Patents Examined by Yevegeny Valenrod
  • 19-nor C3, 3-disubstituted C21-N-pyrazolyl steroids and methods of use thereof
    Patent number: 9512165
    Abstract: Provided herein are 19-nor C3,3-disubstituted C21-pyrazolyl steroids of Formula (I), and pharmaceutically acceptable salts thereof; wherein, R1, R2, R3a, R3b, R4a, R4b, R5, R6, and R7 are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: December 6, 2016
    Assignee: SAGE THERAPEUTICS, INC.
    Inventors: Gabriel Martinez Botella, Boyd L. Harrison, Albert Jean Robichaud, Francesco G. Salituro, Richard Thomas Beresis
  • High-purity sodium p-styrenesulfonate with excellent hue, method for producing the same, poly(sodium p-styrenesulfonate) with excellent hue using the same, and dispersant and synthetic starch for clothing finishing using the poly(sodium p-styrenesulfonate)
    Patent number: 9505713
    Abstract: Provided are high purity sodium p-styrenesulfonate with an excellent hue which is useful as a reactive emulsifier or dispersant for producing a polymer emulsion, or synthetic starch for clothing ironing and poly(sodium p-styrene-sulfonate) with an excellent hue using the same or sodium p-styrenesulfonate improved in fluidity while keeping good solubility. An aqueous p-?-bromoethylbenzenesulfonic acid solution and an aqueous sodium hydroxide solution are reacted under specific conditions to control the particle size, thereby obtaining sodium p-styrenesulfonate particles improved in a balance between fluidity and solubility, and further, impurities such as isomers are reduced, thereby obtaining high-purity sodium p-styrenesulfonate with an excellent hue.
    Type: Grant
    Filed: September 2, 2013
    Date of Patent: November 29, 2016
    Assignee: TOSOH ORGANIC CHEMICAL CO., LTD
    Inventors: Shinji Ozoe, Kenichi Yamanoi, Hideaki Matsunaga
  • Cooled reactor for the production of dimethyl ether from methanol
    Patent number: 9504978
    Abstract: A cooled reactor for the production of dimethyl ether by catalytic dehydration of methanol in the gas phase, the reactor having an adiabatic catalyst bed as starting zone, a moderator zone cooled by direct or indirect heat exchange, and optionally an adiabatic catalyst bed as conditioning zone. The conversion of methanol to dimethyl ether is increased and the formation of undesired by-products is decreased.
    Type: Grant
    Filed: September 18, 2012
    Date of Patent: November 29, 2016
    Assignees: L'AIR LIQUIDE, SOCIÉTÉ ANONYME POUR L'ETUDE ET L'EXPLOITATION DES PROCÉDÉS GEORGES CLAUDE, AIR LIQUIDE GLOBAL E&C SOLUTIONS GERMANY GMBH
    Inventors: Bernd Ahlers, Manuela Gil De Tober, Eckhard Seidel
  • Carbonylation process
    Patent number: 9505703
    Abstract: Process for the production of methyl acetate by carbonylating dimethyl ether with carbon monoxide in the presence of hydrogen and a zeolite catalyst. The process is carried out with a molar ratio of hydrogen to carbon monoxide of at least 1 and the catalyst has been calcined at a temperature of from about 375° C. to about 475° C.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: November 29, 2016
    Assignee: BP CHEMICALS LIMITED
    Inventors: Evert Jan Ditzel, Bogdan Costin Gagea, Nicholas John Hazel, John Glenn Sunley, Gordon John Haining
  • Intermediate for synthesizing treprostinil diethanolamine and method for preparing the same
    Patent number: 9505704
    Abstract: The present invention relates to a method for treprostinil diethanolamine synthesis. The present invention also relates to a novel intermediate used in the method for treprostinil diethanolamine synthesis. The novel intermediate is shown in the following formula (II): wherein R1 and R2 are described in the description.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: November 29, 2016
    Assignee: EVERLIGHT CHEMICAL INDUSTRIAL CORPORATION
    Inventors: Shijay Gao, Chia-Chung Tsai, Tsai-Yung Chou, Yu-Min Chiang, Chi-Hsiang Yao
  • Method for purifying mixtures comprising 4,4?-methylenediphenyl diisocyanate
    Patent number: 9505711
    Abstract: The invention relates to a method for purifying mixtures comprising 4,4?-methylenediphenyl diisocyanate, which comprises purifying by distillation a mixture I comprising 4,4?-methylenediphenyl diisocyanate having a hydrolyzable chlorine content as specified in ASTM D4663-10 of greater than 100 ppm by means of a column K1, wherein the gaseous stream comprising the mixture I is brought into contact in the column K1 with at least one liquid compound A which has the same or higher boiling point than 4,4?-methylenediphenyl diisocyanate and which has a hydrolyzable chlorine content as specified in ASTM D4663-10 of a maximum of 100 ppm, and wherein the gaseous stream O obtained at the top of the column comprises 4,4?-methylenediphenyl diisocyanate has a hydrolyzable chlorine content as specified in ASTM D4663-10 of a maximum of 100 ppm.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: November 29, 2016
    Assignee: BASF SE
    Inventors: Michael Bock, Johannes Jacobs, Kai Thiele, Anne-Kathrin Merten
  • Process for producing acetic acid
    Patent number: 9505691
    Abstract: Process for producing acetic acid is disclosed in which the reaction medium is separated into a liquid recycle and a vapor product stream including acetic acid, methyl iodide, methyl acetate and water in a flash vessel. The vapor product stream is condensed into a liquid stream that is enriched in acetic acid and this liquid stream is further sent to the distillation columns to recover acetic acid. The process advantageously improves the capacity of the acetic acid production while reducing the amount of acetic acid that is recycled.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: November 29, 2016
    Assignee: Celanese International Corporation
    Inventor: Ronald David Shaver
  • Process for the carbonylation of dimethyl ether
    Patent number: 9499470
    Abstract: Process for preparing methyl acetate by the carbonylation of dimethyl ether with carbon monoxide in the presence of hydrogen and a zeolite catalyst. In a first step, the carbonylation is conducted with a carbon monoxide to hydrogen molar ratio of at least 1 and, in a second and subsequent step, the carbonylation is conducted with a hydrogen to carbon monoxide molar ratio of greater than 1.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: November 22, 2016
    Assignee: BP CHEMICALS LIMITED
    Inventors: Evert Jan Ditzel, Bogdan Costin Gagea, John Glenn Sunley
  • Production of two esters using homogeneous catalyst
    Patent number: 9493395
    Abstract: Disclosed is a process for preparing two esters by reacting an aldehyde with an alcohol in the presence of a ruthenium complex compound as a catalyst. The process is particularly useful for preparing ethyl acetate and n-butyl acetate, isobutyl acetate, or 2-ethylhexyl acetate in high yield by coupling acetaldehyde with n-butanol, i-butanol, or 2-ethylhexanol.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: November 15, 2016
    Assignee: Eastman Chemical Company
    Inventors: Mesfin Ejerssa Janka, Robert Thomas Hembre, Stephanie Rollins Testerman
  • Solid-liquid separation with a no-dry rotary pressure filter
    Patent number: 9486722
    Abstract: A process for recovering a solid product from a solid/liquid mixture. The process includes filtering a solid/liquid mixture to form a filter cake in a first solid-liquid separation zone. The filter cake comprises the solid product. The first solid-liquid separation zone comprises a rotary pressure filter apparatus configured to apply a pressure differential across at least one filter member, and the filter cake is formed on the filter member. The filter cake is then washed with fluid in the rotary filter apparatus to form a wet filter cake. The wet filter cake is then transferred to a reslurrying zone. The wet filter is mixed with a reslurrying fluid to form a slurry, and the slurry is transferred to a second solid/liquid separation zone, where the solid product is separated from the slurry.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: November 8, 2016
    Assignee: BP Corporation North America Inc.
    Inventors: Timothy Keyes, Thomas Bartos
  • Pyrrolidine derived beta 3 adrenergic receptor agonists
    Patent number: 9486448
    Abstract: The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of ?3-adrenoceptor.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: November 8, 2016
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Kenneth Jay Barr, Mark E. Scott, Christopher F. Thompson, Neville Anthony, Carolyn Michele Cammarano, Raman Kumar Bakshi, Subhendu Kumar Mohanty, Chandra Sekhar Korapala, Prashant R. Latthe, Vyjayanthi N. Kambam, Sujit Kumar Sarkar, Jayanth Thiruvellore Thatai
  • Compositions and methods for treating non-alcoholic steatohepatitis
    Patent number: 9486433
    Abstract: Compositions and method are disclosed comprising ethyl icosapentate for use in treatment of non-alcoholic steatohepatitis (NASH).
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: November 8, 2016
    Assignee: Mochida Pharmaceuticals Co. Ltd.
    Inventors: Kiyoshi Mizuguchi, Tsuyoshi Harada, Atsushi Osada, Hiroyuki Kawano, Masayuki Ichioka
  • High purity dibasic acid compositions and methods of making the same
    Patent number: 9487463
    Abstract: High-purity dibasic acid compositions are generally disclosed. In some embodiments, the dibasic acid compositions are solutions or suspensions. In some other embodiments, the compositions are solid-state compositions. In some such embodiments, the solid-state compositions include a dibasic acid as a crystalline solid and further include a low quantity of certain impurities, such as monobasic acids, various esters, and the like. Methods and systems for making such high-purity dibasic acid compositions are also disclosed.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: November 8, 2016
    Assignee: Elevance Renewable Sciences, Inc.
    Inventors: Alpeshkumar K. Patel, Brian Pease, Bradon J. Dreyer, Yenamandra Viswanath
  • Esterification process
    Patent number: 9481628
    Abstract: Embodiments of an invention disclosed herein relate to methods to produce terephthalate esters, the methods include esterifying at least one C6-C13 alcohol with dimethyl terephthalate (DMT) in the presence of a catalyst to produce the terephthalate esters.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: November 1, 2016
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventor: Nicholaas A. De Munck
  • Process for the production of high purity glycol esters
    Patent number: 9481629
    Abstract: A process for the production of 2-butoxyethyl benzoate from benzoic acid and 2-butoxy ethanol wherein at least a portion of the crude reaction product is fed to a distillation column comprising a dividing wall or a pasteurizing section.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: November 1, 2016
    Assignee: Dow Global Technologies LLC
    Inventors: Andrei S. Merenov, Edward D. Daugs, Patrick Ho Sing Au-Yeung, Jason L. Trumble
  • N-benzylaniline derivative and uses thereof
    Patent number: 9481636
    Abstract: A N-benzylaniline derivative and uses thereof. The derivative is a compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound protects against cerebral ischemia/reperfusion injury and has analgesic action for chronic pathologic pain, and may be used to treat cerebral apoplexy, neuropathic pain, and inflammatory pain. Moreover, because of the unique mechanism of action of the compound, the compound can be used to treat epilepsy, affective disorder, and neurodegenerative diseases.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: November 1, 2016
    Assignee: NANJING MEDICAL UNIVERSITY
    Inventors: Dongya Zhu, Fei Li, Chunxia Luo
  • Anti-neurodegenerative natural compound isolated from alpiniae oxyphyllae fructose and their total synthesis
    Patent number: 9475749
    Abstract: This invention is directed to novel compounds isolated or derived from Alpiniae oxyphyllae fructus, chemically synthesized novel compounds, methods of preparing the novel compounds and uses thereof as neuroprotectants or drugs for treating neurodegenerative diseases such as Parkinson's disease.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: October 25, 2016
    Assignee: University of Macau
    Inventors: Ming Yuen Lee, Zaijun Zhang, Guohui Li
  • Method for preparing refined lactide from recovered polylactic acid
    Patent number: 9475790
    Abstract: A method for preparing lactide from recovered polylactic acid, the method including the following steps: A. pretreating the recovered polylactic acid; B. extruding the treated polylactic acid from a twin screw extruder to yield a polylactic acid melt, and introducing the polylactic acid melt to a pre-depolymerization kettle; C. carrying out a chain scission reaction to break molecular chains in the polylactic acid melt and to decrease the number-average molecular weight of the polylactic acid melt to below 5000; D. conducting depolymerization reaction to yield a crude lactide; and E. purifying the crude lactide and crystallizing the purified lactide.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: October 25, 2016
    Assignee: XIAOGAN ESUN MATERIAL CO., LTD.
    Inventors: Yihu Yang, Jie Xu
  • Benzazepine dicarboxamide compounds
    Patent number: 9475775
    Abstract: This invention relates to novel benzazepine dicarboxamide compounds of the formula wherein R1 to R4 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: October 25, 2016
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Sabine Hoves, Lisha Wang, Hongying Yun, Weixing Zhang, Wei Zhu
  • Method for manufacturing 3,4,5-tricaffeoylquinic acid
    Patent number: 9475752
    Abstract: Provided are a method for manufacturing 3,4,5-tricaffeoylquinic acid, which can produce 3,4,5-tricaffeoylquinic acid with high efficiency by a simple operation in a short process using inexpensive raw materials, and intermediate compounds.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: October 25, 2016
    Assignee: FUJIFILM Corporation
    Inventors: Kozo Sato, Hiroyuki Naito, Takeshi Murakami