Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

Abstract: A bio-information estimating apparatus includes a sensor part configured to measure a pulse wave signal from an object, a contact force that is applied by the object to the sensor part, and a contact area of the object that is applied to the sensor part, and a processor configured to obtain a first feature value, based on a first change in the contact area with respect to a second change in the contact force, obtain a second feature value, based on the pulse wave signal, and estimate bio-information, based on the first feature value and the second feature value.

Abstract: A wireless, patient-worn, physiological sensor configured to, among other things, help manage a patient that is at risk of forming one or more pressure ulcers is disclosed. According to an embodiment, the sensor includes a base having a top surface and a bottom surface. The sensor also includes a substrate layer including conductive tracks and connection pads, a top side, and a bottom side, where the bottom side of the substrate layer is disposed above the top side of the base. Mounted on the substrate layer are a processor, a data storage device, a wireless transceiver, an accelerometer, and a battery. In use, the sensor senses a patient's motion and wirelessly transmits information indicative of the sensed motion to, for example, a patient monitor. The patient monitor receives, stores, and processes the transmitted information.

Abstract: There is provided a hydration state indicator. The hydration state indicator comprises a watertight shell; a semi-permeable membrane configured to permit the passage of water molecules and to block the passage of molecules of at least one solute; a water-absorbent indicator layer enclosed by the shell and the membrane; and output means configured to provide an output. The water-absorbent indicator layer has a predetermined osmotic strength. The volume of at least one part of the indicator layer is variable in dependence on the water content of the indicator layer. The output is variable in dependence on the volume of the at least one part of the indicator layer.

Abstract: There is provided a kit of parts for an exhaled breath condensate collection device. The kit comprises a mouthpiece module (100) comprising a breath passageway defined in the mouthpiece module (100) providing fluid conduction from a mouthpiece breath inlet port (122) for receiving exhaled breath to a mouthpiece breath outlet port (124) in use. The kit further comprises a collection vessel (300) for insertion into the device for cooling in use. The collection vessel (300) defines a sealed and resealable chamber for collecting exhaled breath condensate in use. The collection vessel has a vessel breath inlet (326) for admitting exhaled breath into the chamber.

Abstract: A sensor system detects a presence or concentration of an analyte in a medium. The sensor system contains a sensor having a sensor head with a chamber. The sensor head has a permeable area through which the analyte can pass into the chamber when the sensor head contacts the medium. A cross-linked hydrogel fills the chamber, the hydrogel is configured to undergo a change in volume when contacting the analyte passed into the chamber which leads to a change in pressure in the chamber. A pressure sensor is configured to measure the pressure in the chamber for detecting the presence or concentration of the analyte.

Abstract: Provided is a blood pressure measuring apparatus, a wrist watch type terminal, and a method of measuring blood pressure. The blood pressure measuring apparatus includes a light source that emits light onto a living body, a light receiver that receives light from the living body, and a signal processing device that calculates the blood pressure based on a detected signal received from the light receiver, wherein the signal processing device includes a subtractor that obtains a subtraction value by subtracting a moving average value of the detected signal in a second duration which is shorter than a first duration from a moving average value of the detection signal in the first duration, an extractor that extracts a feature point of a pulse wave based on the subtraction value, and a converter that converts a feature amount obtained based on the feature point to a blood pressure value.

Abstract: The present invention relates to a method and device for measuring acetone concentrations in breath. Measuring acetone concentrations is based on changes the spectral properties of the fluorophore caused by the chemical interaction of a specific fluorophore with the exhaled air containing acetone which.

Abstract: Nanoparticle-fibrous membrane composites are provided as tunable interfacial scaffolds for flexible chemical sensors and biosensors by assembling gold nanoparticles (Au NPs) in a fibrous membrane. The gold nanoparticles are functionalized with organic, polymeric and/or biological molecules. The fibrous membranes may include different filter papers, with one example featuring a multilayered fibrous membrane consisting of a cellulose nanofiber (CN) top layer, an electrospun polyacrylonitrile (PAN) nanofibrous midlayer (or alternate material), and a nonwoven polyethylene terephthalate (PET) fibrous support layer, with the nanoparticles provided on the fibrous membranes through interparticle molecular/polymeric linkages and nanoparticle-nanofibrous interactions. Molecular linkers may be employed to tune hydrogen bonding and electrostatic and/or hydrophobic/hydrophilic interactions to provide sensor specificity to gases or liquids. The sensors act as chemiresistor-type sensors.

Abstract: A belt to be mounted around a measurement site; first pulse wave sensor and second pulse wave sensor mounted on the belt, separated from each other, configured to detect pulse waves in an artery passing through the measurement site; and pressing member mounted on the belt, capable of pressing first pulse wave sensor and second pulse wave sensor against the measurement site while varying pressing force. Time difference between first and second pulse wave signals is acquired as pulse transit time. Blood pressure is calculated based on the pulse transit time acquired by the measurement processing unit by using a predetermined correspondence equation between pulse transit time and blood pressure. Pulse transit time is acquired with the measurement processing unit while pressing force by pressing member is changed in resting state, and corresponding equation is calibrated based on plurality of pulse transit times corresponding to plurality of respective pressing forces.

Abstract: A wearable device and system has been developed to help users learn the practices of diaphragmatic breathing and breathing patterns to improve running and walking performance. The wearable has a breathing sensor (breathe in-breathe out) and a movement sensor used to identify foot strikes. A processor computes the number of foot strikes occurring while inhaling and the number of foot strikes occurring while exhaling to report breathing patterns as a function of time. The algorithms may be modified to teach breathing patterns to athletes in other sports and deep breathing for numerous movement and minimal movement applications.

Abstract: A pulse wave detecting device includes a sensor section and a control unit. The sensor section is rotatable about a first axis and is rotatable about a second axis. The control unit determines a rotation angle about the second axis and a rotation angle about the first axis in a state where a roll angle of the sensor section is controlled to the optimal roll angle. Then, the control unit, presses the sensor section against the body surface in a state where the sensor section is controlled into the optimal roll angle and the optimal pitch angle, detects a pulse wave based on pressure signals detected by pressure detecting elements during the increase, and calculates vital information based on the detected pulse wave.

Abstract: The exemplified methods and systems facilitate one or more dynamical analyses that can characterize and identify synchronicity between the acquired cardiac signals and photoplethysmographic signals to predict/estimate the presence, non-presence, localization, and/or severity of abnormal cardiovascular conditions or disease, including, for example, but not limited to, coronary artery disease, heart failure (including but not limited to indicators of disease or conduction such as abnormal left ventricular end-diastolic pressure disease), and pulmonary hypertension, among others. In some embodiments, statistical properties of the synchronicity between the cardiac signals and photoplethysmographic signals are evaluated. In some embodiments, statistical properties of a histogram of the synchronicity between the cardiac signals and photoplethysmographic signals are evaluated.

Abstract: Provided is a transdermal microneedle array patch, including: a bottom cover; a top cover; a substrate disposed within the top cover; and a first probe and a second probe disposed between the bottom cover and the top cover and electrically connected the substrate. The first and second probes form an open circuit. While the bottom cover is combined with the top cover to form the transdermal microneedle array patch, the first and second probes form a closed circuit.

Abstract: Waterless electrochemical transdermal alcohol sensor. In one embodiment, the sensor includes a proton exchange membrane imbibed with an imbibing liquid that includes at least one cationic substance that is liquid at room temperature. As examples, the cationic substance may be one or more ionic liquids with an imidazolium, phosphonium, ammonium, pyridinium, pyrrolidinium, or sulfonium backbone structure. The imbibing of the proton exchange membrane with the cationic substance obviates the need for the periodic addition of water to the electrochemical cell. The sensor additionally includes a sensing electrode, which is bonded to one side of the proton exchange membrane, and a counter electrode and a reference electrode, both of which are bonded to the opposite side of the proton exchange membrane. The sensor may be incorporated into a wearable transdermal alcohol sensor device, which, in turn, may be incorporated into a system for detecting transdermal alcohol.

Abstract: A volatile organic compound collector can include a collector material configured to collect volatile organic compounds given off from a patient's skin; a wrapping configured to isolate the collector material from an external environment; a heater comprising a heating element, the heating element configured to emit a thermal pulse to desorb the volatile organic compounds from the collector material; and a mesh layer configured to prevent the collector material from contacting the patient's skin, wherein the collector material is received between the wrapping and the mesh layer.

Abstract: A blood pressure measurement device is equipped with a pressing surface which is formed with pressure sensors, an air bag for pressing the pressing surface toward a radius artery that runs under a skin of a living body; an air bag drive unit for controlling the pressing force of the air bag, and a control unit for calculating blood pressure values in the radius artery on the basis of pressure pulse waves that were detected by all of the pressure sensors in a process that the pressing force was increased or decreased.

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than ?50 C.

Abstract: The present disclosure relates generally to the assessment and treatment of vessels, including for percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). For example, some embodiments of the present disclosure are suited for identifying the available intervention technique(s) suitable to achieve a desired outcome selected or input by a user. For example, in some implementations a method comprises receiving pressure measurements obtained by one or more intravascular pressure-sensing instruments positioned within a vessel of a patient; receiving an input from a user regarding a desired pressure value for the vessel of the patient; identifying an available treatment option based on the received pressure measurements and the desired pressure value; and outputting, to a display device, a screen display including a visual representation of the available treatment option. Related devices and systems are also described.

Abstract: A respiratory gas analyzer device (10), such as a capnograph device, is disclosed. A gas measurement component (28), such as a carbon dioxide measurement component in the case of a capnograph, is configured to measure at least one respired gas component (e.g. carbon dioxide). A pump (20) is connected to draw respired gas through the gas measurement component. A pressure gauge (30) is connected to measure pressure in an airflow pathway including the gas measurement component and the pump. An electronic pump controller (40) is programmed to start the pump in response to pressure measured by the pressure gauge satisfying a pump turn on criterion.