Abstract: A portable food cooler apparatus comprises a box portion having an exterior surface and an interior surface. The interior surface of the box portion defines a food cavity having an open top. A lid may be pivotably mounted to the box portion and is operable between an open position and a closed position. At least one accessory mounting rail is attached to the exterior surface of the box portion of the cooler. One or more accessories, each having at least one rail mounting assembly, is removably attachable to the rail. The accessories, for example, may include one of a rod holder, wheel assembly, cradle or strut.

Abstract: Provided is a construct comprising (i) a nucleotide sequence which encodes tyrosine hydroxylase (TH), (ii) a nucleotide sequence which encodes GTP-cyclohydrolase I (CH1) and (iii) a nucleotide sequence which encodes Aromatic Amino Acid Dopa Decarboxylase (AADC) wherein the nucleotide sequence encoding TH is linked to the nucleotide sequence encoding CH1 such that they encode a fusion protein TH-CH1. Also provided is a construct comprising (i) a nucleotide sequence which encodes tyrosine hydroxylase (TH), (ii) a nucleotide sequence which encodes GTP-cyclohydrolase I (CH1) and (iii) a nucleotide sequence which encodes Aromatic Amino Acid Dopa Decarboxylase (AADC) wherein the nucleotide sequence encoding AADC is linked to the nucleotide sequence encoding TH such that they encode a fusion protein AADC-TH or TH-AADC. Further provided is a viral vector comprising such nucleotide sequences and its use in the treatment and/or prevention of Parkinson's disease.

Abstract: An embodiment of an active dosimeter system for detecting and communicating a radiation dose in real time is described that comprises a peripheral detector configured to be worn on an extremity or a head region of a user that includes a radiation sensor to detect ionizing radiation; a processor to determine a level of the ionizing radiation; and a wireless device to send a transmission comprising the detected level of the ionizing radiation; where the determination of the level of ionizing radiation and the transmission occur in real-time; and a receiver located in close proximity to the user that receives the transmission, and comprises an interface that informs the user of the detected level of the ionizing radiation.

Abstract: A flow generator (21) for a respiratory therapy system configured to deliver a breathable gas flow to a patient comprises a housing (27) comprising an inlet (28) and an outlet (25) and a gas flow path between the inlet (28) and outlet (25). An impeller is mounted within the housing (27) for rotation about an axis, the impeller configured to be rotationally driven by a motor to provide a gas flow along the gas flow path. Various embodiments are disclosed in which the flow generator (21) further comprises a sensor (23) mounted in the housing (27) in the gas flow path and configured to detect a property of the gas flow. The sensor (23) may be mounted in the outlet (25) so as to project into the gas flow path. Flow generator may comprise an axial inlet (28) and a tangential outlet (25). In another embodiment the sensor (23) may be mounted in the inlet (28).

Abstract: The invention relates to a novel administration regime useful in the treatment of diseases or conditions where administration of insulin will be of benefit. In particular, the invention relates to a long-acting or ultra-long acting insulin for use in treating a disease or condition where administration of insulin will be of benefit, wherein the administration of said insulin includes or consists of one or more of the following steps: (a) obtaining a first data set of the subject, (b) obtaining a second data set of the subject, (c) obtaining a first data structure of the subject, and (d) obtaining a second data structure of the subject. When a determination is made that the at least first data structure, second data structure, first data set, and second data set collectively do contain the set of evaluation information, the device further includes providing the long-acting or ultra-long-acting insulin dose guidance recommendation.

Abstract: The invention provides a system for handling gas in a riser. The system comprises a riser flow spool, a riser isolation device and an upper riser disconnect assembly wherein at least the riser flow spool is connected to the riser below a riser tension ring and the upper riser disconnect assembly is located above the riser tension ring.

Abstract: A vacuum cleaner includes a suction nozzle for drawing dirty air into the vacuum cleaner and an exhaust for expelling cleaned air out of the vacuum cleaner; and an air flow passage extending from the suction nozzle to the exhaust through a dirt separator. The vacuum cleaner further includes a vacuum motor arranged to draw a flow of air through the vacuum cleaner from the suction nozzle to the exhaust, the vacuum motor comprising an electric motor and an impeller which rotates about a motor axis. The vacuum cleaner further includes an electronic visual display configured to display information relating to the vacuum cleaner. The vacuum motor is housed inside a motor bucket which is positioned in the flow passage, and the electronic visual display is mounted to the motor bucket and supported thereby.

Abstract: Integrated digital isolators comprise a first transformer coil or capacitor plate mounted on an integrated circuit substrate, and separated from a second transformer coil or capacitor plate via an electrically insulating isolation layer. The electrical isolation that is achieved is dependent upon the material and thickness of the isolation layer. In order to reduce the amount of time required for fabrication while still allowing thick isolation layers to be deployed, in examples of the disclosure pre-formed sheets or tapes of dielectric material are applied to the substrate over the first transformer coil or capacitive plate, for example by being rolled onto the substrate using a heated roller. Such a technique results in a thick isolation layer that is formed using a simple process and much more quickly and reliably than conventional spin-coating or deposition techniques.

Abstract: The invention relates to a brassiere (1) with reinforced support adapted for practicing sports and in particular of the type comprising a front part (2a) comprising two cups (3) for covering the bust (4) of a user (5), a dorsal fixation band (6) which is basically connected to the outer edge (7) of each of the cups (3), and a pair of straps (8) for running over the shoulders (9) of the user (5), which brassiere (1) is characterized in that the front part (2) comprises at least: a central anchoring structure (10) to which the straps (8) are attached and towards which these straps (8) converge; a lower support band (11) extending under the cups (3) approximately from an outer edge (7) to the other edge of these cups (3), a central support band (12) extending between the cups (3) from the lower support band (11) toward the central anchoring structure (10); and two lateral support bands (13) extending laterally from the side of the outer edges (7) of the cups (3) at least from the lower support band (11) to the c

Abstract: A crank arm for a bicycle chainset is provided. The arm comprises means for varying crank length during rotation, whereby to gain mechanical advantage.

Abstract: Integrated digital isolators comprise a first transformer coil or capacitor plate mounted on an integrated circuit substrate, and separated from a second transformer coil or capacitor plate via an electrically insulating isolation layer. The electrical isolation that is achieved is dependent upon the material and thickness of the isolation layer. In order to reduce the amount of time required for fabrication while still allowing thick isolation layers to be deployed, in examples of the disclosure a pre-formed solid layer of dielectric material is bonded to the substrate over the first transformer coil or capacitive plate. The preformed solid layer is formed from a thick layer of solid dielectric material, which is ground to the required thickness, either prior to being bonded to the circuit substrate, or thereafter. Such techniques result in a thick isolation layer that is formed more quickly and with lower outgassing risk than conventional spin-coating or deposition techniques.

Abstract: Methods and systems are provided for automatically securing account access by verifying account information with an email provider. The methods and systems automatically determine whether provided login identification and account information, in the form of an email address, is valid by a server requesting validation information from the email server of the email address. The request is automatically provided, as a background process, in response to receiving login credential information entered by a user. The email server can provide verification of the email address, whether a password associated with the email address has changed, or if the request bounces. Push notifications may be utilized by the email server to notify registered entities of any changes to login credential information associated with an account. The methods provided secure account access and active sessions subsequent to an email account owner changing a password or terminating the email account.

Abstract: There is provided a process for producing proteins from the by-product streams arising from distillation processes, in particular the by-product stream known as “pot ale” or “burnt ale” and the use of such proteins as protein feed ingredients or food additives.

Abstract: A treatment for brain, spinal and nerve injury comprising use of a substance P receptor antagonist optionally in combination with a magnesium compound. There is also provided a formulation for use in this treatment comprising a substance P receptor antagonist and a magnesium compound.

Abstract: The present invention relates to methods of treating autoimmune diseases with siponimod in patients receiving additionally a beta-blocker.

Abstract: A method of incrementally forming workpiece is provided by the present disclosure. In one form, the method includes securing a sacrificial material layer to at least one surface of the workpiece, imparting a force directly to the sacrificial material layer with at least one forming tool, and incrementally forming the workpiece to a desired geometry based on a tool path of the forming tool.

Abstract: A system includes a pulse counter having a selectable pulse counter read-out rate, a pulse counter read-out (PCRO) storage register that stores a PCRO count, and a pulse-burst counter that has a pulse-burst counter read-out rate that is faster than all but the fastest selectable pulse counter read-out rate, a subtractor module in electronic communication with the pulse counter and the PCRO that subtracts the PCRO count from the pulse counter read-out count to output an uncorrected pulse count, a selection module in electronic communication with the pulse-burst counter that selects the pulse counter read-out rate in response to input from the pulse-burst counter, a multiplexer in electronic communication with the subtractor module and the selection module, the multiplexer selecting from among at least two dead-time correction transforms, the transform corresponding to the selected pulse counter read-out rate, and a control-and-readout module that outputs a dead-time corrected pulse rate.

Abstract: Integrated digital isolators comprise a first transformer coil or capacitor plate mounted on an integrated circuit substrate, and separated from a second transformer coil or capacitor plate via an electrically insulating isolation layer. The electrical isolation that is achieved is dependent upon the material and thickness of the isolation layer. In order to reduce the amount of time required for fabrication whilst still allowing thick isolation layers to be deployed, in examples of the disclosure a pre-formed solid layer of dielectric material is bonded to the substrate over the first transformer coil or capacitive plate. The preformed solid layer is formed from a thick layer of solid dielectric material, which is ground to the required thickness, either prior to being bonded to the circuit substrate, or thereafter. Such techniques result in a thick isolation layer that is formed more quickly and with lower outgassing risk than conventional spin-coating or deposition techniques.

Abstract: Integrated digital isolators comprise a first transformer coil or capacitor plate mounted on an integrated circuit substrate, and separated from a second transformer coil or capacitor plate via an electrically insulating isolation layer. The electrical isolation that is achieved is dependent upon the material and thickness of the isolation layer. In order to reduce the amount of time required for fabrication while still allowing thick isolation layers to be deployed, in examples of the disclosure pre-formed sheets or tapes of dielectric material are applied to the substrate over the first transformer coil or capacitive plate, for example by being rolled onto the substrate using a heated roller. Such a technique results in a thick isolation layer that is formed using a simple process and much more quickly and reliably than conventional spin-coating or deposition techniques.

Abstract: An accessory-mounting system having an elongated rail and a rail clamp. The elongated rail has a first channel and a second channel. The rail clamp includes a first lever and a second lever that are pivotally joined such that the rail clamp has a scissor-like configuration. Each of the first lever and the second lever has a tongue for selectively engaging one of the first and second channels of the elongated rail. In addition, the first lever of the rail clamp comprises a first set of spaced apart fingers and the second lever of the rail clamp comprises a second set of spaced apart fingers. The first set of spaced apart fingers and the second set of spaced apart fingers are interlaced. The rail clamp may be joined to the elongated rail at one of a plurality of discrete locations.