Abstract: Pharmaceutical compositions containing FSH, LH or hCG stabilized by means of a combination of sucrose and glycine. The formulation is particularly suitable for stabilizing a lyophilisate of recombinant gonadotropins.

Abstract: The invention relates to a process for the production of (meth)acrylic acid esters of polyhydric alcohols by reaction of the reactants with acrylic acid and/or methacrylic acid in the presence of acidic esterification catalysts with addition of sterically hindered phenolic compounds as polymerization inhibitors. The process is characterized in that tocopherols are used as the sterically hindered phenolic compounds and .alpha.-tocopherol is preferably at least partly used. The process is preferably carried out using reaction mixtures which are liquid at room temperature and which are at least substantially free from solvents and/or azeotropic entraining agents; more particularly, the water of condensation formed is removed from the gas phase of the reaction zone.

Abstract: A safe and reliable method of decomposing halogenated aromatic compounds, wherein a heat-resistant alkaline polar solvent containing halogenated aromatic compounds is contacted with a alkali at a temperature ranging from about 100.degree. C. to 300.degree. C. in order to decompose the halogenated aromatic compounds. The used solvent is removed of solid contents of salts, alkalis and the like, whereby it can be recycled.

Abstract: Compounds having the active site of natural lipoxins, but a longer tissue hlf-life are disclosed. These small molecules are useful for treating vasoconstrictive, inflammatory, myeloid suppressive, cardiovascular, and gastrointestinal diseases.

Abstract: A process for continuously producing acetic anhydride alone or acetic anhydride and acetic acid by reacting methyl acetate and/or dimethyl ether and, optionally, water and/or methanol, with carbon monoxide alone or carbon monoxide and hydrogen in the presence of a rhodium compound and methyl iodide as principal catalysts. Trace impurities causative of tar formation are distilled and separated in an evaporator and/or a subsequent refining step to remove the same. The removal of the trace impurities causative of tar formation serves to decrease the amount of tar formed as an impurity.

Abstract: The present invention is directed to a process for the recovery of an organic acid. The organic acid is generated from the manufacture of a cellulose ester. The first step of the process is to remove the organic acid from the manufacture of cellulose ester. The acid is in the form of a weak acid stream comprising of the organic acid and water. The weak acid stream is resolved, via a solvent extraction, to form an extractor overhead stream and raffinate stream. The raffinate stream comprises solvent, water, and alcohol. The alcohol is produced in the recovery process by hydrolysis of the solvent after the solvent extraction. The raffinate stream is resolved into a overhead stream and a bottom stream. The overhead stream comprises water, alcohol, and solvent. Excess organic acid is added to the overhead stream to form a feed stream. The feed stream is catalyzed, via ion exchange resins, whereby a portion of the alcohol is esterified to the solvent.

Abstract: Formic acid or derivatives thereof are produced from non-toxic carbon dioxide in the supercritical state, using it as raw materials, without using solvents, and at a high efficiency owing to a high reaction velocity, by reacting said carbon dioxide and an active hydrogen group-containing compound.

Abstract: This invention relates to an ocular hypotensive agent which comprises a compound represented by the formula: ##STR1## wherein R.sup.1 represents hydrogen or an optionally substituted hydrocarbon residue that may be bound via a hetero atom; R.sup.2 represents hydrogen or a hydrocarbon residue that may have a substituent; R.sup.3 represents a group capable of forming an anion or a group capable of changing thereto; X is a covalent bond between the 2 benzene rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n represents 1 or 2; ring A is a benzene ring having 1 or 2 optional substituents in addition to the group represented by COOR.sup.2, or a pharmaceutically acceptable salt thereof.

Abstract: The instant invention provides methods for inhibiting bone loss comprising adminstering to a mammal in need of treatment a compound as provided in formula I.

Abstract: The invention concerns a process and an apparatus for preparing tertiary ethers. According to the process, C.sub.4 to C.sub.6 isoolefins and possibly heavier olefins contained in the feedstock are reacted with lower aliphatic alcohols, in particular methanol or ethanol, in a catalytic distillation reactor system in order to produce the corresponding ethers. According to the invention, the reaction between the isoolefins and the alcohols is essentially carried out in at least one reactor (5-7) of the kind, which is combined with a distillation column (3) intended for product separation, by conducting at least a part of the liquid flow of the column through the reactor and returning it to a lower tray than the one from which it was taken. At least half of cation exchange resin is placed in the side reactor (5-7). In the process according to the invention, the catalyst can be rapidly changed without stopping the process.

Abstract: Disclosed is a one-step method for synthesis of methyl tertiary butyl ether, diisopropyl ether and isopropyl ether from crude streams containing acetone, methanol and t-butyl alcohol which comprises reacting an acetone-rich feed over a bifunctional catalyst comprising 5-45% by weight of a catalyst consisting essentially of a hydrogenation catalyst selected from the group consisting of one or more metals selected from the group consisting of IB, VIB or VIII of the Periodic Table and a heteropoly acid on a 55%-95% of the total weight of the catalyst of a support comprising a compound selected from the group consisting of:a. a metal phosphate;b. 5 to 95% by weight metal phosphate supported on 95 to 5 wt % Group III or IV oxide; andc. a large pore silicoaluminophosphate.

Abstract: Formic acid is difficult to separate from acetic acid by conventional distillation or rectification because of the proximity of their boiling points. Formic acid can be readily separated from acetic acid by using azeotropic distillation. Effective agents are acetonitrile and isopropyl acetate.

Abstract: Anandamides useful for the treatment of intraocular hypertension, as well as ophthalmic compositions comprising the same and a cyclodextrin, and methods of use of these compounds to treat intraocular hypertension.

Abstract: A process for preparing purified 2,6-naphthalenedicarboxylic acid which comprises hydrolyzing a dialkyl-2,6-naphthalenedicarboxylate with water at a reaction temperature of at least about 450.degree. F. under liquid phase condition, the amount of water present being sufficient to solubilize, at the reaction temperature, at least about 10 percent of the 2,6-naphthalenedicarboxylic acid formed; and a process for purifying 2,6-naphthalenedicarboxylic acid comprising combining impure 2,6-naphthalenedicarboxylic acid with a purification solvent, heating the resulting mixture under liquid phase conditions at a temperature of at least about 500.degree. F. to form a product mixture and thereafter recovering from the product mixture purified 2,6-naphthalenedicarboxylic acid.

Abstract: A process for the preparation of a gaseous mixture containing hydrogen and carbon monoxide by autothermal reforming, comprising(i) partial oxidation of a gaseous hydrocarbon feed in a partial oxidation zone,(ii) passing the effluent of the partial oxidation zone to a reforming zone; and(iii) reforming in the presence of a reforming catalyst in the reforming zone to form a reformed product stream, wherein the partial oxidation is carried out at a H.sub.2 C/C molar feed ratio of less than 0.2, and, preferably reformed product stream has a temperature in the range from 1000.degree. to 1350.degree. C., or wherein the reformed product stream has a temperature in the range from 1100.degree. to 1300.degree. C., and, preferably the partial oxidation is carried out at a H.sub.2 O/C molar feed ratio of less than 0.5.

Abstract: A high purity acetic acid is prepared by reacting methanol with carbon monoxide in the presence of a rhodium catalyst, iodide salts, and methyl iodide, wherein an acetaldehyde concentration in the reaction liquid is maintained at 400 ppm or lower. This may be attained by contacting the liquid containing carbonyl impurities with water to separate and remove the carbonyl impurities. After that, the liquid can be returned to the reactor.

Abstract: Butadiene or derivative thereof is selectively hydroxycarbonylated into at least one pentenoic acid (the pentenoic acids are themselves facilely converted, via hydroxycarbonylation, into adipic acid, a basic starting material for the production of nylon 66 polymers), by reacting same with carbon monoxide and water, at a pressure greater than atmospheric, in the presence of a catalytically effective amount of (1) a palladium catalyst which is soluble in the medium of reaction and (2) crotyl chloride, the amount of the crotyl chloride being at least two mol thereof per mole of palladium values and said palladium values/crotyl chloride at least in part comprising a palladium/crotyl pi-complex, and the amount of water present in the medium of reaction being no greater than about 20% by weight thereof.

Abstract: An esterification process for producing glycol ether esters which comprises reacting a lower hydrocarbyl carboxylic acid with a glycol ether alcohol in the presence of a long chain alkyl substituted aryl sulfonic acid esterification catalyst, the alkyl radical having from 8 to 20 carbon atoms.

Abstract: A two-stage process for effecting a chemical reaction has been developed. The reactants are contacted with a first stage fixed catalyst bed containing a solid catalyst or mixture of catalysts effective to catalyze the reaction and form a mixture of reactants and products. This reaction mixture and a desorbent are then contacted with a second stage simulated moving bed containing a solid or a mixture of solids effective to catalyze the reaction and to selectively adsorb at least one component from the reaction mixture. At least one product-containing stream is formed and collected. The process may be conducted in the liquid phase or in the vapor phase.

Abstract: A method for inhibiting bacteria in the mouth of a patient which includes placing a particle containing a degradable material and an anti-microbial agent in the mouth of the patient. The exterior of the particle is water-stable. The particles may be coated on dental floss or the bristles of a toothbrush, or incorporated into an oral rinse. Once placed in the mouth, the degradable material degrades to cause release of the anti-microbial agent, resulting in the inhibition of bacteria in the mouth.