Patents by Inventor Alexander A. Gall

Alexander A. Gall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED THYMINE POLYNUCLEOTIDE OLIGOMERS AND METHODS
    Publication number: 20150275278
    Abstract: Disclosed are modified thymine bases that provide enhanced base-pairing affinity for adenine or 2,6-diaminopurine bases in polynucleotide hybridization complexes. Also disclosed are polynucleotide oligomers, polynucleotide hybridization complexes that comprise such modified thymine bases. Also disclosed are various methods of use. For example, in some embodiments, modified polynucleotide oligomers disclosed herein can be used as primers and probes for nucleic acid amplification and/or detection.
    Type: Application
    Filed: March 30, 2015
    Publication date: October 1, 2015
    Inventors: Alexander A. GALL, Sergey G. LOKHOV, Mikhail A. PODYMINOGIN, Ekaterina V. VIAZOVKINA, Kevin Patrick LUND
  • Polar dyes
    Patent number: 8546590
    Abstract: The present invention relates to novel polar fluorescent and quenchers dyes, and minor groove binder with enhanced polarity. The present invention further relates to methods of preparing oligonucleotide probes labeled with polar arsonate dyes under the condition of automated synthesis and method of using such probes.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: October 1, 2013
    Assignee: Cepheid
    Inventor: Alexander A. Gall
  • Prodrugs of heteroaryl compounds
    Patent number: 8324379
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: December 4, 2012
    Assignee: Koronis Pharmaceuticals, Inc.
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • Prodrugs of Heteroaryl Compounds
    Publication number: 20110224434
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Application
    Filed: May 16, 2011
    Publication date: September 15, 2011
    Applicant: Koronis Phamaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • Prodrugs of heteroaryl compounds
    Patent number: 7982034
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: July 19, 2011
    Assignee: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • POLAR DYES
    Publication number: 20110053155
    Abstract: The present invention relates to novel polar fluorescent and quenchers dyes, and minor groove binder with enhanced polarity. The present invention further relates to methods of preparing oligonucleotide probes labeled with polar arsonate dyes under the condition of automated synthesis and method of using such probes.
    Type: Application
    Filed: August 17, 2010
    Publication date: March 3, 2011
    Applicant: CEPHEID
    Inventor: Alexander A. Gall
  • Fluorescent quenching detecting reagents and methods
    Patent number: 7897736
    Abstract: Oligonucleotide probes containing two labels are provided and are useful in hybridization assays. The probes can also contain a minor groove binding group.
    Type: Grant
    Filed: January 6, 2010
    Date of Patent: March 1, 2011
    Assignee: Elitech Holding B.V.
    Inventors: Michael W. Reed, Eugeny Alexander Lukhtanov, Alexander A. Gall, Robert O. Dempcy, Nicolaas M. J. Vermeulen
  • Negatively charged minor groove binders
    Patent number: 7851606
    Abstract: The present invention provides a negatively charged minor groove binding compound, oligonucleotide conjugates comprising the same, and methods for using the same. The negatively charged minor groove binding compounds of the present invention comprises an acidic moiety that is capable of being ionized under physiological conditions. In particular, the negatively charged minor groove binding compound of the present invention comprises a binding moiety that binds preferentially into a minor groove of a double, triple or higher stranded DNA, RNA, PNA or hybrids thereof. The binding moiety comprises at least one aryl moiety and an acidic moiety which is covalently attached to a phenyl portion of the aryl moiety or to a heteroatom of a heteroaryl portion of the aryl moiety.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: December 14, 2010
    Assignee: Elitech Holding B.V.
    Inventors: Eugeny A. Lukhtanov, Nicolaas M. J. Vermeulen, Alexander A. Gall
  • Mutagenic Nucleoside Analogs for the Treatment of Viral Disease
    Publication number: 20100279968
    Abstract: The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs.
    Type: Application
    Filed: December 27, 2006
    Publication date: November 4, 2010
    Applicant: Koronis Pharmaceuticals, Inc.
    Inventors: Ling Li, Alexander Gall, Richard Daifuku
  • Polar dyes
    Patent number: 7799926
    Abstract: The present invention relates to novel polar fluorescent and quenchers dyes, and minor groove binder with enhanced polarity. The present invention further relates to methods of preparing oligonucleotide probes labeled with polar arsonate dyes under the condition of automated synthesis and method of using such probes.
    Type: Grant
    Filed: March 9, 2006
    Date of Patent: September 21, 2010
    Assignee: Cepheid
    Inventor: Alexander A Gall
  • 1,3,5-triazines for treatment of viral diseases
    Patent number: 7772197
    Abstract: The present invention provides compounds and methods for treatment of viral diseases and cancer.
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: August 10, 2010
    Assignee: 1,3,5-Triazines for Treatment of Viral Diseases
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev
  • FLUORESCENT QUENCHING DETECTING REAGENTS AND METHODS
    Publication number: 20100174058
    Abstract: Oligonucleotide probes containing two labels are provided and are useful in hybridization assays. The probes can also contain a minor groove binding group.
    Type: Application
    Filed: January 6, 2010
    Publication date: July 8, 2010
    Inventors: Michael W. Reed, Eugeny Alexander Lukhtanov, Alexander A. Gall, Robert O. Dempcy, Nicolaas M.J. Vermeulen
  • TM leveling methods
    Patent number: 7751982
    Abstract: Methods for designing an oligonucleotide sequence having a selected duplex stability are provided wherein the oligonucleotide portion comprises at least one modified base selected from universal bases, unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally having attached minor groove binders and reporter groups.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: July 6, 2010
    Assignee: Elitech Holding B.V.
    Inventors: Robert O. Dempcy, Alexander A. Gall, Sergey G. Lokhov, Irina A. Afonina, Igor V. Kutyavin, Nicolaas M. J. Vermeulen
  • NEGATIVELY CHARGED MINOR GROOVE BINDERS
    Publication number: 20100137614
    Abstract: The present invention provides a negatively charged minor groove binding compound, oligonucleotide conjugates comprising the same, and methods for using the same. The negatively charged minor groove binding compounds of the present invention comprises an acidic moiety that is capable of being ionized under physiological conditions. In particular, the negatively charged minor groove binding compound of the present invention comprises a binding moiety that binds preferentially into a minor groove of a double, triple or higher stranded DNA, RNA, PNA or hybrids thereof. The binding moiety comprises at least one aryl moiety and an acidic moiety which is covalently attached to a phenyl portion of the aryl moiety or to a heteroatom of a heteroaryl portion of the aryl moiety.
    Type: Application
    Filed: August 14, 2009
    Publication date: June 3, 2010
    Applicant: Epoch Biosciences, Inc.
    Inventors: Eugeny A. Lukhtanov, Nicolaas M.J. Vermeulen, Alexander A. Gall
  • Systems and methods for predicting oligonucleotide melting temperature (TS)
    Patent number: 7715989
    Abstract: Software systems and methods for predicting the melting temperature (Tm) and other characteristics of oligonucleotides, including modified oligonucleotides. Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
    Type: Grant
    Filed: June 18, 2002
    Date of Patent: May 11, 2010
    Assignee: Elitech Holding B.V.
    Inventors: Robert O. Dempcy, Alexander A. Gall, Sergey G. Lokhov, Irina A. Afonina, Michael J. Singer, Karen M. Singer, legal representative, Igor V. Kutyavin, Nicolaas M. J. Vermeulen
  • Fluorescent quenching detection reagents and methods
    Patent number: 7662942
    Abstract: Oligonucleotide probes containing two labels are provided and are useful in hybridization assays. The probes can also contain a minor groove binding group.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: February 16, 2010
    Assignee: Elitech Holdings, B.V.
    Inventors: Michael W. Reed, Eugeny Alexander Lukhtanov, Alexander A. Gall, Robert O. Dempcy, Nicolaas M. J. Vermeulen
  • Mutagenic nucleoside analogs for the treatment of viral disease
    Patent number: 7648967
    Abstract: The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs. In particular, the invention provides isoguanosine nucleosides and derivatives thereof as well a method of increasing the mutation rate of a virus such as bovine viral diarrhea virus (BVDV) and hepatitis C virus (HCV).
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: January 19, 2010
    Assignee: Koronis Pharmaceuticals, Incorporated
    Inventors: Ling Li, Alexander Gall, Richard Daifuku
  • 1,3,5-triazines for treatment of viral diseases
    Patent number: 7642247
    Abstract: The present invention provides compounds and methods for treatment of viral diseases and cancer.
    Type: Grant
    Filed: February 6, 2007
    Date of Patent: January 5, 2010
    Assignee: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev
  • Prodrugs of heteroaryl compounds
    Patent number: 7589092
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: September 15, 2009
    Assignee: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • Negatively charged minor groove binders
    Patent number: 7582739
    Abstract: The present invention provides a negatively charged minor groove binding compound, oligonucleotide conjugates comprising the same, and methods for using the same. The negatively charged minor groove binding compounds of the present invention comprises an acidic moiety that is capable of being ionized under physiological conditions. In particular, the negatively charged minor groove binding compound of the present invention comprises a binding moiety that binds preferentially into a minor groove of a double, triple or higher stranded DNA, RNA, PNA or hybrids thereof. The binding moiety comprises at least one aryl moiety and an acidic moiety which is covalently attached to a phenyl portion of the aryl moiety or to a heteroatom of a heteroaryl portion of the aryl moiety.
    Type: Grant
    Filed: March 11, 2003
    Date of Patent: September 1, 2009
    Assignee: Epoch Biosciences, Inc.
    Inventors: Eugeny A. Lukhtanov, Nicolaas M. J. Vermeulen, Alexander A. Gall