Abstract: The invention relates to novel odorant substances. These are compounds of the formula ##STR1## wherein R and R.sup.1 are H, CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.sub.7 or CH(CH.sub.3).sub.2 and the sum of the carbon atoms in R and R.sup.1 does not exceed 6, and X is caran-yliden (2,2) or caran-yliden (4,4).The invention relates also to the preparation of these novel substances and to odorant compositions containing these substances.

Abstract: The invention discloses a method for purifying butylene oxide by using an anion exchange resin and an adsorbent. The anion exchange resin removes acid and aldehyde impurities while the adsorbent removes water impurities from the butylene oxide. Depending upon the impurity level, the purification steps can be conducted singularly or in combination, and the process can proceed either batchwise in a reactor or continuously in a column. The ion exchange resin of the choice is a sulfonated macroreticular anion exchange resin and the adsorbent of choice is a molecular sieve.

Abstract: Production of novel molybdenum dioxo dialkyleneglycolate compositions, especially adapted for use as catalysts in the epoxidation of olefinic compounds with an organic hydroperoxide, by reaction of molybdenum trioxide with particular dialkylene glycol compounds at specified elevated temperatures while removing water.

Abstract: A process is disclosed for preparing 3-substituted tetrahydrofuran, 3- and 4-substituted butyrolactones and mixtures thereof comprising hydrogenating a hydrogenatable precursor in the presence of an aqueous reaction medium and a catalyst comprising palladium and rhenium and at least one support selected from the group consisting of titanium oxide, zirconium oxide, and carbon.

Abstract: Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): ##STR1## and pharmaceutically acceptable salts of the compounds (II) in which Z is hydrogen are disclosed.

Abstract: An epoxy-sulfonylazide having the general formula ##STR1## wherein R is lower alkyl and R' is hydrogen or lower alkyl.

Abstract: Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): ##STR1## and pharmaceutically acceptable salts of the compounds (II) in which Z is hydrogen are disclosed.

Abstract: A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the anti-microbial compound CL-1957A which also exhibits antitumor properties.The antimicrobial compound CL-1957A is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957A compound is produced, and subsequently isolating the CL-1957A compound.The antibiotic compound CL-1957A and pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.

Abstract: A compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently represent a hydrocarbon gp which can be substituted and/or carry a heteroatom, or R.sub.1 and R.sub.2 together represent a hydrocarbon, optionally substituted, forming with the carbon atom to which they are attached, a ring capable of carrying a heteroatom, R.sub.3 represents hydrogen, lower alkyl or aryl, and R.sub.4 and R.sub.5 each independently represent hydrogen or a hydrocarbon group, as well as the acid addition salts thereof. A method of preparing the compounds and the use thereof as an anti-tumor medicine are disclosed.

Abstract: A method of purifying L-ascorbic acid which comprises: subjecting an acidic aqueous solution of L-ascorbic acid which contains salts of an inorganic acid to electrodialysis to remove the salt therefrom.The method is in particular useful for removing salts of an inorganic acid from an aqueous mixture of L-ascorbic acid and the inorganic salt resulting from the production of L-ascorbic acid in which diacetone-2-keto-L-gulonic acid or 2-keto-L-gulonic acid is heated in the presence of an inorganic acid, or an alkyl ester of 2-keto-L-gulonic acid is enolized and lactonized in the presence of a base.

Abstract: The compound 16-oxa-bicyclo-[13.1.0]-hexadec-7-ene, and a process for its production, having the structural formula: ##STR1## is disclosed. 16-oxa-bicyclo-[13.1.0]-hexadec-7-ene is useful as a fragrance and may be produced by reacting cyclopentadeca-1,8-diene in the presence of an organic peracid.

Abstract: The invention relates to new molecular complexes of general formula: ##STR1## in which R represents a straight- or branched-chain alkyl radical having from 1 to 4 carbon atoms and R.sub.1 represents one of the radicals: ##STR2## These molecular complexes are especially useful for the preparation of 2-alkyl-3-(4-hydroxybenzoyl)benzofurans.

Abstract: Biphenylylpropionic acid derivatives of the formula: ##STR1## wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula: ##STR2## wherein R.sup.1 is a lower alkyl group having 1 to 5 carbon atoms and R.sup.2 is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms, or a lactone having the formula: ##STR3## wherein R.sup.3 and R.sup.4 are hydrogen atom or a lower alkyl group having 1 to 2 carbon atoms, and n is an integer of 1 or 2. The compounds have excellent anti-inflammatory, analgesic and antipyretic activities. Moreover, the compounds have no irritation, rapid and long-acting, and high safety margin.

Abstract: Novel 3-hydroxy-3-methylglutaryl-Coenzyme A(HMG-CoA) reductase inhibitors, which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II) ##STR1## and pharmaceutically acceptable salts of the compound (II) in which Z is hydrogen are disclosed.

Abstract: Asymmetric epoxidation of allylic alcohols using carboxylic acid treated phenethyl hydroperoxide oxidate and titanium tartrate catalyst gave optically active glycidols following an enantioselection rule opposite to that observed from the Sharpless epoxidation (U.S. Pat. No. 4,471,130). Overall yield and enantiomeric excess of the glycidol made are dependent on the amount of carboxylic acid present in the oxidate feed. This novel finding provides a direct epoxidation route to (R)-glycidol using the less expensive natural L-(+)-dialkyl tartrate ligand.

Abstract: Substituted 5-formyl-1,3-dioxepans of the general formula I ##STR1## where R.sup.1 is a straight-chain or branched alkyl radical of 1 to 10 carbon atoms which may furthermore contain oxygen in the form of an ether group, or a 5-membered to 8-membered ring which is unsubstituted or substituted by alkyl groups and/or an alkylene group, has up to 10 carbon atoms and may furthermore contain oxygen in the form of an ether group, R.sup.2 is hydrogen, or R.sup.1 and R.sup.2 together form an alkylene radical of 4 to 10 carbon atoms which is unsubstituted or substituted by alkyl or alkoxy and may furthermore contain oxygen in the form of an ether group, and R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each hydrogen or methyl, and the total number of carbon atoms is not more than 25, their preparation and their use as scents.

Abstract: Novel compounds and processes for making and using them. The compounds include ethyl 1-[3-(1-piperidinyl)propyl]-6-phenyl-3-cyclohexene-1-carboxylate, 1-[3-(1-piperidinyl)propyl]-6-phenyl-3-cyclohexene-1-carboxyamide, and N,N-dimethyl-1-[3-(1-piperidinyl)propyl]-6-phenyl-3-cyclohexene-1-carboxam ide.

Abstract: Aerocavin, a novel antibiotic substance having the structure ##STR1## and aerocyanidin, a novel antibiotic substance having the structure ##STR2## can be prepared by cultivation of the microorganism Aerocavin caviae SC 14,030 A.T.C.C. No. 53434.

Abstract: Compounds having the general formula: ##STR1## wherein X is an alkylene radical containing from 1 to 3 carbon atoms and Y is a residue of L-ascorbic acid or D-isoascorbic acid, or the corresponding salts thereof. The compound may be prepared by esterifying L-ascorbic acid or D-isoascorbic acid with the appropriate acid under acid conditions.

Abstract: Polymorphically pure terfenadine, 1-(p-tert-butylphenyl)-4-[4'-(.alpha.-hydroxydiphenylmethyl)-1'-piperidiny l]-butanol, is prepared by carefully controlled recrystallization methods.