Abstract: A compound of formula (I) wherein R is methyl, ethyl, n-propyl, iso-propyl, n-butyl or allyl; R? is hydrogen, C1-C4 alkyl, C1-C3 alkoxy; halogen, trifluoromethyl or OCHxFy, R? is hydrogen, fluoro or chloro, that R? being fluoro or chloro only when R? is fluoro or chloro; R3 is hydrogen or C1-C5 alkyl R4 is hydrogen, CH2OCOC(CH3)3, pharmaceutically acceptable inorganic or organic cations, or COR4? wherein R4? is C1-C5 alkyl, phenyl, benzyl or phenethyl; R7 is methyl or ethyl; one of A and B is sulphur and the other is C—R2; when A is S, R2 is selected from hydrogen and methyl, with the proviso that R2 is methyl only when R3 is not hydrogen; and when B is S, R2 is hydrogen; and any tautomer thereof. A pharmaceutical composition comprising a compound of formula (I), a method of treating malignant tumours or diseases resulting from autoimmunity or pathologic inflammation.

Abstract: A stable solid pharmaceutical composition consisting essentially of an effective amount of a salt of formula (II) together with an alkaline-reacting component maintaining the pH preferably above 8, or a salt with a divalent metal cation; and at least one pharmaceutical excipient; said salt of formula (II) being essentially stable during storage at room temperature for a period of at least 3 years. A process for stabilizing the salt of formula (II). A crystalline salt of formula (II) and a process for preparing said salt.

Abstract: The invention relates to a device and a method for allowing performance of several separate treatments of a teat of an animal. The device comprises a cup-shaped body (1) having a surface (2) defining an inner space (3), which is arranged to receive a teat of the animal. The device comprises also first means arranged to provide a first treatment by supplying a first medium (4) to the teat via at least a first passage having a plurality of openings (10, 18) to the inner space (3) and at least one additional means arranged to provide an additional treatment by supplying an additional medium (13, 26, 28) to the teat, via at least an additional passage having a plurality of openings (10, 18) to the inner space (3). Thereby, the device provides at least two different treatments of the teats at different occasions.

Abstract: A method and system for controlling the cooling of small milk quantities in a cooling tank (2) having a bottom wall portion (12) with a milk cooling surface (12′) within the tank being part of a cooling circuit an agitator (19) within the tank for stirring the milk therein. The gist of the invention is a) providing an element for measuring the milk quantity in the tank, and a temperature transducer (11) for monitoring the milk temperature in the tank, b) providing, in the cooling circuit, an evaporator (4) connected to the bottom wall portion of the tank, a compressor (5), and a condenser (7), c) controlling the temperature of the refrigerant in the evaporator by regulating the vaporizing pressure, so that the temperature of the milk cooling surface (12′) is always higher than 0° C. when the compressor (5) is running, d) monitoring the milk quantity in the tank, and, when sufficient/insufficient for the agitator to work properly.

Abstract: A system for controlling the cooling of small milk quantities in a cooling tank (4). An agitation pipe (2) extended through a regular milk outlet (26) in a first end wall (6) of the tank is provided, having a nozzle end (32) for introducing incoming/re-circulated milk onto a milk cooling surface (14) at a predetermined position (dp). The position (dp) being situated (1) between a first end wall (6) and a central part of the tank (4) and laterally displaced (b) relative to the perpendicular central axis of the tank. The nozzle end (32) is directed towards a second end wall (8) of the tank (4). Agitation is performed by the agitation pipe (2) upon demand or when the milk quantity is insufficient for a regular agitator element (27) to work properly.

Abstract: A system for controlling the cooling of small milk quantities in a cooling tank (4). An agitation pipe (2) extended through a regular milk outlet (26) in a first end wall (6) of the tank is provided, having a nozzle end (32) for introducing incoming/re-circulated milk onto a milk cooling surface (14) at a predetermined position (dp). The position (dp) being situated (1) between a first end wall (6) and a central part of the tank (4) and laterally displaced (b) relative to the perpendicular central axis of the tank. The nozzle end (32) is directed towards a second end wall (8) of the tank (4). Agitation is performed by the agitation pipe (2) upon demand or when the milk quantity is insufficient for a regular agitator element (27) to work properly.

Abstract: The present invention refers to an apparatus (11) and a method for milk filtration and filter regeneration. The apparatus comprises a filter vessel (13); a loose filter material (37) housed within the vessel for filtering out contaminants in the milk; and a grid (31) arranged in front of the milk flow outlet to prevent the loose filter material from leaving the vessel. The vessel includes inner walls (15, 17); a milk inlet (21); a milk outlet (23); a cleaning fluid inlet (23) arranged substantially vertically at the lowermost portion of the vessel, through which a cleaning fluid jet can be injected, and a cleaning fluid outlet (21) arranged at the upper portion of the vessel. The lower portions (17) of the inner walls of the vessel form an angle (&agr;) with respect to the horizontal plane, the angle being larger than the angle of repose for the filter material in the cleaning fluid.

Abstract: The invention is related to compounds of general formula (I) wherein R is methyl, ethyl, n-propyl, iso-propyl, n-butyl or allyl; R′ is methyl, methoxy, fluoro, chloro, bromo, azido, trifluorometlhyl, or OCHxFy, wherein x=0−2, y=1−3 with the. proviso that x+y=3; R″ is hydrogen, fluoro or chloro; with the proviso that R″ is fluoro or chloro only when R′ is fluoro or chloro; R4 is hydrogen or pharmaceutically acceptable inorganic or organic cations; R5 is dimethylamino or nitro; R6 is hydrogen; and when R′ is azido R5 is also ethyl, n-propyl, iso-propyl, methoxy, ethoxy, chloro, bromo, trifluoromethyl, OCHxFy, wherein x=0−2, y=1−3 with the proviso that x+y=3, or R5 and R6 taken together are methylenedioxy; and any tautomer thereof. The invention also relates to pharmaceutical compositions containing a compound of the general formula (I) together with a pharmaceutically acceptable carrier.

Abstract: A method and system for controlling the cooling of small milk quantities in a cooling tank (2) having a bottom wall portion (12) with a milk cooling surface (12′) within the tank being part of a cooling circuit, an agitator means (19) within the tank for stirring the milk therein. The gist of the invention is: a) providing a means (10) for measuring the milk quantity in the tank, and a temperature transducer (11) for monitoring the milk temperature in the tank, b) providing, in the cooling circuit, an evaporator (4) connected to the bottom wall portion of the tank, a compressor (5), and a condenser (7), c) controlling the temperature of the refrigerant in the evaporator by regulating the vaporizing pressure, so that the temperature of the milk cooling surface (12′) is always higher than 0° C., whereas the refrigerant temperature in the evaporator (4) is below O° C.

Abstract: Compounds of formula (I) and tautomers thereof are effective for the treatment of mammals suffering from diseases resulting from autoimmunity and pathological inflammation.

Abstract: An apparatus for automatically milking an animal, comprising at least one teatcup having a teat entrance end (17a), and a movable arm (6, 40) for moving the teatcup toward a teat of an animal to be milked and attaching it thereto. The teat entrance end of the teatcup is arranged, while being moved by the movable arm (6, 40) toward the teat, to be held in relation to the movable arm (6, 40) at a level which is different from that of the teat entrance end (17a) of a further teatcup, when held in relation to the movable arm.

Abstract: A method for milking and after-treating an animal by using an automatic milking system comprising means for locating the teats of the animal, means for milking the animal and means for performing an after-treatment of the animal. The method comprises an additional step of locating at least one teat of the animal a second time, the additional step being performed prior to the step of performing an after-treatment operation.

Abstract: A method for stimulation of transcription factor AP (activator protein)-1 by administering a compound of the formula (I) wherein R is selected from methyl, ethyl, n-propyl, iso-propyl, c-propyl, n-butyl, sec.-butyl, iso-butyl, tert.-butyl, c-butyl, n-pentyl, sec.-pentyl, iso-pentyl, tert.-pentyl, neo-pentyl, c-pentyl, c-hexyl and c-heptyl; RNa and RNb are the same or different and selected from hydrogen, methyl and ethyl; R2, R3, R5 and R6 are independently selected from hydrogen, methyl, methoxy, thiomethyl, hydroxy, fluoro, chloro, bromo, trifluoromethyl, phenyl and benzyl; n is 1, 2 or 3; R′ and R″ are the same or different and selected from methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec.-butyl, and iso-butyl or R′ and R″ together form a saturated heterocyclic ring of 5-7 atoms; and pharmaceutically acceptable salts, hydrates and solvates thereof, to a mammal in need thereof.

Abstract: The invention is related to compounds of general formula (I) 1

Abstract: Compounds of formula (I) 1

Abstract: A method and device for milking an animal by using at least one milking machine (5) including at least one teatcup (3) having a teatcup liner (11) forming a space defined by a wall surface. The teatcup (3) is arranged to be applied to a teat in such a manner that the wall surface extends around and abuts the teat. The device includes a control unit arranged to control the application of the teatcup (3) in such a manner that an arbitrary portion of the wall surface abuts different teat portions during a first milking occasion with respect to an animal and during a later milking occasion with respect to this animal, respectively.

Abstract: The invention relates to a method for the treatment of tumors in mammals by the administration of compounds of the general formula (I) wherein A is O41 or NR42 R43 wherein R41 is hydrogen or a pharmaceutically acceptable inorganic or organic cation, or CORA wherein RA is alkyl and aryl; R42 and R43 are hydrogen, C1-C4-alkyl, cyclopropyl, cyclopentyl or cyclohexyl; or R42 is benzyl or phenethyl, optionally mono- or disubstituted by methyl, iso-propyl methoxy, fluoro, chloro, bromo, dimethylamino, trifluoromethyl or nitro and R43 is hydrogen; or R42 and R43 form a 5- or 6-membered ring; or R42 is CORB wherein RB is alkyl or aryl, —CH2N(CH3)2 or —CH2CH2COOH or CORB is a 2-acyloxymethylbenzoyl group wherein RC is methyl, ethyl, phenyl or benzyl; R42 is COORD wherein RD is C1-C4-alkyl, phenyl or benzyl; or R42 is —CH2OCO-tert.

Abstract: A method for stimulation of transcription factor AP (activator protein)-1 by administering a compound of the formula (I) 1

Abstract: Use of a compound of formula (I) and the pharmaceutically acceptable acid addition salts thereof, wherein R1 is either halogen or hydrogen and R2 is halogen; X is CH2, O or S; R3 and R4 are the same or different and selected from hydrogen or lower alkyl; n is 2 or 3; A is selected from the pyrimidyl- or pyridyl-groups (a), (b) or (c) wherein R5, R6 and R7 are as defined in the description; for the manufacture of a medicament for the relief or prevention of a withdrawal syndrome resulting from addiction to a drug or substance of abuse or for treatment thereof.

Abstract: The invention is related to compounds of general formula (I) wherein R is methyl, ethyl, n-propyl, iso-propyl, n-butyl or allyl; R' is methyl, methoxy, fluoro, chloro, bromo, trifluoromethyl, or OCH.sub.x F.sub.y, whereinx=0-2, y=1-3 with the proviso that x+y=3, R" is hydrogen, fluoro or chloro; with the proviso that R" is fluoro or chloro only when R' is fluoro or chloro; R.sub.4 is hydrogen or pharmaceutically acceptable inorganic or organic cations;R.sub.5 is ethyl, n-propyl, iso-propyl, methoxy, ethoxy, chloro, bromo, trifluoromethyl, OCH.sub.x F.sub.y, or OCH.sub.2 CH.sub.x F.sub.y wherein x=0-2, y=1-3 with the proviso that x+y=3;R.sub.6 is hydrogen; or R.sub.5 and R.sub.6 taken together are methylenedioxy; and any tautomer thereof.The invention also relates to pharmaceutical compositions containing a compound of the general formula (I) together with a pharmaceutically acceptable carrier.