Abstract: The invention pertains to a method for treating a neoplasm, such as colorectal cancer, using hollow silica spheres (“HSS”). It also is directed to a method for making uncalcined HSS, calcined HSS from which phenyl groups have been removed, and HSS incorporating particles of Fe3O4, as well as compositions containing HSS.
Type:
Grant
Filed:
September 28, 2023
Date of Patent:
April 16, 2024
Assignee:
Imam Abdulrahman Bin Faisal University
Inventors:
Ayhan Bozkurt, Seyda Tugba Gunday Anil, Firdos Alam Khan, Sultan Akhtar
Abstract: Tellurium nanowires synthesized using green chemistry methods and having unique morphologies and functional properties are provided. The nanowires have a core of hexagonal crystal phase tellurium and a polymer coating, and can be used for treating cancer without apparent cytotoxicity toward normal human cells.
Type:
Grant
Filed:
January 6, 2020
Date of Patent:
April 9, 2024
Assignee:
Northeastern University
Inventors:
David Medina Cruz, Ada Vernet Crua, Thomas J. Webster
Abstract: This invention relates to a naproxen formulation suitable for encapsulation into a soft gel dosage unit by increasing the stability, concentration, and bioavailability of naproxen. Fill formulations of the invention may include other active pharmaceutical ingredients and combinations of two or more active pharmaceutical ingredients. This invention also provides for adjusting pH values of fill formulations without additional process steps. A process for increasing the achievable concentration of an active NSAID pharmaceutical ingredient, such as naproxen, relative to fill composition for dosage units is also provided. The highly concentrated formulation of this invention permits a reduction in the fill volume or dosage unit size, or an increase in concentration of the active pharmaceutical ingredient per dosage form. The invention also relates to a formulation of optimal stability suitable for supporting a fill composition compatible with the soft gel dosage unit.
Type:
Grant
Filed:
September 26, 2019
Date of Patent:
February 13, 2024
Assignee:
Catalent Ontario Limited
Inventors:
John Lopez, Peter Draper, Sankalp Vashishtha, Nancy Klassen, Christina Armstrong
Abstract: A pH-responsive polymer formed of a biocompatible polymer to which a group which is electrically neutral under pH environments of more than 7 and which changes to be cationic at pH 7 or less is bonded.
Abstract: Provided are fast relaxing hydrogels that are useful for regulating cell behavior and enhancing tissue regeneration, e.g., bone regeneration.
Type:
Grant
Filed:
June 15, 2021
Date of Patent:
November 7, 2023
Assignee:
President and Fellows of Harvard College
Inventors:
Luo Gu, Ovijit Chaudhuri, Nathaniel D. Huebsch, David J. Mooney, Max Carlton Darnell, Simon Young
Abstract: The present disclosure relates to hair-treatment compositions, typically in the form of an oil-in-water emulsion, comprising: (a) one or more monosaccharides with amine group(s); (b) one or more polysaccharides with amine group(s); wherein (a) and (b) are solubilized in an aqueous phase of the oil-in-water emulsion; (c) one or more oils; (d) one or more nonionic emulsifiers; and (e) water. The compositions strengthen hair fibers and provide additional cosmetic improvements to the hair such as conditioning, detangling, softness, suppleness, moisturizing, and manageability. Methods of treating hair with the compositions are also described. The methods include applying the composition to wet or damp hair, drying the hair (for example, with a blow dryer) and treating the hair with heat (for example, with a hot iron).
Type:
Grant
Filed:
August 30, 2018
Date of Patent:
October 31, 2023
Assignee:
L'OREAL
Inventors:
Rachel Ferebee Maher, Ronak Rughani, Halil Gevgilili
Abstract: An interpenetrating polymer network (IPN) structured hydrogel includes a crosslinked first natural polymer macromer with a first elasticity and an interpenetrating network of crosslinked second natural polymer macromers having a second elasticity higher than the first elasticity, the IPN structured hydrogel being cytocompatible, and, upon degradation, produce substantially non-toxic products.
Abstract: The present disclosure relates generally to tissue engineering. Disclosed herein are biomimetic sponges useful for tissue regeneration and methods for making biomimetic sponges.
Abstract: A fibrous substrate for the removal of Gram negative bacteria (Escherichia coli) from a surface is provided. The fibrous substrate includes a capturing agent, and the affinity of capturing for the Gram negative bacteria allows the fibrous substrate to capture the Gram negative bacteria, thereby removing the Gram negative bacteria from the surface and also inhibiting the spread of the Gram negative bacteria to other surfaces that may contact the fibrous substrate. Of particular advantage, the presence of the capturing agent on the fibrous substrate may help protect against the spread or infection of pathogens without the use of chemicals, such as antiseptics or antibiotics.
Type:
Grant
Filed:
April 1, 2015
Date of Patent:
August 29, 2023
Assignee:
Kimberly-Clark Worldwide, Inc.
Inventors:
David W. Koenig, Amy L. Vanden Heuvel, Vinod Chaudhary, Scott W. Wenzel, Divesh Bhatt, Kathleen Engelbrecht
Abstract: A Rifaximin polymorphic mixture of ?/? form in a relative ratio of 85/15±3 and a process for its preparation. The polymorphic mixture of Rifaximin is for use as a medicament, in particular in the treatment of traveler's diarrhea and hepatic encephalopathy. A pharmaceutical composition comprises the polymorphic mixture of Rifaximin as active ingredient, in particular, a solid formulation, more in particular, a film coated tablet. A polymorphic form of crude wet rifaximin and of purified wet rifaximin their use are used as intermediates in a process for the preparation of Rifaximin polymorphic mixture of ?/? form in a relative ratio of 85/15±3.
Type:
Grant
Filed:
January 26, 2021
Date of Patent:
August 29, 2023
Assignee:
CURIA IP HOLDINGS, LLC
Inventors:
Paride Grisenti, Maria Argese, Daniele Pengo, Maria Donata Grilli, Emanuela Fumagalli, Giuseppe Motta
Abstract: Chitosan nanoparticles are provided for use in the in vivo treatment of connective tissues in root canal therapies. The nanoparticles are optionally linked with one or more photoactivatable compounds for providing antibacterial/antibiofilm properties, neutralizing bacterial byproducts and/or chemical/photodynamic crosslinking to achieve enhanced mechanical properties, chemical stability in connective tissues and/or to improve surface/interfacial integrity between filling material and connective tissue.
Abstract: The present invention concerns polymer particles made from poly(lactic-co-glycolic acid) (PLGA) polymer, poly(lactic-co-glycolic acid)-polyethylene glycol-poly(lactic-co-glycolicacid) (PLGA-PEG-PLGA) copolymer, or the mixture of same, combined with hyaluronic acid molecules or hyaluronic acid salts, and the method for preparing same. The present invention also concerns injectable pharmaceutical or cosmetic compositions comprising such polymer particles, the method for preparing such compositions, and the use thereof for medical purposes, in particular for the prevention and/or treatment of musculoskeletal diseases, diseases and traumatic conditions of the skin, oral disorders, vaginal mucosa dryness and urinary infections or cystitis, dryness of the eye membrane and eye infections, obesity, and the use of same to combat ageing of the skin and/or for repairing the dermal tissue (mesotherapy).
Abstract: The invention pertains to a method for treating a neoplasm, such as colorectal cancer, using hollow silica spheres (“HSS”). It also is directed to a method for making uncalcined HSS, calcined HSS from which phenyl groups have been removed, and HSS incorporating particles of Fe3O4, as well as compositions containing HSS.
Type:
Grant
Filed:
September 30, 2022
Date of Patent:
July 18, 2023
Assignee:
Imam Abdulrahman Bin Faisal University
Inventors:
Ayhan Bozkurt, Seyda Tugba Gunday Anil, Firdos Alam Khan, Sultan Akhtar
Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.
Type:
Grant
Filed:
November 16, 2019
Date of Patent:
July 4, 2023
Assignees:
Coral Bay II, LLC, Agency For Science, Technology And Research
Inventors:
Willy Chin, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L. Z. Lee, Robert J. Ono, Qingxing Xu, Yi Yan Yang
Abstract: The invention pertains to a method for treating a neoplasm, such as colorectal cancer, using hollow silica spheres (“HSS”). It also is directed to a method for making uncalcined HSS, calcined HSS from which phenyl groups have been removed, and HSS incorporating particles of Fe3O4, as well as compositions containing HSS.
Type:
Grant
Filed:
September 30, 2022
Date of Patent:
March 14, 2023
Assignee:
Imam Abdulrahman Bin Faisal University
Inventors:
Ayhan Bozkurt, Seyda Tugba Gunday Anil, Firdos Alam Khan, Sultan Akhtar
Abstract: Provided herein are antioxidant, thermally-responsive copolymer-based compositions and methods of making and using the compositions, e.g., for treatment of ischemia reperfusion injury in a patient. The copolymer comprises a hydrocarbyl backbone, and a plurality of pendant pyrrolidone, antioxidant radical, polyester oligomer, and N-alkyl amide groups.
Type:
Grant
Filed:
October 6, 2017
Date of Patent:
February 28, 2023
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education
Inventors:
William R. Wagner, Yasumoto Matsumura, Murugesan Velayutham, Yang Zhu