Abstract: A biosensor includes a microfluidics layer, a transduction layer and a transceiver layer. The transduction layer further includes a functionalized layer that reacts with a biomarker, and a plurality of carbon nanotubes adjacent the functionalized layer. The conductivity of the carbon nanotubes changes in response to a biomarker reacting with at least a portion of the functionalized layer. The functionalized layer can include dendrimers, such as a tadpole dendrimer scaffolding that includes a plurality of sites for receiving receptors for biomarkers.

Abstract: To provide a headband capable of correctly placing an electrode on a head of a user, a headband apparatus includes a plurality of headband portions integrally connected and configured to be positioned about a head of a user, wherein at least two headband portions are each configured to be positioned behind an ear.

Abstract: Methods and systems for targeting, accessing and diagnosing diseased lung compartments are disclosed. The method comprises introducing a diagnostic catheter with an occluding member at its distal end into a lung segment via an assisted ventilation device; inflating the occluding member to isolate the lung segment; and performing a diagnostic procedure with the catheter while the patient is ventilated. The proximal end of the diagnostic catheter is configured to be attached to a console. The method may also comprise introducing the diagnostic catheter into the lung segment; inflating the occluding member to isolate the lung segment; and monitoring blood oxygen saturation. The method may further comprise introducing the diagnostic catheter into the lung segment; determining tidal flow volume in the lung segment; determining total lung capacity of the patient; and determining a flow rank value based on the tidal flow volume of the lung segment and the total lung capacity.

Abstract: Transdermal microneedles continuous monitoring system is provided. The continuous system monitoring includes a substrate, a microneedle unit, a signal processing unit and a power supply unit. The microneedle unit at least comprises a first microneedle set used as a working electrode and a second microneedle set used as a reference electrode, the first and second microneedle sets arranging on the substrate. Each microneedle set comprises at least a microneedle. The first microneedle set comprises at least a sheet having a through hole on which a barbule forms at the edge. One of the sheets provides the through hole from which the barbules at the edge of the other sheets go through, and the barbules are disposed separately.

Abstract: This disclosure describes systems and methods for monitoring and evaluating data associated with ventilatory parameters to detect expiratory airflow limitation in a ventilated patient. For example, a ventilator may monitor flow and/or pressure during ventilation of the patient. Based on the flow and/or pressure measurements, or ventilatory data derived therefrom, the ventilator may calculate expiratory resistance. Moreover, the ventilator may trend expiratory resistance over time to produce an expiratory resistance waveform. In embodiments, the ventilator may calculate the slope of the expiratory resistance waveform during an initial part of exhalation. If the slope of the expiratory resistance waveform during the initial part of exhalation breaches a defined slope threshold, the ventilator may determine that the patient exhibits expiratory airflow limitation.

Abstract: Bodily fluid indicator devices and methods are provided. Such devices and methods can effectively indicate whether the amount of bodily fluid being produced is within a measurable range. In an exemplary embodiment, a bodily fluid indicator device includes a substrate having a surface. Some portions of the surface are covered with a region of absorbent material and other portions of the surface are devoid of the absorbent material. A graduated scale or a reactive feature is printed on the absorbent material. The device is configured to indicate an amount and/or a composition a bodily fluid present on an area of a patient or subject.

Abstract: A respiratory monitor comprises: a first sensor (20, 70) configured to generate a respiration-related motion monitoring signal (72) indicative of respiration related motion; a second sensor (20, 22, 80, 82) configured to generate a sound monitoring signal (84) indicative of respiration-related sound; and a signals synthesizer (90) configured to synthesize a respiratory monitor signal (46) based on the respiration-related motion monitoring signal and the respiration-related sound monitoring signal. A sensor for use in respiratory monitoring comprises an accelerometer (30) and a magnetometer (32) together defining a unitary sensor (20) configured for attachment to a respiring subject (10) so as to move as a unit responsive to respiration related motion of the respiring subject.

Abstract: Method and apparatus for receiving a first signal from a first working electrode of a glucose sensor positioned at a first predetermined position under the skin layer, receiving a second signal from a second working electrode of the glucose sensor positioned at a second predetermined position under the skin layer, the second signal received substantially contemporaneous to receiving the first signal, detecting a dropout in the signal level associated with one of the first or second signals, comparing the first signal and the second signal to determine a variation between the first and second signals, and confirming one of the first or second signals as a valid glucose sensor signal output when the determined variation between the first and the second signals is less than a predetermined threshold level are provided.

Abstract: The disclosure describes an electronic stethoscope system that automatically detects coronary artery disease in patients. The system uses an electronic stethoscope to record acoustic data from the fourth left intercostal space of a patient. A processing technique is then applied in order to filter the data and produce Fast Fourier Transform (FFT) data of magnitude versus frequency. If a bell curve is identified in the data between a predefined frequency range (e.g., 50 and 80 Hz) with a peak magnitude of greater than a predefined threshold (e.g., 2.5 units), the system automatically provides an output indicating that the patient is likely to have 50 to 99 percent stenosis of the coronary artery. If no bell curve is present, the patient may have artery stenosis of less than 50 percent. An interface module may be used to transfer diagnosis information to the stethoscope and data to a general purpose computer.

Abstract: A transdermal antenna may be partially inserted into a cavity in the body of a mammal to receive wireless data transmissions from devices located within the body and relay the data to devices located outside of the body. The transdermal antenna may include a first antenna which may be inserted inside of the body cavity and receive radio frequency data transmissions from devices located inside the body. The transdermal antenna may conduct the received data transmissions to a relay mechanism located outside of the body using coaxial cables, waveguides or a combination of both. The relay mechanism may relay the conducted data transmissions to a receiver device located outside of the body by using a wire connection, such as a coaxial cable, or a wireless communication link via a transceiver coupled to a second antenna.

Abstract: Embodiments of the present invention relate to a method for analyzing pulse data. In one embodiment, the method comprises receiving a signal containing data representing a plurality of pulses, the signal generated in response to detecting light scattered from blood perfused tissue. Further, one embodiment includes performing a pulse identification or qualification algorithm on at least a portion of the data, the pulse identification or qualification algorithm comprising at least one constant, and modifying the at least one constant based on results obtained from performing the pulse identification or qualification algorithm, wherein the results indicate that a designated number of rejected pulses has been reached.

Abstract: A blood pressure information measurement device cuff includes a wide blood pressure value measurement air bladder wrapped around a fitting area when in a fitted state, and a narrow pulse wave measurement air bladder disposed so as to be closer to the fitting area than the blood pressure value measurement air bladder when in the fitted state, and covered by the blood pressure value measurement air bladder when wrapped around the fitting area. The pulse wave measurement air bladder includes an anchored portion anchored to the blood pressure value measurement air bladder so as to be immobile relative to the blood pressure value measurement air bladder and a mobile portion that is not anchored to the blood pressure value measurement air bladder so as to be mobile relative to the blood pressure value measurement air bladder along a wrapping direction in which the cuff is wrapped around the measurement area.

Abstract: An apparatus for determining a respiratory condition, including: a signal acquiring section which is configured to acquire a signal corresponding to a respiratory flow of a subject; a first index producing section which is configured to produce a first index related to the respiratory flow of the subject obtained from the signal; a second index producing section which is configured to produce a second index related to a respiratory demand of the subject predicted from the first index; a third index producing section which is configured to produce a third index related to a respiratory effort of the subject based on the first index and the second index; and an outputting section which is configured to output the third index.

Abstract: The circulatory dynamics measurement apparatus comprises: a blood pressure-computing unit, which calculates the maximum blood pressure value (SYS); a vascular sclerosis-computing unit, which calculates the vascular sclerosis index (VSI); and a display unit for displaying a graph having a horizontal axis that represents the maximum blood pressure and a vertical axis that represents the vascular sclerosis index. The display unit displays the position determined by the calculated maximum blood pressure value and the calculated vascular sclerosis index in the plotting area of the graph.

Abstract: We report a method for detecting epileptic or non-epileptic seizures, comprising: receiving a heart rate of a patient; calculating a percentage change of the heart rate in reference to at least one of the patient's maximal heart rate, reserve heart rate, or a resting heart rate; detecting an epileptic seizure if the percentage increase in the heart rate reaches a threshold value; and taking at least one responsive action selected from issuing a warning, delivering a therapy, determining a seizure severity, or logging at least one of a date and time of occurrence of the seizure, its severity, the type of therapy, or its effect, in response to the detection. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

Abstract: A blood pressure measurement device includes a cuff and a control unit. The cuff includes a first securing portion, provided on one surface of the cuff, for securing the cuff to the measurement area in a wrapped state, and a second securing portion, provided on another surface of the cuff, for securing the cuff to the measurement area in a wrapped state. At least one of the first securing portion and the second securing portion includes an electromagnet portion. The control unit secures the cuff to the measurement area by controlling a magnetic force emitted from the electromagnet portion and causing the second securing portion to be attracted to the first securing portion.

Abstract: A flowmeter and filter assembly for spirometry have a flowmeter with a turbine rotor and sensor means for detecting the speed of rotation of the rotor, and a filter upstream of the flowmeter. An air-conveying device modifies the direction of the flow of air at an outlet from the filter to set the rotor in rotation within the flowmeter. The air-conveying device is integrated in the filter instead of in the flowmeter.

Abstract: A delivery and fixation system of an implant assembly having an intracorporeal device. The system provides for a low profile delivery system for an implant assembly having an anchor for fixation within a vessel adapted to be delivered via a catheter.

Abstract: The present invention relates to a method and apparatus for determining an exercise parameter during a physical performance or after it. In the method the pulse of the heart is measured by means of a sensor, the pulse value is determined on the basis of the measurement and the said exercise parameter is calculated on the basis of the pulse value. According to the invention, a recovery pulse value is determined on the basis of the pulse value and previously determined pre-data, the value being dynamically varied during the exercise and the said exercise parameter being defined by using the recovery pulse value. With the invention, it is possible to accurately estimate the recovery time required after the performance as well as the energy consumption during the performance.

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.