Abstract: The present invention generally relates to a set of early developmental reference data or “lineage scorecard” for stem cells, and methods, systems and kits to generate a lineage scorecard for predicting the functionality and suitability of stem cell lines. In some aspects, methods for generating a scorecard comprises measuring the gene expression of a plurality of early developmental genes, such as pluripotent, early ectoderm, early mesoderm and early endoderm genes to predict the pluripotency and differentiation potential of the stem cell line and its functionality and/or suitability for a desired use. In some embodiments, a reference scorecard can be compared with the test stem cell line scorecard to accurately predict the utility and/or identify specific characteristics of the stem cell line, e.g., to determine its suitability for downstream applications, e.g., therapeutic use, drug screening, toxicity assays, differentiation into a desired cell lineage, etc.

Abstract: A device is proved for measuring surfaces of joint locations of at least two joint parts to be connected, e.g., for connection thereof. The device comprises an application mechanism for applying an application agent to the joint locations, at least one measurement mechanism for measuring the surfaces of the joint locations, and a movement mechanism for moving the measurement mechanism along the joint locations. At least one application parameter is determined depending on the surfaces measured, whereby a surface-dependent application process can be achieved.

Abstract: The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.

Abstract: A rotary atomizer arrangement and methods for operating the same are disclosed. An exemplary atomizer may be used for the coating of work pieces, and may include a bell plate driven by an electric motor. The exemplary atomizer may further be configured for the detection of errors in the spraying process and/or the drive system of the bell plate, such as by analyzing corresponding parameters of typical values of the drive motor.

Abstract: The invention relates to a control method for a robot (1) having a plurality of movable robot axes (2, 4, 6), in particular for a painting robot (1) or a manipulating robot, comprising the following steps: (a) predetermining a robot path by means of a plurality of path points through which a reference point of the robot (1) is intended to travel; (b) controlling drive motors of the individual robot axes (2, 4, 6) according to the predetermined robot path, such that the reference point of the robot (1) travels through the predetermined robot path; (c) precalculating the mechanical loading (My1, Mx1, Fx1, Fy1, Fz1, Fx2, Fy2, Fz2, Mx2, My2, Mz2) that occurs within at least one of the robot axes (2, 4, 6) between two joints when travelling through the robot path ahead; and also (d) adjusting the control of the drive motors of the robot axes (2, 4, 6) on the basis of the precalculated mechanical loading (My1, Mx1, Fx1, Fy1, Fz1, Fx2, Fy2, Fz2, Mx2, My2, Mz2), such that a mechanical overload is avoided.

Abstract: The invention relates to an operating method for a positioning system 1, in particular for the structural assembly of aircraft, wherein the positioning system 1 comprises a plurality of positioners 2a, 2b, 2c, each of which has at least one manipulator M. The manipulators M grasp a component B and manipulate it in a synchronised manner, while it is jointly grasped by the manipulators M.

Abstract: A robot arrangement, for example for a painting booth, and exemplary methods associated with the same, are disclosed. An exemplary robot arrangement may comprise a displacement rail, a plurality of robots, such as painting robots or handling robots, which can be displaced along the displacement rail, and a plurality of energy supply chains. The energy supply chains may supply one of the robots each, and may be associated with said robot, and each of the energy supply chains may run along the displacement rail in a particular track. The energy supply chains which are associated with the robots on the same displacement rail may run in discrete tracks.

Abstract: Exemplary coating devices and methods are disclosed. An exemplary coating device may include an atomizer for applying a spray jet of a coating means or material to a component, at least one directing air nozzle for outputting shaping or directing air in order to shape the spray jet, and a temperature-control device for controlling the temperature of the directing air. The coating device may further include a control unit which activates the temperature-control device as a function of at least one operating variable of the atomizer in order to set a predetermined directing air temperature.

Abstract: The present invention generally relates set of reference data or “scorecard” for a pluripotent stem cell, and methods, systems and kits to generate a scorecard for predicting the functionality and suitability of a pluripotent stem cell line for a desired use. In some aspects, a method for generating a scorecard comprises using at least 2 stem cell assays selected from: epigenetic profiling, differentiation assay and gene expression assay to predict the functionality and suitability of a pluripotent stem cell line for a desired use.

Abstract: A predetermined robot path includes a plurality of path points defined by spatial coordinates. Spatial coordinates of the individual path points are converted in accordance with inverse robot kinematics into corresponding axis coordinates, the axis coordinates representing the position of the individual robot axes at respective path points. Axis-related controllers are actuated for individual robot axes in accordance with converted axis coordinates. Axis-related drive motors in individual robot axes are actuated by at least associated axis-related controllers. Path correction values are determined for individual path points on the robot path in accordance with a dynamic robot model, the path correction values taking account of the elasticity, friction, and/or inertia of the robot. Corrected axis coordinates are determined for the individual path points from uncorrected axis coordinates of individual path points and path correction values.

Abstract: A dedusting device and method is disclosed for the dry or moist dedusting (i.e., cleaning, dusting, or removal of dirt, dust, or other debris) from components, e.g., of motor vehicles. An exemplary method may generally include positioning a dusting tool driven by a drive motor in a predetermined dusting position such that the tool contacts or touches the component, and determining a first operating variable of the drive motor of the dusting tool when positioning the dusting tool in the predetermined dusting position. The first operating variable may reflect a mechanical load of the drive motor due to the contact with the component to be dusted. The method may further include calculating a corrected dusting position as a function of the predetermined dusting position and the first operating variable of the drive motor, and positioning the dusting tool in the corrected dusting position.

Abstract: A robot arrangement, for example for a painting booth, and exemplary methods associated with the same, are disclosed. An exemplary robot arrangement may comprise a displacement rail, a plurality of robots, such as painting robots or handling robots, which can be displaced along the displacement rail, and a plurality of energy supply chains. The energy supply chains may supply one of the robots each, and may be associated with said robot, and each of the energy supply chains may run along the displacement rail in a particular track. The energy supply chains which are associated with the robots on the same displacement rail may run in discrete tracks.

Abstract: Exemplary coating devices and methods are disclosed. An exemplary coating device may include an atomizer for applying a spray jet of a coating means or material to a component, at least one directing air nozzle for outputting shaping or directing air in order to shape the spray jet, and a temperature-control device for controlling the temperature of the directing air. The coating device may further include a control unit which activates the temperature-control device as a function of at least one operating variable of the atomizer in order to set a predetermined directing air temperature.

Abstract: The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.

Abstract: Exemplary robots and corresponding exemplary operating methods for a painting system are disclosed. In one example, the robot is a handling robot for opening and closing doors or bonnets of motor vehicle bodies. A robot element of a handling robot that is susceptible to dirt retention, e.g., a handling tool, may be arranged away from the spray jet of a paint during the painting operation and is applied to the component that is to be painted. The robot may include a cleaning device for cleaning or for keeping the robot element of the handling robot that is susceptible to dirt retention clean from paint that is applied with spray jet in the painting operation.

Abstract: A dedusting device and method is disclosed for the dry or moist dedusting (i.e., cleaning, dusting, or removal of dirt, dust, or other debris) from components, e.g., of motor vehicles. An exemplary method may generally include positioning a dusting tool driven by a drive motor in a predetermined dusting position such that the tool contacts or touches the component, and determining a first operating variable of the drive motor of the dusting tool when positioning the dusting tool in the predetermined dusting position. The first operating variable may reflect a mechanical load of the drive motor due to the contact with the component to be dusted. The method may further include calculating a corrected dusting position as a function of the predetermined dusting position and the first operating variable of the drive motor, and positioning the dusting tool in the corrected dusting position.

Abstract: Coating installation, specifically for painting automobile body parts, having at least two application robots (3, 5) for applying a coating means to a target, at least two handling robots (4. 6) for handling the target and two linear guides (1, 2) along which the handling robots (4. 6) and the application robots (3, 5) can be driven. It is proposed that each of the two linear guides (1, 2) carries at least one of the application robots (3, 5) and at least one of the handling robots (4. 6).

Abstract: A rotary atomizer arrangement and methods for operating the same are disclosed. An exemplary atomizer may be used for the coating of work pieces, and may include a bell plate driven by an electric motor. The exemplary atomizer may further be configured for the detection of errors in the spraying process and/or the drive system of the bell plate, such as by analyzing corresponding parameters of typical values of the drive motor.

Abstract: The invention relates to a control method for a painting robot, comprising the following steps: (a) a robot path is set using several path points that are to be traversed by a reference point of the robot and are each defined by space coordinates; (b) the space coordinates of the individual path points are converted into corresponding axis coordinates according to inverse robot kinematics, said axis coordinates reproducing the position of the individual robot axes in the respective path points; (c) axis-related regulators for the individual robot axes are triggered according to the converted axis coordinates; (d) axis-related driving motors are triggered in the individual robot axes by means of the associated axis-related regulators; (e) corrective path values for the individual path points are calculated according to a dynamic robot model, said corrective path values taking into account the elasticity and/or friction and/or inertia of the robot; (f) corrected axis coordinates for the individual path points a

Abstract: Coating installation, specifically for painting motor vehicle body parts, having at least two application robots for applying a coating medium to an application target, at least two handling robots for handling the application target and two linear guides along which the handling robots and the application robots can be moved. Each of the two linear guides carries at least one of the application robots and at least one of the handling robots.