Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.

Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.

Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified proteins comprising amino acid sequences set forth within. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.

Abstract: Disclosed herein are methods, media and other compositions relating to high density cell cultures. Also disclosed are exemplary methods for using high density cell cultures and exemplary products that may be obtained from high density cell cultures.

Abstract: The invention provides high throughput assays for rapidly and simultaneously purifying, quantifying, determining the solubility profile, determining the purity and identifying a plurality of recombinant proteins. The method comprises affinity protein purification; proteolytic digestion and analysis of the protein fragments by mass spectrometry in multi-well plates.

Abstract: A method for performing a hash transformation in a network device to generate a hash pointer for an address input by using rotation. The method includes to step of receiving an address input. Rotated copies of the address input are subsequently logically combined in accordance with a key to generate a hashing result corresponding to the address input. The hash result is subsequently output.

Abstract: Proteins can be purified and concentrated from crude cell lysates using high-throughput, automated process control systems that use software application programs to instruct one or more processors, controllers, and actuators to control and/or monitor the operations of filtration, purification, and concentration modules in such systems. The high-throughput production of concentrated proteins can be enabled by filtering the lysates and using compressed, non-reactive gas to concentrate the purified proteins, rather than using more complex centrifugation techniques.

Abstract: A method and device to assist in the determination of protein domain boundaries is described. In particular the device is designed to provide a high throughput of proteolytic digestion of proteins to identify domains and their boundaries, for use in protein structure determination, in a manner that is amenable to automation. Proteases are immobilized in a convenient format such as a microtitre plate and preferably arranged in a matrix thereby allowing for simultaneous degradation of a protein by a number of proteases at a number of concentrations.

Abstract: The present invention relates to methods for learning structural information about a molecule or molecular complex. The invention also provides methods for identifying a compound that binds to a molecule or molecular complex. The invention also provides methods for identifying a compound that binds to one molecule or molecular complex and not to one or more other molecules or molecular complexes. Other methods that are provided can be used to identify a compound that binds to at least two molecules or molecular complexes.

Abstract: The present invention relates to methods for learning structural information about a molecule or molecular complex. The invention also provides methods for identifying a compound that binds to a molecule or molecular complex. The invention also provides methods for identifying a compound that binds to one molecule or molecular complex and not to one or more other molecules or molecular complexes. Other methods that are provided can be used to identify a compound that binds to at least two molecules or molecular complexes.

Abstract: The present invention relates to methods for learning structural information about a molecule or molecular complex. The invention also provides methods for identifying a compound that binds to a molecule or molecular complex. The invention also provides methods for identifying a compound that binds to one molecule or molecular complex and not to one or more other molecules or molecular complexes. Other methods that are provided can be used to identify a compound that binds to at least two molecules or molecular complexes.

Abstract: A method and device to assist in the determination of protein domain boundaries is described. In particular the device is designed to provide a high throughput of proteolytic digestion of proteins to identify domains and their boundaries, for use in protein structure determination, in a manner that is amenable to automation. Proteases are immobilized in a convenient format such as a microtitre plate and preferably arranged in a matrix thereby allowing for simultaneous degradation of a protein by a number of proteases at a number of concentrations.

Abstract: The disclosure includes a description of a method of data mining protein data. The method includes accessing data identifying respective outcomes associated with a set of proteins subjected to a set of conditions and analyzing the data based on the outcomes.