Abstract: A reversible toy includes a body having a first surface and a second surface opposite the first surface. The body may be reversible between a first configuration and a second configuration to alternatingly present the first and second surfaces as an outer body surface defining an exterior of the body. In this regard, the other of the first and second surfaces may alternatingly define a stored body surface defining an interior cavity within the body. The reversible toy may further include an appendage attached to the body at the first surface and comprising a coupling feature. The coupling feature may be configured to couple the reversible toy to an object at the appendage.

Abstract: A portable cooler container with active temperature control includes a double-walled insulated container body with a chamber to receive and hold temperature sensitive products. A control system is at least partially disposed between an outer wall and an inner wall of the container body. An electronic display screen on one of the lid and the container body configured to display shipping address information for the portable cooler container.

Abstract: A refrigerating appliance, or household refrigerating appliance, includes a refrigerated goods container and a machine compartment having a wall facing the goods container, an insulating material region between the goods container and the machine compartment wall, and a water outlet arrangement conducting condensate from the goods container through the insulating material region and machine compartment wall into an evaporation container in the machine compartment. The water outlet arrangement has a trough-shaped wall region of the goods container oriented towards the machine compartment wall and extending funnel-like to a drip edge. A tube facility extends from the wall region through the insulating material region and an opening in the machine compartment wall into the machine compartment. A positioning device mutually positions the wall region and tube facility, securing the drip edge radially in the tube facility and circumferentially spaced from an inner wall of the tube facility.

Abstract: The disclosed subject matter is in the field of molecular diagnostics, and in particular provides diagnostic markers, methods, systems, and kits for detecting a predisposition to, or the presence of colorectal cancer (CRC), such as detecting a change in the expression status or methylation status, or a combination thereof of any one or more of a number of genes. Also described are pharmacogenetic methods for determining suitable treatment regimens for cancer and methods for treating cancer patients, based around selection of the patients according to the disclosed methods.

Abstract: An actuation mechanism for a clutch, includes: an actuation element designed to be applied with an actuating force and to be shifted in an actuation direction by same; a transfer element designed to carry out a shift in the actuation direction; and a compensation mechanism designed to apply a reinforcing clamping force for the frictionally engaged transfer of the actuating force between the transfer element and the actuation element, when an actuating force is applied to the actuation element. The compensation mechanism has a friction element and a counter surface which are designed to bring about the reinforcing clamping force via a frictional connection when applying the actuating force. The friction element and the counter surface are designed to generate the reinforcing clamping force via a supporting force resulting from a deflection of the actuating force. The reinforcing clamping force has at least the value of the supporting force.

Abstract: An article management system collects articles from different sources, processes each article to extract information about the article (such as the topics covered in the article), and stores the information in one or more knowledge graphs. The system also maintains user profiles for each of its users. Each user profile includes a user genome representing the user's interests and preferences. The information in the knowledge graphs can be used to select articles to be displayed to users of the article management system. Articles can be displayed as part of the search results for an associated topic or concept, as part of a personalized feed that is generated based on the data in a user's profile, or as part of a feature that displays multiple articles that cover a given topic from multiple different viewpoints. The system can also provide a platform for users to create and publish research collections.

Abstract: An actuating mechanism for a clutch actuator includes: an actuating element which is designed to be acted on by an actuating force and thereby displaced in an actuation direction, a transmitting element which is designed to carry out a displacement in the actuation direction, wherein a tensioning element is provided between the actuating element and the transmitting element. The tensioning element is designed to generate, for the transmission of the actuating force to the transmitting element, a clamping pressure force which generates a friction force for the transmission of the actuating force. The friction force is configured so as to be capable of transmitting a maximum actuating force.

Abstract: A refrigerating appliance, or household refrigerating appliance, includes a refrigerated goods container and a machine compartment having a wall facing the goods container, an insulating material region between the goods container and the machine compartment wall, and a water outlet arrangement conducting condensate from the goods container through the insulating material region and machine compartment wall into an evaporation container in the machine compartment. The water outlet arrangement has a trough-shaped wall region of the goods container oriented towards the machine compartment wall and extending funnel-like to a drip edge. A tube facility extends from the wall region through the insulating material region and an opening in the machine compartment wall into the machine compartment. A positioning device mutually positions the wall region and tube facility, securing the drip edge radially in the tube facility and circumferentially spaced from an inner wall of the tube facility.

Abstract: An actuating mechanism for a clutch servo unit, includes: an actuating element, which is designed to have an actuating force applied thereto and to be displaced by same in an actuation direction; a transmission element, which is designed to execute a displacement parallel to the actuation direction; and at least one clamping element. The clamping element is configured, when the actuating force is exerted on the actuating element, to enable the actuating force to be transferred to the transfer element by way of a formation of a clamping contact. The actuating element and the at least one clamping element are designed to be movable relative to one another in a circumferential direction, oriented around the actuation direction, if the clamp is not yet fully formed. A clutch servo unit with an actuating mechanism of this kind is provided.

Abstract: An article management system collects articles from different sources, processes each article to extract information about the article (such as the topics covered in the article), and stores the information in one or more knowledge graphs. The system also maintains user profiles for each of its users. Each user profile includes a user genome representing the user's interests and preferences. The information in the knowledge graphs can be used to select articles to be displayed to users of the article management system. Articles can be displayed as part of the search results for an associated topic or concept, as part of a personalized feed that is generated based on the data in a user's profile, or as part of a feature that displays multiple articles that cover a given topic from multiple different viewpoints. The system can also provide a platform for users to create and publish research collections.

Abstract: An article management system collects articles from different sources, processes each article to extract information about the article (such as the topics covered in the article), and stores the information in one or more knowledge graphs. The system also maintains user profiles for each of its users. Each user profile includes a user genome representing the user's interests and preferences. The information in the knowledge graphs can be used to select articles to be displayed to users of the article management system. Articles can be displayed as part of the search results for an associated topic or concept, as part of a personalized feed that is generated based on the data in a user's profile, or as part of a feature that displays multiple articles that cover a given topic from multiple different viewpoints. The system can also provide a platform for users to create and publish research collections.

Abstract: A drive and deceleration unit has a mechanical brake and an electric drive. The mechanical brake and the electric drive are provided as a unit for acting on a single wheel connection. A method provides for the open-loop and/or closed-loop control of such a drive and deceleration unit.

Abstract: An actuating mechanism for a clutch actuator includes: an actuating element which is designed to be acted on by an actuating force and thereby displaced in an actuation direction, a transmitting element which is designed to carry out a displacement in the actuation direction, wherein a tensioning element is provided between the actuating element and the transmitting element. The tensioning element is designed to generate, for the transmission of the actuating force to the transmitting element, a clamping pressure force which generates a friction force for the transmission of the actuating force. The friction force is configured so as to be capable of transmitting a maximum actuating force.

Abstract: An actuation mechanism for a clutch, includes: an actuation element designed to be applied with an actuating force and to be shifted in an actuation direction by same; a transfer element designed to carry out a shift in the actuation direction; and a compensation mechanism designed to apply a reinforcing clamping force for the frictionally engaged transfer of the actuating force between the transfer element and the actuation element, when an actuating force is applied to the actuation element. The compensation mechanism has a friction element and a counter surface which are designed to bring about the reinforcing clamping force via a frictional connection when applying the actuating force. The friction element and the counter surface are designed to generate the reinforcing clamping force via a supporting force resulting from a deflection of the actuating force. The reinforcing clamping force has at least the value of the supporting force.

Abstract: A hoist, a hoisting apparatus with said hoist and a method for securing a hoist. A hoist body having a drive mechanism for raising or lowering a hoist chain or a hoist cable is suspended from a support device by a hoist support. A safety device having a loosely arranged coupling element and a damping element is mounted between the hoist body and the support device. If the hoist support is released, the hoist body can drop by a drop height until the coupling element becomes taut. The damping element then damps the fall under the load of the hoist body, the hoist chain and whatever load is suspended from it.

Abstract: A drive and deceleration unit has a mechanical brake and an electric drive. The mechanical brake and the electric drive are provided as a unit for acting on a single wheel connection. A method provides for the open-loop and/or closed-loop control of such a drive and deceleration unit.

Abstract: An article management system collects articles from different sources, processes each article to extract information about the article (such as the topics covered in the article), and stores the information in one or more knowledge graphs. The system also maintains user profiles for each of its users. Each user profile includes a user genome representing the user's interests and preferences. The information in the knowledge graphs can be used to select articles to be displayed to users of the article management system. Articles can be displayed as part of the search results for an associated topic or concept, as part of a personalized feed that is generated based on the data in a user's profile, or as part of a feature that displays multiple articles that cover a given topic from multiple different viewpoints. The system can also provide a platform for users to create and publish research collections.

Abstract: The present disclosure relates to reversal agents, which specifically bind to anti-Factor XI and/or anti-Factor XIa antibodies, and reverse one or more anticoagulant effects of the anti-Factor XI and/or anti-Factor XIa antibodies, as well as to methods of use thereof, such as methods for reversing anticoagulant effects of such anti-Factor XI and/or anti-Factor XIa antibodies, and to related methods for managing bleeding or bleeding risks.

Abstract: A clutch actuator transmitting a disengaging force to a clutch disengaging device of a includes an actuating element which receives the disengaging force, and a piston rod for transmitting the disengaging force from the actuating element to the disengaging device. The piston rod bears against an actuating element connection region such that the piston rod is movable towards the connection region by the reaction force of the clutch. The positioning of the connection region and the piston rod relative to each other due to the movement can be fixed by applying the disengaging force to the actuating element. The actuating element at least partly deflects the disengaging force, producing a normal force and/or a radial force acting between the connection region and the piston rod. The normal force and/or the radial force fixes the position of the connection region and the piston rod relative to each other.

Abstract: The present disclosure relates to reversal agents, which specifically bind to anti-Factor XI and/or anti-Factor XIa antibodies, and reverse one or more anticoagulant effects of the anti-Factor XI and/or anti-Factor XIa antibodies, as well as to methods of use thereof, such as methods for reversing anticoagulant effects of such anti-Factor XI and/or anti-Factor XIa antibodies, and to related methods for managing bleeding or bleeding risks.