Patents Examined by Vera Afremova
  • Patent number: 11193105
    Abstract: The invention relates to a method for protein enrichment of a microalga grown under heterotrophic conditions, said microalga being of the Chlorella genus, characterized in that the heterotrophic culture comprises a step aimed at limiting the growth of said microalga by means of a deficiency of the fermentation medium in terms of a non-nitrogenous nutritional source.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: December 7, 2021
    Assignee: Corbion Biotech, Inc.
    Inventors: Gabriel Macquart, Sylvain Delaroche, Marie Le Ruyet, Laurent Segueilha
  • Patent number: 11193103
    Abstract: A method of controlling a bioreactor system includes providing a cell culture in a bioreactor, wherein conditions in the bioreactor enable the cell culture to produce a protein of interest (POI), measuring process parameters (PPs) of the culture within the bioreactor by RAMAN, wherein the process parameters are selected from the group consisting of nutrient concentration, viable cell concentration, and protein attributes, measuring a predetermined weight of the bioreactor with the cell culture, removing cell-free spent media from the cell culture using a first output conduit at a first specified rate, removing cells from the cell culture using a second output conduit at a second specified rate, and introducing one or both of fresh media or nutrients into the cell culture using an input conduit at a third specified rate.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: December 7, 2021
    Assignee: Regeneran Pharmaceuticals, Inc.
    Inventors: Matthew Angelini, Ashley Witmer, Anthony Debiase
  • Patent number: 11185562
    Abstract: Compositions for methods of preventing or reducing pathogenic bacterial growth, proliferation, and/or colonization are described containing one or more types of non-pathogenic bacteria to be introduced into the gastrointestinal tract and effectively compete with pathogenic bacteria for monomeric or polymeric carbohydrate nutrients, and/or amino acid nutrients, and/or vitamin nutrients.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: November 30, 2021
    Assignee: Seres Therapeutics, Inc.
    Inventors: David N. Cook, Han Zhang, Anthony Mario D'Onofrio, David Arthur Berry, Mary-Jane Lombardo McKenzie, John Grant Aunins, Gregory McKenzie, Toshiro K. Ohsumi
  • Patent number: 11180723
    Abstract: The invention relates to a method for the simultaneous production of a solid transformation product of the substrate and crude ethanol comprising the following steps: •preparing a substrate from milled or flaked biomass comprising proteinaceous matter which originates from soya bean, rape seed, or mixtures thereof, optionally in further mixture with proteinaceous matter originating from fava beans, peas, sunflower seeds, lupine, cereals, and/or grasses, •mixing said substrate with live yeast in a dry matter ratio of from 1:1 to 10,000:1 and adding water in an amount which provides a ratio of wet bulk density to dry bulk density from 0.60 to 1.45 in the resulting mixture; •incubating said mixture for 1-48 hours at a temperature of about 20-60° C.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: November 23, 2021
    Assignee: HAMLET PROTEIN A/S
    Inventors: Katrine Hvid Ellegård, Jonatan Ahrens Dickow, Stig Victor Petersen, Laila Thirup, Svend Andreas Geleff
  • Patent number: 11155648
    Abstract: In a prior art reactor set up dense aggregates of microorganisms are formed, typically in or embedded in an extracellular matrix. Such may relate to granules, to sphere like entities having a higher viscosity than water, globules, a biofilm, etc. The dense aggregates comprise extracellular polymeric substances, or biopolymers, in particular linear polysaccharides. The present invention is in the field of extraction of a biopolymer from a granular sludge, a biopolymer obtained by such method, and a use of such method.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: October 26, 2021
    Assignee: HASKONINGDHV NEDERLAND B.V.
    Inventors: Yuemei Lin, Salah Al-Zuhairy, Mario Pronk, Marinus Cornelis van Loosdrecht
  • Patent number: 11130943
    Abstract: The invention relates to improved culture methods for expanding epithelial stem cells and obtaining organoids, to culture media involved in said methods, and to uses of said organoids.
    Type: Grant
    Filed: November 27, 2015
    Date of Patent: September 28, 2021
    Assignee: Koninklijke Nederlandse Akademie Van Wetenschappen
    Inventors: Lars Norman Sachs, Jarno Drost
  • Patent number: 11124759
    Abstract: A new Acidithiobacillus ferrooxidans strain as well as a process for bacterially devulcanizing sulphur-vulcanized rubber particles and devulcanized rubber particles obtainable by the process.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: September 21, 2021
    Assignee: TYRE RECYCLING SOLUTIONS SA
    Inventors: Davide Staedler, Thibaud Spinetti, Christian Lowe
  • Patent number: 11123382
    Abstract: Disclosed are hair care compositions containing partially purified extracellular metabolite preparation from strains of Bacillus coagulans. Specifically, the uses of compositions containing extracellular metabolite preparation from a strain of Bacillus coagulans for increasing hair growth, inhibition of 5?-reductase and proliferation of follicle dermal papilla cells and in the management of androgenic alopecia, are disclosed.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: September 21, 2021
    Assignee: SAMI LABS LIMITED
    Inventors: Muhammed Majeed, Kalyanam Nagabhushanam, Sivakumar Arumugam, Furqan Ali, Shaheen Majeed, Lakshmi Mundkur
  • Patent number: 11116806
    Abstract: Provided are a composite probiotic lactic acid bacteria powder and a preparation method and use thereof, the composite probiotic lactic acid bacteria powder can be composited from Lactobacillus casei Zhang bacteria powder, Bifidobacterium animalis V9 bacteria powder, Lactobacillus plantarum P8 bacteria powder, Lactobacillus plantarum C2 bacteria powder, with prebiotics and fruit-vegetable powder. The composite probiotic lactic acid bacteria powder has a significantly protective effect against irritable bowel syndrome, oral infection and nasal cavity infection, and can prevent the occurrence of upper respiratory tract infection, at the same time, it can improve gastrointestinal symptoms, regulate gut microbiota and improve the body's immunity.
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: September 14, 2021
    Assignee: BEIJING SCITOP BIO-TECH CO., LTD.
    Inventors: Jianjun Zhang, Chen Ma, Jicheng Wang
  • Patent number: 11110135
    Abstract: Selected bacterial strains belonging to the genus Bifidobacterium for use in the treatment of hypercholesterolaemia are described. In particular, a food composition or supplement product or medical device or pharmaceutical composition has said bacterial strains in association with sterols or phytosterols and/or stanols or phytostanols and/or glucomannan and/or konjac gum and/or prebiotic fibres and/or fermented red rice and/or betaglucans from oats, oat bran, barley, barley bran and/or Aloe arborescens gel in lyophilized form.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: September 7, 2021
    Assignee: PROBIOTICAL S.P.A.
    Inventors: Giovanni Mogna, Gian Paolo Strozzi, Luca Mogna
  • Patent number: 11111518
    Abstract: A method for distinguishing among a first group of microorganisms belonging to a first taxon of Gram negative bacteria, the first group of bacteria exhibiting a mechanism of resistance to a treatment; a second group of microorganisms belonging to a second taxon of Gram negative bacteria, the second taxon of bacteria being different than said first taxon, and exhibiting a mechanism of resistance to a treatment identical to the mechanism of the first group; and a third group of Gram negative bacteria that is not resistant to the treatment.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: September 7, 2021
    Assignee: BIOMERIEUX
    Inventors: Sylvain Orenga, Céline Roger-Dalbert, John Perry, Vanessa Chanteperdrix, Gilles Zambardi, Nathalie Bal
  • Patent number: 11099172
    Abstract: The present invention provides cell-based assays, including high throughput cell-based assays, for identification of candidate therapeutic agents with the ability to inhibit microglial activation in vivo in response to different ligands.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: August 24, 2021
    Assignees: The J. David Gladstone Insitutes, The Regents of the University of California
    Inventors: Katerina Akassoglou, Michelle Arkin, Kean-Hooi Ang, Anke Meyer-Franke, Christopher Wilson
  • Patent number: 11097991
    Abstract: Endophytic microbial strains as biocatalysts isolated from fresh plant samples, compositions, and methods of use thereof to enhance the growth and/or yield of a plant in the presence of reduced synthetic phosphate fertilizers are provided. Endophytic microbial strains serve as biocatalysts to solubilize mineral-P and mineralize organic-P otherwise unavailable to plants for their nutritional phosphate needs. Thus defined, biocatalysts, will serve to replace synthetic phosphate fertilizers. Also provided are materials and methods for inoculating plants with these biocatalysts at carefully selected inoculum densities to reliably reduce the amount of synthetic phosphate fertilizer by 50% thus accomplishing obtaining optimal yields in technically and cost-effective manner.
    Type: Grant
    Filed: November 20, 2019
    Date of Patent: August 24, 2021
    Assignee: Biomineral Systems LLC
    Inventor: Nadia Adam
  • Patent number: 11085065
    Abstract: The biological functionality of living microbial spores is modified using phenotypic engineering to endow the resulting modified spores with novel functionality that extends the usefulness of the spores for a variety of practical applications including, for example, sterility testing, the release of active compounds, and cell-based biosensing systems. An embodiment entails engineering Bacillus spores to acquire synthetic new functions that enable the modified spores to sense and rapidly transduce specific germination signals in their surroundings. The newly acquired functions allow the spores to perform, for example, as self-reporters of cellular viability, self-indicating components of cell-based biosensors, and in other analytical systems. Also disclosed are methods for testing adequate sterility of a system by using engineered spores.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: August 10, 2021
    Inventor: M. Boris Rotman
  • Patent number: 11085058
    Abstract: This invention is about a process of increased Biogas (9) production, with high methane content, in anaerobic biodigestion plants, with production of electric (11) and thermal energy. The process is based upon biotechnologies, hardware and software specifically developed for this aim. One or more Devices for the Acceleration (4) of autochthon methanogenic bacteria multiplication, originally contained in the Organic Wastes (1), collect a portion of the biological material from the Anaerobic Biodigester (3) and, successively, gives it back at a higher rate, with its methanogenic bacteria population remarkably multiplied. The increase and stabilization of the reproduction and nutrition of these bacterial strains allows the increase of the biogas produced in the Anaerobic Biodigester (3) along with the percentage of methane contained in this very Biogas (9).
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: August 10, 2021
    Assignees: G-META CONSULTORIA, PARTICIPAÇÕES E SERVIÇOS LTDA, BIO-TRONIC ENERGY CO. LLC
    Inventor: Luciano Pesce
  • Patent number: 11066316
    Abstract: A method for treating an oil-containing medium including oil or grease or both oil and grease includes the steps of combining algae with an oil-containing medium and allowing the algae to engulf or uptake at least a portion of the oil or grease in the oil-containing medium. A mixture for treating oil or grease or both oil and grease includes an oil-containing medium including oil or grease or both oil and grease and phagotrophic algae that engulf or uptake at least a portion of the oil or grease in the oil-containing medium.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: July 20, 2021
    Assignee: The University of Akron
    Inventors: Lu-Kwang Ju, Majid Hosseini
  • Patent number: 11033032
    Abstract: The present invention relates to the microbiological field, and particularly relates to a Leclercia adcarboxglata biocontrol strain efficiently inhibiting production of aflatoxins by Aspergillus flavus. The Leclercia adcarboxglata biocontrol strain Wt16 was deposited at China Center for Type Culture Collection (CCTCC) on Jun. 13, 2017, and the accession number of the strain is CCTCC No. M2017331. The Leclercia adcarboxglata strain Wt16 is isolated from peanut pods for the first time which can significantly inhibit aflatoxins production by Aspergillus flavus, and also has an extremely good effect on inhibiting aflatoxins production by Aspergillus flavus for peanuts from different sources.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: June 15, 2021
    Assignee: OIL CROPS RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCES
    Inventors: Peiwu Li, Xiaoxia Ding, Yizhen Bai, Wen Zhang, Qi Zhang
  • Patent number: 11034968
    Abstract: The invention pertains to a method for synthesizing a product of interest by culturing a microalgal cell producing the product of interest in the dark in a culture medium comprising an organic acid as a fixed carbon source, wherein the microalgal cell is a facultative heterotroph. The product of interest can be a microalgal biomass, a pigment, terpene, recombinant molecule, biogas, or a precursor thereof. In an embodiment, the culture medium comprises urea as a primary source of nitrogen. In one embodiment, the microalgal cell belongs to the order Chlamydomonadales. A method of identifying and isolating a microalgal cell having a preferred characteristic that is suitable for synthesis of a product of interest is also provided, the method comprising identifying and isolating a non-mutagenized or recombinant microalgal cell from a microalgal culture using a fluorescence activated cell sorting technique and/or a phototaxic response.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: June 15, 2021
    Assignee: Kuehnle AgroSystems, Inc.
    Inventors: Robert J. Schurr, Adelheid R. Kuehnle
  • Patent number: 11026983
    Abstract: The present invention relates to a novel Bifidobacterium strain having an excellent growth promoting effect, and a nutraceutical composition for promotion of growth, which contains the strain. The strain of the present invention has a beneficial effect of promoting growth by promoting the digestion of human milk oligosaccharides to enhance immunity together with physical strength.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: June 8, 2021
    Assignee: Cell Biotech Co., Ltd.
    Inventor: Myung Jun Chung
  • Patent number: 11007137
    Abstract: The present invention provides a use for probiotic preparing skin care composition, wherein the probiotic comprises Lactobacillus plantarum (GMNL-6) with preservation number of BCRC 910777 or CCTCC M 2017765. The composition may be externally-coating drug, pharmaceuticals for external use, care products for external use or cosmetics, and may achieve the effects of improving the skin conditions or aesthetic appearance by promoting secretion of collagen or expression of ceramide synthase.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: May 18, 2021
    Assignee: GENMONT BIOTECH INCORPORATION
    Inventors: Yi-Hsing Chen, Wan-Hua Tsai, Chia-Hsuan Chou, Ying-Ju Chiang