Abstract: A multivesicular liposome composition includes a plurality of multivesicular liposomes. Each multivesicular liposome includes a carrier liposome particle including carrier phospholipid bilayer and having an average diameter less than 1 micron; and at least one sub-chamber liposome nanoparticle including a sub-chamber liposome nanoparticle bilayer and having an average diameter less than about 50 nm. The carrier liposome particle encapsulates the at least one sub-chamber liposome nanoparticle. Characteristically, tail groups of the carrier liposome phospholipids are larger than tail groups phospholipids of the at least one sub-chamber liposome nanoparticle.

Abstract: A connector includes a first body, a second body, a first fastener, and a second fastener. The first body has a base portion and a protrusion, the protrusion extends away from the base portion along a first direction, and the first body has a first cavity that extends into the protrusion and towards the base portion along the first direction. The second body has a second cavity, which is shaped to receive the protrusion such that rotation of the first body relative to the second body is blocked. The connector may be used to attach structural members, for example during the construction of a modular structure.

Abstract: The present invention is directed to a cosmetic composition precursor that is rapidly hydratable and conducive to creating a personalized end-product. This invention thus relates to a cosmetic composition precursor having fatty acid, inorganic base, and high HLB surfactants and methods of using said precursors in creating the end-product. The invention also relates to end-use compositions made from the hydratable cosmetic composition precursor of the invention.

Abstract: The present invention provides processes for the preparation of sugammadex: (I) In one aspect, there is provided a process for the preparation of sugammadex from 8-per-deoxy-8-bromo-?-cyclodextrin and 3-mercaptopropionic acid. In another aspect, there is provided an alternative process for the preparation of sugammadex from 8-per-deoxy-8-bromo-?-cyclodextrin and disodium 3 -mercaptopropionate. In another aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-?-cyclod extrin, which may be used in the production of sugammadex. In one such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-y-cyclodextrin from ?-cyclodextrin and a brominating agent. In another such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-?-cyclodextrin comprising, inter alia, reacting ?-cyclodextrin with an electrophilic brominating agent, a deoxygenating agent, and an acid in the presence of an organic solvent.

Abstract: Directional capacity of interfaces for networking devices are dynamically modified. Network traffic utilization of one direction of a network interface may be determined. A modification to a capacity of the networking device to process network traffic in the one direction of the network may be determined. The modification may then be applied to the networking device so that subsequent network traffic is processed according to the modified capacity in the one direction of the interface.

Abstract: A toy apparatus for a horse to play with when kept in a stall of a stable. The toy apparatus includes an elongated rod member, a base frame member to support the elongated rod member on the stall, and a connection system to pivotally connect the elongated rod member to the base frame member in a manner such that, when the toy apparatus is in an installation position on the stall, the elongated rod member is to project into the stall for engagement by the horse which causes the elongated rod member to pivot relative to the base frame member.

Abstract: A frozen battered fish product, method and apparatus for production. The product comprises a fried batter coating with a pre-defined pattern of ridges and troughs which create a textured batter surface. A frozen aqueous protective layer is disposed over a part of the batter coating to protect textured features including the pattern of ridges and troughs. The aqueous protective layer is designed particularly to provide protection when a more brittle frying batter is used, as a result of using a frying medium with lower saturated fat content.

Abstract: Directional capacity of interfaces for networking devices are dynamically modified. Network traffic utilization of one direction of a network interface may be determined. A modification to a capacity of the networking device to process network traffic in the one direction of the network may be determined. The modification may then be applied to the networking device so that subsequent network traffic is processed according to the modified capacity in the one direction of the interface.

Abstract: A computer-readable storage medium may include executable instructions stored thereon that, when executed by a processor, may be configured to establish a connection to a node of a distributed ledger network that maintains a distributed ledger. The processor may obtain a first dataset from a first user, perform pre-processing on the first dataset to obtain a first data asset based on the first dataset, and store the first data asset. The processor may calculate a first value for the first data asset and generate a first data proposition based on the first data asset. The processor may obtain acceptance data from a second user, which may include data indicating acceptance by the second user of the first data proposition. The processor may transmit a first distributed ledger record to the node of the distributed ledger network.

Abstract: Methods, computer readable storage medium, and systems for mobile devices to locate persons or places are described. In a feature, the invention is a method implemented in a server for providing beaconing sequences to the mobile devices for location sharing. In a feature, the invention is a server executing a method of locating a user using a beaconing mobile device. In a feature, the invention is a non-transitory computer readable medium on a server that encodes a program to execute a method on a first mobile device that determine directions and/or distance between the first mobile device and a second mobile device. In a feature, the invention is a server executing a method to remember a place on a mobile device.

Abstract: The present invention provides processes for the preparation of sugammadex: (I) In one aspect, there is provided a process for the preparation of sugammadex from 8-per-deoxy-8-bromo-?-cyclodextrin and 3-mercaptopropionic acid. In another aspect, there is provided an alternative process for the preparation of sugammadex from 8-per-deoxy-8-bromo-?-cyclodextrin and disodium 3-mercaptopropionate. In another aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-?-cyclodextrin, which may be used in the production of sugammadex. In one such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-?-cyclodextrin from ?-cyclodextrin and a brominating agent. In another such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-?-cyclodextrin comprising, inter alia, reacting ?-cyclodextrin with an electrophilic brominating agent, a deoxygenating agent, and an acid in the presence of an organic solvent.

Abstract: A multivesicular liposome composition includes a plurality of multivesicular liposomes. Each multivesicular liposome includes a carrier liposome particle including carrier phospholipid bilayer and having an average diameter less than 1 micron; and at least one sub-chamber liposome nanoparticle including a sub-chamber liposome nanoparticle bilayer and having an average diameter less than about 50 nm. The carrier liposome particle encapsulates the at least one sub-chamber liposome nanoparticle. Characteristically, tail groups of the carrier liposome phospholipids are larger than tail groups phospholipids of the at least one sub-chamber liposome nanoparticle.

Abstract: A heat transfer interface structure and a method of manufacturing the same are disclosed. A substrate has a plurality of raised features formed on at least one surface the substrate. The raised features are deformable under a compressive force and have respective openings at end portions thereof. A thickness of a raised feature at the end portion thereof is smaller than a thickness of the raised feature at an intermediate portion of the raised feature.

Abstract: Methods, computer readable storage medium, and systems for mobile devices to locate persons or places are described. In a feature, the invention is a method implemented in a server for providing beaconing sequences to the mobile devices for location sharing. In a feature, the invention is a server executing a method of locating a user using a beaconing mobile device. In a feature, the invention is a non-transitory computer readable medium on a server that encodes a program to execute a method on a first mobile device that determine directions and/or distance between the first mobile device and a second mobile device. In a feature, the invention is a server executing a method to remember a place on a mobile device.

Abstract: A connector includes a first body, a second body, a first fastener, and a second fastener. The first body has a base portion and a protrusion, the protrusion extends away from the base portion along a first direction, and the first body has a first cavity that extends into the protrusion and towards the base portion along the first direction. The second body has a second cavity, which is shaped to receive the protrusion such that rotation of the first body relative to the second body is blocked. The connector may be used to attach structural members, for example during the construction of a modular structure.

Abstract: A High-Order PSK Signaling (HOPS) communications system which adapts sequence-based spread spectrum signaling techniques to the needs of low-power commercial standards. A HOPS signal generation apparatus incudes a seed calculator configured to calculate a series of seed vectors in response to a plurality of time-evolving key values wherein each of the seed vectors includes a plurality of index values calculated based upon the current key values. A sequence generator is configured to generate a series of time-evolving spreading sequences using the series of seed vectors. A modulator is operative to generate the communications signal by spreading the data signal using the spreading sequences. A transmitter transmits an analog version of the communications signal.

Abstract: A tie bolt retention assembly includes a retention ring configured to contact a tie bolt head of a tie bolt; a retention washer configured to be disposed between the tie bolt head and a wheel section of a wheel assembly; and a retainer configured to engage with the retention washer; wherein the retention washer and the retainer are configured to secure the retention ring to the tie bolt head.

Abstract: A High-Order PSK Signaling (HOPS) communications system which adapts sequence-based spread spectrum signaling techniques to the needs of low-power commercial standards. A HOPS signal generation apparatus incudes a seed calculator configured to calculate a series of seed vectors in response to a plurality of time-evolving key values wherein each of the seed vectors includes a plurality of index values calculated based upon the current key values. A sequence generator is configured to generate a series of time-evolving spreading sequences using the series of seed vectors. A modulator is operative to generate the communications signal by spreading the data signal using the spreading sequences. A transmitter transmits an analog version of the communications signal.

Abstract: The following description is directed to managing routing resources of a communication network. In one example, a method can include determining an amount of routing capacity from a network device and toward a routing prefix. An attribute associated with the routing prefix can be modified based on the amount of routing capacity toward the routing prefix. The modified attribute associated with the routing prefix can be announced to a peer of the network device.

Abstract: A correlation apparatus including a sequence generator configured to generate a non-repeating preamble sequence which changes during each of a plurality of time epochs. The correlation apparatus includes a fallthrough correlator having a tapped delay line for receiving a set of complex-valued samples of a received signal. Each of a plurality of complex multipliers of the correlator is coupled to one of the delay line taps. Each multiplier multiplies, during one of the plurality of time epochs, one of the complex-valued samples of the received signal by one of a plurality of matched filter coefficients corresponding to the preamble sequence. A summation module includes a plurality of adders where a last of the plurality of adders outputs a correlation signal. A peak value of the correlation signals exceeds a threshold value when a sufficient correlation exists between the received signal and the values of the preamble sequence.