Abstract: The present invention provides a panel of monoclonal antibodies and binding proteins which specifically bind to human Fas antigen. Some of the antibodies and binding proteins are capable of stimulating T cell proliferation, inhibiting binding of anti-Fas CH-11 monoclonal antibody to cells expressing Fas antigen, blocking anti-Fas CH-11 monoclonal antibody-mediated lysis of cells, and blocking Fas ligand-mediated lysis of cells. The invention also provides for therapeutic compositions comprising the monoclonal antibodies.

Abstract: DNA fragments from Porphyromonas gingivalis which express proteins that elicit anti-P. gingivalis immunologic responses are described. Microorganisms, genetically modified to express P. gingivalis antigens, are provided. Also disclosed are probes, vaccines, and monoclonal antibodies for the detection and prevention of periodontal disease.

Abstract: A method for producing a layer of a multi-layer electronic circuit package and resulting article of manufacture is provided comprising the steps of selecting a core material from one of three iron/nickel alloys, namely either (i) 58% Fe/42% Ni; (ii) 60% Fe/39% Ni/1% Cu; or (iii) 60% Fe/38.7% Ni/0.12% Mn/0.07% Si; forming the core material into a panel suitable for an intended application; cleaning the panel in preparation for plating; plating the panel with copper; subjecting the plated panel to heat treatment; and circuitizing the panel as appropriate for the intended application.

Abstract: A method for forming a Spin-On-Glass (SOG) residue free Inter-Metal Dielectric (IMD) spacer layer as a substrate layer for a void free conformal insulator layer within a high aspect ratio exceedingly narrowly spaced patterned layer within an integrated circuit. First there is provided a semiconductor substrate having formed thereupon a patterned layer. The patterned layer has a first aperture formed therein. Formed upon the patterned layer and into the first aperture is a conformal Inter-Metal Dielectric (IMD) layer. The conformal Inter-Metal Dielectric (IMD) layer has a second aperture formed therein where the conformal Inter-Metal Dielectric (IMD) layer is formed into the first aperture. Formed upon the conformal Inter-Metal Dielectric (IMD) layer and filling the second aperture is a planarizing Spin-On-Glass (SOG) layer.

Abstract: DNA fragments from Porphyromonas gingivalis which express proteins that elicit anti-P. gingivalis immunologic responses are described. Microorganisms, genetically modified to express P. gingivalis antigens, are provided. Also disclosed are probes, vaccines, and monoclonal antibodies for the detection and prevention of periodontal disease.

Abstract: This invention provides novel antibodies specifically reactive with a nuclear retinoblastoma-associated polypeptide, wherein the polypeptide specifically binds to the protein product of the retinoblastoma gene. Also provided by this invention are antibodies specifically reactive with proteins having E2F biological activity. Methods of using these antibodies also are claimed.

Abstract: An absorbent composition of matter including a non-crosslinked gel forming polymer and at least one clay and preferably including a trivalent cation. The absorbency of the composition exceeds the sum of absorbencies of the components of the blend. The gel formed as a result of absorbency of fluid is non-slimy and has a high gel strength. The composition can be used with food products when made with all food safe ingredients. An absorbent article incorporating the absorbent material can be used for storage of food products.

Abstract: A method of manufacturing a panel unit constituted of a panel and a frame provided on the periphery of the panel. The method comprises the steps of providing a first die having a molding groove and a panel receiving space formed therein, and a second die engageable with the first die and having a molding groove formed therein, mounting the first die on the periphery of the panel, engaging the second die with the first die to form on the periphery of the panel a molding space of which the cross-sectional configuration corresponds to that of the frame, extruding molding material into the molding space, and applying relative motion between the second die and the first die to move the second die along the first die, thereby integrally forming the frame on the periphery of the panel.

Abstract: The direct, concentrated local delivery of antibodies, and pooled human immunoglobulins in particular, to tissue surfaces (e.g., wounds, burns, etc.), and biomaterial implant surfaces significantly decreases the rate of infection at those sites and enhances healing. The immunoglobulins serve to opsonize circulating infectants for phagocytosis and killing, prior to microbial adhesion and biofilm formation, and neutralize bacterial toxins. The treatment methodology results in reduced inflammation, reduced complement and tissue damage, and reduced rejection of biomaterials and transplants.

Abstract: Process for the identification or assay of a particular polypeptide antigen X in which an immunological determination of the presence of said polypeptide antigen X is carried out in a sample, characterized in that the sample is treated in vitro using at least one chemical reagent reactingon an epsilon -NH.sub.2 function of a lysine residue oron a terminal alpha -NH.sub.2 function of a peptidein order to carry out the linking of said reagent to said polypeptide antigen X and in this way to obtain a modified polypeptide antigen X, (polypeptide antigen Xm), the immunological determination of the presence of said polypeptide antigen X in said sample is then carried out using at least one antibody produced by immunization against a polypeptide antigen Y identical to the polypeptide antigen Xm or to an antigenic fragment of this antigen Xm.

Abstract: A technique for analyzing target chemicals is provided. The apparatus of the technique contains an array of two or more light sources. Each of the array elements includes a light source. The light source has an emitting surface from which light can be emitted. Two or more binder chemical moieties are associated with the light sources at the emitting surfaces. These binder chemical moieties can bind target chemicals such that different target chemicals can be bound to the array. Light emitted by the light sources impinges on target chemicals bound to the light sources and will cause light interaction (e.g., fluorescence) with the target chemicals to result in a light pattern or patterns to indicate the presence or quantity of the target chemicals. The array is formed by a tiling technique involving the arrangement of tiles of array elements in a desired pattern.

Abstract: A device for the parallel processing of ions is provided. The device may be utilized for thin film deposition or ion implantation and may include the following: an ion source, ion capture and storage ion optics, mass selection ion optics, neutral trapping elements, extraction ion optics, beam neutralization mechanisms, and a substrate on which deposition and thin film growth occurs is provided. Ions are captured and stored within a closely packed array of parallel ion conducting channels. The ion conducting channels transport high current low energy ions from the ion source to irradiate the substrate target. During transport, ion species can be mass selected, merged with ions from multiple sources, and undergo gas phase charge exchange ion molecule reactions.

Abstract: A method of controlling, in a warm-blooded animal, an infectious microorganism expressing a chorionic gonadotropin-like growth-regulating protein comprises modulating the activity of the protein by administering to the warm-blooded animal an effective amount of an antibody capable of inhibiting the activity of the protein, the chorionic gonadotropin-like growth-regulating protein itself such that the animal develops a neutralizing immune response, or peptides that block the receptors of the chorionic gonadotropin-like growth-regulating protein in the infectious microorganism. Candida albicans is one such microorganism that can be controlled by delivering an antibody against the growth-regulating protein, CaCGLP. Mycobacteria can also be controlled by this method. A method of inhibiting transition of Candida albicans blastospores in vitro by contacting the blastospores with an antibody against CaCGLP is also disclosed.

Abstract: Humoral and cellular immune responses against tumor cells and infectious agents are induced in a mammal using a vaccine comprising antibodies and anti-idiotype antibodies that mimic an epitope of antigen that is associated with a tumor or infectious agent. Antibodies and cytokines also may be used to amplify the immune cascade. Moreover, antibodies and anti-idiotype antibodies can be used to produce T cells that are not MHC-restricted and that are targeted to tumor cells and infectious agents.

Abstract: Tumor necrosis factor antagonists are administered in therapeutically effective doses to suppress inflammatory immune-potentiated events. The antagonists of this invention typically are selected from among several classes but preferably are neutralizing antibodies directed against tumor necrosis factor. The antagonists are useful in suppressing transplantation immunity and in the treatment of autoimmune diseases.

Abstract: Reactivity between an alloantigen and an anti-alloantigen is indicative of immunological reactivity between two biological samples of the same species. Reactivity between a xenoantigen and an anti-xenoantigen is indicative of immunological reactivity between two biological samples of different species. In many cases both of the reactions are indicative of an antibody-mediated rejection. Anti-antibodies can be employed to reduce cross-reactivity in many transplantation-type situations, either within a similar species, or across species lines. These anti-antibodies are prepared against the antibodies responsible for the antibody-mediated rejection. These anti-antibodies can then be used in vivo or in vitro to complex with the antibodies thus reducing or eliminating reactivity between an alloantigen and an anti-alloantigen or reactivity between a xenoantigen and an anti-xenoantigen between any two species combinations.

Abstract: The effective treatment of Clostridium difficile associated diseases, such as Clostridium difficile colitis, pseudomembranous colitis and antibiotic associated diarrhea, by administering an antibody having specific activity against Clostridium difficile colitis and toxins thereof alone or in combination with vancomycin, bacitracin or metronidazole is herein described as well as pharmaceutical compositions therefor.

Abstract: The present invention describes methods for inhibiting angiogenesis in tissues using vitronectin .alpha..sub.v .beta..sub.3 antagonists, and particularly for inhibiting angiogenesis in inflamed tissues and in tumor tissues and metastases using therapeutic compositions containing .alpha..sub.v .beta..sub.3 antagonists.

Abstract: Bispecific molecules which react both with an Fc.gamma. receptor for immunoglobulin G (IgG) of human effector cells and with either human low density lipoprotein (LDL), or fragment thereof, or human high density lipoprotein (HDL), or a fragment thereof, are disclosed. The bispecific molecules bind to an Fc.gamma. receptor without being blocked by the binding of IgG to the same receptor. The bispecific molecules having a binding specificity for human LDL are useful for targeting human effector cells for degradation of LDL in vivo. The bispecific molecules of the present invention which have a binding specificity for human HDL are useful for targeting human HDL to human effector cells such that the HDL takes up cholesterol from the effector cells. Also disclosed are methods of treating atherosclerosis using these bispecific molecules.

Abstract: By using first mixed gas containing carbon atoms and fluorine atoms, a semiconductor substrate is etched. In order to remove a damage layer formed on the surface of the semiconductor substrate by this etching processing, the semiconductor substrate is etched by second mixed gas including gas containing fluorine atoms and oxygen gas having a partial pressure ratio of at least 70%. Thereafter, a semiconductor oxide film is formed on the semiconductor substrate to fabricate a semiconductor device.