Abstract: The present invention relates to a skin application agent containing a polyisoprene latex.

Abstract: The present invention describes an autoclavable ophthalmic composition comprising an ophthalmically effective drug. The invention further relates to a method for stabilizing an ophthalmic drug.

Abstract: This invention relates to a controlled-release combination drug product comprising troglitazone, e.g. its hydrochloride, and a biguamide, e.g. metformin. In particular, the product comprises a core of metformin, at least a portion thereof has a layer or coat thereon of troglitazone.

Abstract: This invention relates to an external patch for an antiinflammatory drug containing nonsteroidal antiinflammatory drug which is excellent in the dermal absorption and the skin adhesion, has hardly the skin stimulus. The nonsteroidal antiinflammatory drug composition comprised of nonsteroidal antiinflammatory drug, alkylpyrrolidone, hydrophilic polyethyleneglycol and hydrophilic nonionic surfactant was diffused in the water containing base comprised of water soluble polymer material, water soluble vinyl polymer and water insoluble multivalent metallic salt to provide the external patch containing nonsteroidal drug dissolved and diffused in the water containing base in the microemulsion state, which is excellent in the dermal absorption and also good in the skin adhesion, has hardly the skin irritations.

Abstract: The invention provides crystalline forms of adefovir dipivoxil and methods to prepare the crystals. The compositions and methods of the present invention have desirable properties for large scale synthesis of crystalline adefovir dipivoxil or for its formulation into therapeutic dosages. Invention compositions include an anhydrous crystal form of adefovir dipivoxil.

Abstract: The conditioning performance of small particle size emulsified silicone in a surfactant-based shampoo composition can be significantly boosted by the inclusion in the shampoo composition of an amino functionalised silicone. Accordingly, the invention provides an aqueous shampoo composition comprising, in addition to water: i) at least one surfactant chosen from anionic, nonionic, zwitterionic or amphoteric surfactants or mixtures thereof; ii) an amino functionalised silicone; and iii) emulsified particles of an insoluble, non-amino functionalised silicone, in which the average silicone particle size of the emulsified non-amino functional silicone in the shampoo composition is less than 2 microns.

Abstract: The present invention relates to a process for the preparation of bisphonate-containing pharmaceutical compositions for oral administration wherein the active substance is wet-granulated in a fluidized-bed granulator and the wet granulate is dried in the fluidised bed granulator. The dried granulate is further processed to produce desired dosage forms.

Abstract: A composition of neutralizing the venom of bees, wasps, hornets, yellow jackets and other sting any hymenoptera insects. The composition comprises a proteclytic enzyme with a carrier suitable for topical application to the skin. In a preferred embodiment the enzyme triethanolamine and the composition also includes anhydrous aluminum silicate to increase the penetrating ability of the composition and methyl red as an indicator solutior.

Abstract: A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymer, an active agent, and a solvent. A second phase is prepared. The first and second phases are combined to form an emulsion in which the first phase is discontinuous and the second phase is continuous. The discontinuous first phase is separated from the continuous second phase. The residual level of solvent in the discontinuous first phase is reduced to less than about 2% by weight.

Abstract: A nasal and pharyngeal spray solution for use in spraying into the nose and mouth to protect the mucosa from noxious viruses, bacteria and fungi and excessive drying, in situations of high risk, such as the cabins of commercial aircraft, is comprised of a saline solution of Proanthocyanidins and ascorbic acid. The ‘fresh mix’ delivery system is an appropriately closed, sterile, oxygen-excluding, pressurized container.

Abstract: Dental compositions are provided with a fluoride releasing material that is a metal complex described by formula M(G)g(F)n or M(G)g(ZFm)n where M represents an element capable of forming a cationic species and having a valency of 2 or more, G is an organic chelating moiety capable of complexing with the element M Z is hydrogen, boron, nitrogen, phosphorus, sulfur, antimony, arsenic F is a fluoride atom g, m and n are at least 1.

Abstract: The mastitis control teat dip composition of the invention provides a softening, soothing, smoothing, relaxing property, a rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpected long term microbial control when compared to the prior art materials disclosed in patents and used in the marketplace. The compositions of the invention are made by combining an aqueous thickened liquid composition containing the organic components which can be combined with a simple aqueous solution of a salt of chlorous acid, preferably an alkali metal chlorite. The materials can be combined, blended into a smooth viscous material containing an emollient package and can be immediately contacted with the target animals. The compositions of the invention provide rapid initial kill, consistent long term kill and chemical and rheological stability.

Abstract: Topically administrable anti-allergy compositions comprising olopatadine and a polymeric quaternary ammonium preservative are suitable for use by patients wearing contact lenses.

Abstract: The invention provides a sustained release composition free of food effect comprising a core comprising an active agent except for carbamazepine or verapamil, and a coating comprising, based on the weight of the coating, from 30 to 80% of a gastroresistant polymer and from 10 to 40% of a hydrophilic silicon dioxide. The invention also provides a method of alleviating food effect in a pharmaceutical composition. The invention also provides a dispersion useful thereof.

Abstract: The hair treatment composition has the Theological properties of an oil but contains non-hydrophobic ingredients. It includes at least one fatty acid glyceride polyalkylene glycol ether or at least one fatty acid partial glyceride polyalkylene glycol ether with at least 30 alkylene glycol units respectively; at least one surfactant different from the at least one fatty acid glyceride polyalkylene glycol ether and the at least one fatty acid partial glyceride polyalkylene glycol ether with at least 30 alkylene glycol units and at least one thickener. The hair treatment composition is dfree of ingredients that cause foaming of the composition prior to or during application to hair. It provides hair to which it is applied with improved hair shaping, long-lasting luster and soft feel. It behaves like an oil, without having an oil in the classical sense as its principal ingredient.

Abstract: A local and site-specific drug delivery apparatus for delivering a drug to a specific site is characterized by the combination of a carrier material which reflects or absorbs or emits electromagnetic or mechanical (e.g. ultrasonic) vibrations enabling the monitoring of the material, a drug associated with the carrier material, and a local-delivery mechanism for delivering the carrier material and the drug to a specific site. The local-delivery mechanism may comprise a local-delivery catheter, such as a balloon-type catheter, and the drug delivery apparatus may additionally include a monitor for monitoring the delivery of the drug to the specific site, such as an ultrasonic imaging system. The drug delivery apparatus may also include a vibration generator for inducing release of the drug from the carrier material when the carrier material is at the specific site, such as a generator of ultrasonic energy.

Abstract: An aerosol device comprising a container containing an aerosol composition including a liquid phase containing at least one fixing material in a suitable solvent and a propellant and a means for distributing the aerosol composition, where the fixing material has a glass transition temperature (Tg) of greater than or equal to 30° C., and the aerosol device is suitable for obtaining a solids flow rate for the aerosol composition ranging from approximately 4 to approximately 17 mg/s and a wetting power for the aerosol composition of greater than or equal to 50 mg/s, and a process for treating keratin fibers using the aerosol device.

Abstract: The present application relates to novel oil-in-water emulsions comprising i) at least one specific 1,3,5-triazine derivative and ii) at least one polyalkyl-polyethersiloxane carrying polyoxyalkylene groups grafted onto the main silicone chain; with the proviso that the said emulsions do not comprise cetylstearyltrimethylammonium chloride. Another subject-matter of the present invention is the use of such emulsions in the manufacture of cosmetic or dermatological compositions intended for the photoprotection of the skin and/or hair and/or other keratinous substances against ultraviolet radiation, in particular solar radiation.

Abstract: A disinfectant and odorizing system for an evaporation cooler for disinfecting and odorizing water within a reservoir of an evaporation cooler. The disinfectant and odorizing system for an evaporation cooler includes a mixture. The mixture comprises a disinfectant and an aromatic oil. A water soluble tablet is hollow and is filled with the mixture.

Abstract: A solid or semi-solid hydrocarbon gel comprising: a) a solid or semi-solid hydrocarbon; and b) at least one block copolymer selected from the group consisting of: a triblock copolymer; a radial block copolymer; a multiblock copolymer a diblock copolymer; and mixtures of these polymers. The hydrocarbon gel is useful as an ointment, balm or salve for wounds. Medicinal ingredients may be included in the hydrocarbon gel for application of such ingredients to wounds, burns or injuries.