Abstract: A pressurized refill canister containing a composition including a propellant. The canister has an outlet valve having a stem biased to a closed position by a first resilient member. The stem has a maximum outer diameter of greater than 3 mm. At the outlet end of the stem, at least part of the wall of the stem extends inwardly from the outside diameter for at least 50% of the radius.

Abstract: A pressurised refill canister containing a reservoir of composition including a propellant, and a non-metered refill outlet valve comprising a stem displaceable from a first position to a dispensing position against the action of a resilient member. The stem comprises a blind bore open at an outlet end and closed at the opposite end and a lateral bore in the side wall of the stem leading to the blind bore. The refill outlet valve further comprises an annular seal which surrounds the stem whereby, in the first position, the lateral bore is not in communication with the inside of the canister, and in the dispensing position, the lateral bore is arranged to move inside the canister with respect to the seal to open a flow path from the inside of the canister via the lateral bore and along the blind bore to the outlet end.

Abstract: The present invention provides a cannabinoid inhaler, compositions, and methods for delivering a cannabinoid composition to a subject. The cannabinoid composition is delivered in the form of inhaled droplets of respirable size via pulmonary administration. The invention may be used in the treatment of a condition or disorder selected from the group consisting of neuropathic pain, cannabis addiction, nausea, motion sickness, arthritis, and neurodegenerative disease.

Abstract: A pressurized refill canister containing a reservoir of composition including a propellant, and a non-metered refill outlet valve comprising a stem displaceable from a first position to a dispensing position against the action of a resilient member. The stem comprises a blind bore open at an outlet end and closed at the opposite end and a lateral bore in the side wall of the stem leading to the blind bore. The refill outlet valve further comprises an annular seal which surrounds the stem whereby, in the first position, the lateral bore is not in communication with the inside of the canister, and in the dispensing position, the lateral bore is arranged to move inside the canister with respect to the seal to open a flow path from the inside of the canister via the lateral bore and along the blind bore to the outlet end.

Abstract: A method of assembling a tubular simulated cigarette, the method comprising providing an elongate hollow housing having an inhaling end and a refill end; inserting an outlet valve tube, a dip tube and a support from the refill end so that the support supports the proximal end of the dip tube in the housing; inserting a refill valve into the refill end and fixing it in place to form a composition reservoir with the dip tube placing the reservoir in fluid communication with an outlet orifice when the outlet valve tube is open; inserting a valve element into a recess in the side of the housing so that the valve element is positioned to selectively close the outlet valve tube; inserting a breath operated valve actuation mechanism laterally into the recess; and applying a cover to the recess.

Abstract: A simulated smoking device (1) comprising a simulated cigarette having a substantially cylindrical cigarette-like shape and a refill device (2, 50) having a substantially cuboid housing with a cigarette pack-like shape containing refill gas (32, 59) for the simulated cigarette and having means for selectively retaining the simulated cigarette. The simulated cigarette may be retained wholly within the housing. It may be retained at a location different from the refill location. A dose counter may be provided to give a visual indication of the doses in the refill device.

Abstract: A simulated cigarette which has a reservoir of an inhalable composition and an outlet valve to control the outlet flow. The outlet end is provided with a deformable material to provide a more realistic feel and optionally to allow the user to vary the flow characteristics in the manner of a real cigarette. The outlet end can also be provided with a chemical heater. The simulated cigarette is wrapped in a paper or paper-like wrap to provide a more realistic feel.

Abstract: A method of assembling and testing a simulated cigarette. Assembling the simulated cigarette to have an elongate main body containing a reservoir for an inhalable composition, a breath operated valve, and a refill valve. Testing the integrity of the reservoir requires applying a pressured gas to open the refill valve to pressurise the reservoir, measuring the pressure drop in the reservoir, and providing a pass indication if the pressure drop remains below a predetermined threshold. It also requires testing the breath operated valve by applying suction at an inhaling end, measuring the flow rate from the cigarette and providing a pass indication if the flow rate falls outside a predetermined limit.

Abstract: A simulated smoking device (1) comprising a simulated cigarette having a substantially cylindrical cigarette-like shape and a refill device (2, 50) having a substantially cuboid housing with a cigarette pack-like shape containing refill gas (32, 59) for the simulated cigarette and having means for selectively retaining the simulated cigarette. The simulated cigarette may be retained wholly within the housing. It may be retained at a location different from the refill location. A dose counter may be provided to give a visual indication of the doses in the refill device.

Abstract: A simulated cigarette device with a substantially cylindrical cigarette-like shape comprising a reservoir of a pressurized composition including an inhalable substance and a propellant. A refill valve is in communication with the reservoir via which the reservoir is refilled. A breath-activated valve selectively controls the flow through a reservoir outlet and hence through an inhaling outlet in the device. The size of the reservoir, the pressure within the reservoir and the size of the reservoir outlet at its narrowest point are arranged so that, when the breath-activated valve is fully opened, the reservoir will discharge in less than 30 seconds.

Abstract: A simulated cigarette includes a housing having a generally cigarette-like shape and size; a reservoir of inhalable composition within the housing; an actuator controlling the flow from the reservoir; and an outlet passage from the actuator to an outlet in the housing from which outlet a user inhales the composition, wherein the housing adjacent to the outlet end has a deformable material at its outer periphery.

Abstract: An inhalable composition comprising: nicotine or a pharmaceutically acceptable derivative or salt thereof; a propellant; a monohydric alcohol; and a glycol and/or glycol ether, characterized in that the ratio of monohydric alcohol:glycol or glycol ether by weight is from 6:1 to 1:1.

Abstract: An inhaler comprising a reservoir of an inhalable composition, a heater to selectably volatilise at least some components of the composition, and a power source arranged to selectively supply electrical power to the heater when the user inhales from the inhaler. The power source is arranged to heat the heater to a temperature that will volatilise some, but not all of the components of the composition.

Abstract: An inhaler comprising a reservoir for an inhalable composition and a heating element and/or vibrating transducer to selectively volatilise at least some components of the composition. A power source supplies electrical power to the heater/transducer when the user inhales from the inhaler. The inhaler further comprises at least one airflow path arranged to draw air in through the inhaler as a user inhales from an inhaling end, and impinge on a plume of composition downstream of the heater/transducer at the inhaling end to reduce the mean particle size of the plume.

Abstract: A combination of an inhaler and a refill pack. The inhaler comprises a reservoir for an inhalable composition, a heating element and/or vibrating transducer to selectively volatilise at least some components of the composition and at least one inhaler capacitor arranged to supply electrical power to the heater and/or vibrating transducer when a user inhales from the inhaler. The refill pack comprises a refill reservoir of inhalable composition and a battery coupled to a refill capacitor, and is arranged to engage with the inhaler and to simultaneously refill the reservoir and recharge the inhaler capacitor from the refill capacitor. The invention also extends to the inhaler and refill pack separately and to a method of refilling and recharging the inhaler.

Abstract: An inhalable composition for use as a medicament in the treatment of a subject wherein said composition comprises: one or more cannabinoids or a pharmaceutically acceptable derivative or salt thereof; a propellant; a monohydric or polyhydric alcohol; and a glycol and/or glycol ether, characterized in that the ratio of monohydric or polyhydric alcohol to glycol or glycol ether by weight is from 6:1 to 1:1, wherein the composition is administered in the form of an aerosol having a fine particle fraction of 60% or more.

Abstract: An inhaler comprising a reservoir of an inhalable composition with an outlet at one end through which the inhalable composition is discharged. A non-metered breath-activated valve is provided between the one end and the reservoir, the breath-activated valve comprising a flow path extending from the reservoir to the outlet end. At least a portion of the flow path is a deformable tube. A clamping member pinches the deformable tube closed when no suction force is applied to the device and releases the tube to open the flow path when suction is applied at the outlet, to provide uninterrupted flow from the reservoir to the outlet.

Abstract: Testing apparatus comprising an air pump downstream of measuring equipment which measures the characteristics of an inhaler is provided. An induction port upstream of the measuring equipment has an adaptor connected at a first end. The adaptor comprises a through-bore extending through the adaptor from the first end to a second end to receive an inhaler and a bypass channel in communication with the through-bore. The invention also includes a testing method and the adapter.