Abstract: The invention pertains to a method for treating a neoplasm, such as colorectal cancer, using hollow silica spheres (“HSS”). It also is directed to a method for making uncalcined HSS, calcined HSS from which phenyl groups have been removed, and HSS incorporating particles of Fe3O4, as well as compositions containing HSS.

Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.

Abstract: The invention pertains to a method for treating a neoplasm, such as colorectal cancer, using hollow silica spheres (“HSS”). It also is directed to a method for making uncalcined HSS, calcined HSS from which phenyl groups have been removed, and HSS incorporating particles of Fe3O4, as well as compositions containing HSS.

Abstract: Provided herein are antioxidant, thermally-responsive copolymer-based compositions and methods of making and using the compositions, e.g., for treatment of ischemia reperfusion injury in a patient. The copolymer comprises a hydrocarbyl backbone, and a plurality of pendant pyrrolidone, antioxidant radical, polyester oligomer, and N-alkyl amide groups.

Abstract: Gastric residence systems comprising therapeutic agent formulations for sustained gastric release of therapeutic agents are disclosed, as well as methods for using such systems. The systems are characterized by use of a dispersant in the formulations, which improves the burst release characteristics and long-term release rate characteristics of the systems. Milling of therapeutic agent can also be performed to prepare agent particles of desired size.

Abstract: The coating formation method of the present invention is a method for forming a coating on a surface of a coating formation target. The formation method of the present invention includes an electrostatic spraying step of electrostatically spraying a composition directly onto the coating formation target, thereby forming a coating composed of a deposit containing fibers. The composition contains a component (a), a component (b), and a component (c) below. (a) One or more volatile substances selected from water, alcohols, and ketones. (b) A polymer having coating formability. (c) A liquid agent containing one or more selected from oils and polyols that are in a liquid form at 20° C.

Abstract: The present invention provides a multi-drug-loading site and high drug-loading capacity ligand-drug conjugate. The ligand-drug conjugate has a structure of general formula (I). The ligand-drug conjugate has the characteristics of high loading capacity, high drug efficacy, low toxicity, and low risks. The ligand-drug conjugate can be used particularly to connect to a low toxicity chemical molecule, thereby extending a therapeutic window. Furthermore, the present invention provides an antibody-drug conjugate molecule. The antibody-drug conjugate molecule has the characteristics of multiple drug-loading ability and high drug-loading capacity, such that the antibody-drug conjugate can carry a large amount of a low toxicity chemical molecule and achieve a therapeutic effect without depending on antibody targeting or high toxicity chemicals.

Abstract: An emulsion contains A) an alkyl ester quat of formula I wherein R1 is an acyl radical of a fatty acid with a chain length of from 6 to 24 carbon atoms, with the proviso that a mass fraction of saturated, linear fatty acids with a chain length of from 12 to 24 carbon atoms, is more than 50% by weight, based on all acyl radicals R1, wherein R2 is an alkyl radical having 1 to 6 carbon atoms, wherein a=1-3 and b=1-3, with the proviso that a+b=4, B) at least one consistency regulator, and C) at least one cosmetic oil.

Abstract: The present invention relates generally to polyelectrolyte-layer forming block copolymers adsorbed at colloid interfaces in aqua solution and compositions and uses thereof. In particular, the present invention relates to agricultural material compositions comprising particles of at least one agricultural material and a polyelectrolyte-layer forming block copolymer. The present invention also relates to non-agricultural material compositions comprising particles of at least one non-agricultural material and a polyelectrolyte-layer forming block co-polymer.

Abstract: The present invention relates to preventing color transfer and sticking of powder-containing cosmetics to clothes or the like. A coating formation method of the present invention includes an electrostatic spraying step of electrostatically spraying a composition directly onto a skin surface onto which powder-containing cosmetics have been applied, thereby forming a coating on the skin. The composition contains a component (a) and a component (b) below. It is preferable that the method further includes a liquid agent applying step of applying a liquid agent containing one or more selected from water and oils that are in liquid form at 20° C. on the skin onto which the powder-containing cosmetics have been applied, wherein the liquid agent applying step is performed subsequent to the electrostatic spraying step. (a) One or more volatile substances selected from water, alcohols, and ketones; and (b) a polymer having a coating formation ability.

Abstract: Improved methods for the manufacture of pharmaceutical compositions comprising at least one surfactant, involving prefiltration of the surfactant prior to formulation into final products.

Abstract: Disclosed is a transfer-resistant and long-lasting two-step cosmetic system, and a method for applying the cosmetic system. The disclosed system includes a first composition that includes a styrenic block copolymer, a silicone acrylate copolymer, and a volatile oil and a second composition that includes a silicone oil.

Abstract: The invention provides ingestible particles comprising a water-swellable or water-soluble polymeric component, a lipid component, and optionally an amino acid, a vitamin and/or a micro-nutrient. The polymeric component may be embedded in the lipid component. The particle may further comprise an inert core and/or an outer layer which rapidly disintegrates after oral ingestion. The invention further provides methods for preparing the ingestible particles and uses thereof.

Abstract: Hemostatic compositions including a combination of more than one hemostatic agent, and devices coated or impregnated therewith, have been developed. Nanotechnology yields hemostatic agents with large surface areas thereof, thereby increasing the hemostatic properties of the device to which they are applied. By combining more than one hemostatic agent and utilizing one or more different nanotechnology approaches to enhance the surface areas thereof, the capability of the dressing to stop bleeding is improved via more than one mechanism, and thus provides better hemostasis.

Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.

Abstract: The present invention provides a coating formation method with which adhesion between skin and a coating formed by electrostatic spraying is enhanced. The coating formation method of the present invention includes a liquid agent applying step of applying a liquid agent containing one or more selected from water, polyols and oils that are in a liquid form at 20° C., and an electrostatic spraying step of electrostatically spraying a composition directly on skin to form a coating. The liquid agent applying step and the electrostatic spraying step are performed in this order or in a reversed order. The composition includes a component (a) and a component (b) below: (a) one or more volatile substances selected from the group consisting of water, alcohols, and ketones, and (b) a polymer having a coating formation ability.

Abstract: The present invention relates to a method for manufacturing a support for regenerating core-shell structured hard tissue and a support for regenerating core-shell structured hard tissue manufactured thereby, wherein the support may further comprise bio-functional materials, such as cells, in a core-shell structure. The method for manufacturing a support for regenerating core-shell structured hard tissue according to the present invention has an effect of manufacturing a support for regenerating core-shell structured hard tissue by a method by which a 3-dimensional structure is prepared by a layer manufacturing process through an extrusion container having a double nozzle. In addition, the support can be manufactured at room temperature, thereby having an effect of containing cells or various bio-functional materials.

Abstract: The invention pertains to a method for treating a neoplasm, such as colorectal cancer, using hollow silica spheres (“HSS”). It also is directed to a method for making uncalcined HSS, calcined HSS from which phenyl groups have been removed, and HSS incorporating particles of Fe3O4, as well as compositions containing HSS.

Abstract: The present invention relates to compositions of spherical microparticles composed of a wall material and at least one cavity that comprises a gas and/or a liquid, which have pores on the surface thereof, wherein the spherical microparticles have a mean particle diameter of 10-600 ?m and wherein at least 80% of those microparticles, the particle diameter of which does not deviate from the mean particle diameter of the microparticles of the composition by more than 20%, each have on average at least 10 pores, the diameter of which is in the range from 1/5000 to ? of the mean particle diameter, and, furthermore, the diameter of each of these pores is at least 20 nm, wherein the wall material consists of a composition comprising at least one aliphatic-aromatic polyester, and the wall material has a solubility at 25° C. of at least 50 g/l in dichloromethane, a method for the preparation thereof and also the use thereof.

Abstract: A method for surface modification of nanoparticles includes the separate steps of removing ligands from the surface of the nanoparticles to form ligand-free nanoparticles, and mixing new ligands with the ligand-free nanoparticles to form modified nanoparticles.