Patents Examined by Tigabu Kassa
  • Method of preparing coating film containing nitrogen monoxide on surface of material using catecholamine
    Patent number: 9623156
    Abstract: A method of coating surfaces of various body-implantable materials with control-releasable nitrogen monoxide using a catecholamine, more particularly, technology of preparing a coating film containing a diazeniumdiolate functional group on a surface of a material to be coated using a catecholamine, is provided. The coating film prepared by the method has advantages in that nitrogen monoxide can be stably supplied under an in vivo environment, and can be suitably used in a living body without causing cytotoxicity. Therefore, among the materials having a coating film formed on a surface thereof, the body-implantable material is especially expected to be widely used for medical and health applications including treatment of ischemic disorders such as arteriosclerosis through controlled release of nitrogen monoxide, regulation of penile erections, antibacterial and antiviral effects, and wound healing.
    Type: Grant
    Filed: April 11, 2013
    Date of Patent: April 18, 2017
    Assignee: POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Won Jong Kim, Jihoon Kim, Haeshin Lee, Seonki Hong
  • Method of inhibiting copper deposition on hair
    Patent number: 9586063
    Abstract: A method of inhibiting copper deposition on hair and facilitating the removal of copper deposited on hair including applying to the hair a shampoo composition having ethylenediamine-N,N?-disuccinic acid (EDDS) and/or histidine, rinsing the shampoo composition from the hair, applying to the hair a conditioner composition comprising histidine, rinsing the conditioner composition from the hair, and applying to the hair a leave-on treatment comprising ethylenediamine-N,N?-disuccinic acid (EDDS).
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: March 7, 2017
    Assignee: The Procter & Gamble Company
    Inventors: Jennifer Mary Marsh, Casey Patrick Kelly
  • Nanocarriers for drug delivery
    Patent number: 9579400
    Abstract: The present invention provides a nanocarrier having an interior and an exterior, the nanocarrier comprising at least one conjugate, wherein each conjugate includes a polyethylene glycol (PEG) polymer. Each conjugate also includes at least two amphiphilic compounds having both a hydrophilic face and a hydrophobic face. In addition, each conjugate includes an oligomer, wherein at least 2 of the amphiphilic compounds are covalently attached to the oligomer which is covalently attached to the PEG. The nanocarrier is such that each conjugate self-assembles in an aqueous solvent to form the nanocarrier such that a hydrophobic pocket is formed in the interior of the nanocarrier by the orientation of the hydrophobic face of each amphiphilic compound towards each other, and wherein the PEG of each conjugate self-assembles on the exterior of the nanocarrier.
    Type: Grant
    Filed: September 22, 2009
    Date of Patent: February 28, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kit S. Lam, Juntao Luo
  • Fenton reaction catalyst using coffee grounds or tea dregs as raw material
    Patent number: 9566360
    Abstract: A Fenton reaction catalyst including a reaction product as an active component, in which the reaction product is obtained by using roasted and ground coffee beans (in particular, coffee grounds) or tea leaves (in particular, tea dregs) as feedstocks for supplying a component having a reduction effect, and mixing the feedstocks for supplying the component having a reduction effect with an iron-supplying source containing divalent or trivalent iron in the presence of water. The Fenton reaction catalyst can be used to generate hydroxy radicals from hydrogen peroxide. The Fenton reaction catalyst can maintain iron in a divalent state for a long period of time.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: February 14, 2017
    Assignee: INCORPORATED ADMINISTRATIVE AGENCY NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION
    Inventors: Claudio Kendi Morikawa, Makoto Shinohara
  • Method for catalyzing a fenton reaction
    Patent number: 9566361
    Abstract: A method for catalyzing a Fenton reaction, including adding hydrogen peroxide to a Fenton reaction catalyst, the Fenton reaction catalyst including a reaction product, wherein the reaction product is obtained by using roasted and ground coffee beans and/or tea leaves as a feedstock for supplying a component having a reduction effect, and mixing the feedstock for supplying the component having a reduction effect with an iron-supplying source containing divalent or trivalent iron in the presence of water.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: February 14, 2017
    Assignee: INCORPORATED ADMINISTRATIVE AGENCY, NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION
    Inventors: Claudio Kendi Morikawa, Makoto Shinohara
  • Polysaccharide products with improved performance and clarity in phosphate ester surfactant-based aqueous formulations and process for preparation
    Patent number: 9561166
    Abstract: A personal or household care product includes cationic, nonionic or cationic/nonionic derivatized polysaccharide in combination with a phosphate ester surfactant. The derivatized polysaccharide polymer is formed by reacting the polysaccharide ester surfactant for a sufficient time and at a sufficient temperature in the presence of water, caustic, and at least one surfactant. The polysaccharide polymer may optionally be reacted with an oxidizing agent, hydrolytic or proteolytic enzymes, molecular weight reducing agents and a cationizing agent and nonionic agent. The formed derivatized polysaccharide has a lower clarity in water than in an aqueous surfactant system.
    Type: Grant
    Filed: February 20, 2012
    Date of Patent: February 7, 2017
    Assignee: HERCULES INCORPORATED
    Inventors: Anita N. Chan, Louis Patrick Dziuk, Jr., Paquita Erazo-Majewicz, Jashawant J. Modi, M. Olaf Michelson, Bruce Kevin Fillipo, Nabil Naouli
  • Corticosteroids for the treatment of joint pain
    Patent number: 9555048
    Abstract: Corticosteroid microparticle formulations are provided for use for treating pain, including pain caused by inflammatory diseases such as osteoarthritis or rheumatoid arthritis, and for slowing, arresting or reversing structural damage to tissues caused by an inflammatory disease, for example damage to articular and/or peri-articular tissues caused by osteoarthritis or rheumatoid arthritis. Corticosteroid microparticle formulations are administered locally as a sustained release dosage form (with or without an immediate release component) that results in efficacy accompanied by clinically insignificant or no measurable effect on endogenous cortisol production.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: January 31, 2017
    Assignee: FLEXION THERAPEUTICS, INC.
    Inventors: Neil Bodick, Robert C. Blanks, Anjali Kumar, Michael D. Clayman, Mark Moran
  • Corticosteroids for the treatment of joint pain
    Patent number: 9555047
    Abstract: Corticosteroid microparticle formulations are provided for use for treating pain, including pain caused by inflammatory diseases such as osteoarthritis or rheumatoid arthritis, and for slowing, arresting or reversing structural damage to tissues caused by an inflammatory disease, for example damage to articular and/or peri-articular tissues caused by osteoarthritis or rheumatoid arthritis. Corticosteroid microparticle formulations are administered locally as a sustained release dosage form (with or without an immediate release component) that results in efficacy accompanied by clinically insignificant or no measurable effect on endogenous cortisol production.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: January 31, 2017
    Assignee: FLEXION THERAPEUTICS, INC.
    Inventors: Neil Bodick, Robert C. Blanks, Anjali Kumar, Michael D. Clayman, Mark Moran
  • Poorly soluble drug containing microspheres with improved bioavailability and method of preparing the same
    Patent number: 9511026
    Abstract: A poorly soluble drug containing microsphere with improved bioavailability, an oral formulation comprising the same, and a method of preparing the same are provided, wherein the poorly soluble drug containing microsphere is a solid dispersion wherein the poorly soluble drug is dispersed in the water-soluble polymer carrier in a noncrystalline form by spray drying, thus increasing bioavailability of the poorly soluble drug.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: December 6, 2016
    Assignee: SAMYANG BIOPHARMACEUTICALS CORPORATION
    Inventors: Kyung-Hee Kim, Hyun-Ki Lee, Jun-Seok Hwang, Su-Jong Hwang, Chaul-Min Pai
  • Pharmaceutical compositions resistant to abuse
    Patent number: 9498446
    Abstract: The present invention provides immediate release pharmaceutical compositions for oral administration that are resistant to abuse.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: November 22, 2016
    Assignee: EGALET LTD.
    Inventors: Peter Holm Tygesen, Jan Martin Oevergaard, Karsten Lindhardt, Louise Inoka Lyhne-Iversen, Martin Rex Olsen, Anne-Mette Haahr, Jocob Aas Hoeilund-Jensen, Pernille Kristine Hoeyrup Hemmingsen
  • Pharmaceutical formulations of naproxen for soft gel encapsulation and combinations thereof
    Patent number: 9480667
    Abstract: An NSAID formulation for encapsulation into a soft gel capsule with increased stability, concentration and bioavailability of the NSAID. The preferred NSAIDS are naproxen, ibprofen, indomethacin and diclofenac, which are provided in both an acidic and basic form in the fill formulation. The pH values of fill formulations may be adjusted without additional process steps. A process for increasing the achievable concentration of an NASAID pharmaceutical ingredient in a fill composition for dosage units is also provided. The highly concentrated NASAID formulation permits a reduction in the fill volume or dosage unit size or an increase in concentration of the NSAID in each dosage it.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: November 1, 2016
    Assignee: ACCUCAPS INDUSTRIES LIMITED
    Inventors: John Lopez, Peter Draper, Sankalp Vashishtha, Nancy Klassen, Christina Armstrong
  • Insecticidal compositions and method for insect control
    Patent number: 9480251
    Abstract: An environmentally safe, non-phytotoxic pesticidal composition comprising natural plant oils geraniol and cedar oil and methods of controlling insects is provided.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: November 1, 2016
    Assignee: FMC Corporation
    Inventors: James F. Walter, Reid M. Ipser
  • Polymeric particles comprising vinyl formal, vinyl alcohol and vinyl acetate monomer units
    Patent number: 9481752
    Abstract: Particles, such as particles including a polymer including vinyl formal monomer units, and related compositions and methods, are disclosed.
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: November 1, 2016
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Steve Keenan, Goldi Kaul
  • Sustained-release formulation for injection
    Patent number: 9469630
    Abstract: The present invention relates to a composition comprising N-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]-(2R,3R)-2,3-tetramethylene-butyl]-(1?R,2?S,3?R,4?S)-2,3-bicyclo[2,2,1]heptanedicarboximide or a pharmaceutically acceptable acid addition salt thereof. In detail, the composition relates to a sustained release formulation for injection which maintains an effective blood level of the above-mentioned compound.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: October 18, 2016
    Assignee: SUMITOMO DAINIPPON PHARMA CO., LTD.
    Inventors: Takashi Nakagawa, Norimasa Koseki
  • Delayed release pharmaceutical composition of mesalamine
    Patent number: 9463163
    Abstract: The invention relates to a delayed release pharmaceutical composition of mesalamine comprising: a) granules comprising mesalamine or pharmaceutically acceptable salts thereof and a hydrophilic polymer; b) extragranular excipients; wherein the pharmaceutical composition is further coated with a single layer of polymer.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: October 11, 2016
    Assignee: SUN PHARMACEUTICAL INDUSTRIES LIMITED
    Inventors: Vasu Kumar Kakumanu, Anju Bansal, Shashikanth P. Isloor, Vinod Kumar Arora
  • Tablet having improved elution properties
    Patent number: 9463164
    Abstract: The present invention provides a tablet having improved dissolution property, which comprises (+)-3-{1-[3-(trifluoromethoxy)benzyl]piperidin-4-yl}-4-phenyl-3,4-dihydro-2(1H)-quinazolinone or a pharmaceutically acceptable salt thereof as an active component, and a production method thereof. A film-coated tablet obtained by mixing granulated particles obtained by granulating a mixture containing (a) the aforementioned active component, (b) one or more kinds of fillers selected from lactose, D-mannitol, erythritol and crystalline cellulose, (c) a cellulose-based disintegrant and (d) a water-soluble binder with a later powder containing (e) one or more kinds of fillers selected from lactose, D-mannitol and crystalline cellulose and/or (f) a cellulose-based disintegrant, forming the mixture, and applying film coating.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: October 11, 2016
    Assignee: SUMITOMO DAINIPPON PHARMA CO., LTD.
    Inventors: Makiko Yanagida, Hiroyuki Nishii, Masayuki Nakazono
  • Drug-delivering composite structures
    Patent number: 9446226
    Abstract: Composite structures composed of a fibril core and a polymeric coat and designed capable of encapsulating both hydrophobic and hydrophilic bioactive agents while retaining the activity of these agents are disclosed. Further disclosed are processes of preparing such composite structures, and medical devices and disposable articles made therefrom.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: September 20, 2016
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventor: Meital Zilberman
  • Disintegrating particle composition and orally rapidly disintegrating tablet
    Patent number: 9446055
    Abstract: There has been a need for an orally rapidly disintegrating tablet which has a good texture and taste in the oral cavity, such a sufficient hardness as not giving any worry of being chipped or dusted during production or transportation and good disintegrating properties in the oral cavity and can sustain a sufficient hardness even under humid conditions after opening. Disclosed are a disintegrating particle composition which is prepared by dispersing, in the presence of water, mannitol, xylitol, an inorganic excipient, a disintegrating agent and carmellose and drying, and an orally rapidly disintegrating tablet which comprises said disintegrating particle composition, an active substance and a disintegrating agent. The disintegrating tablet has a good texture and taste, an appropriate hardness and good disintegrating properties and can sustain a sufficient hardness under humid conditions.
    Type: Grant
    Filed: August 11, 2010
    Date of Patent: September 20, 2016
    Assignee: FUJI CHEMICAL INDUSTRY CO., LTD.
    Inventors: Keiichi Fujiwara, Tadashi Fukami, Haruka Koizumi
  • Pharmaceutical composition
    Patent number: 9399021
    Abstract: Disclosed are novel pharmaceutical compositions containing N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxide solvate, methods of using the compositions in therapy and processes for preparing the same.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: July 26, 2016
    Assignee: Novartis AG
    Inventors: Douglas J. DeMarini, Francisco Henriquez, Ngocdiep T. Le, Lihong Wang
  • Pill-enveloping material to aid in swallowing pills
    Patent number: 9393209
    Abstract: The present invention relates to a malleable, palatable pill enveloping material that becomes slippery when in contact with water or saliva making the wrapped pill easier to swallow. The enveloping material is made of a mixture of glycerin, xanthan gum, and agar which is cut into an appropriate shape for wrapping a pill.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: July 19, 2016
    Inventor: Shelley Corrine Gath