Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

Abstract: Systems and methods are provided for fabricating composite parts. The method includes subdividing a laminate into zones, laying up tows of fiber reinforced material for the laminate over a layup mandrel via multiple laminations such that each lamination head applies tows in a different zone, and splicing the zones together to form the laminate during the laying up of the tows while moving the layup mandrel in a process direction during fabrication of the composite parts.

Abstract: Systems and methods suitable for making skin-formulation applicators through additive manufacturing are described.

Abstract: The bottle-sealing and preservation device provides for the sealing of necked bottles, including those designed to hold pressure such as champagne bottles, using mechanical advantage to compress an O-ring against the inner surface of the bottle neck. The device can accommodate a wide range of bottle-neck diameters and includes a stabilizing ring that engages the bottle mouth. Optionally, the device may be fitted with a cylindrical cage in which an oxygen-scavenging sachet may be inserted to pull oxygen out of the bottle headspace, thereby preserving any remaining liquid therein that is susceptible to oxidation.

Abstract: Systems, methods, and computer program products for alarm response automation in manufacturing, distribution, and general supply chain environments. Sensors categorized as part of an industrial IoT environment are used to detect asset health, including asset abnormalities and trends. Alarm exceptions generate actionable events, which are used to invoke a multi-tiered, hierarchical application of asset entitlements. This data guidance provides enhanced alarm response automation via intelligent filtration and consolidation by grouping recurrent or related alarms from assets, models, model types, components, customers, and sites into a single actionable event. This actionable event has its own unique categorizations that work in concert. At any point, additional, definable processes may be executed to further refine the data. The resulting layered, asset entitlement approach thereby creates a high level of filtration and intelligence from the IoT-generated data.

Abstract: A dispensing device comprising a body with an attachment mechanism configured to connect to a subject, a reservoir disposed inside the body, a removable selected fragrance disposed inside the reservoir, a dispenser coupled to the reservoir, a controller coupled to the dispenser and configured to dispense the selected fragrance, and a plurality of sensors on the body configured to provide data streams to a smart device.

Abstract: A personal care device that is capable of two-way communication is provided. In some embodiments, the personal care device operates in a first mode and a second mode depending on whether a signal has been received from a networked computing device, thus allowing a single human-machine interface (HMI) device to both control the personal care device and to cause signals to be sent to the networked computing device. In some embodiments, the personal care device is configured to present media streamed from the networked computing device, and/or to stream audio detected by the personal care device to the networked computing device.

Abstract: A non-transitory computer-readable medium storing instructions readable and executable by a workstation (18) including at least one electronic processor (20) to perform a quality control (QC) method (100). The method includes: receiving a current QC data set acquired by a pixelated detector (14) and one or more prior QC data sets acquired by the pixelated detector; determining stability levels of detector pixels (16) of the pixelated detector over time from the current QC data set and the one or more prior QC data sets; labeling a detector pixel of the pixelated detector as dead when the stability level determined for the detector pixel is outside of a stability threshold range; and displaying, on a display device (24) operatively connected with the workstation, an identification (28) of the detector pixels labelled as dead.

Abstract: A system for displaying a simulated room can comprise a projector, a wall structure element, a physical object, and a room customization station. The room customization station can view images of selectable products and allows a selection thereof to be displayed on the wall structure element or the physical object. The projector can display the selectable product(s) on the wall structure element or the physical object. The physical object can be adjustable in size for different selectable product sizes. The system can include a physical accessory placeable in the simulated room to facilitate visualization of how the physical accessory would appear in the simulated room with the selectable product. Further, the room customization station can prevent a portion of the images from being projected onto a physical feature in the simulated room and allow other portions of the images to be projected into a portion of the simulated room.

Abstract: In some embodiments, the present disclosure provides a travel product system. The travel product system determines user product preferences for personal care products that the user may wish to use at a travel destination. In an embodiment, the system comprises a system for processing personal care products for use during travel. The travel product system may obtain these preferences directly from the user, or may automatically obtain the preferences from other sources. The travel product system may cause appropriate amounts of the products to be packaged and delivered to the user's travel destination, thus reducing waste and making the products available at the destination without having to carry them while in transit.

Abstract: In some embodiments, an authorization server device receives a request for an activation token to activate a personal care device. The authorization server device determines an authorized usage amount, and generates an activation token based on the authorized usage amount to be transmitted to the personal care device. Activation of a personal care device may be authorized based on consumable products obtained for use with the personal care device. By limiting activation of the personal care device based on consumable products obtained for use with the personal care device, the technical problems in overuse of some consumable products (such as brush heads) or underuse of other consumable products (such as serums or cleansers) can be avoided, and maximum results from use of the personal care devices can be easier to obtain.

Abstract: Phototherapy systems and methods of phototherapy are described. In an example, the phototherapy system includes a therapeutic light source configured to emit phototherapeutic light towards a subject; and a placebo light source configured to emit placebo light towards the subject. In an embodiment, the light, including the phototherapeutic light and the placebo light, emitted by the phototherapy system is configured to be visually perceived by the subject as continuous light. In an embodiment, the placebo light is a metameric match of the phototherapeutic light. In an embodiment, the method includes emitting the placebo light in a wavelength range and at an intensity configured to be visually perceived by the user as the phototherapeutic light, such as where the placebo light is a metameric match of the phototherapeutic light.

Abstract: In some embodiments, usage of a personal care device in compliance with a recommended use is improved. A usage monitor computing device may detect and store records of use of the personal care device. The usage monitor computing device may transmit the records of use to a monitoring server device via a network. The usage monitor computing device may determine whether the records of use indicate that the personal care device has been used as directed by the recommendations, and if so, may determine whether one or more rewards for use should be provided to the user. The usage monitor computing device may receive notifications of the rewards, and may present notifications of the rewards to the user.

Abstract: Systems and methods for manufacturing eyelash prostheses are described.

Abstract: A system for displaying a simulated room can comprise at least one projector, at least one wall structure element, at least one physical object, and a room customization station. The room customization station can be configured to permit viewing images of selectable products and selecting at least one of the selectable products to be displayed on at least one of the at least one wall structure element or the at least one physical object. The projector(s) can be adapted to display the selectable product(s) on at least one of the at least one wall structure element or the physical object(s). The physical object can be adjustable in size to correspond to different sizes of selectable products. The system can further include at least one physical accessory adapted to be placed in the simulated room to facilitate visualization of how the at least one physical accessory would appear in the presence of the simulated room and the at least one selectable product.

Abstract: Systems and methods are provided for paying out material. One embodiment is a method for dispensing film onto a surface. the method includes operating vacuum ports at a suction table, adhering a leading edge of a web of film to the suction table, driving the payout system across the suction table while the vacuum ports are being operated and while unrolling the web of film, unrolling a web of film from a roll of a payout system that is mounted for traversal across the upper surface of the suction table, and enforcing tension at the web of film between the suction table and the roll while payout system is drawn across the suction table.

Abstract: The bottle-sealing and preservation device provides for the sealing of necked bottles, including those designed to hold pressure such as champagne bottles, using mechanical advantage to compress an O-ring against the inner surface of the bottle neck. The device can accommodate a wide range of bottle-neck diameters and includes a stabilizing ring that engages the bottle mouth. Optionally, the device may be fitted with a cylindrical cage in which an oxygen-scavenging sachet may be inserted to pull oxygen out of the bottle headspace, thereby preserving any remaining liquid therein that is susceptible to oxidation.

Abstract: A personal care device comprises at least one treatment application unit configured to apply a treatment to user; a human-machine interface (HMI) comprising a speaker; and a personal care unit operably coupled to the HMI and to the at least one treatment application unit. The personal care unit includes circuitry for presenting voice cues via the HMI in a computer-guided care routine to guide user operation of the personal care device, and circuitry for controlling the at least one treatment application unit. In an embodiment, the circuitry for presenting voice cues via the HMI includes circuitry for generating a random selection from a set of voice cues stored in memory and/or computational circuitry including one or more processors operably connected to a speaker and configured to enable one or voice cues via the HMI that sequence in concert with a computer-guided care routine stored in memory.

Abstract: Sunscreen formulations and systems for sun protection and related methods of use are described herein.

Abstract: An adjustable misting system and method for treating a region of a biological surface is presented. In an embodiment, a reconfigurable misting nebulizer includes a first misting panel having a plurality of apertures configured to atomize a formulation, and a second misting panel coupled to the first misting panel having a plurality of apertures configured to atomize the formulation. In some embodiments, a relative position of the first misting panel with respect to the second misting panel is adjustable.