Abstract: The present invention provides a diaryl sulfone compound represented by Formula (1): wherein R1 to R4 and R1? to R4? are the same or different, and each represents hydrogen, C1-4 alkyl, or halogen, and R5 represents C2-6 alkenyl, C1-4 alkyl, or aromatic heterocyclic group; a method for producing the diaryl sulfone compound represented by Formula (1) by reacting a 4,4?-dihaloarylsulfone compound with thiol salt compound having an alkylene group; and a method for producing the diaryl sulfone compound represented by Formula (1) by reacting a 4,4?-dihaloarylsulfone compound with a thiol salt compound having a hydroxyl group, and subjecting the resulting compound to reaction with a halogenating agent, followed by a dehydrohalogenation reaction.

Abstract: The present invention provides a process for preparing a crystalline form of halobetasol propionate, comprising the step of crystallizing halobetasol propionate from absolute ethanol or a mixture of ethanol and water, wherein the crystalline form of halobetasol propionate is characterized by an x-ray powder diffraction pattern having peaks at 10.0, 11.6, 12.9, 13.4, 14.5, 16.4, 17.6, and 23.5±0.2 degrees 2?.

Abstract: Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.

Abstract: The present invention is directed to the separation of ethanol from a crude ethanol product obtained from the vaporization and hydrogenation of acetic acid using reduced residence time for the vapor phase reactants between exiting the vaporizer and entering the reactor. The crude ethanol product is separated in at least one column to recover an ethanol product.

Abstract: Preparations of polysaccharides lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.

Abstract: Digestion of cellulosic biomass solids can be enhanced in the presence of a phenolic solvent. Methods for digesting cellulosic biomass solids can comprise providing cellulosic biomass solids in a digestion medium comprising a phenolic solvent; and heating the cellulosic biomass solids and the digestion medium in a digestion unit in the presence of molecular hydrogen and a slurry catalyst capable of activating molecular hydrogen, thereby forming an alcoholic component derived from the cellulosic biomass solids and liberating lignin from the cellulosic biomass solids into the digestion medium. The methods can further comprise converting at least a portion of the lignin into a phenolic solvent and returning the phenolic solvent formed from lignin to the cellulosic biomass solids.

Abstract: Carboxylated, mercerized cellulose fiber having at least 12 meq/100 g of carboxyl substitution at the C-6 position of the anhydroglucose units, which includes at least 20% cellulose II, may be produced by catalytically carboxylating mercerized cellulose fiber in at least two catalytic carboxylation stages in a continuous series in which the pH is adjusted, and a primary oxoammonium salt catalyst (or precursor thereof) and secondary oxidant is added, at the beginning of each stage. Optionally, the carboxylated, mercerized cellulose may be made substantially free of aldehyde groups by means of a stabilizing step following the final carboxylation stage, in which aldehyde groups present in the fibers are converted to carboxyl groups.

Abstract: A process for producing bortezomib N-(pyrazin-2-yl)carbonyl-L-phenylalanine-L-leucine boronic acid) comprising the step of deprotecting the compound of formula XII: to yield bortezomib.

Abstract: The present invention presents the isolation, characterization and synthesis of oligosaccharides of Bacillus anthracis. Also presented are antibodies that bind to such saccharide moieties and various methods of use for such saccharide moieties and antibodies.

Abstract: The present invention relates to a new method for preparing microcrystalline cellulose, comprising a prior step of compaction of the cellulose before degradation of the glucose chains and obtaining the suitable degree of polymerization. It is also described that the method of the invention allows a considerable reduction in the consumption of energy, water and possible chemicals which are used for reducing the degree of polymerization. The microcrystalline cellulose obtained can be used as a pharmaceutical excipient in tablets, and presents disintegration features comparable to those of the microcrystalline cellulose obtained by a spraying process.

Abstract: A halogenated dideoxy sugar derivative, having the following general structure I wherein X is halogen, R1 and R2 are H or Br; R3 and R4 are OH or OAc. The compounds 1-14 of the current invention has strong inhibition effect on human nasopharyngeal cancer CNE-2Z cells, human lung cancer A549 cells. human colon cancer HT-29 cells, human liver cancer Bel-7402 cells, human rectum cancer cells HCE 8693, human stomach cancer BGC-803 cells, human esophagus cancer CaEs-17 cells, human breast cancer cells MCF-7, human ovarian cancer cells A2780, pancreatic cancer cells PC-3, human bladder cells EJ, human brain glia cells TG-905, human leukemia cells K562, human melanoma M 14 cells and human anaplastic thyroid carcinoma TA-K cells. They can be used to prepare anti-tumor medicament and have significant clinic value.

Abstract: The present invention discloses a system for converting methanol or synthesis gas to liquid hydrocarbons with comparable energy content to gasoline within a mixed bed single reactor or double reactor systems. Varying catalyst composition and temperature profiles allow for significant tailoring of reaction conditions to the specific feedstocks or the desired products.

Abstract: This invention provides a method for hydrophilic cellulose fibers capable of inhibiting decrease in the degree of polymerization and whiteness degree of oxidized cellulose fibers in oxidized cellulose in which a carbon at position 6 of each glucose unit in the cellulose fiber starting material is oxidized to a carboxyl group, the method comprising (A) the step of performing dehalogenation together with reduction, the dehalogenation comprising mixing a dehalogenation agent, a reducing agent, and oxidized cellulose fibers, and removing halogens remaining in the oxidized cellulose fibers, and the reduction comprising reducing a ketone group at position 2 and/or position 3 of each glucose unit in the oxidized cellulose fibers.

Abstract: This invention relates to oral and intra-articular formulations based on sulphated hyaluronic acid which are effective in the treatment of degenerative osteoarthritis.

Abstract: An arylamine compound including: a partial structure shown in formula (1-1) or (1-2), wherein either X or Y is one of leaving substituents and the other is a hydrogen atom; either (X1, X2) or (Y1, Y2) is one of the leaving substituents respectively and the other is the hydrogen atom respectively; each of Q1, Q2, Q3, Q4, Q5, and Q6 is selected from the hydrogen atom, a halogen atom, organic substituents other than the leaving substituents, and an atomic bonding to link with an adjacent arylamine group respectively; and adjacent two substituents selected from Q1, Q2, Q3, Q4, Q5, and Q6 may be linked together to form the ring which may be a part of an arylamine group.

Abstract: Disclosed herein are novel C4-monomethyl triterpenoid compounds and derivatives thereof, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example as antioxidant inflammation modulators, and compositions thereof are also provided.

Abstract: Disclosed are naphtho[2,3-f]quinoxaline compounds and pharmaceutical composition thereof. The compounds of the invention have been demonstrated as having analgesic effects and therefore may be applicable for use as a novel agent in relieving acute or chronic pain.

Abstract: The present invention relates to novel jasmonate derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for prevention and treatment of cancers.

Abstract: Digestion of cellulosic biomass solids may be complicated by release of lignin therefrom. Methods for digesting cellulosic biomass solids may comprise: providing cellulosic biomass solids in a digestion solvent; at least partially converting the cellulosic biomass solids into a phenolics liquid phase comprising lignin, an aqueous phase comprising an alcoholic component derived from the cellulosic biomass solids, and an optional light organics phase; combining at least the phenolics liquid phase and the aqueous phase with one another, thereby forming a combined phase; and separating at least a portion of the alcoholic component from at least a portion of the combined phase.

Abstract: The present disclosure provides compounds of general formula A: useful as potential anti-tubercular agents.