Abstract: The invention discloses particular water-dispersible solid formulation of a cannabinoid or a cannabis extract, wherein they are present in the form of a nanoemulsion, and upon dispersion in water said formulation produces nanoparticles (droplets of a submicron size) with an average size of up to about 500 nm. The present disclosure further relates to methods of making thereof, as well as therapeutic applications in humans for treating disorders and broader application for a range of medical conditions.
Type:
Grant
Filed:
March 11, 2019
Date of Patent:
August 1, 2023
Assignee:
Karnak Technologies, LLC
Inventors:
Shlomo Magdassi, Liraz Larush, Rafael Ezra
Abstract: The kit for locating a vein is configured for use in inserting an intravenous (IV) catheter into a targeted vein of a patient. The kit for locating a vein is a transparent structure. The kit for locating a vein: a) removably attaches to the skin of the patient; b) numbs the skin of the patient; c) generates a vasomotor response; d) provides the ability to insert the IV catheter into the targeted vein while the kit for locating a vein remains attached to the patient; and, e) forms a dressing that captures bodily fluids. The kit for locating a vein comprises a parchment sheeting, a working media, a transparent pocket, and a plurality of apertures. The parchment sheeting, the working media, and the transparent pocket form a transparent composite textile structure. The plurality of apertures are apertures that are formed through the composite textile structure.
Abstract: Disclosed herein is a fast-dispersing suspending composition which promotes the formation of a suspension for pharmaceutical, food and veterinary products. The composition includes a suspending agent, a diluent, and a glidant, wherein the amounts of these agents are selected to enable the dispersion of the composition and the formation of the suspension. Also disclosed are a method of forming a suspension of a solid dosage form and a method of administering the resulting suspension to a subject.
Type:
Grant
Filed:
June 8, 2022
Date of Patent:
August 1, 2023
Assignee:
AUSON PHARMACEUTICALS INC.
Inventors:
Enxian Lu, Peng Hou, Longlong Feng, Long Wang
Abstract: Ultraviolet radiation sun protective compositions are reported which feature micronized metal oxide inorganic particles selected from zinc oxide, titanium oxide and mixtures thereof, the inorganic particles being coated with poly[C8-C20 hydroxycarboxylic acid], the coated particles measured at a 10% loading in dodecane and 1 minute elapsed time having a Zeta Potential ranging from 2 to 10 mv, amounts of the poly[C8-C20 hydroxycarboxylic acid] to the inorganic particles being in a relative weight ratio of 1:100 to 1:10.
Abstract: Provided herein are methods for killing nematodes, said method comprising contacting said nematodes with an effective nematodes killing amount of a fatty-ammonium salt polysaccharide inclusion complex, and optionally a carrier. The fatty-ammonium salt starch inclusion complexes comprise one or more of a variety of fatty amines.
Type:
Grant
Filed:
April 7, 2020
Date of Patent:
July 25, 2023
Assignee:
The United States of America, as represented by the Secretary of Agriculture
Inventors:
Gordon W. Selling, William T. Hay, George F. Fanta, Susan L. Meyer, Inga A. Zasada
Abstract: Compositions include highly-concentrated Alpha-1 Proteinase Inhibitor (A1PI) in a concentration greater than or equal to 100 mg/ml. Pharmaceutical compositions can be prepared from these compositions. The pharmaceutical compositions can be suitable for subcutaneous administration. The highly-concentrated A1PI solutions can be obtained by single-pass tangential flow filtration (SPTFF).
Type:
Grant
Filed:
September 22, 2021
Date of Patent:
July 18, 2023
Assignee:
GRIFOLS WORLDWIDE OPERATIONS LIMITED
Inventors:
James Rebbeor, Charles Miller, Anthony Klos, Eric Allgaier, Thomas P. Zimmerman, Kevin Wee, Michelle StPeter, Kelly Glancy
Abstract: Compositions for improving plant health, the compositions comprising at least one water-soluble pesticide and at least one non-herbicidal water-insoluble agrochemical, are described. Also described are processes for preparing the compositions and methods of improving agronomic crop plant health using the compositions.
Type:
Grant
Filed:
June 9, 2020
Date of Patent:
July 18, 2023
Assignee:
Monsanto Technology LLC
Inventors:
William Abraham, Andrew Dyszlewski, John W. Hemminghaus, Frank C. Kohn, Daniel R. Wright, Junhua Zhang
Abstract: The present invention is directed to an aripiprazole oral soluble film and a preparation method thereof. The aripiprazole oral soluble film comprises 10-60% w/w of aripiprazole in a crystalline state and 30-95% w/w of one or more film-forming materials, wherein 90% of the aripiprazole particles have a size of ?14.3 ?m and are uniformly blended in the film without visible undispersed particles. The aripiprazole oral soluble film has excellent bioavailability, uniformity, stability, and palatability. The oral soluble film preparation is prepared by first grinding aripiprazole particles to have desired small particle sizes, then blending the aripiprazole particles with film forming materials in an aqueous solution to a uniform suspension, defoaming the suspension, and coating the suspension on a substrate and drying it to form a film.
Abstract: Provided herein are stable amlodipine liquid formulations. Also provided herein are methods of using amlodipine liquid formulations for the treatment of certain diseases including hypertension and Coronary Artery Disease (CAD).
Abstract: The present disclosure relates to microneedle devices and methods for treating a disease (for example, diabetes) using a degradable cross-linked gel for self-regulated delivery of a therapeutic agent (for example, insulin).
Abstract: The present invention aims to provide a preparation expected to improve the bitter taste of an organic acid salt of vonoprazan and permit rapid dissolution of the organic acid salt of vonoprazan after administration. The present invention provides a preparation containing fine granules or granules containing (1) a core granule containing an organic acid salt of vonoprazan, (2) an intermediate layer containing the same organic acid as the organic acid forming the salt of vonoprazan in (1), or a salt thereof, and (3) a coating layer containing a water-insoluble polymer.
Abstract: Disclosed is a curcumin nanoparticle, including curcumin as core material and a wall material, where a weight ratio of the curcumin to the wall material is (5.5-7.5):100, and the wall material includes gum arabic and zein in a weight ratio of (1-5):5. The disclosure further provides a method of making the curcumin nanoparticle and a curcumin beverage containing the curcumin nanoparticle.
Abstract: Provided is an antimicrobial composition comprised of at least one degradation product of oxidized cellulose (OC), such as oxidized regenerate cellulose (ORC), and minocycline, methods of preparation thereof and uses thereof.
Type:
Grant
Filed:
June 11, 2021
Date of Patent:
July 4, 2023
Assignees:
Omrix Biopharmaceuticals Ltd., Ethicon, Inc.
Inventors:
Eve Montia, Dwayne Looney, Theresa Scheuble, Ronen Eavri, Roi Mashiach
Abstract: Embodiments herein relate to cell encapsulation membranes, devices including the same, and related methods. In an embodiment, a cell encapsulation membrane is included. The cell encapsulation membrane can include a mesh substrate. The mesh substrate can include a first series of fibers extending in a first direction and a second series of fibers extending in a second direction, the first series of fibers intersecting with the second series of fibers, the mesh substrate defining a plurality of apertures disposed between adjacent fibers of the first series and the second series. The cell encapsulation membrane can further include a coating disposed on the mesh substrate, the coating partially occluding the plurality of apertures defined by the mesh substrate and forming pores. Other embodiments are also included herein.
Type:
Grant
Filed:
April 5, 2021
Date of Patent:
July 4, 2023
Assignee:
Boston Scientific Limited
Inventors:
Martin Lawrence Fawdry, Aiden Flanagan, Matthew McEvaddy, Garry Duffy, Eamonn J. Tuohy
Abstract: The present invention relates to new, oil-based suspension concentrates of agrochemical active compounds, a process for the preparation of these formulations and their use for the application of the active compounds contained.
Type:
Grant
Filed:
August 16, 2016
Date of Patent:
June 27, 2023
Assignee:
BAYER CROPSCIENCE AKTIENGESELLSCHAFT
Inventors:
Malcolm Faers, Oliver Gaertzen, Andreas Roechling, Arno Ratschinski
Abstract: Embodiments are directed to a secnidazole formulations and the use of a secnidazole formulation for the treatment of bacterial vaginosis (BV).
Type:
Grant
Filed:
May 31, 2021
Date of Patent:
June 27, 2023
Assignee:
LUPIN, INC.
Inventors:
Helen S. Pentikis, David Palling, Carol J. Braun
Abstract: The mixture of certain amine salts of glyphosate and 2,4-D allows the preparation of high-strength liquid compositions containing up to greater than 450 gae/L of total active ingredient loading if the pH is adjusted to about 6.0 to about 8.0. Compositions are particularly well-suited for application to crops that are resistant or tolerant to both glyphosate and 2,4-D.
Type:
Grant
Filed:
March 11, 2016
Date of Patent:
June 20, 2023
Assignee:
CORTEVA AGRISCIENCE LLC
Inventors:
Mei Li, Holger Tank, Lei Liu, Kuide Qin, Stephen L. Wilson, David G. Ouse
Abstract: A reagent composition for delivery nucleic acid therapeutics to cells is provided. The reagent includes ionizable lipid, structural lipid, and a stabilizing agent which improves the transfection efficiency of nucleic acids, and leaves transfected cells viable. The 5 transfection reagent is effective in plasmid and mRNA delivery, and in neurons and progenitor-like cells. It may be used for ex vivo cell therapy.
Type:
Grant
Filed:
April 15, 2019
Date of Patent:
June 20, 2023
Assignee:
Precision Nanosystems ULC
Inventors:
Anitha Thomas, Andrew William Brown, Rebecca Anne Grace De Souza, Tara L. Fernandez
Abstract: Described is an aqueous calcium gluconate solution formulated without calcium saccharate, which can be stored in a flexible plastic bag and can be terminally sterilized.
Abstract: Disclosed are methods, systems, media, apparatus, devices, and other implementations, including a method that includes determining blood flow characteristics at an ocular surface of an eye of a patient, determining characteristics of blood vessels at the ocular surface of the eye based on the determined blood flow characteristics, and deriving one or more ocular redness grading scales indicative of inflammation levels of the eye of the patient based on the determined characteristics of the blood vessels at the ocular surface of the eye.
Type:
Grant
Filed:
October 7, 2020
Date of Patent:
June 13, 2023
Assignee:
Tufts Medical Center, Inc.
Inventors:
Pedram Hamrah, William Warr Binotti, Ricardo Menon Nose