Abstract: The present invention relates to methods of determining a cancer treatment prognosis for a subject in need thereof by evaluating epigenetic and genetic changes within a tumor sample from the subject. The present invention further provides methods of treating cancer in a subject by evaluating epigenetic and genetic changes within a tumor sample from the subject. In addition, the present invention provides methods of screening test agents to identify agents that decrease tumor cell plasticity.

Abstract: The disclosure relates to an operating method for a coating system, in particular for a painting system, for coating components (2), in particular motor vehicle body components (2), having the following steps: conveying, by means of a conveying device (3), the components (2) to be coated in a conveying direction through a coating booth (1), coating the components (2) in the coating booth (1) with a coating product by means of an application device (17-19) which applies a spray jet of the coating product, a portion of the applied coating product being deposited on the components (2) to be coated while another portion of the applied coating product floats into the interior of the coating booth (1) as an excess coating product mist (21), and reducing the excess coating product mist (21) from the interior of the booth by means in addition to or other than the downwardly directed air flow generated by a filter ceiling. In addition, the disclosure includes a correspondingly designed coating system.

Abstract: The present invention generally relates to a set of early developmental reference data or “lineage scorecard” for stem cells, and methods, systems and kits to generate a lineage scorecard for predicting the functionality and suitability of stem cell lines. In some aspects, methods for generating a scorecard comprises measuring the gene expression of a plurality of early developmental genes, such as pluripotent, early ectoderm, early mesoderm and early endoderm genes to predict the pluripotency and differentiation potential of the stem cell line and its functionality and/or suitability for a desired use. In some embodiments, a reference scorecard can be compared with the test stem cell line scorecard to accurately predict the utility and/or identify specific characteristics of the stem cell line, e.g., to determine its suitability for downstream applications, e.g., therapeutic use, drug screening, toxicity assays, differentiation into a desired cell lineage, etc.

Abstract: The present invention relates to methods of determining a cancer treatment prognosis for a subject in need thereof by evaluating epigenetic and genetic changes within a tumor sample from the subject. The present invention further provides methods of treating cancer in a subject by evaluating epigenetic and genetic changes within a tumor sample from the subject. In addition, the present invention provides methods of screening test agents to identify agents that decrease tumor cell plasticity.

Abstract: The present invention relates to methods of determining a cancer treatment prognosis for a subject in need thereof by evaluating epigenetic and genetic changes within a tumor sample from the subject. The present invention further provides methods of treating cancer in a subject by evaluating epigenetic and genetic changes within a tumor sample from the subject. In addition, the present invention provides methods of screening test agents to identify agents that decrease tumor cell plasticity.

Abstract: The disclosure relates to an operating method for a coating system, in particular for a painting system, for coating components (2), in particular motor vehicle body components (2), having the following steps: conveying, by means of a conveying device (3), the components (2) to be coated in a conveying direction through a coating booth (1), coating the components (2) in the coating booth (1) with a coating product by means of an application device (17-19) which applies a spray jet of the coating product, a portion of the applied coating product being deposited on the components (2) to be coated while another portion of the applied coating product floats into the interior of the coating booth (1) as an excess coating product mist (21), and reducing the excess coating product mist (21) from the interior of the booth by means in addition to or other than the downwardly directed air flow generated by a filter ceiling. In addition, the disclosure includes a correspondingly designed coating system.

Abstract: The present invention generally relates to a set of early developmental reference data or “lineage scorecard” for stem cells, and methods, systems and kits to generate a lineage scorecard for predicting the functionality and suitability of stem cell lines. In some aspects, methods for generating a scorecard comprises measuring the gene expression of a plurality of early developmental genes, such as pluripotent, early ectoderm, early mesoderm and early endoderm genes to predict the pluripotency and differentiation potential of the stem cell line and its functionality and/or suitability for a desired use. In some embodiments, a reference scorecard can be compared with the test stem cell line scorecard to accurately predict the utility and/or identify specific characteristics of the stem cell line, e.g., to determine its suitability for downstream applications, e.g., therapeutic use, drug screening, toxicity assays, differentiation into a desired cell lineage, etc.

Abstract: Methods for quantifying DNA methylation that may be utilized for screening for diseases (e.g., cancer), diagnosing diseases (e.g., cancer type), monitoring progression of a disease, and monitoring response to a therapeutic treatment.

Abstract: The disclosure relates to an operating method for a coating system, in particular for a painting system, for coating components (2), in particular motor vehicle body components (2), having the following steps: conveying, by means of a conveying device (3), the components (2) to be coated in a conveying direction through a coating booth (1), coating the components (2) in the coating booth (1) with a coating product by means of an application device (17-19) which applies a spray jet of the coating product, a portion of the applied coating product being deposited on the components (2) to be coated while another portion of the applied coating product floats into the interior of the coating booth (1) as an excess coating product mist (21), and reducing the excess coating product mist (21) from the interior of the booth by means in addition to or other than the downwardly directed air flow generated by a filter ceiling. In addition, the disclosure includes a correspondingly designed coating system.

Abstract: The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.

Abstract: A coating system for coating components, e.g., for paining motor vehicle body components, is provided. The system includes a coating booth, a conveying system, an application system, a process technology system, a safety system, and a robot system. The robot system includes at least one multi-axis coating robot for guiding the application device and a control unit. The control unit also controls the conveying system, the application system, the safety system and/or the process technology system.

Abstract: The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.

Abstract: The present invention generally relates to a set of early developmental reference data or “lineage scorecard” for stem cells, and methods, systems and kits to generate a lineage scorecard for predicting the functionality and suitability of stem cell lines. In some aspects, methods for generating a scorecard comprises measuring the gene expression of a plurality of early developmental genes, such as pluripotent, early ectoderm, early mesoderm and early endoderm genes to predict the pluripotency and differentiation potential of the stem cell line and its functionality and/or suitability for a desired use. In some embodiments, a reference scorecard can be compared with the test stem cell line scorecard to accurately predict the utility and/or identify specific characteristics of the stem cell line, e.g., to determine its suitability for downstream applications, e.g., therapeutic use, drug screening, toxicity assays, differentiation into a desired cell lineage, etc.

Abstract: The disclosure relates to an operating method for a coating system, in particular for a painting system, for coating components (2), in particular motor vehicle body components (2), having the following steps: conveying, by means of a conveying device (3), the components (2) to be coated in a conveying direction through a coating booth (1), coating the components (2) in the coating booth (1) with a coating product by means of an application device (17-19) which applies a spray jet of the coating product, a portion of the applied coating product being deposited on the components (2) to be coated while another portion of the applied coating product floats into the interior of the coating booth (1) as an excess coating product mist (21), and reducing the excess coating product mist (21) from the interior of the booth by means in addition to or other than the downwardly directed air flow generated by a filter ceiling. In addition, the disclosure includes a correspondingly designed coating system.

Abstract: The invention relates to a control method for a robot (1) having a plurality of movable robot axes (2, 4, 6), in particular for a painting robot (1) or a manipulating robot, comprising the following steps: (a) predetermining a robot path by means of a plurality of path points through which a reference point of the robot (1) is intended to travel; (b) controlling drive motors of the individual robot axes (2, 4, 6) according to the predetermined robot path, such that the reference point of the robot (1) travels through the predetermined robot path; (c) precalculating the mechanical loading (My1, Mx1, Fx1, Fy1, Fz1, Fx2, Fy2, Fz2, Mx2, My2, Mz2) that occurs within at least one of the robot axes (2, 4, 6) between two joints when travelling through the robot path ahead; and also (d) adjusting the control of the drive motors of the robot axes (2, 4, 6) on the basis of the precalculated mechanical loading (My1, Mx1, Fx1, Fy1, Fz1, Fx2, Fy2, Fz2, Mx2, My2, Mz2), such that a mechanical overload is avoided.

Abstract: The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.

Abstract: The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.

Abstract: A coating system for coating components, e.g., for paining motor vehicle body components, is provided. The system includes a coating booth, a conveying system, an application system, a process technology system, a safety system, and a robot system. The robot system includes at least one multi-axis coating robot for guiding the application device and a control unit. The control unit also controls the conveying system, the application system, the safety system and/or the process technology system.

Abstract: The present invention relates to methods of determining a cancer treatment prognosis for a subject in need thereof by evaluating epigenetic and genetic changes within a tumor sample from the subject. The present invention further provides methods of treating cancer in a subject by evaluating epigenetic and genetic changes within a tumor sample from the subject. In addition, the present invention provides methods of screening test agents to identify agents that decrease tumor cell plasticity.

Abstract: The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.