Patents Examined by Tigabu Kassa
  • Methods and systems of making nanostructures
    Patent number: 9801829
    Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of making nanostructures (e.g., nanoparticles, nanofibers), systems for making nanostructures, and the like.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: October 31, 2017
    Assignees: University of Florida Research Foundation, Inc., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Peng Guo, Charles R. Marin, Yaping Zhao, Richard N. Zare
  • Dosage forms for administering combinations of drugs
    Patent number: 9801827
    Abstract: The present invention is directed to dosage forms that can be used in therapeutic methods involving the oral co-administration of a combination of at least two drugs, one of which impairs gastrointestinal absorption and one of which does not. The dosage forms are designed so that the drug impairing absorption is not released into the gastrointestinal tract of a patient until after the drugs that do not impair absorption have been released and substantially absorbed. The invention may be used in treatment of migraine using a combination of triptans and NSAIDs or in the treatment of pain using a combination of NSAIDs and opioid analgesics.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: October 31, 2017
    Assignee: Pozen Inc.
    Inventors: John Plachetka, Donna Gilbert
  • Method and compositions for whitening teeth
    Patent number: 9775790
    Abstract: A tooth whitening method applies a light transmitting oxidizing composition to teeth in an oral cavity, after which a hand-held LED light source with a light transmitting lens and a cup forming a chamber having an open end is moved over the teeth so that the cup distributes the oxidizing composition while the teeth are exposed to light transmitted through the lens. This not only ensures intimate contact of the teeth with the oxidizing composition, but also maintains a more or less constant spacing between the light source and the tooth surfaces for optimum results. A sealant is then applied to the teeth to resist moisture contamination of the oxidizing composition.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: October 3, 2017
    Assignee: Oraceutical LLC
    Inventor: R. Eric Montgomery
  • Formulations of rifaximin and uses thereof
    Patent number: 9737610
    Abstract: The present invention relates to new rifaximin forms comprising solid dispersions of rifaximin, methods of making same and to their use in medicinal preparations and therapeutic methods.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: August 22, 2017
    Assignee: Salix Pharmaceuticals, Ltd
    Inventors: Jon Selbo, Jing Teng, Mohammed A. Kabir, Pam Golden
  • Controlled release pharmaceutical composition with resistance against the influence of ethanol employing a coating comprising neutral vinyl polymers and excipients
    Patent number: 9730899
    Abstract: The invention relates to a controlled release pharmaceutical composition, comprising a core, comprising a pharmaceutical active ingredient, whereby the core is coated by an ethanol resistance conferring coating layer which has the effect of conferring the release profile of the pharmaceutical active ingredient to be resistant against the influence of ethanol, whereby the ethanol resistance conferring coating layer comprises at least 70% by weight of a mixture of a polymeric portion a) and an excipients portion b), with the polymeric portion a) is consisting of a water insoluble essentially neutral vinyl polymer or vinyl copolymer and the excipients portion b) is consisting of the excipients b1) 100 to 250% by weight of a non-porous inert lubricant, b2) 1 to 35% by weight of a cellulosic compound, b3) 0.1 to 25% by weight of an emulsifier and additionally or alternatively to b3), b4) 0.
    Type: Grant
    Filed: March 18, 2009
    Date of Patent: August 15, 2017
    Assignee: Evonik Roehm GmbH
    Inventors: Hans Bär, Thomas Fürst, Gerhard Renner, Michael Gottschalk
  • Method for providing modified release of ibuprofen
    Patent number: 9730895
    Abstract: A method for providing immediate and sustained release of ibuprofen to a subject, including administering, in a single dose, a modified release formulation of ibuprofen including a hydrophilic polymer, ibuprofen in solid dosage form uniformly dispersed in the polymer, and a dissolution additive and an inert formulation additive dispersed in the polymer. The hydrophilic polymer comprises a first hydroxypropyl methylcellulose (HPMC) having a viscosity of about 100 cps and a second HPMC having a viscosity between about 200 cps to about 50,000 cps. The solid dosage form is a monolithic tablet that demonstrates a mean ibuprofen plasma concentration in a subject greater than or equal to 6.4 ?g/ml within two hours of administration, and also demonstrates a mean ibuprofen plasma concentration in a subject greater than or equal to 6.4 ?g/ml for at least 8 hours after administration.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: August 15, 2017
    Inventors: Michael Hite, Cathy Federici, Alan Brunelle, Stephen Turner
  • Crystalline forms of ponatinib hydrochloride
    Patent number: 9725454
    Abstract: The present disclosure relates to polymorphic forms of the hydrochloride salt of ponatinib (“compound 1”) and to processes for the preparation of these polymorphic forms. The present disclosure also generally relates to a pharmaceutical composition comprising the forms, as well of methods of using the form(s) in the treatment of disorders associated with pathological cellular proliferation, such as neoplasms, and cancer.
    Type: Grant
    Filed: July 4, 2014
    Date of Patent: August 8, 2017
    Assignee: SANDOZ AG
    Inventors: Marijan Stefinovic, Hayley Reece, Asha Sunkara
  • Matrix-based pulse release pharmaceutical formulation
    Patent number: 9713592
    Abstract: The present invention relates to an oral pulse release pharmaceutical composition, which comprises a polymer matrix core, wherein at least one pharmaceutically active ingredient is distributed within the core and on the outer surface of the core. Amphetamine salts, among a number of other pharmaceutically active ingredients, can be formulated as a pharmaceutical composition described herein. The present invention also provides a method for preparing an immediate release component on a solid pharmaceutical formulation.
    Type: Grant
    Filed: March 22, 2006
    Date of Patent: July 25, 2017
    Assignee: MALLINCKRODT LLC
    Inventors: Ashwini Gadre, Mark R. Benmuvhar, Brian Kai-Ming Cheng, Vishal K. Gupta, Cliff J. Herman
  • Methods for whitening teeth
    Patent number: 9662284
    Abstract: Compositions and methods for whitening the teeth of a patient or subject include the application of at least one tooth whitening composition having a viscosity of at least 100 centipoise to the surface of a stained tooth, accompanied by the application of a sealant composition that forms protective film or coating on the tooth surface to resist moisture contamination of the oxidizing composition. The whitening procedure can be further enhanced by removal of acquired pellicle from the tooth surface prior to application of oxidizing and sealant compositions. The novel procedure allows for a high degree of tooth whitening by protecting the oxidizing composition while it is in contact with the tooth surface.
    Type: Grant
    Filed: March 22, 2015
    Date of Patent: May 30, 2017
    Assignee: Oraceutical LLC
    Inventor: R. Eric Montgomery
  • Self-adhesive fragranced gels
    Patent number: 9662413
    Abstract: A method for dispensing an active volatile in the environment surrounding a surface, which comprises applying to the surface a self-adhering, water-resistant gel composition of at least one active volatile ingredient, silica, and a water-soluble cationic polysaccharide, and diffusing or releasing the volatile ingredient(s) from the gel in an amount sufficient to purify or sanitize the surrounding air, both in a dry condition or in the presence of humidity or water. The gel composition remains adhered to the surface and actively releases the volatile ingredient(s) even after being exposed to repeated water flows over the composition.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: May 30, 2017
    Assignee: FIRMENICH SA
    Inventors: Simon Hurry, Jane Summers
  • Pesticidal composition comprising sulphur, acaricide and an agrochemical excipient
    Patent number: 9655369
    Abstract: The present invention relates to a pesticidal composition comprising an effective amount of sulphur, an effective amount of at least one acaricide selected from the group consisting of bifenazate, fenpyroximate, fenazaquin, hexythiazox, spirodiclofen, spiromesifen and their salts thereof and at least one agrochemically acceptable excipient.
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: May 23, 2017
    Inventor: Deepak Pranjivandas Shah
  • Solid pharmaceutical compositions containing an integrase inhibitor
    Patent number: 9649311
    Abstract: Compressed tablets for oral administration containing raltegravir in the form of a pharmaceutically acceptable salt are described. The tablets comprise: (A) an intragranular component comprising (i) an effective amount of an alkali metal salt of raltegravir, (ii) optionally a first superdisintegrant, and (iii) a binder; and (B) an extragranular component comprising (i) a second superdisintegrant, (ii) a filler, and (iii) a lubricant. Methods for preparing the tablets and the use of the tablets, optionally in combination with other anti-HIV agents, for the inhibition of HIV integrase, for the treatment or prophylaxis of HIV infection, or for the treatment, delay in the onset, or prophylaxis of AIDS are also described.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: May 16, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Majid Mahjour, Feng Li, Decheng Ma, Sutthilug Sotthivirat
  • Compositions and/or articles comprising cyclodextrin complexing material
    Patent number: 9649386
    Abstract: Personal care products are provided. An exemplary personal care product includes a composition that is applied to the body or clothing, or an article applied against the body; a plurality of particles associated with the composition or a component of the article, the plurality of particles, at least some of the plurality of particles comprising a cyclodextrin complexing material and a first fragrance material, wherein the percent of the first fragrance material that is complexed with the cyclodextrin is greater than about 90%, so that the perceptibility of the first fragrance is minimized prior to its release; and a second fragrance material that is not complexed with the cyclodextrin and that is different from the first fragrance material, wherein the composition or article does not contain an antiperspirant active.
    Type: Grant
    Filed: May 5, 2011
    Date of Patent: May 16, 2017
    Assignee: The Procter & Gamble Company
    Inventors: Timothy Alan Scavone, Michael Jude Leblanc, Lowell Alan Sanker, Adrian Gregory Switzer
  • Compositions and/or articles comprising cyclodextrin complexing material
    Patent number: 9649387
    Abstract: Personal care products are provided. An exemplary personal care product includes a composition that is applied to the body or clothing, or an article applied against the body; a plurality of particles associated with the composition or a component of the article, the plurality of particles, at least some of the plurality of particles comprising a cyclodextrin complexing material and a first fragrance material, wherein the percent of the first fragrance material that is complexed with the cyclodextrin is greater than about 90%, so that the perceptibility of the first fragrance is minimized prior to its release; and a second fragrance material that is not complexed with the cyclodextrin and that is different from the first fragrance material, wherein the composition or article does not contain an antiperspirant active.
    Type: Grant
    Filed: May 5, 2011
    Date of Patent: May 16, 2017
    Assignee: The Procter & Gamble Company
    Inventors: Timothy Alan Scavone, Michael Jude Leblanc, Lowell Alan Sanker, Adrian Gregory Switzer
  • Porphyrin modified telodendrimers
    Patent number: 9642916
    Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 9, 2017
    Assignee: The Regents of the University of California
    Inventors: Kit S. Lam, Yuanpei Li, Chong-Xian Pan, Tzu-yin Lin
  • Shampoo composition comprising gel matrix and histidine
    Patent number: 9642788
    Abstract: A shampoo composition having from about 0.025% to about 0.25% histidine, by weight of the shampoo composition; from about 2% to about 50% of one or more detersive surfactants, by weight of the shampoo composition; and a gel matrix having from about 0.1% to about 20% of one or more fatty alcohols, by weight of the gel matrix; from about 0.1% to about 10% of one or more gel matrix surfactants, by weight of the gel matrix; and from about 20% to about 95% of an aqueous carrier, by weight of the gel matrix.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: May 9, 2017
    Assignee: The Procter & Gamble Company
    Inventors: Jennifer Mary Marsh, Casey Patrick Kelly, Howard David Hutton, III
  • Method of inhibiting copper deposition on hair
    Patent number: 9642787
    Abstract: A method of inhibiting copper deposition on hair and facilitating the removal of copper deposited on hair including applying to the hair a shampoo composition having histidine, rinsing the shampoo composition from the hair, applying to the hair a conditioner composition comprising histidine, and rinsing the conditioner composition from the hair.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: May 9, 2017
    Assignee: The Procter & Gamble Company
    Inventors: Jennifer Mary Marsh, Casey Patrick Kelly
  • Antiemetic extended release solid dosage forms
    Patent number: 9636305
    Abstract: A solid oral dosage form includes a core comprising a non-ionic polymer matrix, a first amount of a first antiemetic drug or a pharmaceutically acceptable salt thereof dispersed within the matrix, and a salt dispersed within the matrix; a first seal coat of a non-ionic polymer matrix surrounding the core; and an immediate release drug layer surrounding the first seal coat, wherein the immediate release drug layer comprises a non-ionic polymer and a second amount of a second antiemetic drug or a pharmaceutically acceptable salt thereof dispersed therein, wherein the drug layer is sufficiently designed to release the second amount of the antiemetic drug over a period of at least 1 hour, wherein the solid oral dosage form is sufficiently designed to release the first amount of the first antiemetic drug and the second amount of the second antiemetic drug over a minimum period of 16 hours.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 2, 2017
    Assignee: RedHill Biopharma Ltd.
    Inventors: Reza Fathi, Gilead Raday
  • Hydrophilically-modified silicone compositions
    Patent number: 9624334
    Abstract: In various embodiments, provided are hydrophilically-modified silicone compositions comprising substantially spherical elastomeric microparticles, methods of making such compositions, and silicone pastes, personal care, and healthcare products comprising such silicone compositions.
    Type: Grant
    Filed: October 19, 2010
    Date of Patent: April 18, 2017
    Assignee: Dow Corning Corporation
    Inventors: Dongchan Ahn, Qi Huang, Maria M. Puscau, William Schulz, James Thompson, Kevin Wier
  • Nail polish
    Patent number: 9623268
    Abstract: This invention relates to nail coating compositions, to packages including the nail coating compositions, to methods of applying the nail coating composition to a nail and to a use of an additive compound to improve the properties of the nail coating composition of the present invention. In particular, the invention relates to nail coating compositions having improved chip resistance, good adhesion to the nail, a high gloss finish and a short dry-to-touch time.
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: April 18, 2017
    Assignee: Chemence Limited
    Inventors: Hugh Cooke, Colin John Brunton, Maria Dincheva