Abstract: The present disclosure relates to a system and method for use in performing clinical endpoint adjudication to provide: efficient, automated clinical event classification and medical review triage; reduce the time to identify clinical events; a unified, consistent process for classification of clinical events; and proactive identification of events in near real-time.

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, for use in combination with a 5-ASA agent, in the treatment of a disease resulting from pathologic inflammation. The combination of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof and 5-ASA agent and use of such combination. A kit-of-parts and a pharmaceutical composition comprising such a combination.

Abstract: A method for the treatment a disease resulting from spondyloarthritis, such as axial spondyloarthritis, psoriatic arthritis and enteropathic arthritis, by administering, to a mammal in need of such treatment, a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof.

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, for use in combination with a 5-ASA agent, in the treatment of a disease resulting from pathologic inflammation. The combination of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof and 5-ASA agent and use of such combination. A kit-of-parts and a pharmaceutical composition comprising such a combination.

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutical composition comprising the compound. The compound is useful for the treatment a disease resulting from pathologic inflammation, such as inflammatory bowel disease, psoriasis or rheumatoid arthritis.

Abstract: A method for the treatment a disease resulting from spondyloarthritis, such as axial spondyloarthritis, psoriatic arthritis and enteropathic arthritis, by administering, to a mammal in need of such treatment, a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof.

Abstract: A long twist drill includes a shank and a drill body having a drill tip (16). The twist drill has a length L and an outer diameter D, and has a cemented carbide or high speed steel substrate and a coating of at least one layer. The quota L/D is at least 16. The twist drill has two cutting segments at the tip and two flutes chip. The twist drill is provided with holes for fluid opening in the tip. The twist drill has an axial web thinning angle GAA, which is 40 to 50°. The twist drill further has a web that back tapers such that a web diameter gets smaller in a direction away from the tip towards the shank within an axial distance.

Abstract: A long twist drill includes a shank and a drill body having a drill tip (16). The twist drill has a length L and an outer diameter D, and has a cemented carbide or high speed steel substrate and a coating of at least one layer. The quota L/D is at least 16. The twist drill has two cutting segments at the tip and two flutes chip. The twist drill is provided with holes for fluid opening in the tip. The twist drill has an axial web thinning angle GAA, which is 40 to 50°. The twist drill further has a web that back tapers such that a web diameter gets smaller in a direction away from the tip towards the shank within an axial distance.

Abstract: A stable solid pharmaceutical composition consisting essentially of an effective amount of a crystalline salt of formula (II) together with an alkaline-reacting component maintaining the pH preferably above 8, or a salt with a divalent metal cation; and at least one pharmaceutical excipient; said salt of formula (II) being essentially stable during storage at room temperature for a period of at least 3 years. A process for stabilizing the salt of formula (II). A crystalline salt of formula (II) and a process for preparing said salt.

Abstract: A method for milking animals in a milking station (9) including a milking machine (14) for milking said animals, and a first feeding device (21) for feeding said animals intermittently or continuously with feed, is disclosed, the method comprising the steps of allowing a milking animal to enter the milking station (9); feeding the milking animal in the milking station intermittently or continuously with feed by means of the first feeding device (21); and milking the milking animal in the milking station (9) by means of the milking machine (14). According to the present invention, the feeding of the milking animal is terminated at a non-final stage of the milking in order to secure that the milking animal has terminated to consume the feed when the milking is finished.

Abstract: A stable solid pharmaceutical composition consisting essentially of an effective amount of a crystalline salt of formula (II) together with an alkaline-reacting component maintaining the pH preferably above 8, or a salt with a divalent metal cation; and at least one pharmaceutical excipient; said salt of formula (II) being essentially stable during storage at room temperature for a period of at least 3 years. A process for stabilizing the salt of formula (II). A crystalline salt of formula (II) and a process for preparing said salt.

Abstract: A stable solid pharmaceutical composition consisting essentially of an effective amount of a crystalline salt of formula (II) together with an alkaline-reacting component maintaining the pH preferably above 8, or a salt with a divalent metal cation; and at least one pharmaceutical excipient; said salt of formula (II) being essentially stable during storage at room temperature for a period of at least 3 years. A process for stabilizing the salt of formula (II). A crystalline salt of formula (II) and a process for preparing said salt.

Abstract: A stable solid pharmaceutical composition consisting essentially of an effective amount of a salt of formula (II) together with an alkaline-reacting component maintaining the pH preferably above 8, or a salt with a divalent metal cation; and at least one pharmaceutical excipient; said salt of formula (II) being essentially stable during storage at room temperature for a period of at least 3 years. A process for stabilizing the salt of formula (II). A crystalline salt of formula (II) and a process for preparing said salt.

Abstract: A compound of formula (I) wherein R is methyl, ethyl, n-propyl, iso-propyl, n-butyl or allyl; R? is hydrogen, C1-C4 alkyl, C1-C3 alkoxy; halogen, trifluoromethyl or OCHxFy, R? is hydrogen, fluoro or chloro, that R? being fluoro or chloro only when R? is fluoro or chloro; R3 is hydrogen or C1-C5 alkyl R4 is hydrogen, CH2OCOC(CH3)3, pharmaceutically acceptable inorganic or organic cations, or COR4? wherein R4? is C1-C5 alkyl, phenyl, benzyl or phenethyl; R7 is methyl or ethyl; one of A and B is sulphur and the other is C-R2; when A is S, R2 is selected from hydrogen and methyl, with the proviso that R2 is methyl only when R3 is not hydrogen; and when B is S, R2 is hydrogen; and any tautomer thereof. A pharmaceutical composition comprising a compound of formula (I), a method of treating malignant tumours or diseases resulting from autoimmunity or pathologic inflammation.

Abstract: A stable solid pharmaceutical composition consisting essentially of an effective amount of a salt of formula (II) together with an alkaline-reacting component maintaining the pH preferably above 8, or a salt with a divalent metal cation; and at least one pharmaceutical excipient; said salt of formula (II) being essentially stable during storage at room temperature for a period of at least 3 years. A process for stabilizing the salt of formula (II). A crystalline salt of formula (II) and a process for preparing said salt.

Abstract: A method includes the steps of recording milk yields (MY?1#191, MY?2#191, MY?N#191) from milkings of an udder quarter or udder of a milking animal; recording the times (t1, t2, . . . , tN) of the milkings; calculating milk secretion rates (MSR1, MSR2, . . . , MSRN) for said udder quarter or udder based on the milk yields and times; fitting a time dependent function (F(t)) to the calculated secretion rates, said time dependent function comprising one portion, which increases with time, and one portion, which decreases with time; estimating an expected milk secretion rate (EMSRt1+N) for said udder quarter or udder at a time (tN+1) following the last milking based on said function (F(t)); determining an expected milk yield (EMYtN+1) for said udder quarter or udder at said time based on the expected secretion rate and, at said time, the time period lapsed since last milking; and initiating an action to be performed with respect to said animal depending on said expected milk yield.

Abstract: The present invention relates to a tool as well as a blank for manufacturing of the tool. The tool is made of solid cemented carbide and includes a shank for mounting in a rotatable spindle and chip flutes. Lines of intersection between the chip flutes and clearance surfaces form cutting edges at a cutting end of the tool. The flush channels extend through the entire tool in order to transfer flushing medium to the cutting end of the tool. The flush channels have varying pitch.

Abstract: A method for milking animals in a milking station (9) including a milking machine (14) for milking said animals, and a first feeding device (21) for feeding said animals intermittently or continuously with feed, is disclosed, the method comprising the steps of allowing a milking animal to enter the milking station (9); feeding the milking animal in the milking station intermittently or continuously with feed by means of the first feeding device (21); and milking the milking animal in the milking station (9) by means of the milking machine (14). According to the present invention, the feeding of the milking animal is terminated at a non-final stage of the milking in order to secure that the milking animal has terminated to consume the feed when the milking is finished.

Abstract: The present invention relates to a tool as well as a blank for manufacturing of the tool. The tool is made of solid cemented carbide and includes a shank for mounting in a rotatable spindle and chip flutes. Lines of intersection between the chip flutes and clearance surfaces form cutting edges at a cutting end of the tool. The flush channels extend through the entire tool in order to transfer flushing medium to the cutting end of the tool. The flush channels have varying pitch.

Abstract: This invention relates to a device and a method for allowing performance of several separate treatment of a teat of an animal. The device includes a cup-shaped body (1) having a surface (2) defining an inner space (3), which is arranged to receive the teat of the animal. The device also includes a first delivery mechanism arranged to provide a first treatment by supplying a first medium (4) to the teat via at least a first passage having a plurality of openings (10, 18) to the inner space (3) and at least one additional delivery mechanism arranged to provide an additional medium (13, 26, 28) to the teat, via at least an additional passage having a plurality of openings (10,18) to the inner space(3). Thereby, the device provides at least two different treatments of the teats at different occasions.