Abstract: A lab system configures robots to performs protocols in labs. The lab automation system receives, via a user interface, an instruction from a user to perform a protocol within a lab. The instruction may comprise text, and the lab may comprise a robot configured to perform the protocol. The lab system converts, using a machine learned model, the text into steps and, for each step, identifies one or more of an operation, lab equipment, and reagent associated with the step. In response to detecting an ambiguity/error associated with the step, the lab system notifies the user via the user interface of the ambiguity/error. The lab system may receive one or more indications from the user that resolve the ambiguity/error and update the associated steps. For each step, the lab system configures the robot to perform an identified operation, interact with identified lab equipment, and/or access/use an identified reagent.

Abstract: A lab automation system receives an instruction from a user to perform a protocol within a lab via an interface including a graphical representation of the lab. The lab includes a robot and set of equipment rendered within the graphical representation of the lab. The lab automation system identifies an ambiguous term of the instruction and pieces of equipment corresponding to the ambiguous term and modifies the interface to include a predictive text interface element listing the pieces of equipment. Upon a mouseover of a listed piece of equipment within the predictive text interface element, the lab automation system modifies the graphical representation of the lab to highlight the listed piece of equipment corresponding to the mouseover. Upon a selection of the listed piece of equipment within the predictive text interface element, the lab automation system modifies the instruction to include the listed piece of equipment.

Abstract: A lab system accesses a first protocol for performance by a first robot in a first lab. The first protocol includes a set of steps, each associated with an operation, reagent, and equipment. For each of one or more steps, the lab system modifies the step by: (1) identifying one or more replacement operations that achieve an equivalent or substantially similar result as a performance of the operation, (2) identifying replacement equipment that operates substantially similarly to the equipment, and/or (3) identifying one or more replacement reagents that, when substituted for the reagent, do not substantially affect the performance of the step. The lab system generates a modified protocol by replacing one or more of the set of steps with the modified steps. The lab system selects a second lab including a second and configures the second robot to perform the modified protocol in the second lab.

Abstract: A lab system identifies a set of steps associated with a protocol for a lab meant to be performed by a robot within the lab using equipment and reagents. The lab system renders, within a user interface, a virtual representation of the lab, a virtual robot, and virtual equipment and reagents. Responsive to operating in a first mode, the lab system simulates the identified set of steps identify virtual positions of the virtual robot within the lab as the virtual robot performs the steps and modifies the virtual representation of the lab to mirror the identified positions of the virtual robot in real-time. Responsive to operating in a second mode, the lab system identifies positions of the robot within the lab as the robot performs the identified set of steps and modifies the virtual representation of the lab to mirror the identified positions of the robot in real-time.

Abstract: A lab system calibrates robots and cameras within a lab. The lab system accesses, via a camera within a lab, an image of a robot arm, which comprises a visible tag located on an exterior. The lab system determines a position of the robot arm using position sensors located within the robot arm and determines a location of the camera relative to the robot arm based on the determined position and the location of the tag. The lab system calibrates the camera using the determined location of the camera relative to the robot arm. After calibrating the camera, the lab system accesses, via the camera, a second image of equipment in the lab that comprises a second visible tag on an exterior. The lab system determines, based on a location of the second visible tag within the accessed second image, a location of the equipment relative to the robot arm.

Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the HSD17B 13 gene, as well as methods of inhibiting expression of HSD17B13, and methods of treating subjects that would benefit from reduction in expression of HSD17B13, such as subjects having a HSD17B13-associated disease, disorder, or condition, using such dsRNA compositions.

Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the HSD17B13 gene, as well as methods of inhibiting expression of HSD17B13, and methods of treating subjects that would benefit from reduction in expression of HSD17B13, such as subjects having a HSD17B13-associated disease, disorder, or condition, using such dsRNA compositions.

Abstract: An image creation and editing tool can use the data produced from training a neural network to add stylized representations of an object to an image. An object classification will correspond to an object representation, and pixel values for the object representation can be added to, or blended with, the pixel values of an image in order to add a visualization of a type of object to the image. Such an approach can be used to add stylized representations of objects to existing images or create new images based on those representations. The visualizations can be used to create patterns and textures as well, as may be used to paint or fill various regions of an image. Such patterns can enable regions to be filled where image data has been deleted, such as to remove an undesired object, in a way that appears natural for the contents of the image.

Abstract: Provided are compositions related to HSD17B13 variants, including isolated nucleic acids and proteins related to variants of HSD17B13, and cells comprising those nucleic acids and proteins. Also provided are methods related to HSD17B13 variants. Such methods include methods for modifying a cell through use of any combination of nuclease agents, exogenous donor sequences, transcriptional activators, transcriptional repressors, and expression vectors for expressing a recombinant HSD17B13 gene or a nucleic acid encoding an HSD17B13 protein. Also provided are therapeutic and prophylactic methods for treating a subject having or at risk of developing chronic liver disease.

Abstract: Provided are compositions related to HSD17B13 variants, including isolated nucleic acids and proteins related to variants of HSD17B13, and cells comprising those nucleic acids and proteins. Also provided are methods related to HSD17B13 variants. Such methods include methods for modifying a cell through use of any combination of nuclease agents, exogenous donor sequences, transcriptional activators, transcriptional repressors, and expression vectors for expressing a recombinant HSD17B13 gene or a nucleic acid encoding an HSD17B13 protein. Also provided are therapeutic and prophylactic methods for treating a subject having or at risk of developing chronic liver disease.

Abstract: A backpack frame assembly for a user during activity is described. The frame includes a substantially flat panel configured to be attached to a back area of a backpack, a vented portion configured to allow air to reach a user's back, and a plurality of spacers positioned on the panel to contact the user's back and create a gap between the user's back and the frame/backpack. Preferably, the backpack frame assembly also includes at least one air diverter attached to the panel to direct air into the gap.

Abstract: An image creation and editing tool can use the data produced from training a neural network to add stylized representations of an object to an image. An object classification will correspond to an object representation, and pixel values for the object representation can be added to, or blended with, the pixel values of an image in order to add a visualization of a type of object to the image. Such an approach can be used to add stylized representations of objects to existing images or create new images based on those representations. The visualizations can be used to create patterns and textures as well, as may be used to paint or fill various regions of an image. Such patterns can enable regions to be filled where image data has been deleted, such as to remove an undesired object, in a way that appears natural for the contents of the image.

Abstract: An image creation and editing tool can use the data produced from training a neural network to add stylized representations of an object to an image. An object classification will correspond to an object representation, and pixel values for the object representation can be added to, or blended with, the pixel values of an image in order to add a visualization of a type of object to the image. Such an approach can be used to add stylized representations of objects to existing images or create new images based on those representations. The visualizations can be used to create patterns and textures as well, as may be used to paint or fill various regions of an image. Such patterns can enable regions to be filled where image data has been deleted, such as to remove an undesired object, in a way that appears natural for the contents of the image.

Abstract: Provided are compositions related to HSD17B13 variants, including isolated nucleic acids and proteins related to variants of HSD17B13, and cells comprising those nucleic acids and proteins. Also provided are methods related to HSD17B13 variants. Such methods include methods for modifying a cell through use of any combination of nuclease agents, exogenous donor sequences, transcriptional activators, transcriptional repressors, and expression vectors for expressing a recombinant HSD17B13 gene or a nucleic acid encoding an HSD17B13 protein. Also provided are therapeutic and prophylactic methods for treating a subject having or at risk of developing chronic liver disease.

Abstract: Provided are compositions related to HSD17B13 variants, including nucleic acid molecules and polypeptides related to variants of HSD17B13, and cells comprising those nucleic acid molecules and polypeptides. Also provided are methods related to HSD17B3 variants. Such methods include methods for detecting the presence of the HSD17B13 rs72613567 variant in a biological sample comprising genomic DNA, for detecting the presence or levels of any one of variant HSD17B13 Transcripts C, D, E, F, G, and H, and particularly D, in a biological sample comprising mRNA or cDNA, or for detecting the presence or levels of any one of variant HSD17B13 protein Isoforms C, D, E, F, G, or H, and particularly D, in a biological sample comprising protein. Also provided are methods for determining a subject's susceptibility to developing a liver disease or of diagnosing a subject with liver disease.

Abstract: Approaches are described for managing a display of content on a computing device. Content (e.g., images, application data, etc.) is displayed on an interface of the device. An activation movement performed by a user (e.g., a double-tap) can cause the device to enable a content view control mode (such as a zoom control mode) that can be used to adjust a portion of the content being displayed on the interface. The activation movement can also be used to set an area of interest and display a graphical element indicating that the content view control mode is activated. In response to a motion being detected (e.g., a forward tilt or backward of the device), the device can adjust a portion of the content being displayed on the interface, such as displaying a “zoomed-in” portion or a “zoomed-out” portion of the image.

Abstract: A user interface exposing content at a direct focal point is disclosed herein. In one embodiment, content can be assigned to a plurality of tiles. The tiles can be arranged by placing at least one tile at a center of the user interface. Additional tiles can extend from the at least one tile at the center towards at least one side of the user interface. Each tile extending from the at least one tile at the center can expose less content as they reach the at least one side. The tiles at the center can be replaced by the additional tiles exposing more content as they are rotated towards the center. A number of mechanisms can be used to rotate the tiles backwards and forwards.

Abstract: An electronic device can be configured to enable a user to provide input via a tap of the device without the use of touch sensors (e.g., resistive, capacitive, ultrasonic or other acoustic, infrared or other optical, or piezoelectric touch technologies) and/or mechanical switches. Such a device can include other sensors, including inertial sensors (e.g., accelerometers, gyroscopes, or a combination thereof), microphones, proximity sensors, ambient light sensors, and/or cameras, among others, that can be used to capture respective sensor data. Feature values with respect to the respective sensor data can be extracted, and the feature values can be analyzed using machine learning to determine when the user has tapped on the electronic device. Detection of a single tap or multiple taps performed on the electronic device can be utilized to control the device.

Abstract: An electronic device can be configured to enable a user to provide input via a tap of the device without the use of touch sensors (e.g., resistive, capacitive, ultrasonic or other acoustic, infrared or other optical, or piezoelectric touch technologies) and/or mechanical switches. Such a device can include other sensors, including inertial sensors (e.g., accelerometers, gyroscopes, or a combination thereof), microphones, proximity sensors, ambient light sensors, and/or cameras, among others, that can be used to capture respective sensor data. Feature values with respect to the respective sensor data can be extracted, and the feature values can be analyzed using machine learning to determine when the user has tapped on the electronic device. Detection of a single tap or multiple taps performed on the electronic device can be utilized to control the device.

Abstract: Disclosed herein are novel probes, which can be used to detect and identify target molecules of interest in a sample. The disclosed probes can be used to monitor conformational changes induced by molecular recognition events in addition to providing signaling the presence and/or identity of a target molecule. Methods, including solid phase synthesis techniques, for making probe molecules that exhibit changes in their optical properties upon target molecule binding are described in the disclosure. Also disclosed herein are novel chromophore moieties, which have tailored fluorescent emission spectra.