Patents by Inventor Akira Kobayashi

Akira Kobayashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10398738
    Abstract: An object of the present invention is to provide a method for producing a mesenchymal stromal cell composition, comprising conveniently and aseptically separating high-purity amnion-derived MSCs by performing enzyme treatment only once. According to the present invention, the following are provided: a method for producing a mesenchymal stromal cell composition, comprising: performing enzyme treatment of an amnion with collagenase and thermolysin and/or dispase; and filtering the enzyme-treated amnion through a mesh; a method for producing a cryopreserved mesenchymal stromal cell composition; and a therapeutic agent comprising as an active ingredient the mesenchymal stromal cell composition for a disease selected from graft-versus-host disease, inflammatory bowel disease, systemic lupus erythematosus, liver cirrhosis, or radiation enteritis.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: September 3, 2019
    Assignees: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION AT KOBE, HYOGO COLLEGE OF MEDICINE, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, KANEKA CORPORATION
    Inventors: Kenichi Yamahara, Akihiko Taguchi, Toshihiro Soma, Shunsuke Ohnishi, Akira Kobayashi
  • Publication number: 20190247930
    Abstract: Provided is a surface-coated cutting tool including a base material and a coating including a super-multilayer-structure layer where A layers and B layers different from the A layers in composition are alternately laminated. The super-multilayer-structure layer includes an X area and a Y area those are alternately repeated. In the X area, A layers having a thickness AX and B layers having a thickness BX are alternately laminated. In the Y area, A layers having a thickness AY and B layers having a thickness BY are alternately laminated. The thickness AX is larger than the thickness AY, and the thickness BX is smaller than the thickness BY. Each of the A layers and the B layers comprising one or more elements selected from a group consisting of Ti, Al, Cr, Si, Ta, Nb, and W, and one or more elements selected from a group consisting of C and N.
    Type: Application
    Filed: September 20, 2017
    Publication date: August 15, 2019
    Inventors: Keizo Tanaka, Makoto Setoyama, Yutaka Kobayashi, Akira Kobayashi
  • Publication number: 20190241983
    Abstract: The present invention provides a colored sweet potato that has a high anthocyanin content, and that is useful as a pigment material. Further, the present invention also provides a processed product of the colored sweet potato useful as a purple pigment, more specifically, an extract composition, as well as the purified matter thereof (including roughly purified matter). A colored sweet potato having the following characteristics is used. (A) the color value (530 nm) per gram of wet weight of colored sweet potato (color value (530 nm)/g) is not less than 15; (B) the absorbance ratio (320 nm/530 nm) per gram of wet weight of colored sweet potato (absorbance ratio (320 nm/530 nm)/g) is not less than 1.
    Type: Application
    Filed: October 3, 2017
    Publication date: August 8, 2019
    Applicant: SAN-EI GEN F.F.I., INC.
    Inventors: Tetsufumi SAKAI, Masaru YOSHINAGA, Yasuhiro TAKAHATA, Yumi KAI, Akira KOBAYASHI, Kenji KATAYAMA, Toshiro FUJITA, Hironori ONISHI, Kazuya MORIYUKI, Koji NISHIYAMA
  • Publication number: 20190170079
    Abstract: In the communication interruption state in which the transmission of a drive control command value DUTY from an engine control unit (ECU) 1 to a fuel pump driver (FPD) 2 is disabled, the FPD 2 is configured so as to drive a fuel pump 4 by using the maximum command value DTYMAX (100%) as a drive control command value DUTY. A stop state of the fuel pump 4 is maintained even if the drive control command value DUTY is the maximum command value DTYMAX when an ignition switch 21 is in the OFF State so as to have stopped the fuel pump 4, while the fuel pump 4 is driven when the ignition switch 21 is in the ON state and the drive control command value DUTY is the maximum command value DTYMAX.
    Type: Application
    Filed: December 5, 2018
    Publication date: June 6, 2019
    Applicant: HONDA MOTOR CO., LTD.
    Inventors: Shoji Sasaki, Kazunori Kawamura, Kazuhiro Kobayashi, Akira Kobayashi
  • Publication number: 20190143338
    Abstract: A vertical roller mill includes a housing, a chute that supplies materials to be grinded to a center portion of the housing, a grinder that is provided below the chute and grinds the materials to be grinded, an exhaust pipe that is provided above the grinder, a transport mechanism that forms an air flow for transporting, to the exhaust pipe, grinded materials grinded by the grinder, and a flow-constricting flow path provided between the grinder and the exhaust pipe and narrows a flow path area for the air flow, in which the flow-constricting flow path is formed between a first flow-constricting ring provided in the center portion of the housing and a second flow-constricting ring provided to protrude from the housing toward the center portion of the housing.
    Type: Application
    Filed: January 17, 2019
    Publication date: May 16, 2019
    Applicant: IHI Corporation
    Inventors: Kentaro NARIAI, Emi Ohno, Kazuhiro Watanabe, Takahiro Kozaki, Akira Kobayashi
  • Publication number: 20190118495
    Abstract: Provided is a flat fiber-reinforced plastic strand which is produced by curing a twisted resin-impregnated strand and has no disturbed fiber orientation, and a flat fiber-reinforced plastic strand sheet which is produced by using said flat fiber-reinforced plastic strands. According to a method of manufacturing the flat fiber-reinforced plastic strand 2, (a) a twisted resin-impregnated strand f2 in an uncured state, the strand including a plurality of reinforcing fibers f, is fed in a state of tension between a pair of heated steel belts 41A and 41B facing each other and making rotation movements; and (b) the resin-impregnated strand f2 is sandwiched and heated by the steel belts 41A and 41B, and pressurized from both sides of the strand f2 to form a cross section of the strand into a flat shape, and, with the shape being kept, a resin is cured and cooled.
    Type: Application
    Filed: October 16, 2018
    Publication date: April 25, 2019
    Inventors: Makiji MIYAO, Akira KOBAYASHI, Masaki ARAZOE, Akihiro TATEISHI
  • Publication number: 20190118863
    Abstract: In a vehicle body front structure, a sub frame is fixed to front mount brackets and rear mount brackets of a pair of front side frames. A power unit is arranged on the front side of the sub frame in the vehicle body, and the power unit is supported by the pair of front side frames. A tilt surface is formed on the sub frame, and the tilt surface tilts to ascend toward the rear of the vehicle body. A rear portion of the power unit faces the tilt surface.
    Type: Application
    Filed: January 10, 2017
    Publication date: April 25, 2019
    Applicant: HONDA MOTOR CO., LTD.
    Inventors: Yukiyasu HARA, Tetsuhiro ARIMA, Yasuhito SATO, Tomoya TAKEDA, Hirokazu KOBAYASHI, Akihiro IKEYA, Akira KOBAYASHI, Ken YASUI, Eisei HIGUCHI
  • Publication number: 20190022763
    Abstract: A surface-coated cutting tool includes a substrate composed of cemented carbide and a coating film. The coating film includes an intermediate layer in contact with the substrate and an upper layer formed on the intermediate layer. The upper layer is made up of a single layer consisting of an upper base layer which is a layer in contact with the intermediate layer or multiple layers constituted of two or more layers. A mismatch in lattice interplanar spacing in an interface region between the substrate and the intermediate layer is not higher than 65% of a theoretical value of a mismatch in lattice interplanar spacing between the substrate and the upper base layer. A mismatch in lattice interplanar spacing in an interface region between the intermediate layer and the upper base layer is not higher than 65% of the theoretical value of the mismatch in lattice interplanar spacing between the substrate and the upper base layer.
    Type: Application
    Filed: November 22, 2017
    Publication date: January 24, 2019
    Inventors: Keizo Tanaka, Makoto Setoyama, Haruyo Fukui, Akira Kobayashi, Koji Kuramochi
  • Publication number: 20190013511
    Abstract: The present invention provides a method of manufacturing an electrode sheet including a compression step of causing a band-shaped electrode sheet provided with an active substance layer which is an active substance forming portion between at least a pair of rotating columnar compression rolls, and pressing and compressing the electrode sheet by the pair of compression rolls, and a cutting step of cutting the electrode sheet undergoing the compression step parallel to a longitudinal direction of the electrode sheet. When the width of the active substance layer is assumed as a first width, the compression step compresses the electrode sheet using the compression rolls having a second width equal to or less than the first width.
    Type: Application
    Filed: July 22, 2016
    Publication date: January 10, 2019
    Applicant: NEC ENERGY DEVICES, LTD.
    Inventors: Kenji SATO, Kenichi ITO, Akira KOBAYASHI
  • Publication number: 20180362922
    Abstract: The object of the present invention is to provide a method for producing a cell population comprising mesenchymal stem cells having a high specific growth rate which are useful for promptly producing large amounts of cell formulations. The present invention provides a method for producing a cell population comprising mesenchymal stem cells, comprising: a step of treating a cell population comprising mesenchymal stem cells having different proliferative ability by physical stimulation or chemical stimulation, so as to select mesenchymal stem cells having relatively high proliferative ability, wherein the selected mesenchymal stem cells having relatively high proliferative ability are negative for CD106, and the expression level of a metallothionein family gene is increased in comparison to the expression level thereof in the cell population before the treatment by the physical stimulation or chemical stimulation.
    Type: Application
    Filed: October 27, 2016
    Publication date: December 20, 2018
    Applicants: KANEKA CORPORATION, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER
    Inventors: Kenichi YAMAHARA, Yuta KITA, Keita INO, Akira KOBAYASHI
  • Patent number: 10144184
    Abstract: Provided is a flat fiber-reinforced plastic strand which is produced by curing a twisted resin-impregnated strand and has no disturbed fiber orientation, and a flat fiber-reinforced plastic strand sheet which is produced by using said flat fiber-reinforced plastic strands. According to a method of manufacturing the flat fiber-reinforced plastic strand 2, (a) a twisted resin-impregnated strand f2 in an uncured state, the strand including a plurality of reinforcing fibers f, is fed in a state of tension between a pair of heated steel belts 41A and 41B facing each other and making rotation movements; and (b) the resin-impregnated strand f2 is sandwiched and heated by the steel belts 41A and 41B, and pressurized from both sides of the strand f2 to form a cross section of the strand into a flat shape, and, with the shape being kept, a resin is cured and cooled.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: December 4, 2018
    Assignee: Nippon Steel & Sumikin Materials Co., Ltd.
    Inventors: Makiji Miyao, Akira Kobayashi, Masaki Arazoe, Akihiro Tateishi
  • Patent number: 9787094
    Abstract: A power demand regulation system has a power demand regulation device that regulates the load applied to equipment of an electrical power system by a load apparatus operating by means of power from the electrical power system, which supplies power to consumers. When regulating the load to the equipment, the power demand regulation device selects a load apparatus as the subject of a request for an alteration of operating state on the basis of by-apparatus load information, which is information of each load apparatus, and a regulation target value, which is the amount of load that is to be regulated, and, in the period from the start to the end of regulation, executes a plurality of times the outputting of an alteration request that requests the alteration of the operating state of the selected load apparatus.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: October 10, 2017
    Assignee: Hitachi, Ltd.
    Inventors: Hirotaka Takahashi, Yasushi Tomita, Ikuma Sugamata, Akira Kobayashi, Tsukasa Onishi, Takafumi Ebara
  • Patent number: 9708581
    Abstract: The present invention has its object to provide a material for separating stem cell and a filter for separating stem cell, each is capable of selectively separating and recovering, in a simple and easy manner, stem cells from body fluids or biological tissue-derived treated fluids, a method for separating and recovering stem cells, and stem cells obtained by such method. The present invention is a material for separating stem cell which has a density K of 1.0×104?K?1.0×106 and a fiber diameter of 3 to 40 ?m; a filter for separating stem cell which comprises the material for separating stem cell as packed in a container having a fluid inlet port and a fluid outlet port; a method of separating and recovering stem cells which comprises using the material for separating stem cell or the filter for separating stem cell; and a method of producing a multipotent cell fraction.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: July 18, 2017
    Assignee: KANEKA CORPORATION
    Inventors: Akira Kobayashi, Kazuaki Yamamoto, Shinya Yoshida, Hideo Niwa, Naohiro Imai, Hirokazu Kurata, Yoshiaki Miyamoto
  • Patent number: 9682535
    Abstract: A reinforcing method and structure for a steel structure and an elastic layer forming material for reinforcing a steel structure are provided that can prevent a reinforcing effect from being lowered by direct sunlight, can obtain a sufficient reinforcing effect, and can prevent a fiber sheet from being peeled away from a steel structure surface before the fiber sheet is torn. The reinforcing method for a steel structure, in which a fiber sheet including reinforcing fibers is bonded to a surface of the steel structure to integrate the fiber sheet with the steel structure, includes (a) a step of applying and hardening a polyurea resin putty to the surface of the steel structure to form an elastic layer, and (b) a step of bonding the fiber sheet to the surface of the steel structure having the elastic layer formed thereon with an adhesive agent.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: June 20, 2017
    Assignee: Nippon Steel & Sumikin Materials Co., Ltd.
    Inventors: Atsuya Komori, Akira Kobayashi, Yuya Hidekuma, Kazuo Ohgaki
  • Patent number: 9649424
    Abstract: The present invention relates to a separation system and a separation material for easily and rapidly separating a red blood cell-rich fraction, a white blood cell-rich fraction, and/or a platelet-rich fraction from a biological fluid containing these blood cell components without the necessity of performing centrifugation. The separation of a red blood cell-rich fraction, a white blood cell-rich fraction, and/or a platelet-rich fraction from a biological fluid can be accomplished by capturing white blood cells and platelets on a blood cell separation material by contacting the biological fluid with the blood cell separation material, thereby providing a red blood cell-rich fraction; and recovering a white blood cell-rich fraction by separating white blood cells captured from the resulting blood cell separation material using a separation solution.
    Type: Grant
    Filed: June 28, 2010
    Date of Patent: May 16, 2017
    Assignee: KANEKA CORPORATION
    Inventors: Nobuhiko Sato, Shinya Yoshida, Akira Kobayashi, Masaru Nakatani
  • Publication number: 20170073547
    Abstract: A first curable composition has flowability and include a photopolymerizable group-containing silicone compound (A), a photopolymerization initiator, a photoacid generator and at least one kind of metal compound selected from the group consisting of metal carbonates, metal hydroxides and metal oxides. This curable composition provides a temporary bonding material capable of easily temporarily bonding a component part and a substrate, without trapping an air bubble in a temporary bonding surface of the component, and allowing easy separation of the component part and the substrate after performing various processing on the component part.
    Type: Application
    Filed: April 15, 2015
    Publication date: March 16, 2017
    Inventors: Tsuyoshi OGAWA, Kiminori SATO, Akira KOBAYASHI
  • Publication number: 20160228474
    Abstract: An object of the present invention is to provide a method for producing a mesenchymal stromal cell composition, comprising conveniently and aseptically separating high-purity amnion-derived MSCs by performing enzyme treatment only once. According to the present invention, the following are provided: a method for producing a mesenchymal stromal cell composition, comprising: performing enzyme treatment of an amnion with collagenase and thermolysis and/or dispase; and filtering the enzyme-treated amnion through a mesh; a method for producing a cryopreserved mesenchymal stromal cell composition; and a therapeutic agent comprising as an active ingredient the mesenchymal stromal cell composition for a disease selected from graft-versus-host disease, inflammatory bowel disease, systemic lupus erythematosus, liver cirrhosis, or radiation enteritis.
    Type: Application
    Filed: August 18, 2014
    Publication date: August 11, 2016
    Applicants: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION, HYOGO COLLEGE OF MEDICINE, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, KANEKA CORPORATION
    Inventors: Kenichi YAMAHARA, Akihiko TAGUCHI, Toshihiro SOMA, Shunsuke OHNISHI, Akira KOBAYASHI
  • Patent number: 9273275
    Abstract: It is an object to achieve a closed system that has a simple structure without resorting to large scale equipment and that sequentially carries out all of the step of separating useful cells, the step of culturing the useful cells separated in the separation step, and the step of washing and concentrating the cells cultured in the culturing step and to enable the preparation of useful cells having high safety and quality, while improving operability.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: March 1, 2016
    Assignee: KANEKA CORPORATION
    Inventors: Akira Kobayashi, Masaki Ichimura, Masaru Nakatani
  • Patent number: D819728
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: June 5, 2018
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Yasutomo Kato, Akira Kobayashi
  • Patent number: D834640
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: November 27, 2018
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Yasutomo Kato, Akira Kobayashi