Patents Examined by Yevegeny Valenrod
  • Patent number: 9469603
    Abstract: The present invention relates to the synthesis of a novel compound, in which liquid hydrazine and the derivatives thereof react with excess carbon dioxide to enable the carbon dioxide to chemically bond to the hydrazine and the derivatives thereof. To this end, high-pressure carbon dioxide is used to synthesize hydrazine and the derivatives thereof to which the carbon dioxide is bonded in a pure form with no water and no by-product. Furthermore, the present invention provides a method for utilizing the above-described compounds by reacting the compounds with carbonyl compounds.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: October 18, 2016
    Assignee: Sogang University Research Foundation
    Inventors: Nam Hwi Hur, Byeong No Lee
  • Patent number: 9464076
    Abstract: Compounds having PDE10A inhibitory activity and having general formula (I), or an isotope thereof or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: October 11, 2016
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Hidekazu Inoue, Yoshito Kawamoto, Katsuhide Kamei, Kenichi Hiramatsu, Minako Tomino
  • Patent number: 9464026
    Abstract: A process for recovering and using an carboxylic acid derived from a fermentation broth by means of making an ester of the free carboxylic acid and alcohol in carbon dioxide (CO2) without the presence of any other acid catalyst at a reaction temperature and pressure that corresponds to supercritical, critical or near critical conditions for the alcohol and/or CO2 is described. The process can constitute part of a general process of refining carboxylic acids derived from a fermentation broth for use in the production of a variety of chemical compounds, such as C4 platform compounds, polymers, or fuels.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: October 11, 2016
    Assignee: ARCHER-DANIELS MIDLAND COMPANY
    Inventors: Kenneth Stensrud, Padmesh Venkitasubramanian
  • Patent number: 9464045
    Abstract: This disclosure relates to a process for preparing D,L-methionine by feeding carbon dioxide to an aqueous potassium methioninate solution obtained by hydrolysis of 5-(2-methylmercaptoethyl)hydantoin, in order to precipitate out crude methionine, which is separated off and purified. In this process an aqueous solution of the separated-off crude methionine is purified by recrystallization from a solution containing potassium ions and also a crystallization additive. The crystallization additive is a nonionic or anionic surfactant, or a mixture of different nonionic or anionic surfactants. The recrystallization occurs by introducing a 60 to 110° C.-hot methionine solution into a 35 to 80° C.-warm methionine suspension, a temperature of which is lower than that of the introduced solution, such that the temperature of the methionine suspension being maintained between 35 and 80° C. during the addition. The crystallization additive is a sorbitan fatty acid ester or a mixture of different sorbitan fatty acid esters.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: October 11, 2016
    Assignee: EVONIK DEGUSSA GmbH
    Inventors: Martin Koerfer, Hans Joachim Hasselbach, Stefan Reichert, Harald Jakob, Christoph Weckbecker, Klaus Huthmacher, Horst Krull, Bernd Drapal, Rainer Peter
  • Patent number: 9464021
    Abstract: The description provides processes for the regio and stereospecific synthesis of polyprenylatedquinone derivatives, such as Vitamin K1, K2 and Ubiquinone, exploiting dithioacetals, especially 1,3-dithiane, mediated Umpolung chemistry which works along a new concept “Inhibiting resonance delocalization (IRD)” to overcome isomerization generated due to delocalization of allyliccarbanion on the ?-electron cloud of an allylic systems by the conventional synthesis.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: October 11, 2016
    Inventors: Dilip S. Mehta, Priya Mohan, Mayank Shastri, Ted Reid
  • Patent number: 9458078
    Abstract: A process for producing high purity acetic acid from a carbonylation reaction, wherein the carbonylation reaction is carried out while maintaining a low ethyl iodide content in the reaction medium. The ethyl iodide concentration may be maintained by removing acetaldehyde from the reaction medium and/or by adjusting at least one A) hydrogen partial pressure in the reactor, B) methyl acetate concentration of the reaction medium; and/or C) methyl iodide concentration of the reaction medium.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: October 4, 2016
    Assignee: CELANESE INTERNATIONAL CORPORATION
    Inventors: Yaw-Hwa Liu, Mark O. Scates
  • Patent number: 9458088
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: October 4, 2016
    Assignee: ACUCELA INC.
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas L. Little, Jr., Anna Gall, Feng Hong
  • Patent number: 9453181
    Abstract: Methods for removing contaminants from algal oil are provided. In an embodiment, a method comprises the steps of combining a sulfuric acid-aqueous solution that has a pH of about 1 or less with a contaminant-containing algal oil at treatment conditions effective to form an effluent. The effluent comprises a treated algal oil phase and contaminants in an acidic aqueous phase. The contaminants comprise metals, phosphorus, or combinations thereof. The acidic aqueous phase is removed from the effluent to form a contaminant-depleted algal oil.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: September 27, 2016
    Assignee: UOP LLC
    Inventor: Francis Stephen Lupton
  • Patent number: 9452425
    Abstract: An ionic liquid is used as liquid matrix for organic synthesis in homogeneous phase on soluble support, the ionic liquid being presented in liquid or solid form at ambient temperature, of formula A1+X1?, A1+ representing a cation, functional or non-functional, or a mixture of cations in which either none of the cations is functional or at least one of the cations is functional, and X1? an anion, functional or non-functional, or a mixture of anions in which either none of the anions is functional or at least one of the anions is functional.
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: September 27, 2016
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE RENNES 1
    Inventors: Michel Vaultier, Said Gmouh
  • Patent number: 9446060
    Abstract: The present invention relates to a therapeutic agent, wherein the therapeutic agent is D-Boramine. The therapeutic agent is prepared by mixing L-carnitine tartrate, pyridoxal 5? phosphate and fumaric acid. D-Boramine, when administered orally or parenterally in therapeutic quantities, is effective for use in the prevention of cancer that arises from mutations to the BRCA1 and BRCA2 genes, i.e., breast and ovarian and the treatment of several types of human diseases including, but not limited to, Antiphospholipid Syndrome, Disseminate Intravascular Coagulation (DIC), infections arising from viruses (including strains of Human Papillomavirus, Herpes Simplex Virus and Simian Virus), tuberculosis (including XDR Tuberculosis) and mycoplasma, Hepatitis A, B and C, MTHFR genetic mutations.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: September 20, 2016
    Inventor: Deborah Warner
  • Patent number: 9446028
    Abstract: Methods of increasing tonic inhibition in a subject in need thereof, for example a subject with Fragile X syndrome or Angelman syndrome are disclosed. Methods of treating secondary insomnia in a subject with a neurodegenerative disease or disorder are also disclosed.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: September 20, 2016
    Assignee: OVID THERAPEUTICS INC
    Inventor: Matthew During
  • Patent number: 9439888
    Abstract: The present disclosure provides compounds that include a tetrazolone derivative of a carboxyl group of an active agent. This disclosure also relates to pharmaceutical compositions that include these compounds, methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: September 13, 2016
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Matthew Duncton, Rajinder Singh
  • Patent number: 9440916
    Abstract: The present invention is directed to a method of treating an inflammatory skin disease or disorder, such as dermatitis, psoriasis, acne, or rosacea. The method comprises administering to the subject 3, 4-bis-benzylsulfonylbutyronitrile in an amount effective to reduce or eliminate the symptoms of the inflammatory skin disease or disorder. Topical administration and oral administration are preferred route of administration.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: September 13, 2016
    Assignee: OLATEC THERAPEUTICS LLC
    Inventors: Joseph P. St. Laurent, Gerald S. Jones, David M. Bresse, Scott A. Goodrich
  • Patent number: 9440917
    Abstract: A process is described for preparing 4-haloalkyl-3-mercapto-substituted 2-hydroxybenzoic acid derivatives of the general formula (I) by reaction of 4-thio-substituted ?-keto esters of the formula (II) with alkoxyvinyl haloalkyl ketones of the formula (III) in the presence of a base. In the above formulae, X, R1, R2 and R3 are each hydrogen, halogen, alkyl, alkoxy and cycloalkyl.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: September 13, 2016
    Assignee: Bayer Cropscience AG
    Inventors: Mark James Ford, Gunter Karig
  • Patent number: 9440920
    Abstract: Described herein are antimicrobial compounds identified via a high-throughput screen to identify compounds that produce anucleate cells in E. coli after cell division occurs. Compound 1 (5-nonyloxytryptamine) and its analogs are small molecule inhibitors of the nucleoid occlusion system and/or proteins that are responsible for maintaining the structure of the chromosome. The antimicrobial compounds are useful to treat bacterial infections as well as to inhibit bacterial growth.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: September 13, 2016
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Douglas Benjamin Weibel, Katherine Ann Hurley, Katherine Cassidy Faulkner
  • Patent number: 9434682
    Abstract: Disclosed are a novel reactive mesogen compound having superior thermostability, high birefringence and a simple preparation process while possessing unique liquid crystal characteristics having molecular orientation by forming a polymer network through photopolymerization, and a method of preparing the same. The novel reactive mesogen compound according to the present invention is represented by Formula 3 below.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: September 6, 2016
    Assignee: Aekyung Chemical Co., Ltd.
    Inventors: Yoon-Tae Jeon, Do-Yeon Kim, Yun-Sun Do, Gi-Woo Lee, Hueong-Nam Park, Kwang-Sik Choi
  • Patent number: 9433593
    Abstract: 5-Adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide disclosed in the present disclosure lacks toxicity and can exhibit superior anti-inflammatory effect. It exhibits superior anti-inflammatory effect, for example, by inhibiting the production of one or more of NO and PGE2, by inhibiting the activity of one or more of the transcription factors NF-?B and AP-1 or by inhibiting proinflammatory cytokines such as IL-1?.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: September 6, 2016
    Assignee: Amorepacific Corporation
    Inventors: Yung Hyup Joo, Heung Soo Baek, Jeong Hwan Kim, Chang Geun Yi, Hyung Jun Lim, Hong-Ju Shin, Yongjin Kim, Jon Hwan Lee
  • Patent number: 9433571
    Abstract: The present invention provides mild cleansing and cleaning compositions and methods for mitigating irritation induced by harsh detersive surfactants. The invention relates to a method of reducing skin irritation associated with a cleansing composition comprising at least one surfactant, the method comprising combining an effective amount of at least one nonionic amphiphilic polymer with at least one detersive surfactant selected from anionic surfactants, amphoteric surfactants, nonionic surfactants and combinations of two or more thereof.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: September 6, 2016
    Assignee: Lubrizol Advanced Materials, Inc.
    Inventors: Brian D. Figura, Krishnan Chari, Wei-Yeih Yang
  • Patent number: 9428618
    Abstract: The invention relates to a method for producing halogenated oligomers and/or halogenated polymers of elements of the third to fifth main group, wherein the halogenated oligomers and/or halogenated polymers are synthesized from a first chain-forming agent and a second chain-forming agent in a plasma-chemical reaction. At least one of the two chain-forming agents is a halogen compound of an element of the third to fifth main group.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: August 30, 2016
    Assignee: SPAWNT PRIVATE S.A.R.L.
    Inventors: Norbert Auner, Sven Holl, Christian Bauch, Gerd Lippold, Rumen Deltschew, Thoralf Gebel, Javad Mohsseni
  • Patent number: 9427727
    Abstract: Disclosed is a process for producing an oxide catalyst for use in the gas-phase catalytic oxidation reaction or the like of propane or the like, the process comprising the steps of: (I) obtaining a preparation containing compounds of Mo, V, Nb, and Sb or Te at the predetermined atomic ratios; (II) drying the preparation to obtain a dry powder; and (III) calcining the dry powder, wherein the step (III) comprises the step of calcining the dry powder in the presence of a compound containing W in the form of a solid to obtain a pre-stage calcined powder or a mainly calcined powder, or the step of calcining the dry powder and calcining the obtained pre-stage calcined powder in the presence of the solid to obtain a mainly calcined powder, the solid satisfies the predetermined conditions, and the oxide catalyst comprises a catalytic component having the predetermined composition.
    Type: Grant
    Filed: October 3, 2011
    Date of Patent: August 30, 2016
    Assignee: ASAHI KASEI CHEMICALS CORPORATION
    Inventors: Eri Tateno, Takeo Ichihara, Takaaki Kato