Abstract: The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate or related products using the microbial organisms.

Abstract: The present invention provides a composite structure, a method for its manufacture, a sewn product containing the composite structure, and a method for manufacturing the sewn product. The composite structure comprises a foam layer, a textile layer, a cover layer and a lacquer layer in this order, wherein the foam layer has a density of at most 300 kg/m3 and contains a polyolefin, the cover layer is thermoplastic and comprises at least two compact sublayers of different composition, each sublayer containing at least one thermoplastic selected from polyolefin and polyvinyl chloride.

Abstract: Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material. Wherein, when the eyelid is positioned between the energy transducer and the scleral shield, the light energy from the energy transducer and the heated energy-absorbing material of the scleral shield conductively heats a target tissue region sufficiently to melt meibum within meibomian glands located within or adjacent to the target tissue region.

Abstract: Methods, systems, and computer programs are presented for estimating downtime and recovery time after a disaster. One method includes an operation for calculating component fragility functions for components of a facility that are vulnerable to damage after a disaster. Further, the method includes calculating component recovery functions for the components of the facility. The component recovery functions indicate a probability of recovery after a disaster over time. The method further includes operations for calculating a facility fragility function and a facility recovery function based on the component fragility functions and the component recovery functions, and for determining a downtime for the facility for a given intensity associated with the disaster. Further, the method includes an operation for causing presentation of the downtime for the facility on a user interface (UI).

Abstract: A uniform protocol can facilitate secure, authenticated communication between a controller device and an accessory device that is controlled by the controller. An accessory and a controller can establish a pairing, the existence of which can be verified at a later time and used to create a secure communication session. The accessory can provide an accessory definition record that defines the accessory as a collection of services, each service having one or more characteristics. Within a secure communication session, the controller can interrogate the characteristics to determine accessory state and/or modify the characteristics to instruct the accessory to change its state.

Abstract: The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.

Abstract: A system for detecting manual ventilation and selectively delivering a high flow of oxygen. The system comprises a source of compressed oxygen coupled to a first lumen of a nasal cannula, with an oxygen flow control valve coupled to a processor to control the flow of oxygen to the nasal cannula. A second lumen of the nasal cannula is in connection with a pressure sensor and the pressure sensor in connection with the processor. The processor may receive the pressure values and be programmed to determine when manual ventilation has occurred, and send a signal to the oxygen flow control valve to send a high flow of oxygen in response to manual ventilation.

Abstract: This disclosure is directed to systems, methods, apparatuses, and techniques that utilize enhanced gesture-based input mechanisms to facilitate rapid creation and editing of digital music compositions. These technologies can be specially designed and configured to optimize creation, editing, and/or sharing of digital music compositions on mobile electronic devices that include capacitive sensing mechanisms. The technologies include multi-gesture functionalities that enable users to view and access various notation customization features in a compact space of a mobile device display. Additionally, the technologies encompass improved data storage models that enable underlying notation data to be accessed in multiple operational modes, and permit frequencies or pitches of notations to be accurately generated and incorporated into audio signals.

Abstract: A pressure vessel assembly incudes a pressure vessel and a gas density gauge. The pressure vessel includes a vessel wall defining an interior cavity. The gas density gauge includes a parallel plate capacitor having a pair of plates. Opposing surfaces of the plates are separated by a distance across an open gap. A capacitance of the capacitor is related to a density of a gas within the open gap.

Abstract: A plate provides clearance between a camera and a quick-release receiver securing the camera to a support.

Abstract: A tripod suitable for travel.

Abstract: A computer implemented method and apparatus for determining a location at which a given feature is represented in medical imaging data is disclosed. A first descriptor for a first location in first medical imaging data is obtained. The first location is the location within the first medical imaging data at which the given feature is represented. A second descriptor for each of a plurality of candidate second locations in second medical imaging data is obtained. A similarity metric indicating a degree of similarity with the first descriptor is calculated for each of the plurality of candidate second locations. A candidate second location is selected from among the plurality of candidate second locations based on the calculated similarity metrics. The location at which the given feature is represented in the second medical imaging data is determined based on the selected candidate second location.

Abstract: Ultrasonic audio processing circuitry and a method useful in ultrasonic presence detection. An ultrasonic burst generator produces an ultrasonic burst signal at one or more ultrasonic frequencies, and an equalizer equalizes that ultrasonic burst signal according to frequency response characteristics of the speaker and microphone at those ultrasonic frequencies. Driver circuitry drives a speaker with the ultrasonic burst signal, which may be combined with an audible audio signal. An ultrasonic separation filter separates an ultrasonic portion from a signal received at a microphone, and processing circuitry is provided to determine a delay time of an echo corresponding to the ultrasonic burst signal in that separated ultrasonic portion of the received signal. In another aspect, the equalizer equalizes an ultrasonic portion of the signal received at a microphone, according to frequency response characteristics of the speaker and microphone at the ultrasonic frequencies of the burst.

Abstract: A vehicle can have a user profile securely deployed in it according to a security protocol. The vehicle can include a body, a powertrain, vehicle electronics, and a computing system. The computing system of the vehicle can be configured to: retrieve information from a user profile according to a security protocol. The computing system of the vehicle can also be configured to receive a request for at least a part of the retrieved information from the vehicle electronics and send a portion of the retrieved information to the vehicle electronics according to the request. The computing system of the vehicle can also be configured to propagate information sent from the vehicle electronics back into the user profile according to the security protocol. And, the computing system of the vehicle can also be configured to store in its memory, according to the security protocol, information sent from the vehicle electronics.

Abstract: A sensor mounting assembly is configured for use with a vessel arrangement including at least four vessels. The assembly includes first and second elongated frame members, first and second rollers, and first and second sensors. The first sensor is attached to the first elongated frame member and is configured to contact the surface of the first vessel upon actuation in a first direction. The second sensor is attached to the second elongated frame member and is configured to contact the surface of the second vessel upon actuation in a second direction that is substantially orthogonal to the first direction. This disclosure also describes a method of mounting at least six sensors for use with a vessel arrangement including at least four vessels, the vessel arrangement disposed in a container in a two-by-two stacked configuration having a central space.

Abstract: A sensor mounting assembly is configured for use with a vessel arrangement including at least four vessels. The assembly includes first and second elongated frame members, first and second rollers, and first and second sensors. The first sensor is attached to the first elongated frame member and is configured to contact the surface of the first vessel upon actuation in a first direction. The second sensor is attached to the second elongated frame member and is configured to contact the surface of the second vessel upon actuation in a second direction that is substantially orthogonal to the first direction. This disclosure also describes a method of mounting at least six sensors for use with a vessel arrangement including at least four vessels, the vessel arrangement disposed in a container in a two-by-two stacked configuration having a central space.

Abstract: Technologies are disclosed for machine learning assisted automation of workflows based on observation of user interaction with operating system (OS) platform features. User interaction data is collected that defines the activity of a user with respect to platform features provided by an OS. The user interaction data is provided to a trained machine learning model that is configured to identify a workflow for performing a task based on the user interaction data. If the trained machine learning model identifies a relevant workflow, a user interface (UI) can be presented to the user that includes data identifying the workflow selected by the trained machine learning model. The UI can also include an element which, when selected, will cause the computing device to execute the workflow selected by the trained machine learning model based on the user interaction data.

Abstract: Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula: The compounds are useful for treating inflammatory and autoimmune diseases.

Abstract: Zeolite catalysts and systems and methods for preparing and using zeolite catalysts having the CHA crystal structure are disclosed. The catalysts can be used to remove nitrogen oxides from a gaseous medium across a broad temperature range and exhibit hydrothermal stable at high reaction temperatures. The zeolite catalysts include a zeolite carrier having a silica to alumina ratio from about 15:1 to about 256:1 and a copper to alumina ratio from about 0.25:1 to about 1:1.

Abstract: This invention relates to a curable composition comprising: I. a first component comprising a resin having at least one functional group selected from the group consisting of ?-ketoester and malonate functional groups, II. a second component comprising at least one curing agent having at least one aldehyde functional group, and III. a third component comprising at least one primary amine or at least one secondary amine, salts thereof, or combinations thereof.