Abstract: A deployable and flexible tooltip camera is provided for integration within a shaft of an endoscopic tool. The tooltip camera includes a camera mounted to a distal tip of a curved tube which is capable of rotational and translational movement to provide a wide field of view of a tooltip of the endoscopic tool during an endoscopic procedure. The tube retains its curved shape when in use to provide a unique perspective view of the tooltip, but can then be withdrawn into a shaft of the endoscopic tool such that the entire tooltip camera and tube are retained within the shaft of the endoscopic tool and can pass through a cannula. The curved tube may be formed of a super-elastic memory alloy like Nitinol and pre-shaped into an s-curve using a two-step heat treatment process to attain the necessary curvature, and further laser-patterned with holes to attain the necessary flexibility.

Abstract: Novel crystalline forms of molnupiravir, including crystalline Forms I and II, which are crystalline forms of uridine 4-oxime 5?-(2-methylpropanoate), may be useful as antiviral agents, specifically as antiviral treatments for infections caused by Eastern Equine Encephalitis Virus (EEEV), Western Equine Encephalitis Virus (WEEV), and Venezuelan Equine Encephalitis Virus (VEEV), Chikungunya fever virus (CHIK), Ebola virus, influenza virus, respiratory syncytial virus (RSV), Zika virus, and coronaviruses, such as Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and, most recently, SARS-CoV-2 (also known as 2019-nCoV).

Abstract: A deployable and flexible tooltip camera is provided for integration within a shaft of an endoscopic tool. The tooltip camera includes a camera mounted to a distal tip of a curved tube which is capable of rotational and translational movement to provide a wide field of view of a tooltip of the endoscopic tool during an endoscopic procedure. The tube retains its curved shape when in use to provide a unique perspective view of the tooltip, but can then be withdrawn into a shaft of the endoscopic tool such that the entire tooltip camera and tube are retained within the shaft of the endoscopic tool and can pass through a cannula. The curved tube may be formed of a super-elastic memory alloy like Nitinol and pre-shaped into an s-curve using a two-step heat treatment process to attain the necessary curvature, and further laser-patterned with holes to attain the necessary flexibility.

Abstract: Systems, methods and devices for performing an endoscopic procedure are provided herein, including an endoscopic plug designed to create a sealed environment within a body cavity using an internal expandable portion which maintains a collapsed configuration during an insertion process or removal process, but which can be expanded upon insertion into the body cavity to secure an internal portion of the endoscopic plug within the body cavity while creating a seal to prevent leakage of gas or fluid out of the body cavity during the endoscopic procedure.

Abstract: A deployable and flexible tooltip camera is provided for integration within a shaft of an endoscopic tool. The tooltip camera includes a camera mounted to a distal tip of a curved tube which is capable of rotational and translational movement to provide a wide field of view of a tooltip of the endoscopic tool during an endoscopic procedure. The tube retains its curved shape when in use to provide a unique perspective view of the tooltip, but can then be withdrawn into a shaft of the endoscopic tool such that the entire tooltip camera and tube are retained within the shaft of the endoscopic tool and can pass through a cannula. The curved tube may be formed of a super-elastic memory alloy like Nitinol and pre-shaped into an s-curve using a two-step heat treatment process to attain the necessary curvature, and further laser-patterned with holes to attain the necessary flexibility.

Abstract: Systems, methods and devices for performing water aided endoscopy (WAE) are provided herein. The systems include a plurality of devices designed to create a sealed environment within the body cavity, including a multi-functional plug, valves, balloons and pumps. The systems also provide specialized tools configured for operation within a liquid environment which are designed to interface with the multi-functional seal for insertion into the body cavity while maintaining the seal, including an adjustable constant shape snare. Additional features of the systems and methods include specialized fluids for increasing visibility with the body cavity, dyes and other solutions for image-enhancement and diagnostics, and software for increasing the clarity of the image in real-time.

Abstract: An endoscopic plug for performing an endoscopic procedure includes an external housing and internal tubing for securing within a body cavity opening, the external housing including a plurality of support tabs to secure the external housing to an exterior of the body cavity opening, and the internal tubing including an expandable balloon on an outer surface for expanding within the body cavity to secure the plug within the body cavity. The support tabs, expandable balloon and other features help to create a sealed internal environment for performing water aided endoscopy (“WAE”). The endoscopic plug additionally includes an air passage within the internal tubing to inflate the expandable balloon, sloped edges adjacent to the support tabs to seal the external housing to an external opening of the body cavity, and a plurality of valves, seals and pumps which allow for the introduction and retention of liquid into the body cavity.

Abstract: An endoscope and methods of use thereof is provided with at least one multi-functional, multi-directional arm supporting a plurality of imaging, lighting and other sensory elements. The multi-functional arms provide a mounting platform upon which cameras, lights and sensors may be mounted to generate multiple-angled images and video, arena-like lighting and other data relevant to performing a diagnostic or MIS procedure. The multi-directional arms may be inserted through a single portal in the endoscope and deployed in multiple directions from a single portal once inserted into a body cavity. The pitch, roll, length and curvature of each of the extending arms may be individually or jointly adjusted to create a customized view of an internal space during an endoscopic procedure. The extending arms may also include communication elements to wirelessly transmit the images and other data generated by the sensory elements to a remote computing and display device.

Abstract: Systems, methods and devices for performing water-aided endoscopy (WAE) are provided herein, including an endoscopic plug with a bulbous distal portion and a separate compressible exterior housing which are designed to create a sealed environment within the body cavity. The endoscopic plug may additionally include valves, balloons and pumps which provide means for introducing and removing liquid into the body cavity and maintaining the sealed environment to prevent fluid from within the body cavity from leaking to an external environment. The endoscopic plug provides a channel for insertion of specialized tools designed to interface with the multi-functional plug for insertion into the body cavity while maintaining the seal.

Abstract: Systems, methods and devices for performing water aided endoscopy (WAE) are provided herein. The systems include a plurality of devices designed to create a sealed environment within the body cavity, including a multi-functional plug, valves, balloons and pumps. The systems also provide specialized tools configured for operation within a liquid environment which are designed to interface with the multi-functional seal for insertion into the body cavity while maintaining the seal, including an adjustable constant shape snare. Additional features of the systems and methods include specialized fluids for increasing visibility with the body cavity, dyes and other solutions for image-enhancement and diagnostics, and software for increasing the clarity of the image in real-time.

Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.

Abstract: Methods for determining the 3-D structures of proteins. Such a method includes incorporating a compound into a protein crystal such that the compound enhances the activity of the protein crystal to second harmonic generation, illuminating the protein crystal with a sufficiently intense light to cause second harmonic generation by the protein crystal, and detecting a second harmonic generation response produced by the protein crystal that is suitable for protein structure determination by diffraction analysis.

Abstract: Methods for determining the 3-D structures of proteins. Such a method includes incorporating a compound into a protein crystal such that the compound enhances the activity of the protein crystal to second harmonic generation, illuminating the protein crystal with a sufficiently intense light to cause second harmonic generation by the protein crystal, and detecting a second harmonic generation response produced by the protein crystal that is suitable for protein structure determination by diffraction analysis.

Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.

Abstract: An endoscope and methods of use thereof is provided with at least one multi-functional, multi-directional arm supporting a plurality of imaging, lighting and other sensory elements. The multi-functional arms provide a mounting platform upon which cameras, lights and sensors may be mounted to generate multiple-angled images and video, arena-like lighting and other data relevant to performing a diagnostic or MIS procedure. The multi-directional arms may be inserted through a single portal in the endoscope and deployed in multiple directions from a single portal once inserted into a body cavity. The pitch, roll, length and curvature of each of the extending arms may be individually or jointly adjusted to create a customized view of an internal space during an endoscopic procedure. The extending arms may also include communication elements to wirelessly transmit the images and other data generated by the sensory elements to a remote computing and display device.

Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.

Abstract: An endoscope and methods of use thereof are provided, which includes at least one multi-functional extending arm supporting a plurality of imaging, lighting and other sensory elements. The arms provide a mounting platform upon which cameras, lights and sensors may be mounted to generate multiple-angled images and video, arena-like lighting and other data for performing a minimally-invasive surgical (MIS) procedure. The arms may be inserted through a single portal in the endoscope and extended outward in multiple directions from the single portal once inserted into a body cavity. The endoscope may also include support arms which support the extending arms within the body cavity and a stabilization plate which anchors the endoscope to an external surface of the body. An endoscopic tool with optical, lighting and other sensors integrated into a functional end is also provided.

Abstract: A time-based visual notification device (TND) provides visual, time-based notifications relating to a usability of an item via a visual indicator, power source and microcontroller programmed to track time intervals and illuminate the visual indicator with particular colors or patterns of illuminations to provide customized visual indications of the time intervals. The TND may be embodied as a sticker or tag, embedded within packaging, labels, storage containers, or even integrated within a product such as a medical device. The time intervals may be customized for a particular item, device or application and may either be pre-programmed for a desired time interval or customized to a desired time interval at the time of activation. A dispensing mechanism may be provided with a housing which contains a plurality of TNDs connected in sequence and a dispensing activator to activate each TND as it is removed from the dispensing mechanism.

Abstract: Systems, methods and devices for performing water aided endoscopy (WAE) are provided herein. The systems include a plurality of devices designed to create a sealed environment within the body cavity, including a multi-functional plug, valves, balloons and pumps. The systems also provide specialized tools configured for operation within a liquid environment which are designed to interface with the multi-functional seal for insertion into the body cavity while maintaining the seal, including an adjustable constant shape snare. Additional features of the systems and methods include specialized fluids for increasing visibility with the body cavity, dyes and other solutions for image-enhancement and diagnostics, and software for increasing the clarity of the image in real-time.

Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.