Abstract: Recovery of ethanol from a crude ethanol product obtained from the hydrogenation of acetic acid and by reacting a portion of the crude ethanol product or one or more derivative streams containing ethyl acetate obtained therefrom in the presence of hydrogen, via hydrogenolyzis. The one or more derivative streams comprise ethyl acetate that are reacted via hydrogenolyzis to form additional ethanol that may be directly or indirectly fed to the separation zone or the hydrogenation reactor.
Type:
Grant
Filed:
July 8, 2011
Date of Patent:
March 1, 2016
Assignee:
Celanese International Corporation
Inventors:
R. Jay Warner, Trinity Horton, Radmila Jevtic, Victor J. Johnston, David Lee, Adam Orosco, Lincoln Sarager
Abstract: A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.
Type:
Grant
Filed:
January 19, 2012
Date of Patent:
March 1, 2016
Assignee:
3M INNOVATIVE PROPERTIES COMPANY
Inventors:
Jerald K. Rasmussen, Catherine A. Bothof, Kannan Seshadri, James I. Hembre, Robert T. Fitzsimons, Jr., George W. Griesgraber, Yi He
Abstract: This invention relates to compounds of Formula (I) wherein Cy1, L1, Y, R1, L2, and Ar2 are defined herein, for the treatment of cancers, inflammatory disorders, and neurological conditions.
Type:
Grant
Filed:
September 3, 2009
Date of Patent:
February 23, 2016
Assignee:
BIOMARIN PHARMACEUTICAL INC.
Inventors:
James R. Rusche, Norton P. Peet, Allen T. Hopper
Abstract: The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Type:
Grant
Filed:
September 26, 2011
Date of Patent:
February 23, 2016
Assignee:
AbbVie Deutschland GmbH & Co. KG
Inventors:
Sean Colm Turner, Margaretha Henrica Maria Bakker, Marcel Van Gaalen, Falko Ernst Wolter, Wilfried Hornberger, Marjoleen Nijsen
Abstract: The invention is directed to improvements in the indirect hydration process for the production of alcohols that enable high alcohol yield by increasing ether recycle in an olefin hydration process, such as the hydration process to produce isopropyl alcohol (IPA) from propylene or the hydration process to produce sec-butyl alcohol (SBA) from butylene.
Type:
Grant
Filed:
June 17, 2010
Date of Patent:
February 23, 2016
Assignee:
ExxonMobil Chemical Patents Inc.
Inventors:
Charles Morris Yarbrough, Seth McConkie Washburn, Dennis Jay Davoren, Michael Alan Better
Abstract: Provided is hydroxypropylmethylcellulose having a high thermal gelation temperature and a high thermal gel strength and a method for producing the same and a food comprising the hydroxypropylmethylcellulose. More specifically, provided is hydroxypropylmethylcellulose having an average substitution degree of a methoxy group of 1.0 to 2.0 per glucose unit, an average substitution degree of a hydroxypropoxy group of 0.05 to 0.4 per glucose unit, and a A/B value of 0.305 or greater wherein A represents a substitution degree of a methoxy group directly substituted for a hydroxy group on carbon at position 6 in a glucose unit free from a hydroxypropoxy group-substituted hydroxy group, B represents a substitution degree of a methoxy group per glucose unit, and the A/B represents a value of A divided by B.
Abstract: The present invention relates to crystalline polymorphs of (2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide (GDC-0032, taselisib), methods of use, and processes of preparing thereof.
Abstract: Thermal interface materials are disclosed that include or are based on thermally reversible gels, such as thermally reversible gelled fluids, oil gels and solvent gel resins. In an exemplary embodiment, a thermal interface material includes at least one thermally conductive filler in a thermally reversible gel.
Abstract: The present invention relates to an improved method for preparing dipeptidyl peptidase-IV inhibitor intermediates. The present invention is able to reduce preparation costs by using low cost reagents on reaction and is able to be used in mass production by improving yield.
Type:
Grant
Filed:
October 3, 2014
Date of Patent:
February 2, 2016
Assignee:
DONG-A PHARMACEUTICAL CO., LTD.
Inventors:
Woo Young Kwak, Heung Jae Kim, Jong Pil Min, Tae Hyun Yoon, Moohi Yoo, Geun Gho Lim, Sun Ki Chang
Abstract: The present invention encompasses compounds of general formula (1) wherein R1 to R3 and X are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
Type:
Grant
Filed:
April 22, 2010
Date of Patent:
January 26, 2016
Assignee:
Boehringer Ingelheim International GmbH
Inventors:
Lars Van Der Veen, Darryl McConnell, Siegfried Schneider, Matthias Grauert, Andreas Schoop, Tobias Wunberg
Abstract: The invention relates to lipochitooligosaccharides obtainable from arbuscular mycorrhizal fungi, and which are useful for stimulating arbuscular mycorrhizal symbiosis, and lateral root formation.
Type:
Grant
Filed:
October 28, 2009
Date of Patent:
January 26, 2016
Assignees:
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE PAUL SABATIER
Inventors:
Jean Denarie, Fabienne Maillet, Véréna Poinsot, Olivier Andre, Guillaume Becard, Monique Gueunier, Laurence Cromer, Alexandra Haouy, Delphine Giraudet
Abstract: Pharmaceutical compositions that bind to a predicted FK506 Binding Protein 52 (FKBP52) interaction surface on the androgen receptor hormone binding domain, otherwise known as FKBP52 Targeting Agents (FTAs) are provided. These compositions of the present invention are found to specifically recognize the FKBP52 regulatory surface on the androgen receptor and inhibit FKBP52 from functionally interacting with the androgen receptor. Compositions comprising the pharmaceutical composition, as well as methods of use, treatment and screening are also provided.
Type:
Grant
Filed:
July 21, 2014
Date of Patent:
January 12, 2016
Assignees:
The United States of America, as represented by The Secretary, Department of Health and Human Services, The Regents of the University of California, a California Corporation, Board of Regents, The University of Texas System
Inventors:
Leonard M. Neckers, Marc B. Cox, Jane B. Neckers, Yeong Sang Kim, Aki Iwai, Yangmin Ning, Johanny Kugelman-Tonos, Heather A. Balsiger, Robert Fletterick
Abstract: The present invention relates to novel heterocyclic compounds, to processes for preparation thereof and to the use thereof for controlling animal pests, which include arthropods and especially insects.
Type:
Grant
Filed:
July 15, 2011
Date of Patent:
January 12, 2016
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Friedrich August Mühlthau, Thomas Bretschneider, Reiner Fischer, Martin Füβlein, Markus Heil, Achim Hense, Joachim Kluth, Adeline Köhler, Eva-Maria Franken, Olga Malsam, Arnd Voerste, Peter Jeschke, Angela Becker, Peter Lösel, Yoshitaka Sato
Abstract: This invention relates to oral veterinary compositions for combating ectoparasites and endoparasites in animals, comprising at least one systemically-acting active agent in combination with a pharmaceutically acceptable carrier. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.
Type:
Grant
Filed:
January 31, 2013
Date of Patent:
January 12, 2016
Assignee:
MERIAL, INC.
Inventors:
Mark David Soll, Diane Larsen, Susan Mancini Cady, Peter Cheifetz, Izabela Galeska, Saijun Gong
Abstract: Methods for purifying fucoidan in extracts from brown seaweed are disclosed. In particular, methods of purifying fucoidan in the extract to remove heavy metal ions, bacterial and endotoxin contaminants, and other impurities are disclosed. The methods include the use of a chelating agent, selective precipitation, and filtration.
Type:
Grant
Filed:
May 1, 2014
Date of Patent:
January 12, 2016
Assignees:
BAXALTA INCORPORATED, BAXALTA GMBH
Inventors:
Patrick N. Shaklee, Jennifer Bahr-Davidson, Srinivasa Prasad, Kirk W. Johnson
Abstract: Thiazolyl oxime ethers and hydrazones of the formula (I), in which the symbols A, L1, L2, Y, W, X, R1, R2, R3, R4, R5, R6 and R7 have the meanings given in the description, and also agrochemically active salts thereof, and their use for controlling phytopathogenic harmful fungi, and also methods for controlling phytopathogenic harmful fungi and processes for preparing compounds of the formula (I).
Type:
Grant
Filed:
February 28, 2014
Date of Patent:
December 22, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Pierre Cristau, Nicola Rahn, Tomoki Tsuchiya, Ulrike Wachendorff-Neumann, Arnd Voerste, Jürgen Benting
Abstract: The present invention provides a crosslinked hyaluronic acid composition including self-crosslinking hyaluronic acid particles having an equilibrium swelling capacity of 3-fold to 10-fold, and an aqueous solvent, wherein a dry weight of the self-crosslinking hyaluronic acid particles based on the total volume of the crosslinked hyaluronic acid composition is 3 w/v % to 8 w/v %. The crosslinked hyaluronic acid composition of the invention uses self-crosslinking hyaluronic acid particles of which the equilibrium swelling capacity is within the above predetermined range. Accordingly, the viscosity does not sharply increase even if the concentration thereof is increased. Therefore, if the crosslinked hyaluronic acid composition is applied to an injection, it is possible to obtain a sufficient curative effect on knee osteoarthritis even with a small frequency of administration.
Abstract: Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.
Type:
Grant
Filed:
September 27, 2013
Date of Patent:
December 15, 2015
Assignee:
MOMENTA PHARMACEUTICALS, INC.
Inventors:
Mallikarjun Sundaram, Takashi Kei Kishimoto, Sucharita Roy
Abstract: Methods of treating cancer comprising administering inhibitors of glucose transporters (GLUTs) are provided. Methods of predicting whether a cancer will respond to treatment with a GLUT inhibitor also are provided.
Type:
Grant
Filed:
March 30, 2012
Date of Patent:
December 8, 2015
Assignee:
Northwestern University
Inventors:
Malathy Shanmugam, Samuel K. McBrayer, Steven T. Rosen
Abstract: The present invention relates to method for the preparation of a particulate reversibly-crosslinked polymeric material comprising: treating a particulate water-soluble hydroxyl-functional polymer in a liquid phase comprising a solvent mixture in that the hydroxyl-functional polymer is insoluble containing an organic solvent and water; a tetracarboxylic acid dianhydride represented by formula (I), 10 (I) wherein: U and V are independently selected from CH, N and P; 15 X is selected from a single bond, a saturated divalent (C1-C10) hydrocarbon group, O, S, NR, and PR, wherein R is selected from hydrogen and (C1-C4) alkyl; n and m are independently selected from 0 and 1; w is 1 or 2 with the proviso that; 20 if w is 1 then Y is X and if w is 2 then Y is selected from H and (C1-C4) alkyl, whereby there is no bond between both Y; and optionally a catalyst; to form a particulate reversibly-crosslinked polymeric material and 25 to a particulate reversibly-crosslinked polymeric material obtainable thereby.