Abstract: An improved process for the resolution of (+)-6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid into the corresponding enantiomers by using L-threo-(+)-2-amino-1-(4-nitrophenyl)-1,3-propanediol and L-threo-(+)-2-amino-1-(4-methylmercaptophenyl)-1,3-propanediol.

Abstract: A high yield process for preparing beta-lactam antibiotics having a high purity degree, in particular derivatives of the cephalosporanic and penicillanic acids, of the formula: ##STR1## by condensation of the compounds ##STR2## where X.dbd.H --OCH.sub.3 (suitably blocked), with a chloride of the formula ##STR3## wherein R.dbd.H, OH in which said condensation is carried out in the presence of a nicotinic or isonicotinic base.

Abstract: Aryl oxo-alkynoates are 5-lipoxygenase inhibitors, making them useful for the treatment of inflammation, chronic obstructive lung disease or psoriasis. These compounds have the formula: ##STR1## wherein n is 1-12;R.sup.1 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, or phenyl; andAryl is naphthyl, phenyl or phenyl substituted with a variety of groups.

Abstract: A process for preparing an optically active 2-(4-hydroxyphenoxy)propionic acid compound, which comprises reacting an optically active compound having the formula: ##STR1## wherein X is a chlorine atom or a bromine atom, and M is a hydrogen atom or an alkali metal atom, with hydroquinone or an alkali metal salt of hydroquinone, in the presence of an alkali metal hydroxide and water, and precipitating optically active disodium 2-(4-hydroxyphenoxy)propionate.

Abstract: This invention provides a process for producing an oxy-acetyl compound by carbonylating an oxy-methyl compound with carbon monoxide in the presence of a rhodium catalyst, an iodine compound, and a metallic accelerator, and also in the presence of at least one compound selected from the group consisting of boron compounds, bismuth compounds, and tertiary amide compounds in the reaction system. When at least one of the bismuth or boron compound is present in the reaction system, the carbonylation reaction can proceed without precipitation of any metallic accelerator.

Abstract: Polyhydroxy-substituted benz, phenylacet and mandelamidines, amidates, amidoximes and hydroxyamidoximes--ribonucleotide reductase inhibitors, and free radical scavengers.

Abstract: This invention relates to a process for converting propylene/butylene oligomers to dialkyl adipates where said adipates have higher flash points than conventionally prepared adipates.

Abstract: Halogenated aliphatic carboxylic acid fluorides are prepared by reacting halogenated aliphatic carboxylic acids with trihalogenomethyl aromatic compounds containing, as a predominant total or exclusively, fluorine atoms in the trihalogenomethyl groups, in particular with benzotrifluoride, in the presence of Lewis acids as catalysts. The reaction products are intermediate products having a multiplicity of uses.

Abstract: This invention relates to the hybridization of streptolydigin, tirandamycin and sorbic acid to penicillin and cephalosporin nuclei.

Abstract: A process for producing long-chained diesters of C.sub.22 and C.sub.32 diacids. The process comprises the steps of reacting cyclohexanone with an alcohol of 1-6 carbon atoms and hydrogen peroxide in the presence of an acid catalyst and water at a temperature below the boiling point of the alcohol. Methoxycyclohexyl hydroperoxide is thus produced and reacted with a terpene diene in the presence of a transition metal salt in a nitrogen atmosphere to produce long-chained diesters of C.sub.22 and C.sub.32 diacids. These long-chained diesters are then separated from the reaction mixture.

Abstract: Norbornane- and norbornene-carboxylic acid amides of the formula ##STR1## in which ##STR2## represents the part structure ##STR3## A represents a ##STR4## or --CH.sub.2 --CH.sub.2 -- group, R.sup.1 and R.sup.2 each independently is hydrogen or an alkyl radical with 1-6 carbon atoms,R.sup.3 is alkyl or alkenyl which has 1-8 carbon atoms and is optionally substituted by halogen or alkyl with 1 or 2 carbon atoms, cycloalkyl or cycloalkeny wtih 3 to 7 carbon atoms, an aromatic radical which has 6 or 10 carbon atoms and and is optionally substituted by halogen, by alkyl with 1 or 2 carbon atoms or by halogenoalkyl with 1 or 2 carbon atoms, or is a five-membered or six-membered heteroaromatic radical,R.sup.4 is hydrogen or a hydroxyl group,R.sup.5 and R.sup.6 each independently is hydrogen or alkyl with 1 to 4 carbon atoms, andn is a number from 2 to 6,and, if R.sup.1 is hydrogen, also physiologically acceptable salts thereof, perform as thromboxan antagonists.

Abstract: Amino acid ester hydrohalide is produced by reacting amino acid, alcohol, and halocarbonyl compound represented by the formula: ##STR1## in the presence of an excess of the alcohol and under substantially anhydrous conditions, wherein X.sub.1 and X.sub.2 are each independently fluoro, chloro, bromo, trichloromethoxy or tribromomethoxy.

Abstract: Sulfone-ester polymers containing pendent ethynyl groups and a direct and multi-step process for preparing same are disclosed. The multi-step process involves the conversion of a pendent bromo group to the ethynyl group while the direct route involves reacting hydroxy-terminated sulfone oligomer or polymers with a stoichiometric amount of 5-(4-ethynylphenoxy)isophthaloyl chloride. The 5-(4-ethynylphenoxy)isophthaloyl chloride and process for preparing same are also disclosed.

Abstract: The present invention is directed to 2-hydroxy-4-alkylidenecyclohexanealkanoic acids having a mercaptoalkanoic acid substituent at the 3-position. Esters and amides corresponding to the acids referred to above are also encompassed by the present invention. These compounds are useful in the treatment of bronchial asthma and they are obtained by the reaction of an appropriate 2,3-epoxy-4-alkylidenecyclohexanealkanoate with a mercapto alkanoic acid ester in the presence of a tertiary amine. The indicated process gives the esters of the present invention which can be hydrolyzed to the corresponding free acids by standard procedures. The compounds described can be subjected to other known reactions to give the other compounds of the present invention.

Abstract: Partially hydrogenated derivatives of 2-nitro-1,1,1-trifluoroalkanes, in particular 2-oximino- and 2-hydroxylamino-1,1,1-trifluoroalkanes, are prepared by catalytically hydrogenating 2-nitro-1,1,1-trifluoroalkanes until a maximum of 2.2 moles of hydrogen per mole of 2-nitro-1,1,1-trifluoroalkane have reacted.

Abstract: A process for the optical resolution of racemic mixtures of .alpha.-naphthyl-propionic acids of formula I ##STR1## which consists of reacting a racemic mixture of a compound of formula II ##STR2## with an optically active compound of formula IIIR.sub.4 --NH.sub.2wherein R.sub.4 is the residue of a primary or secondary alcohol which, taken with the NH.sub.2 radical, forms an optically active .beta.-aminoalcohol, to give a pair of diastereoisomeric amides, which is resolved into the single diastereoisomeric amides. Acid hydrolysis gives the optically active d or l .alpha.-naphthyl-propionic acids. The meaning of R.sub.1, R.sub.2, R.sub.3 is given.

Abstract: The invention relates to a process for the resolution of mixtures of D and L-6-methoxy-alpha-methyl-2-naphthaleneacetic acid in their respective antipodes.L-threo(+)-2-amino-1-p-nitrophenyl-1,3-propandiol is proposed as new resolving agent.

Abstract: A process for manufacturing synthesis gas (16) from hydrocarbons, water, free oxygen, and a transfer gas containing steam and carbon oxides. The transfer gas is passed through a succession of essentially adiabatic catalyst beds (2, 3, 4, 5, 6, 7) and the hydrocarbons (9, 10,11) and oxygen (13, 14, 15) are alternately introduced at the input of each catalyst bed. The transfer gas may be prepared by vivid combustion of hydrocarbon or by hydrocarbon steam-reforming.

Abstract: Disclosed is a method of optical resolution of DL-cysteine utilizing optically active mandelic acid. The method facilitates commercial production of optically active cysteine, particularly L-cysteine which is in great demand.

Abstract: A method for making a diester of oxalic acid which comprises oxidatively carbonylating an alcohol having 1 to 10 carbon atoms with carbon monoxide and with oxygen at a pressure from 1 to 700 bars and at a temperature from 20.degree. C. to 250.degree. C. in a reaction phase comprising said alcohol having dissolved therein a catalyst system consisting essentially of, as cations, ions of palladium(II) and copper ions in a molar ratio of at least 0.2 and, as anions, halide ions and carboxylate ions having 1 to 6 carbon atoms, the amounts of all ions in said catalyst system being such that the solution of the cations and anions in the alcohol has a formal pH value, as determined electrometrically, between 8 and 5.