Abstract: Systems and methods for accessing account information are provided. For example, an indication to launch an application that may provide account information may be received. A determination may be made regarding whether the indication is an initial interaction with the application. If the indication is an initial interaction, one or more credentials may be received via an interface that may be displayed via the application. If the indication is not the initial interaction, a token may be accessed. A request that may include the credentials or token may then be generated and transmitted such that credentials or token may be used to authenticate a device that includes the application and a user thereof, a new token may be generated, and a response with the new token and/or account information may be transmitted. The account information may then be displayed by an interface of the application.

Abstract: Aspects of the disclosure relate to compositions and methods for multiplexed gene silencing in a cell or subject. In some embodiments, the disclosure provides an isolated nucleic acid or an rAAV encoding a transgene comprising a RNA-guided nuclease (RGN) operably linked to a first promoter, and a second promoter operably linked to a multi guide-RNA (multi-gRNA) expression cassette encoding one or more gRNAs targeting a gene associated with hypercholesterolemia or dyslipidemia. In some embodiments, the disclosure provides methods of treating a subject having hypercholesterolemia or dyslipidemia by administering the compositions.

Abstract: In a system with a master processor and slave processors, sync points are used in boot instructions. While executing the boot instructions, the slave processor determines whether the sync point is enabled. In response to determining the sync point is enabled, the slave processor pauses execution of the boot instructions, waits for commands from the master processor, receives commands from the master processor, executes the received commands until a release command is received, and then continues to execute boot instructions. In response to determining the sync point is not enabled, the slave processor continues to execute boot instructions.

Abstract: Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Abstract: Compounds of formula (I): (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Abstract: The invention provides a method for generating medical isotopes, the method comprising contacting a primary radiation beam with a converter for a time sufficient to produce a secondary beam of gamma particles, and contacting the beam of gamma particles to a target, where the cross section dimension of the beam of gamma particles is similar to the cross section dimension of the target. Both the converter and target are small in diameter and very closely spaced. Also provided is a system for producing medical isotopes, the device comprising a housing having a first upstream end and a second downstream end, a radiotransparent channel (collimator) with a first upstream end and a downstream end, wherein the upstream end is adapted to receive a radiation beam, a target positioned downstream of the downstream end of the channel and coaxially aligned with the channel, wherein the target has a cross section that is similar to the cross section of the channel.

Abstract: Aspects of the disclosure relate to integration of a transgene packaged into recombinant adeno-associated virus (rAAV) by nuclease-assisted vector integration (NAVI).

Abstract: Compounds of formula (I) and salts thereof: wherein R1, R2, R3, R4 are defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.

Abstract: Disclosed are various embodiments for a knife configured to be positioned, at least partially, within a grip of a firearm. The knife may include a blade body having a first blade side and a second blade side. The blade body may include a base and a knife edge portion. The knife may further include a handle portion. The handle portion may include the base of the blade body, a first handle attachment coupled to the base on the first blade side, and a second handle attachment coupled to the base on the second blade side. The knife may include an attachment mechanism for positioning at least the knife edge portion within an interior of the grip of the firearm.

Abstract: A lid for a beverage container may include an upper rim and a lower rim, an upper surface extending between the upper rim, a lid sidewall extending between the lower rim and the upper rim, a fitting including a resiliently compressible material positioned along the sidewall to sealingly engage with an inner surface of a sidewall of a vessel, a grip dimensioned to be grasped by a user to manipulate a position of the lid, and a nozzle extending from the upper surface of the lid.

Abstract: Some implementations of the disclosure are directed to a method, comprising: retrieving, using a device associated with an entity, a document from a system of record; uploading the document for storage in an off-chain system accessible by entities having access to a distributed ledger of a distributed ledger network, the entities comprising the entity; hashing, using the device, one or more fields contained in the document to generate a hash representing a unique reference to the document; generating, using the device, a message comprising a plurality of fields contained in the document and the hash; digitally signing, by the device, using a private key associated with the entity, the message to endorse the hash and the fields contained in the document; and after digitally signing the message, transmitting, by the device, the message to the distributed ledger network to store the hash and the fields in the distributed ledger.

Abstract: A beverage container system may include a vessel having an interior volume for containing a beverage and shell having an interior volume for removably coupling vessel therein. The shell may include an inner wall, an outer sidewall, and a sealed volume between the inner wall and the outer wall. The sealed volume may be at a vacuum pressure. The vessel may be constructed from glass while the shell may be constructed from a durable material such as stainless steel.

Abstract: Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Abstract: A beverage container system may include a vessel having an interior volume for containing a beverage and shell having an interior volume for removably coupling vessel therein. The shell may include an inner wall, an outer sidewall, and a sealed volume between the inner wall and the outer wall. The sealed volume may be at a vacuum pressure. The vessel may be constructed from glass while the shell may be constructed from a durable material such as stainless steel.

Abstract: Disclosed are various embodiments for a knife configured to be positioned, at least partially, within a grip of a firearm. The knife may include a blade body having a first blade side and a second blade side. The blade body may include a base and a knife edge portion. The knife may further include a handle portion. The handle portion may include the base of the blade body, a first handle attachment coupled to the base on the first blade side, and a second handle attachment coupled to the base on the second blade side. The knife may include an attachment mechanism for positioning at least the knife edge portion within an interior of the grip of the firearm.

Abstract: The invention provides a method for isolating medical isotopes, the method having the steps of dissolving titanium nuclear targets to create a solution; contacting the solution with a resin so as to retain the isotopes on the resin and generate an eluent containing titanium; contacting the isotope-containing resin with acid of a first concentration to remove impurities from the resin; and contacting the isotope-containing resin with an acid of a second concentration to remove isotope from the resin.

Abstract: The present invention relates to methods of prognosing the survival of a diseased subject, particularly a subject with chronic kidney disease (CKD), as well as selecting an end-stage renal disease subject for a kidney transplant. The methods involve detecting an elevated amount of macrophage inhibitory cytoking-1 (MID-1) in a test body sample from the diseased subject. A method of preventing or reducing the risk of death in a CKD subject which involves removing or inactivating MIC-1 present in the blood, plasma or serum of the subject, is also disclosed.

Abstract: A packet is identified at a port of a serial data link, and it is determined that the packet is associated with an error. Entry into an error recovery mode is initiated based on the determination that the packet is associated with the error. Entry into the error recovery mode can cause the serial data link to be forced down. In one aspect, forcing the data link down causes all subsequent inbound packets to be dropped and all pending outbound requests and completions to be aborted during the error recovery mode.

Abstract: Areas of non-conformances in a manufactured object are electronically mapped within a coordinate system of the object. Boundary lines of the areas containing the non-conformances are displayed on a 3-D image of the product. Visualization of the boundary lines of areas containing multiple non-conformances allows tracking of non-conformances, identification of trends in non-conformances and correction of production processes in order to reduce non-conformances.

Abstract: A system for producing and harvesting radioisotopes is provided, the system having a converter housing defining a first beam window; a converter carrier and cartridge in slidable communication with the converter housing; a target housing positioned downstream from the converter housing, the target housing defining a second beam window; and a target carrier in slidable communication with the target housing.