Abstract: A tissue-implantable sensor for measurement of solutes in fluids and gases, such as oxygen and glucose, is provided. The sensor includes: i) a detector array including at least one detector; ii) a telemetry transmission portal; iii) an electrical power source; and iv) circuitry electrically connected to the detector array including signal processing means for determining an analyte level, such as glucose level, in a body fluid contacting the detectors. The sensor components are disposed in a hermetically sealed housing having a size and shape suitable for comfortable, safe, and unobtrusive subcutaneous implantation allowing for in vivo detection and long term monitoring of tissue glucose concentrations by wireless telemetry.

Abstract: Devices and methods for detecting events indicative of heart failure (HF) decompensation status are described. An ambulatory medical device can determine the present physiologic state as being either a drift state or a stable state, and applies an algorithm to detect HF decompensation event according to the physiologic state. In some embodiments, the ambulatory medical device uses the present physiologic state to estimate one ore more expected future signal characteristics, and to detect HF decompensation event using the one or more expected futures signal characteristics.

Abstract: The present invention relates to a method for evaluating a value representing the mass or the concentration of a substance comprised by a tissue or a bodily fluid of a patient, the method including the steps of a) determining a relation between one or more calculated or measured value(s) reflecting the mass or the concentration and a distribution space of the patient or an approximation thereof, and b) assessing whether the relation fulfils a criterion. The present invention further relates to systems and computer programs for performing this method.

Abstract: Adaptive attachments used in combination with a blood pressure cuff enable various blood pressure measurements to be taken in a hospital or other setting having various single and/or dual lumen manual or electronic blood pressure measuring equipment with a single, patient-worn cuff.

Abstract: A method, including positioning body-electrodes in galvanic contact with a body of a patient and locating a probe in the body of the patient. The method further includes tracking positions of the probe during respiration of the patient and determining indications related to impedances between the body-electrodes during the respiration. The method also includes calculating a function relating the positions of the probe to the indications, and applying the function to identify end-expirium points of the respiration based on subsequent indications related to the impedances.

Abstract: The present disclosure relates to a method and a system for validating inspiratory muscle activity of a patient. Left and right electrical activity signals respectively representing activity of a left muscle and of a right muscle synchronized with an inspiratory effort of the patient are acquired from non-invasive sensors. A cardiac activity signal is extracted from the left and right electrical activity signals. A synchrony, a symmetry or a proportionality of the left and right electrical activity signals from which the cardiac activity signal is extracted is verified. A mechanical ventilation system incorporating the system for validating inspiratory muscle activity of the patient is also disclosed.

Abstract: A system and method for monitoring respiration of a user, comprising: a respiration sensing module including a sensor configured to detect a set of respiration signals of the user based upon movement resulting from the user's respiration; a supplementary sensing module comprising an accelerometer and configured to detect a set of supplemental signals from the user; an electronics subsystem comprising a power module configured to power the system and a signal processing module configured to condition the set of respiration signals and the set of supplemental signals; a housing configured to facilitate coupling of the respiration sensing module and the supplementary sensing module to the user; and a data link coupled to the electronics subsystem through the housing and configured to transmit data generated from the set of respiration signals and the set of supplemental signals, thereby facilitating monitoring of the user's respiration.

Abstract: A respiratory therapy instrument providing a telehealth platform for pulmonary care includes a housing with opposed extension arms, an airway tube removably clamped between the opposed extension arms, a pair of pressure sensors, and a circuit board retained within the housing. The pressure sensors are in communication with an interior of the airway tube and are configured to detect pulmonary flow data within the airway tube. The circuit board is configured to collect the pulmonary flow data detected by the pair of pressure sensors and includes a transmitter to send data, including the collected pulmonary flow data, wirelessly to a computing device. The collected pulmonary flow data is utilized in game play for an incentivization game operated on the computing device.

Abstract: Devices are presented for measurement of an analyte concentration. The devices comprise: a sensor configured to generate a signal indicative of a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme domain comprising an enzyme, a base polymer, and a hydrophilic polymer which makes up from about 5 wt. % to about 30 wt. % of the enzyme domain.

Abstract: A novel technique for analyzing a biological state is provided. A body trunk biological signal (aortic pulse wave) extracted from the back of a body trunk is differentiated twice. By using a resultant second derivative waveform, a waveform component of a maximum amplitude of a low frequency appearing as a result of switch of an amplitude from attenuation to amplification in transition from a contracting phase to a diastolic phase of a ventricle is specified in each period of the second derivative waveform. Inflection points are specified that appear before and after the maximum amplitude waveform component. A biological state is analyzed using information about each of the inflection points. The two inflection points obtained from a reference form of the second derivative waveform of the aortic pulse wave substantially agree in time phase with first heart sound and second heart sound (or an R wave and a T wave in an electrocardiogram) indicating the dynamic state of a cardiovascular system.

Abstract: This disclosure concerns improved capabilities for evaluating whether additional medical tests need to be conducted for a diagnosis of a pulmonary arterial hypertension (PAH) condition in a patient. The method includes determining that the patient is at rest and measuring a partial pressure of carbon dioxide in a composite gas, comprising: transferring an expiration from the patient's mouth to a carbon dioxide analyzer; measuring end tidal carbon dioxide (EtCO2) from each of a plurality of oral expirations from the patient; and calculating a composite EtCO2 value. The method further includes comparing the composite EtCO2 value to a range of stored carbon dioxide partial pressure values; generating a signal indicating whether additional medical tests need to be conducted in response to the comparing; and providing the generated signal to an indicator, the indicator adapted to respond to the generated signal to provide an output in a human cognizable format.

Abstract: Disclosed are systems and methods to provide a patient care recommendation. The systems and methods receive patient information and a plurality of patient physiological signals that are related to a patient. The systems and methods are then operable to produce at least one derived patient signal from at least one of the plurality of patient physiological signals. The systems and methods use the patient information, at least one of the plurality of patient physiological signals, and the at least one derived patient signal to provide at least one patient care recommendation.

Abstract: An implantable device having a communication system, a sensor, and a monolithic substrate is described. The monolithic substrate has an integrated sensor circuit configured to process input from the sensor into a form conveyable by the communication system.

Abstract: Provided according to embodiments of the present invention are methods of monitoring individuals that include securing a photoplethysmograph probe to at least one of a pre-auricular region and a post-auricular region of the individual and obtaining photoplethysmography signals from the photoplethysmography probe. Photoplethysmography probes and helmets related to such methods are also described herein.

Abstract: A sleep monitoring system includes an ECG device and a respiration inductance plethysmogram which monitor cardiac activity and physical respiration respectively and feed representative signals to a digital data processor. Operations process the beat interval data, while in a second thread, operations independently process the amplitude modulation of the ECG data caused by the respiratory motion of the subject. The inductance plethysmogram device provides an input to the processor which represents respiration as directly monitored independently of the ECG. Operations process this direct respiration data independently and in parallel, in a third thread. All extracted features are fed to a classifier which in step combines selected combinations of features to make decisions in real time.

Abstract: A method and system for determining a respiratory rate of a user using an electrocardiogram (ECG) segment of the user are disclosed. The method comprises decomposing the ECG segment into a plurality of functions and evaluating the plurality of functions to choose one of the plurality of functions based on a respiratory band power. The method includes determining the respiratory rate using the one of the plurality of functions and a domain detection.

Abstract: A single, optimal, fused sensor glucose value may be calculated based on respective sensor glucose values of a plurality of redundant working electrodes (WEs) of a glucose sensor. Respective electrochemical impedance spectroscopy (EIS) procedures may be performed for each of the WEs to obtain values of membrane resistance (Rmem) for each WE. A noise value and a calibration factor (CF) value may be calculated for each WE, and respective fusion weights may be calculated for Rmem, noise, and CF for each WE. An overall fusion weight may then be calculated based on the WE's Rmem fusion weight, noise fusion weight, and CF fusion weight, such that a single, optimal, fused sensor glucose value may be calculated based on the respective overall fusion weight and sensor glucose value of each of the plurality of redundant working electrodes.

Abstract: A detection device is retained in the rumen of a cow by being orally administered to the cow, and detects the state of the inside of the rumen. The detection device wirelessly transmits measured values of the rumen pH as detection results. A monitoring unit (receiver and monitoring server) acquires information transmitted from the detection device, and monitors the state of the inside of the rumen. The detection device is configured to be recoverable orally from the rumen of the cow. The operating conditions of the detection device are recorded in the detection device ahead of time, and can be updated by means of a wireless signal transmitted from a setting unit to the detection device.

Abstract: Embodiments of the present invention are related to a method and device for the determination and calculation of the depth of chest compressions during the administration of cardiopulmonary resuscitation (CPR). Embodiments use an optical sensor to monitor the distance that a victim's chest is displaced during each compression throughout the administration of CPR. The optical sensor is most commonly an image sensor such as a CMOS or CCD sensor, and more specifically a CMOS image sensor capable of three-dimensional imaging based on the time-of-flight principle. An infrared emitter may illuminate the victim's body and any visible piece of ground beside the victim. As the infrared light interacts with any surfaces it encounters, it is reflected and returns to the image sensor where the time of flight of the infrared light is calculated for every pixel in the image sensor. The distance data is used to gauge the effective displacement of the victim's chest.

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.