Abstract: The present application discloses a pulse simulator. The pulse simulator includes a pulse simulation assembly configured to receive a pulse simulation signal and simulate a pulse of a living body based on the pulse simulation signal. The pulse simulation assembly includes a mounting plate; a plurality of retractable bolts on the mounting plate; and a plurality of drivers coupled to the plurality of retractable bolts. Each of the plurality of retractable bolts has a first end attached to the mounting plate and a second end opposite to the first end. Each of the plurality of drivers is configured to drive one of the plurality of retractable bolts to retract and extend between a first position and a second position thereby adjusting a distance between a simulated skin portion and the mounting plate in a region corresponding to the one of the plurality of retractable bolts.

Abstract: A fluid bladder includes multiple segment bladders that are each formed by folding one sheet in half in a width direction X extending along an artery passing through the measurement site, welding or adhering edge portions on a side opposite to the folding location for folding in half, and welding or adhering edge portions in a lengthwise direction Y. The multiple segment bladders are stacked in a width direction orthogonal to the measurement site and integrated, and the folding locations are arranged alternatingly on opposite sides in the width direction.

Abstract: Devices and methods for blood flow enhancement and hemodynamic power monitoring are provided. A blood flow enhancement device includes a pump system configured to be coupled to a central vasculature of a subject during cardiopulmonary resuscitation (CPR). The pump system includes a pumping mechanism configured to increase forward blood flow generated during the CPR while substantially limiting backward blood flow generated during the CPR. The pumping mechanism being operated concurrently with the CPR. The hemodynamic power monitor is configured to control a chest compression device and an active valve.

Abstract: Techniques and apparatuses for determining fluid volumes of a patient are described. In one embodiment, for example, an apparatus may include at least one memory, and logic coupled to the at least one memory. The logic may be configured to receive baseline bioimpedance information for at least a portion of a human body at a baseline pressure, receive pressurized bioimpedance information of the portion of the human body at a pressurized pressure, the pressurized pressure greater than the baseline pressure and configured to substantially remove blood volume from the portion at the pressurized pressure, and determine at least one of interstitial fluid volume (VIT) or peripheral blood volume (BVP) based on the baseline bioimpedance information and the pressurized bioimpedance information. Other embodiments are described.

Abstract: A device is described for interrogating human skin using tight coupling between the transmitter and receiver of the millimeter waves (MMWs). Methods are provided to evaluate changes in the amplitude and/or phase of the transmitted MMWs in order to estimate the blood concentration of glucose. Using this device and the related methods, the blood glucose concentration or a change in the blood glucose concentration can be monitored for diagnosing diabetes mellitus and other metabolic disorders of carbohydrate metabolism characterized by either high blood glucose level (hyperglycemia) or low blood glucose level (hypoglycemia), as well as for monitoring (including self-monitoring) a metabolic disorder progression or an efficacy of treatment.

Abstract: In one aspect, embodiments of the present disclosure can comprise a non-contact signal detection system for detecting movement associated with a subject. The system can comprise a carrier source configured to generate a first carrier signal in phase coherence with a second carrier signal. Additionally, the system may incorporate a phase-locked loop including noise pre-cancellation system for suppressing the noise associated with a beat signal and a controlled oscillation system. The noise pre-cancellation system can be configured to phase-lock the beat signal to a first reference signal in order to stabilize the phase of the beat signal and pre-cancel the noise associated with the beat signal. The controlled oscillation system can include a propagation pathway on which a transmission signal is phase-modulated with a vibratory signal of the subject. Once acquired, the vibratory signal can have suppressed noise.

Abstract: An integrated cardio-respiratory system that fuses continuously recorded data from multiple physiological sensor sources to acquire signals representative of acoustic events caused by physiological phenomena occurring in the cardiac and/or arterial structures underneath particular areas of the chest and/or neck to monitor cardiac and respiratory conditions.

Abstract: Systems and methods for quantifying the likelihood of the contribution of multiple possible forms of chronic disease to patient reported dyspnea can include the testing protocol having a flow/volume loop, performed at rest, flowed by the measurement of cardiopulmonary exercise gas exchange variables during rest, exercise and recovery as unique data sets. The data sets are analyzed using feature extraction steps to produce a pictorial image consisting of disease silos displaying the likelihood of the contribution of various chronic diseases to patient reported dyspnea. In some embodiments, the silos are split into subclass silos. In some embodiments, multiple chronic disease indexes are used to differentiate between sub-types of a particular chronic disease (e.g., differentiating WHO 1 PH from WHO 2 or WHO 3 PH). Test results are plotted serially to asses to provide feedback to the physician on the efficacy of therapy provided to the patient.

Abstract: A non-invasive product customization system and a method of customizing a product formulation is provided. Brain activity of a user is detected in response to an input of a product formulation into a brain of the user via a sensory nervous system of the user. A mental state of the user is detected based on the detected brain activity. The product formulation is modified based on the determined mental state of the user. The modified product formulation may be presented to the user in a manner that modulates the mental state of the user.

Abstract: A system, wearable device, and method include a light emitter configured to emit light at a first wavelength of between approximately 900 and 1000 nanometers and at a second wavelength of approximately 1350 nanometers, a first light detector spaced at a first distance from the light emitter, and a second light detector spaced at a second distance from the light emitter, the second distance approximately twice the first distance. At least one of hydration and glycogen of muscle tissue is determinable based on a relationship between backscatter light from the muscle tissue as detected by the second light detector and backscatter light from non-muscle tissue as detected by the first light detector.

Abstract: Handheld steering devices for use with intravascular devices and associated systems and methods are disclosed. In some instances, the handheld steering device includes a housing sized and shaped for grasping by a hand of a user, the housing including a proximal portion and a distal portion, wherein the distal portion includes an opening sized and shaped to receive an intravascular device; an adaptor positioned within the opening of the housing, the adaptor including a bore sized and shaped to allow a proximal end of the intravascular device to pass therethrough; a steering controller coupled to the housing; and an actuator positioned within the housing and in communication with the steering controller, the actuator interfacing with the proximal end of the intravascular device based on inputs to the steering controller to steer a distal end of the intravascular device. Associated systems and methods are also disclosed.

Abstract: An apparatus includes a sensor module, a data processing module, a quality assessment module and an event prediction module. The sensor module provides biosignal data samples and motion data samples. The data processing module processes the biosignal data samples to remove baseline and processes the motion data samples to generate a motion significant measure. The quality assessment module generates a signal quality indicator based on the processed biosignal data sample segments and the corresponding motion significance measure using a first deep learning model. The event prediction module generates an event prediction result based on the processed biosignal data sample segments associated with a desired signal quality indicator using a second deep learning model.

Abstract: A hypertonicity measuring device comprises at least one wearable item. The hypertonicity measuring device comprises at least one communication pathway. The at least one communication pathway is configured to communicate with a processing device. The hypertonicity measuring device comprises a sensor array. The sensor array is disposed to the at least one wearable item. The sensor array comprises a plurality of capacitive pressure sensors. The sensor array is configured to communicate capacitive pressure sensor data to the processing device employing the at least one communication pathway. The plurality of capacitive pressure sensors comprises at least one structured dielectric. The hypertonicity measuring device comprises an inertial measurement unit. The inertial measurement unit is disposed to the at least one wearable item. The inertial measurement unit is configured to communicate motion data to the processing device employing the at least one communication pathway.

Abstract: A patient monitoring system includes an inflatable cuff, a gas reservoir containing a compressed gas, and a sensor. When the inflatable cuff is coupled to a wearer, the gas reservoir supplies gas to the inflatable cuff to inflate the inflatable cuff via gas pathways. As the inflatable cuff inflates, a patient monitor can receive blood pressure data from the sensor and use the blood pressure data to determine the blood pressure of the wearer. The patient monitor can also receive blood pressure data during deflation of the inflatable cuff to determine the blood pressure of the wearer.

Abstract: A biopsy device may include a first jaw having a first distal tip configured to pierce tissue, and a second jaw movable relative to the first jaw between a closed configuration where the first jaw and the second jaw are axially aligned, and an open configuration where the first jaw and the second jaw are offset from one another, the second jaw having a second distal tip proximal to the first distal tip in the closed configuration.

Abstract: Embodiments of a system can include a temperature monitoring device including: a heat flux channel, a first temperature sensor thermally coupled to the heat flux channel, a second temperature sensor thermally coupled to the heat flux channel, a thermal cage thermally coupled to and arranged around the heat flux channel along a length of the heat flux channel, and a processing system operable to determine a core body temperature measurement based on temperature data collected at the first and the second temperature sensors.

Abstract: Apparatus and methods for the measurement, control, or both, of thermodilution injectate flow for calculation of transpulmonary thermodilution parameters. An injectate delivery system includes a syringe for holding an injectate and a conduit configured at one end to be connected to a catheter. A flow measurement device is interposed in the conduit to generate a signal for determining the flow rate of the fluid from the syringe to the catheter. A processor receives the signal from the flow measurement device and calculates the injectate volume to be used as input for calculating a transpulmonary thermodilution parameter such as cardiac output. A GUI is provided to direct a user on whether the injection rate is too fast or too slow. Rather than measuring or calculating flow rate, a system may include a constant flow valve to provide a constant flow rate from the syringe.

Abstract: A method and system for detection of coronary artery disease (CAD) in a person using a fusion approach has been described. The invention the detection of CAD in the person by capturing of a plurality of physiological signals such as phonocardiogram (PCG), photoplethysmograph (PPG), ECG, galvanic skin response (GSR) etc. from the person. A plurality of features are extracted from the physiological signals. The person is then classified as CAD or normal using the each of the features independently. The classification is done based on supervised machine learning technique. The output of the classification is then fused and used for the detection of the CAD in the person using a predefined criteria.

Abstract: An apparatus for measuring biometric information is provided. The apparatus may include: a main body configured to be worn on an object to be examined. The main body may include a contact pressure sensor configured to measure a contact pressure of the object while a hand shape is changing; a pulse wave sensor configured to measure a pulse wave signal of the object; and a processor configured to measure biometric information on the basis of the measured contact pressure and pulse wave signal.

Abstract: A wearable device for continuous monitoring of the respiratory rate of a patient, using a first inertial sensor positioned on the abdomen, a second inertial sensor positioned on the thorax, and a third inertial sensor being positioned on a part of the body not subject to respiratory movements, fixed with respect to the torso. Each inertial sensor includes a microprocessor connected to a transmitter configured for processing the signals and supplying a signal represented by a quaternion that describes the orientation of the inertial sensors with respect to the Earth's reference system. A receiver is configured for receiving the abdominal quaternion of the first inertial sensor, the thoracic quaternion of the second inertial sensor, and the reference quaternion of the third inertial sensor and sending them to a control center configured for calculating the respiratory rate from the signals represented by a filtered abdominal quaternion and a filtered thoracic quaternion.