Abstract: Antineoplastic illudin analogs are provided of the formula: wherein R.sub.4, R.sub.5 and R.sub.6 are (C.sub.1 -C.sub.4)alkyl, Y is H, (C.sub.1 -C.sub.3)alkyl, (R.sub.4)R.sub.5)(R.sub.6)Si or alkanoyl ((C.sub.1 -C.sub.4)alkylC(O)) and R is CH.sub.2 OH, halo, benzyl optionally substituted with OY, or alkanoylmethyl (CH.sub.2 OC(O)R.sub.7), wherein R.sub.7 is (C.sub.1 -C.sub.4)alkyl, (C.sub.6 -C.sub.2)aryl or N(X).sub.2, wherein each X is H or (C.sub.1 -C.sub.4)alkyl, and the pharmaceutically-acceptable salts thereof.

Abstract: A poly(methylene oxalate) polymer, [poly(oxy(1,2-dioxo-1,2-ethanediyl)oxymethylene)], a bis(tetrabutylammonium) oxalate salt, methods of synthesis thereof and methods of use are provided. Poly(methylene oxalate) is nearly insoluble in all common organic solvents, does not melt and is resistant to fire. Applications are as a light-weight material for use at high temperatures, e.g., as a structural material in aircraft and space vehicles, as a binder for brake systems, and as an insulator for microelectronic components.

Abstract: In a process for producing acetic anhydride and acetic acid by reacting methanol and methyl acetate, optionally together with dimethyl ether, with carbon monoxide, acetic anhydride and acetic acid are effectively produced with the use of a sequence of production facilities by carrying out separation of low-boiling point fraction mainly consisting of methyl iodide, methyl acetate and dimethyl ether with the use of at least two distillation zones, separating catalyst drops entrained from the vapor-liquid separation zone in at least one distillation zone and further by controlling the pressurization of the vapor-liquid separation zone and the above distillation zones under 5 bar to a pressure greater than atmospheric pressure.

Abstract: A fodder and a method are provided for increasing the amount of unsaturated fatty acids in the tissues and milk of ruminants. Specifically, the present invention includes feeding to a ruminant a composition containing the reaction product of an unsaturated fatty acid with a primary amine. The reaction product escapes hydrogenation in the stomachs of the ruminant allowing unsaturated fatty acids to be absorbed into the blood stream of the animal. In one embodiment, the unsaturated fatty acids used to react with the amine are derived from soybean oil. By increasing the amount of unsaturated fatty acids in the tissues and milk of ruminants, the food products obtained from those animals is healthier for human consumption.

Abstract: A catalyst comprising 70-99% by wt. of cobaltic salt and 1-30% by wt. of ferric salt, the acid component of the salt being such as acetate; propionate; naphthenate adipate and phthalate; a process for preparing the above catalyst, and a process for the preparation of carboxylic acids by oxidation of a hydrocarbon with oxygen or air in the presence of the above catalyst.

Abstract: An improved method for recovery of alkali metal or alkaline-earth metal terephthalate and of alkylene glycol, from polyalkylene terephthalate, in particular from polyethylene terephthalate (P.E.T.), alkylene glycol, in particular ethylene glycol produced in the form of vapor during the saponification reaction, initiated by the action of intensive kneading of polyalkylene terephthalate and the alkaline reagent at a temperature of 100.degree. to 200.degree. C. The alkylene glycol is recovered in gaseous form by entrainment by an inert gas or by extraction under low pressure. The alkaline terephthalate or alkaline-earth terephthalate is obtained in solid or powder form; it can easily be stored, transported and redissolved, in order to be purified and possibly transformed into terephthalic acid or ester.

Abstract: Aspartic acid is reacted with prussic acid and formaldehyde to give an amino-polycarboxylic acid or a salt thereof represented by-the following formula: ##STR1## wherein each of R.sup.1 and R.sup.2 represents a hydrogen atom, an alkali metal or an ammonium group; and each of R.sup.3 and R.sup.4 represents a hydrogen atom or --CH.sub.2 --COOR.sup.1, provided that R.sup.3 and R.sup.4 do not represent a hydrogen atom simultaneously. The amino-polycarboxylic acid which is readily biodegradable and has an excellent chelating ability can be obtained from aspartic acid in a high yield and in a high purity.

Abstract: This invention relates to a method of inhibiting platelet aggregation comprising administering compounds having the following formula ##STR1##

Abstract: A method for the hydrogenolytic reduction of peroxidic ozonolysis products to the corresponding carbonyl compounds in the presence of an inert organic diluting agent and in the presence of a monolith catalyst at hydrogen pressures of 0.01 to 2.0 MPa and at temperatures of -10.degree. to 150.degree. C., and a device for the catalytic hydrogenolysis of chemical compounds which yield uniform, new products by means of hydrogenolysis with hydrogen.

Abstract: The present invention relates to a process for the preparation of 5-fluoroanthranilic alkyl esters and/or 5-fluoroanthranilic acid, which comprises dissolving a 3-fluorobenzoic alkyl ester in sulfuric acid and reacting the solution with a nitrating acid at from -10.degree. to 30.degree. C., then adding water, separating off the nitrated reaction product and reacting it with hydrogen at from 50.degree. to 120.degree. C. under elevated pressure in the presence of a catalyst comprising a metal of the platinum group and sulfur, and, if desired, removing 5-fluoroanthranilic alkyl esters by distillation and hydrolyzing them to give 5-fluoroanthranilic acid.

Abstract: The active agent ursodeoxycholic acid has proved therapeutically active in infants, inter alia for the treatment of cholestatic hepatic diseases. A problem when administering this active agent, a bile acid, to infants is its extreme bitterness. As a result of the present invention a taste-acceptable, liquid administration form for ursodeoxycholic acid with an adequately high active agent concentration is described. The liquid to be ingested is a suspension prepared accompanied by the addition of a swelling and/or thickening agent, which contains the active agent mainly in fine crystalline form as the disperse phase and only in a much smaller proportion dissolved in the aqueous dispersant. A remaining residual bitterness can be additionally masked by the addition of .beta.-cyclodextrin or suitable taste correcting agents.

Abstract: .gamma.-Mercaptocarboxylic acids and their derivatives, in particular esters and amides, are prepared from .gamma.-butyrolactones via the corresponding thiolactones. The thiolactones are obtained by reaction of a .gamma.-lactone with thiocarboxylates in polar solvents and are converted by ring opening using nucleophilic reagents, such as, alkali metal alkoxides, into the .gamma.-mercaptocarboxylic acid derivatives. These are intermediates, for example, for the synthesis of leucotriene antagonists.

Abstract: A process for the esterification of acids or anhydrides with alcohols or a polyhydroxy compound wherein the lower boiling point reactant is added to the reaction vessel in stages such that it is present in an amount of at least about 5% of the stoichiometric requirements of the total lower boiling point reactant required to react with the limiting reagent, and wherein the concentration of the lower boiling point reactant is monitored so that additional reactant having the lower boiling point can be subsequently added in stages to the reaction mixture in order to maintain a certain predetermined concentration of the lower boiling point reactant.

Abstract: An improved process for recovering reaction products from polymers such as polyesters or polyamides, especially those having a desired polymer level below about 98%. The process involves depolymerization and vapor phase extraction of monomers in the presence of a solid support.

Abstract: A hydromorphone composition, a hydromorphone dosage form and a method for administering hydromorphone are disclosed, indicated for the management of pain.

Abstract: The invention relates to a process for preparing .beta.-alaninediacetic acid (Ia) or its alkali metal or ammonium salts (Ib) which comprises reacting iminodiacetic acid with acrylonitrile or C.sub.1 -C.sub.4 -alkyl acrylates in weakly acid to weakly basic aqueous medium and subsequently hydrolyzing the nitrile or ester moiety to the acid or a salt.The products prepared according to the invention can be used, in particular, to form complexes.

Abstract: The present invention provides a novel process for producing 4-acyloxy-2-methyl-2-buten-1-al readily in high yield from a readily available inexpensive industrial starting compound without using special reaction apparatuses and conditions.

Abstract: Provided is a process for the production of 2-fluoroisobutyric acid or its ester, which comprises reacting 2-hydroxyisobutyric acid or its ester with thionyl chloride and a hydrogen fluoride source.

Abstract: A process for the isolation of L-leucine and L-isoleucine from an aqueous solution containing these amino acids and their separation from each other by contacting the solution with a zeolite under acid conditions.

Abstract: A method for making an amine includes the steps of heating a reaction mixture including a nitrile, an acid, water and a substrate compound capable of generating a carbonium ion by reaction with the acid to generate a first reaction intermediate; treating the first reaction intermediate with an acid in the presence of a primary alkanol to form a second reaction intermediate and an alkyl ester; separating the alkyl ester from the second reaction intermediate; and treating the second reaction intermediate with a base to form the amine.