Patents Examined by Susan D. Coe
  • Patent number: 6770301
    Abstract: The invention is a composition and method for non-specific enhancement of immune responses in human and animal recipients. A colostrum-derived feed additive (CDFA) for human or veterinary use comprises a sprayed-dried preparation of pasteurized and homogenized first milking colostrum that enhances immune responses in a recipient receiving an oral administration. Generally, CDFA is administered in a conditioning dose once per day during a conditioning period of time from about 7 to 14 days, and then in a maintenance dose administered once per day during a period that follows the conditioning period. The maintenance dose is about one-half the concentration of the conditioning dose. Administration of CFDA enhances immune response in a recipient in a dose-dependent manner.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: August 3, 2004
    Assignee: Immuno-Dynamics, Inc.
    Inventor: Richard Cockrum
  • Patent number: 6770302
    Abstract: The present invention relates to the use of Indian Green Mussel (Perna viridis) as a source of anti-HIV activity. More particularly, the present invention relates to the use of an extract of Indian Green Mussel (Perna viridis) as a source of anti-HIV activity in vitro.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: August 3, 2004
    Assignees: Department of Biotechnology, Council of Scientific and Industrial Research
    Inventors: Debasis Mitra, Anil Chatterji
  • Patent number: 6767563
    Abstract: An inventive and proprietary food supplement formula per unit to enhance the body's natural immune function against viral and infectious diseases and cancer. The food supplement per unit in liquid or capsule gel caplets consists of: 200 to 600 mg. of Chrysin; 200 to 600 mg. of Coriolus Versicolor PSK; 50 to 150 mg. of 3,3′ Diindolylmethane DIM; 50 to 150 mg. of Resveratrol 25 %; 50 to 150 mg. Turmeric Extract 95 %; 40 to 140 mg. Green Tea Extract 95 %; 20 to 80 mg. of Quercitin Dihydrate 99 %; and 15 to 75 mg. of Phosphatidyl Choline 50 %. Advantageously, each dose unit preferably includes 25 mg to about 150 mgs. of Myricetin.
    Type: Grant
    Filed: August 26, 2002
    Date of Patent: July 27, 2004
    Inventor: Michael D. Farley
  • Patent number: 6761913
    Abstract: Biologically active extracts of celery seed are produced by controlled ethanolic extraction, distillation and drying, and further processing by supercritical fluid extractions (SFE), and may be further fractionated by column fractionation, distillation, LiAlH reduction and the like. These extracts possess activity for the treatment and prevention of acute and chronic pain, inflammation and gastrointestinal irritation.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: July 13, 2004
    Assignee: International Celery Development Alliance PTY. Ltd.
    Inventors: Desley Ethel Butters, Craig Kendall Charles Davis, Ross Peter McGeary, Michael Christopher Powanda, Kim Drummond Rainsford, Michael Wellesley Whitehouse
  • Patent number: 6759061
    Abstract: A food supplement formulation effective to improve the function of the liver comprises selenium, milk thistle seed, phosphatidyl choline, dandelion root, l-methionine, l-taurine, N-acetyl-cysteine, alpha lipoic arid, artichoke leaf, green tea leaf, turmeric root, belleric myrobalan fruit, boerhavia diffusa, eclipta alba, wedelolactones tinospora cordifolia, andrographis paniculata, and picrorhiza kurroa.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: July 6, 2004
    Assignee: Renew Life, Inc.
    Inventors: Brenda F. Watson, Leonard O. Smith
  • Patent number: 6746689
    Abstract: A non-invasive and non-systemic method for administering a local anesthetic. The method comprises topical application of a local anesthetic in combination with an intradermal-penetration agent selected from the group consisting an aloe composition, a triglyceride, and a mixture thereof.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: June 8, 2004
    Assignee: EpiCept Corporation
    Inventors: Wilfried Fischer, Petra Huber, Paul Mason
  • Patent number: 6740343
    Abstract: The present invention relates to an improved extract of Scutellaria lateriflora, a method of preparing the same, and a pharmaceutical composition prepared from the present extract suitable for treating anxiety, insomnia, convulsions, muscle tension and spasm, and related manifestations and disorders in humans and other mammals. The invention also relates to an improved method of treating anxiety, insomnia, convulsions, muscle tension and spasm, and related manifestations and disorders in humans and other mammals by administering the improved extract of Scutellaria lateriflora.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: May 25, 2004
    Assignee: Phytos, Inc.
    Inventors: Philip E. Wolfson, David Ludwig Hoffmann
  • Patent number: 6737087
    Abstract: The present invention discloses that fractions of Asiasari Radix extract have the ability to induce neuroprotection against AMPA (-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-induced damages in brain cells as well as stimulation of memory.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: May 18, 2004
    Inventor: Sung-Jin Kim
  • Patent number: 6733797
    Abstract: The present invention relates to a neurochemical formulation comprising a supplement for improving function of neurons, improving memory and cognitive abilities, and reversing free radical damage caused by aging or neurodegenerative disease. The formulation comprises phosphoesters and antioxidants. Components may have antioxidant properties or enhance properties of other components. The synergistic combinations allow individual component dosages to be reduced, thereby minimizing potential toxicity.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: May 11, 2004
    Inventor: William K. Summers
  • Patent number: 6733795
    Abstract: The present invention relates to a method for producing an avocado leaf extract rich in furanic lipids, the raw material for which consists of avocado leaves, and which comprises the following steps: a liquid-solid extraction step followed by evaporation under vacuum, and a heat treatment step between 80 and 120° C. which is continued for a period of between 5 and 72 hours, it being possible for these two steps to be carried out in this order or in the reverse order.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: May 11, 2004
    Assignee: Laboratoires Expanscience
    Inventors: Antoine Piccirilli, Jacques Legrand
  • Patent number: 6713092
    Abstract: This invention relates to a composition of the plant Withania Somnifera, and, more particularly to a high purity extract composition with advantageous levels of withanolide glycosides and oligosaccharides, a minimum of polysaccharides, and substantially low levels of free withaferin A and equivalents (withanolide aglycones), which composition provides enhanced cognition-enhancing effects for the user, and an extraction process for obtaining such composition, as well as pharmaceutical, nutritional and personal care use products thereof.
    Type: Grant
    Filed: December 3, 2002
    Date of Patent: March 30, 2004
    Assignees: Natreon Inc., Indian Herbs Research & Supply Company Ltd.
    Inventor: Shibnath Ghosal
  • Patent number: 6709682
    Abstract: A compound and method of using such compound is disclosed that, when administered to an animal, is capable of arresting the inflammatory response in affected tissues and facilitates the repair and maintenance of damaged tissues in the joints of vertebrates. The combination of natural physiological metabolites and herbal phytochemicals is used to treat connective tissue diseases, the composition preferably orally administered. One embodiment of the composition includes chondroitin sulfate and glucosamine that, when ingested by a vertebrate, suppresses the degradation of connective tissue by an autoimmune response. A preferred composition of the present invention includes a palatability agent, an herbal phytochemical, and a metabolic precursor that synergistically acts to increase blood circulation, thereby enhancing transport of the phytochemical and metabolic precursors to an affected site whereby deleterious inflammatory byproducts are removed.
    Type: Grant
    Filed: January 8, 2002
    Date of Patent: March 23, 2004
    Assignee: In Clover, Inc.
    Inventors: Rebecca Rose, Gerald L. Chrisope
  • Patent number: 6709683
    Abstract: This invention relates to a method of producing fermented extract to obtain composition that has inhibition action on bacteria infection. The fermented extract is prepared by symbiotic culture of yeast and lactic acid bacteria, removing microbial cells from the resultant culture solution and concentrating the prepared culture solution.
    Type: Grant
    Filed: August 16, 2002
    Date of Patent: March 23, 2004
    Assignee: Micorbio Co., Ltd.
    Inventor: Kung-Ming Lu
  • Patent number: 6706293
    Abstract: Pharmaceutical composition with adhesion molecule expression regulating activity. The invention relates to a novel pharmaceutical application of a pharmaceutical composition exhibiting regulating activity of the expression of adhesion molecules integrins, selectins and immunoglobulins and its application as anti-inflammatory agent. Said pharmaceutical composition contains Anapsos, a water-soluble extract and a lipo-soluble extract of the rhizomes of Polypodium leucotomos as active substance in addition to acceptable excipients.
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: March 16, 2004
    Assignee: Especialidades Farmaceuticas Centrum, S.A.
    Inventors: Eliseo Quintanilla Almagro, JoaquĆ­n Diaz Alperi
  • Patent number: 6706284
    Abstract: The invention relates to an oral pharmaceutical composition which has excellent drug release-controlling ability in the mouth even 5 to 10 minutes after its administration and also has excellent drug releasing ability in the digestive tract without using capsules. It also relates to an oral pharmaceutical composition which comprises one or more drugs having a bitter taste, one or more solid proteins, and one or more pharmaceutically acceptable polymer bases, wherein the proteins are present in the polymer bases preferably as particles.
    Type: Grant
    Filed: March 14, 2002
    Date of Patent: March 16, 2004
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Masahiro Yanagisawa, Takao Mizumoto
  • Patent number: 6682763
    Abstract: The present invention relates to an external agent for the skin comprising an extract prepared from olive plants and also relates to an external agent for the skin comprising the extract as a skin-beautifying component, in particular, as an ant-aging component for the skin and/or a whitening component. The extract can be prepared by extracting olive plants and/or products generated during and after the olive oil-manufacturing processes with water and/or an organic solvent and further the extract can further be subjected to a concentration treatment and/or a fractionation-purification treatment to thus improve each effect. Moreover, the present invention also relates to a skin-beautifying agent, in particular, an anti-aging agent and a skin-whitening agent, containing the extract as an effective component.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: January 27, 2004
    Assignee: The Nisshin Oil Mills, Ltd.
    Inventors: Noriyasu Kuno, Miho Matsumoto
  • Patent number: 6682912
    Abstract: A method for producing L-glutamic acid which comprises culturing a microorganism belonging to the genus Klebsiella, Erwinia or Pantoea and having an ability to produce L-glutamic acid in a culture medium, and collecting produced L-glutamic acid from the culture medium. The microbial strain used is preferably a strain which decreases in or is deficient in an activity of an enzyme catalyzing a reaction branching from a pathway for L-glutamic acid biosynthesis and producing a compound other than L-glutamic acid, or a strain which increase in an activity of an enzyme catalyzing a reaction for L-glutamic acid biosynthesis.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: January 27, 2004
    Assignee: Ajinomoto Co., Inc.
    Inventors: Mika Moriya, Hiroshi Izui, Eiji Ono, Kazuhiko Matsui, Hisao Ito, Yoshihiko Hara
  • Patent number: 6676976
    Abstract: The present invention relates to an improved process for the production of vasicine of formula (1) from the Adhatoda vasica, said process comprising the steps of: extracting the dried and pulverized leaves with an alcoholic extract at an ambient temperature, concentrating the alcoholic extract to obtain a concentrated extract, treating and stirring extract with an aqueous organic acid for 2-24 hours, extracting the acid solution of with an organic solvent, separating the organic layer and aqueous acidic layer, basifying the aqueous acidic solution with a base, extracting the basified solution with an organic solvent, separating the organic layer, drying and filtering, evaporating the organic layer to obtain an amorphous residue, and treating the amorphous residue with an organic solvent or mixture of organic solvents to obtain vasicine.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: January 13, 2004
    Assignee: Council of Scientific and Industrial Research
    Inventors: Sunil Kumar Chattopadhyay, Guru Das Bagchi, Prem Dutt Dwivedi, Sachin Srivastava
  • Patent number: 6660308
    Abstract: The invention is a beverage made of a fluid and a one time daily dosage amount in an ingestible amount for treating an inflammatory tissue or arthritic condition in a mammal involving tissue that is underperfused tissue, inflamed joints, and inflamed muscle, wherein said dosage is a rapid absorbing large amount made of a glucosamine sulfate, a glucosamine hydrochloride, and an n-acetyl glucosamine and combinations thereof, a chondroitin sulfate, a chondroitin hydrochloride and combinations thereof, a vasodialating sulfonate with at least one methyl group, and a buffer to reduce adverse symptoms from large amounts of glucosamine and chondroitin selected from the family of araliaceae and a B3 vitamin.
    Type: Grant
    Filed: September 11, 2002
    Date of Patent: December 9, 2003
    Inventors: Kenneth A. Martin, Teresa Leigh Barr
  • Patent number: 6656511
    Abstract: There are provided a calcium absorption enhancing agent produced by subjecting a vegetable protein to at least a treatment of removing a phytate with an anion exchange resin and a deamidation treatment with a weakly acidic cation exchange resin, and a method for producing it. Thereby, calcium absorption enhancing agents which can be widely applied and excellent in processability can be obtained.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: December 2, 2003
    Assignee: Nihon University
    Inventor: Hitomi Kumagai