Patents by Inventor Alexander A. Gall

Alexander A. Gall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRODRUGS OF HETEROARYL COMPOUNDS
    Publication number: 20090209505
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Application
    Filed: April 7, 2009
    Publication date: August 20, 2009
    Applicant: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • PRODRUGS OF HETEROARYL COMPOUNDS
    Publication number: 20090192099
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Application
    Filed: March 30, 2009
    Publication date: July 30, 2009
    Applicant: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • PRODRUGS OF HETEROARYL COMPOUNDS
    Publication number: 20080249097
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Application
    Filed: December 27, 2006
    Publication date: October 9, 2008
    Applicant: Koronis Pharmaceuticals, Incorporation
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • Tleveling compositions
    Patent number: 7368549
    Abstract: Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
    Type: Grant
    Filed: April 19, 2005
    Date of Patent: May 6, 2008
    Assignee: Epoch Biosciences, Inc.
    Inventors: Robert O. Dempcy, Alexander A Gall, Sergey G. Lokhov, Irina A. Afonina, Michael J. Singer, Igor V. Kutyavin, Nicolaas M. J. Vermeulen
  • Mutagenic Heterocycles
    Publication number: 20080033172
    Abstract: The present invention provides compounds as well as methods of using the compounds as antiviral and anti-cancer chemotherapeutic agents.
    Type: Application
    Filed: December 10, 2004
    Publication date: February 7, 2008
    Applicant: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev
  • MUTAGENIC HETEROCYCLES
    Publication number: 20080009496
    Abstract: The present invention provides compounds as well as methods of using the compounds as antiviral and anti-cancer chemotherapeutic agents.
    Type: Application
    Filed: December 27, 2006
    Publication date: January 10, 2008
    Applicant: Koronis Pharmaceuticals, Inc.
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev
  • PRODRUGS OF HETEROARYL COMPOUNDS
    Publication number: 20070219200
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Application
    Filed: May 15, 2007
    Publication date: September 20, 2007
    Applicant: Koronos Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • 1,3,5-Triazines for Treatment of Viral Diseases
    Publication number: 20070207973
    Abstract: The present invention provides compounds and methods for treatment of viral diseases and cancer.
    Type: Application
    Filed: December 27, 2006
    Publication date: September 6, 2007
    Applicant: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev
  • Prodrugs of heteroaryl compounds
    Patent number: 7244732
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: July 17, 2007
    Assignee: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • Mutagenic nucleoside analogs for the treatment of viral disease
    Patent number: 7244717
    Abstract: The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs. In particular, the invention provides 5-aldehydo-uracil nucleosides and derivatives thereof, and methods of administration thereof to increase the virus mutation rate in a virally infected cell.
    Type: Grant
    Filed: August 21, 2002
    Date of Patent: July 17, 2007
    Assignee: Koronis Pharmaceuticals, Incorporated
    Inventors: Ling Li, Alexander Gall, Richard Daifuku
  • 1,3,5-TRIAZINES FOR TREATMENT OF VIRAL DISEASES
    Publication number: 20070142310
    Abstract: The present invention provides compounds and methods for treatment of viral diseases and cancer.
    Type: Application
    Filed: February 6, 2007
    Publication date: June 21, 2007
    Applicant: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev
  • Fluorescent quenching detection reagents and methods
    Publication number: 20060292589
    Abstract: Oligonucleotide probes containing two labels are provided and are useful in hybridization assays. The probes can also contain a minor groove binding group.
    Type: Application
    Filed: January 23, 2006
    Publication date: December 28, 2006
    Applicant: Epoch Biosciences, Inc.
    Inventors: Michael Reed, Eugeny Lukhtanov, Alexander Gall, Robert Dempcy, Nicolaas Vermeulen
  • Polar dyes
    Publication number: 20060229441
    Abstract: The present invention relates to novel polar fluorescent and quenchers dyes, and minor groove binder with enhanced polarity. The present invention further relates to methods of preparing oligonucleotide probes labeled with polar arsonate dyes under the condition of automated synthesis and method of using such probes.
    Type: Application
    Filed: March 9, 2006
    Publication date: October 12, 2006
    Applicant: Cepheid
    Inventor: Alexander Gall
  • Mutagenic nucleoside analogs for the treatment of viral disease
    Publication number: 20060142240
    Abstract: The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs.
    Type: Application
    Filed: February 13, 2006
    Publication date: June 29, 2006
    Inventors: Ling Li, Alexander Gall, Richard Daifuku
  • Modified oligonucleotides for mismatch discrimination
    Patent number: 7045610
    Abstract: Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: May 16, 2006
    Assignee: Epoch Biosciences, Inc.
    Inventors: Robert O. Dempcy, Alexander A. Gall, Sergey G. Lokhov, Irina A. Afonina, Michael J. Singer, Igor V. Kutyavin, Nicolaas M. J. Vermeulen
  • MODIFIED OLIGONUCLEOTIDES FOR MISMATCH DISCRIMINATION
    Publication number: 20060009628
    Abstract: Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
    Type: Application
    Filed: February 28, 2001
    Publication date: January 12, 2006
    Inventors: Robert Dempcy, Alexander Gall, Sergey Lokhov, Irina Afonina, Michael Singer, Igor Kutyavin, Nicolaas Vermeulen
  • Tm leveling compositions
    Publication number: 20060003349
    Abstract: Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
    Type: Application
    Filed: April 19, 2005
    Publication date: January 5, 2006
    Applicant: Epoch Biosciences, Inc.
    Inventors: Robert Dempcy, Alexander Gall, Sergey Lokhov, Irina Afonina, Michael Singer, Igor Kutyavin, Nicolaas Vermeulen
  • Non-aggregating non-quenching oligomer comprising nucelotide analogs, method of synthesis and use thereof
    Patent number: 6972328
    Abstract: The invention provides compositions and methods for improved hybridization analysis utilizing DNA, RNA, PNA and chimeric oligomers in which one or more purine bases are substituted by a pyrazolo[5,4-d]pyrimidine or by a 7-deazapurine purine analogue. Reduced self-aggregation and reduced fluorescence quenching are obtained when the oligomers are used in various methods involving hybridization. Methods of synthesis, as well as novel synthetic precursors, are also provided.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: December 6, 2005
    Assignee: Epoch Biosciences, Inc.
    Inventors: Alexander A. Gall, Igor V. Kutyavin, Nicolaas M. J. Vermeulen, Robert O. Dempcy
  • Non-aggregating non-quenching oligomers comprising nucleotide analogs; methods of synthesis and use thereof
    Publication number: 20050239121
    Abstract: The invention provides compositions and methods for improved hybridization analysis utilizing DNA, RNA, PNA and chimeric oligomers in which one or more purine bases are substituted by a pyrazolo[5,4-d]pyrimidine or by a 7-deazapurine purine analogue. Reduced self-aggregation and reduced fluorescence quenching are obtained when the oligomers are used in various methods involving hybridization. Methods of synthesis, as well as novel synthetic precursors, are also provided.
    Type: Application
    Filed: May 13, 2005
    Publication date: October 27, 2005
    Applicant: Epoch Biosciences, Inc.
    Inventors: Alexander Gall, Igor Kutyavin, Nicolaas Vermeulen, Robert Dempcy
  • TM leveling methods
    Publication number: 20050075491
    Abstract: Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
    Type: Application
    Filed: September 26, 2003
    Publication date: April 7, 2005
    Applicant: Epoch Biosciences, Inc.
    Inventors: Robert Dempcy, Alexander Gall, Sergey Lokhov, Irina Afonina, Igor Kutyavin, Nicolaas Vermeulen