, Kaolin Clays, Silver, Zinc Oxide, Glycyrrhetinic Acid, Natural exfoliating beads, and silica beads.

Abstract: The present disclosure relates to thienyloxazolones and analogues thereof of formula (III) that may be used for protecting plants from bacterial diseases, in particular from bacterial diseases caused by bacteria belonging to the genus Xanthomonas.

Abstract: The specification generally relates to compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, where R, A1, A2 and A3 have any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent DNA-PK mediated disease, including cancer. The specification further relates to pharmaceutical compositions comprising such compounds and salts; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; intermediates useful in the manufacture of such compounds and salts; and to methods of treating DNA-PK mediated disease, including cancer, using such compounds and salts.

Abstract: The invention relates to a personal cleansing composition that delivers enhanced deposition of sunscreens on to the topical surface of the body. The composition more particularly provides for such wash off compositions that ensure that the sunscreens incorporated therein are stable and due to the high deposition on to surface provide high Sun Protection Factor (SPF). This is achieved through combination of two select water-soluble sunscreens in a high surfactant containing composition.

Abstract: A composition for treating acne includes an anti-acne active agent that includes salicylic acid, an emulsifier, an emollient, particles of zinc oxide, water and a humectant. The composition has a sun protection factor (SPF) of at least 5. The zinc oxide can be included in a powder with particles that are formed as aggregates of smaller particles which, when used in a dispersion at a concentration of 50 weight % of zinc oxide, produces a transparent composition.

Abstract: A topical lotion composition for promoting hair growth includes honey, Aloe vera gel, rosemary oil, coconut oil, olive oil, rose oil, almond oil, and vitamin E oil, in a base. Application of the topical lotion composition to a scalp of a user promotes hair growth.

Abstract: The present disclosure provides for topical emulsion comprising about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; and about 0.4% to about 4% carbomer; wherein particles comprising the Montelukast in the emulsion have D90 of less than about 50 wherein the Montelukast or pharmaceutically acceptable salt thereof is homogeneously dispersed in the emulsion, and wherein the emulsion has a pH of about 3.0 to about 6.5. The present disclosure also provides a topical gel comprising (a) about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; (b) about 0.2% to about 8% cellulose polymer; and (c) about 80% to about 95% amphiphilic compound; wherein the gel comprises less than 4% water.

Abstract: The present invention relates to a cosmetic composition to be used on the skin comprising the combination of a particular whitening system, a UVA filter system, and a combination of antioxidants for effectively whitening the skin, in particular the skin of the face, while also protecting these materials from the damages caused by UVA radiation.

Abstract: In one aspect, the disclosure relates to topical formulations, methods of making same, and methods of treating hair loss using same. In an aspect, the present disclosure pertains to topical formulations for treatment of hair loss and/or to increase hair growth, the formulation comprising: a therapeutic composition comprising therapeutically effective amounts of azelaic acid, minoxidil, finasteride, and duasteride; and one or more compounding agents. In a further aspect, the present disclosure pertains to a method of treating hair loss by applying a disclosed topical formulation. In a further aspect, the present disclosure pertains to a method of enhancing hair grow by applying a disclosed topical formulation. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: An improved broad-spectrum sunscreen formulation is provided. The sunscreen formulation comprises at least one organic sunscreen filter, at least one of which avobenzone, and an alkyl benzoate comprising 25-55 mole % C12-14 alkyl benzoate and 45-75 mole % C12-C15 alkyl benzoate.