Abstract: Process for improving the quality of propylene oxide contaminated with minute quantities of high molecular weight poly(propylene oxide) by contacting liquid propylene oxide with certain solid adsorbents, such as activated carbon and attapulgite, thereby obtaining a substantially pure oxide product essentially free of high molecular weight poly(propylene oxide) suitable for conversion of polyether polyols capable of producing high resilient flexible polyurethane foams exhibiting high rise and substantially free of blow hole formation.

Abstract: Compounds of the formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, trifluoromethyl, alkyl, hydroxyl, alkyoxy, benzyloxy, alkanoyloxy, or benzoyloxy, or when R.sub.2 is hydroxyl or methoxy in the 4-position and R.sub.3 is hydrogen, R.sub.1 may also represent hydroxymethyl carbamoyl or alkoxycarbonyl,R.sub.2 is hydrogen, halogen, alkyl, hydroxyl, or alkoxy,R.sub.3 is hydrogen or alkyl,R.sub.4 is alkyl (in which case the compounds are (.+-.)-erythro) or when R.sub.3 represents hydrogen, R.sub.4 may also be hydrogen, and R.sub.5 is hydrogen, halogen, alkyl, alkoxy, or three methoxy groups in the 3-, 4- and 5-positions and pharmaceutically acceptable acid addition salts thereof, with the exclusion of compounds wherein:(a) one of R.sub.1 and R.sub.2 is in the 4-position and is hydroxyl, alkoxy or benzyloxy, the other is in the 3-position and is hydrogen, hydroxyl, alkoxy or benzyloxy, and R.sub.3 and R.sub.5 are hydrogen and wherein:(b) R.sub.1 is in the 4-position and is halogen, R.sub.4 is methyl and R.sub.

Abstract: Methyl formate is removed from propylene oxide by treatment with a selected base such as sodium hydroxide in water and glycerol. Selected inert salts may be added. The rate of methyl formate hydrolysis by selected bases was increased to commercially acceptable levels by addition of the glycerol. The glycerol and inert salts reduced the amount of residual water in the propylene oxide.

Abstract: Methyl formate is removed from propylene oxide by treatment with aqueous calcium hydroxide slurry. Calcium hydroxide solubility is increased by adding a solubilizer selected from the group consisting of sucrose, fructose, maltose, glycerol and mixtures thereof. Methyl formate hydrolysis rate is improved by propylene oxide/water ratio control. Addition of an aldehyde scavenger improves propylene oxide purity.

Abstract: Aerocavin, a novel antibiotic substance having the structure ##STR1## and aerocyanidin, a novel antibiotic substance having the structure ##STR2## can be prepared by cultivation of the microorganism Aerocavin caviae SC 14,030 A.T.C.C. No. 53434.

Abstract: This invention relates to 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(substituted phenylsulfinyl)alkanoyl]hydrazides and 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(substituted phenylsulfonyl)alkanoyl]hydrazides that are useful as prostaglandin antagonists and analgesic agents. This invention also relates to 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(substituted phenylthio)alkanoyl]hydrazides that are useful as intermediates in the preparation of the corresponding sulfinyl and sulfonyl compounds.

Abstract: Novel pyranone compounds and related compounds, methods of preparing the compounds, and their use as cytotoxic and/or antileukemic agents or precursors, are provided.

Abstract: Intermediate products usable in particular for preparing corresponding amino derivatives by converting their nitro function, said products being of formula: ##STR1## in which: R.sub.1, R.sub.2 and R.sub.3, which are identical or different, each represent an atom of hydrogen, a halogen, a lower alkyl group or a lower alkoxy group;R.sub.5 and R.sub.6, which are identical or different, each represent an atom of hydrogen, a lower alkyl group, an OH group, a phenyl group or a benzyl group.

Abstract: The present invention relates to 1-alkyl-3-hydroxy-3-phenylpiperidine derivatives of the formula ##STR1## wherein R is a C.sub.2 -C.sub.4 alkyl group, and their addition salts. These derivatives are useful as pharmaceuticals, especially as CNS-antidepressants.

Abstract: A novel sequence of highly selective chemical reactions for conversion of 3-Aryl-2-propyn-1-ols into cis-1-Aryl-3-fluoro-1-propene and into D,L-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanols is disclosed. Preparation of D-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanol antibacterial agents including the D-(threo)-3-fluoro-3-deoxy derivatives of chloramphenicol and thiamphenicol is also disclosed.

Abstract: A new and novel process for the preparation of encainide (4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]-benzanilide) has been developed. The process utilizes .alpha.-picoline, O-nitrobenzaldehyde, and anisoyl chloride as starting materials.

Abstract: A method for the preparation of 3,4-dihydro-alpha-pyrones by the thermolysis of 5-hydroxymethyl-gamma-butyrolactone in a liquid medium at temperatures between 300.degree. and 400.degree. C. and in the presence of aluminosilicates as catalysts is disclosed. The dihydropyrone that forms is distilled out of the reaction medium together with the reaction water immediately after its formation. Heat transfer oils, including, for example, polynuclear aromatic compounds joined together by methylene bridges or other bridge groupings, are especially suitable as heat transfer oils. The method has the advantage of permitting the temperature to be regulated within a definable range so that secondary reactions due to local overheating or imprecise temperature control occur to only a limited degree if at all.

Abstract: According to the invention, there are provided novel amide derivatives and 5-lipoxygenase inhibitors containing the same as an effective ingredient.The above-mentioned compounds of the invention have been demonstrated to posses 5-lipoxygenase-inhibiting activities. These compounds can inhibit the production of leucotrienes such as LTC.sub.4 and LTD.sub.4 which are allergy-inducing factors by inhibiting the activity of 5-lipoxygenase. Accordingly, the amide derivatives can be used as 5-lipoxygenase inhibitors effective for allergic asthma, allergic rhinitis and the like.

Abstract: Compounds having the structure: ##STR1## wherein X may be hydrogen, bromine, chlorine, fluorine or iodine are provided, together with methods for synthesizing these compounds, pharmaceutical compositions and use therof for reducing vascular blood flow.Also provided are compounds having the structure: ##STR2## wherein X may be bromine, chlorine, fluorine or iodine, together with methods for preparing the compounds, pharmaceutical compositions and use thereof for reducing vascular blood flow.

Abstract: 3-amino-2,3-dihydro-1-benzoxepine compounds corresponding to the general Formula I ##STR1## wherein R.sub.1 and R.sub.2 may each be hydrogen, halogen, lower alkyl or lower alkoxy, or if one of R.sub.1 and R.sub.2 is hydrogen, the other may also be nitro or trifluoromethyl, R.sub.3 represents hydrogen or a lower alkyl group which optionally may be substituted by hydroxy, lower alnoxy, an optionally substituted phenyl group or an optionally substituted amino group, and R.sub.4 represents hydrogen or lower alkyl, or R.sub.3 and R.sub.4 together with the nitrogen atom form a 5 or 6 member heterocycle. The compounds exhibit pharmacological, especially antidepressive, activity.

Abstract: To reduce the content of hydrolyzable chlorine in glycidyl compounds, these are dissolved in a halogen-free organic solvent and treated with an equivalent excess of aqueous alkali metal hydroxide solution at elevated temperature, the excess being 100 to 200% of the equivalent amount theoretically required for complete dehydrochlorination of the hydrolyzable chlorine, the water is then removed from the organic solution, the organic solution is treated with 5 to 500 times the amount, based on the amount of alkali metal hydroxide employed, of moist cellulose containing up to 35% by weight of water at elevated temperature and, after filtration, the glycidyl compound is isolated from the organic solution.

Abstract: Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3-pyrrolidine] compounds of the formula ##STR1## where the substituents are as defined herein, are useful in the treatment of hypertension in mammals. Such compounds, their use as antihypertensive agents, pharmaceutical compositions containing the compounds, intermediates and processes for preparing the compounds are provided.

Abstract: Aromatic mono or polycarboxylic acid glycidyl esters are obtained in good yields and high purity by transesterification of the corresponding aromatic carboxylic acid alkyl esters with glycidol in the presence of weakly toxic catalysts, namely the alkali, ammonium, and alkaline earth metal salts of pseudohalogen hydride acids with readily polarizable anions.

Abstract: The prostacyclins 7-fluoro-6,9-epoxy-16-substituted-15-hydroxyprost-[4 or 5,13]-dienoic acids and esters useful as anti-secretory agents, blood pressure lowering agents, anti-ulcerogenic agents, anti-hypertensive agents, bronchodilation agents and for combating gastro-hyperacidity and as anti-blood platelet aggregating agents.

Abstract: Novel antineoplastic ailanthone derivatives (IIb) represented by the following formula wherein R.sub.2 is C.sub.5 -C.sub.18 .alpha.,.beta.-unsaturated acyl group and its related compounds are disclosed. ##STR1## Particularly, some of the above compounds are far more effective than mitomycin C against mouse lymphocytic leucemia p388.These compounds can be synthesized from known ailanthone via important intermediates, triacyloxy ailanthone, represented by the formula: ##STR2## wherein R.sub.1 is acyl group.