Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: The invention is directed to curable polyurethane coating compositions which may be used to form fouling release coatings, e.g., for use in protecting boat hulls. A curable coating composition of the invention comprises a) at least one amphiphilic additive; b) at least one polyisocyanate; c) at least one polyol; and d) optionally, at least one amphiphilic PEG-PDMS isocyanate prepolymer. Another curable coating composition of the invention comprises the at least one polyisocyanate, b), the at least one polyol, c), and the at least one amphiphilic PEG-PDMS isocyanate prepolymer, d). The invention further relates to methods for reducing or preventing biofouling of a surface exposed to an aqueous environment comprising the steps of coating the surface with the curable coating compositions of the invention to form a coated surface, and curing the coating composition on the coated surface.

Abstract: The invention relates to a curable coating composition comprising at least one glycidyl carbamate (GC) resin, at least one amphiphilic GC-functional prepolymer, and at least one curing agent. The invention also relates to a method of making the curable coating compositions. The invention also relates to an article of manufacture comprising the curable coating composition of the invention and a method of making such article. The invention also relates to a fouling-release (FR) coating system and an anti-coating system, each of which comprises the curable coating compositions of the invention, methods of applying the FR coating systems and anti-coating systems to substrates, and methods for reducing or preventing biofouling or icing of a surface exposed to an aqueous environment using the FR coating systems.

Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: The invention relates to a curable coating composition comprising at least one glycidyl carbamate (GC) resin, at least one amphiphilic GC-functional prepolymer, and at least one curing agent. The invention also relates to a method of making the curable coating compositions. The invention also relates to an article of manufacture comprising the curable coating composition of the invention and a method of making such article. The invention also relates to a fouling-release (FR) coating system and an anti-coating system, each of which comprises the curable coating compositions of the invention, methods of applying the FR coating systems and anti-coating systems to substrates, and methods for reducing or preventing biofouling or icing of a surface exposed to an aqueous environment using the FR coating systems.

Abstract: The present disclosure is drawn to aqueous ink compositions, methods of printing on offset coated print media, and printing systems. In one example, the aqueous ink compositions can include from 2 wt % to 5 wt % pigment, from 70 wt % to 95 wt % water, from 1 wt % to 10 wt % binder, from 0.1 wt % to 3 wt % non-ionic surfactant, from 1 wt % to 15 wt % humectant solvent including a hydrophilic group, and from 0.3 wt % to 4.5 wt % non-volatile glycol ether co-solvent having a boiling point of 220 C or greater.

Abstract: The invention relates to a hygiene device, having a material body, which covers a region in the intended positioned state, and in particular has multiple plies (a, b, c) of material, in particular moisture absorption material, which is made of a plastic material, wood, paper, and/or granular material, wherein the hygiene device has at least one sensor (4) for measuring a parameter. It is proposed that the hygiene device has at least one transmitter module (5) on or in the material of the material body, the at least one sensor (4) is integrated in the transmitter module (5), and the transmitter module (5) is designed for the contactless transmission of sensor data of the at least one sensor (4) and without its own electrical energy source.

Abstract: A composite substrate comprising a mesh layer and a composite material layer is provided, wherein the mesh layer comprises a mesh material and an adhesive, said adhesive permeating the mesh material and adhering the mesh material directly to a surface of the composite material layer. A metal-coated composite substrate is provided. The metal-coated composite substrate comprises a composite substrate, as defined in the section above, and a metal layer covering a side of the mesh layer opposite the composite layer. Furthermore, a method for producing the composite substrate is provided. Moreover, a method for producing the metal-coated composite substrate is provided.

Abstract: The invention is directed to curable polyurethane coating compositions which may be used to form fouling release coatings, e.g., for use in protecting boat hulls. A curable coating composition of the invention comprises a) at least one amphiphilic additive; b) at least one polyisocyanate; c) at least one polyol; and d) optionally, at least one amphiphilic PEG-PDMS isocyanate prepolymer. Another curable coating composition of the invention comprises the at least one polyisocyanate, b), the at least one polyol, c), and the at least one amphiphilic PEG-PDMS isocyanate prepolymer, d). The invention further relates to methods for reducing or preventing biofouling of a surface exposed to an aqueous environment comprising the steps of coating the surface with the curable coating compositions of the invention to form a coated surface, and curing the coating composition on the coated surface.

Abstract: The invention relates to a curable coating composition comprising at least one surface-modifying amphiphilic additive and at least one siloxane-polyurethane coating composition. The invention also relates to methods of making and using the curable coating composition of the invention. The invention also relates to methods for reducing or preventing biofouling of a surface exposed to an aqueous environment comprising the use of the curable coating composition of the invention.

Abstract: The present disclosure is drawn to an ink set, which can include an ink composition and a fixer composition. The ink composition can include from 2 wt % to 8 wt % pigment, from 0.1 wt % to 0.5 wt % dye, from 2 wt % to 10 wt % polyurethane, and an aqueous ink vehicle. The fixer composition can include from 3 wt % to 15 wt % divalent metal salt, and an aqueous fixer vehicle.

Abstract: The present disclosure refers to an inkjet ink set including a black ink with a black pigment, a yellow ink with a yellow pigment, a cyan ink with a cyan pigment and a magenta ink with a magenta pigment, wherein at least one of the ink further contains a polyurethane binder; non-ionic surfactants; humectant solvent; non-volatile glycol ether co-solvent; a polyethylene wax emulsion and a balance of water. The inkjet ink set can also includes an orange ink, a green ink and/or a violet ink. The present disclosure refers also to a system for printing the ink set described herein.

Abstract: An inkjet ink for an offset coated medium includes: water; a colorant; a binder that is a polyurethane-based dispersion; a co-solvent; and two or more surfactants. A first surfactant has a first hydrophilic lipophilic balance (HLB) value either within a water dispersible range or within a hydrophobic range and a second surfactant has a second HLB value within a hydrophobic range. The combination of the first surfactant and the second surfactant is to adjust a surface tension of the inkjet ink to a value lower than a surface tension of the offset coated medium on which the inkjet ink is to be printed.

Abstract: A pre-treatment fixing fluid for an offset coated medium is disclosed. The pre-treatment fixing fluid includes calcium-containing cationic crashing agents consisting of calcium propionate and calcium nitrate, wherein the calcium propionate is present in an amount ranging from about 0 wt % to about 10 wt %, and wherein the calcium nitrate is present in an amount ranging from about 15 wt % to 0 wt %, both based on the total wt % of the pre-treatment fixing fluid. The pre-treatment fixing further includes a co-solvent, a surfactant, and a balance of water. The surfactant is selected from the group consisting of a first surfactant having a first hydrophilic lipophilic balance (HLB) value within a hydrophobic range and a combination of the first surfactant and a second surfactant having a second HLB value within a water dispersible range.

Abstract: Extrudable compositions were prepared comprising poly(propylene) and a liquid additive comprising a lactam group. The compositions can comprise other optional additives that include a polyhemiaminal, antioxidants, UV light absorbers, and surfactants. The extruded compositions have higher percent elongation at break and lower Young's modulus compared to extruded poly(propylene) lacking the liquid additive. These and other property improvements make the extruded compositions attractive for forming field joint coatings for undersea pipeline applications.

Abstract: An inkjet ink set containing a pre-treatment fixing fluid including calcium-containing crashing agents; at least a co-solvent; one or more surfactants and a balance of water; and, at least, a liquid ink. The liquid ink includes a pigment dispersion, a surfactant, a polyurethane binder, a co-solvent and a balance of water. Also disclosed are and inkjet printing system containing such ink set and the method for printing in such inkjet printing system.

Abstract: Extrudable compositions were prepared comprising poly(propylene) and a liquid additive comprising a lactam group. The compositions can comprise other optional additives that include a polyhemiaminal, antioxidants, UV light absorbers, and surfactants. The extruded compositions have higher percent elongation at break and lower Young's modulus compared to extruded poly(propylene) lacking the liquid additive. These and other property improvements make the extruded compositions attractive for forming field joint coatings for undersea pipeline applications.

Abstract: An inkjet ink set comprising a liquid ink and an over-print varnish composition comprising a latex polymer, a boron-containing compound and water. The liquid ink includes a pigment dispersion, a surfactant, a polyurethane binder, a co-solvent and a balance of water. Also disclosed are and inkjet printing system containing such ink set and the method for printing in such inkjet printing system.