Abstract: It relates to a pharmaceutical combination comprising a KRAS G12C inhibitor, in particular 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro [3.3] heptan-2-yl} prop-2-en-1-one (Compound A) and one or more therapeutically active agents selected from a SHP2 inhibitor (e.g. TNO155) and a PD-1 inhibitor, pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutated.

Abstract: A device (1) and method for media filtration with a preparation container (2). A chamber (5) containing a dissolvable medium (29) is situated between the container inflow and outflow, and has a filter (22). A mixing arm (6, 7), connected to the inflow, protrudes into the medium in the chamber with at least one mixing nozzle (19, 20), disposed at the free end (17, 18) of the mixing arm for generating a directed jet of solvent. The preparation container has bottom (10) and top (8) parts bracketing the chamber. The filter is a sterile, has on the filtrate side facing the outflow, a circumferential outer edge (23) resting on a circumferential rest edge (37) of the bottom part of the preparation container and is connected fixedly thereto. A sterilised filtrate space (39) is formed between the filtrate side (38) of the filter and the outflow situated in the bottom part.

Abstract: A device (1) and method for media filtration with a preparation container (2). A chamber (5) containing a dissolvable medium (29) is situated between the container inflow and outflow, and has a filter (22). A mixing arm (6, 7), connected to the inflow, protrudes into the medium in the chamber with at least one mixing nozzle (19, 20), disposed at the free end (17, 18) of the mixing arm for generating a directed jet of solvent. The preparation container has bottom (10) and top (8) parts bracketing the chamber. The filter is a sterile, has on the filtrate side facing the outflow, a circumferential outer edge (23) resting on a circumferential rest edge (37) of the bottom part of the preparation container and is connected fixedly thereto. A sterilised filtrate space (39) is formed between the filtrate side (38) of the filter and the outflow situated in the bottom part.

Abstract: Disclosed is a filtration device for liquid samples as well as a close and push-through device for said filtration device.

Abstract: Disclosed is a filtration device for liquid samples as well as a close and push-through device for said filtration device.

Abstract: A container has an outflow arranged in the vicinity of the bottom and a vortex breaker mounted upstream from the outflow for preventing foaming. The vortex breaker has a vertical main wall and two vertical side wings oriented away from one another to define a T-shape. The main wall merges into a fixing arm. A method also is provided for producing the vortex breaker. The method includes a) cutting a flat plate to define a main wall, two side wings, and a fixing arm connected to the main wall; and b) folding out the side wings in opposing directions in each case into a final position arranged transverse to the main wall. The vortex breaker is applicable in chemistry, biotechnology, and filtration technology.

Abstract: In a metering unit (10) having at least one outlet (20) for dispensing an aerosol with a defined concentration, with at least one inlet (180) for a carrier gas, at least one inlet for a liquid, preferably for a hydrogen peroxide solution, and a buffer container (30) for the liquid, it is provided that the metering unit (10) has at least one liquid flow controller (90) on the outflow side.

Abstract: In an electromagnetic actuator for a solenoid valve, the electromagnetic actuator has a magnetic coil and a first electrical connector adapted to receive a control signal which determines a switching position of the electromagnetic actuator. The electromagnetic actuator further has a second electrical connector which is provided directly on the electromagnetic actuator and is separate with respect to the first electrical connector. The magnetic coil and the first electrical connector are coupled by an electrical connection which is interrupted at the second electrical connector. Further proposed are a valve terminal having at least one solenoid valve, and a module arrangement.

Abstract: The invention relates to closure, in particular for a nutrient medium container, wherein a lower part can be covered by an upper part, wherein the lower part and the upper part can be locked against each other by means of at least one locking receptacle and at least one locking part by rotating the lower part and the upper part about a longitudinal axis, and wherein the locking receptacle has a receptacle groove that is covered by a shoulder and that extends perpendicularly to the longitudinal axis, in which receptacle groove the locking part engages, wherein the shoulder has at least one ramp surface extending at an angle from the longitudinal axis on the outer face of the shoulder facing away from the receptacle groove.

Abstract: A container has an outflow arranged in the vicinity of the bottom and a vortex breaker mounted upstream from the outflow for preventing foaming. The vortex breaker has a vertical main wall and two vertical side wings oriented away from one another to define a T-shape. The main wall merges into a fixing arm. A method also is provided for producing the vortex breaker. The method includes a) cutting a flat plate to define a main wall, two side wings, and a fixing arm connected to the main wall; and b) folding out the side wings in opposing directions in each case into a final position arranged transverse to the main wall. The vortex breaker is applicable in chemistry, biotechnology, and filtration technology.

Abstract: In an electromagnetic actuator for a solenoid valve, the electromagnetic actuator has a magnetic coil and a first electrical connector adapted to receive a control signal which determines a switching position of the electromagnetic actuator. The electromagnetic actuator further has a second electrical connector which is provided directly on the electromagnetic actuator and is separate with respect to the first electrical connector. The magnetic coil and the first electrical connector are coupled by an electrical connection which is interrupted at the second electrical connector. Further proposed are a valve terminal having at least one solenoid valve, and a module arrangement.

Abstract: The invention relates to a transfer unit for receiving in particular a porous disc-shaped medium from a first treatment device, having an upper part, wherein the upper part comprises a fixing edge that can be connected to an edge of the medium for removing the medium from the first treatment device, wherein the upper part comprises an opening closed by a removable cover, by means of which successive treatments in a further treatment device can be performed. The invention further relates to a method wherein an upper part of a transfer unit is placed on a disc-shaped medium disposed in a first lower part of a first treatment device and exposed to the liquid sample and is connected to an edge of the medium, wherein the upper part is lifted off from the first lower part with the disc-shaped medium connected thereto, and is placed on a further lower part of a corresponding treatment device, and is further processed through an opening in the upper part.

Abstract: In a metering unit (10) having at least one outlet (20) for dispensing an aerosol with a defined concentration, with at least one inlet (180) for a carrier gas, at least one inlet for a liquid, preferably for a hydrogen peroxide solution, and a buffer container (30) for the liquid, it is provided that the metering unit (10) has at least one liquid flow controller (90) on the outflow side.

Abstract: The invention relates to closure, in particular for a nutrient medium container, wherein a lower part can be covered by an upper part, wherein the lower part and the upper part can be locked against each other by means of at least one locking receptacle and at least one locking part by rotating the lower part and the upper part about a longitudinal axis, and wherein the locking receptacle has a receptacle groove that is covered by a shoulder and that extends perpendicularly to the longitudinal axis, in which receptacle groove the locking part engages, wherein the shoulder has at least one ramp surface extending at an angle from the longitudinal axis on the outer face of the shoulder facing away from the receptacle groove.

Abstract: The invention relates to a transfer unit for receiving in particular a porous disc-shaped medium from a first treatment device, having an upper part, wherein the upper part comprises a fixing edge that can be connected to an edge of the medium for removing the medium from the first treatment device, wherein the upper part comprises an opening closed by a removable cover, by means of which successive treatments in a further treatment device can be performed. The invention further relates to a method wherein an upper part of a transfer unit is placed on a disc-shaped medium disposed in a first lower part of a first treatment device and exposed to the liquid sample and is connected to an edge of the medium, wherein the upper part is lifted off from the first lower part with the disc-shaped medium connected thereto, and is placed on a further lower part of a corresponding treatment device, and is further processed through an opening in the upper part.

Abstract: An apparatus for estimating a yield of a financial product, as well as to a corresponding method and a corresponding computer program product. The present disclosure can be loosely summarized, in one aspect, as teaching a method of pricing a financial product under a number of potential future scenarios wherein, instead of carrying out a separate (and perhaps nested) Monte Carlo simulation for each scenario under consideration, a smoothing function is generated from the results of a proportionately small number of representative (nested) simulations and the pricing is estimated at each scenario using the smoothing function. Each Monte Carlo simulation simulates the yield of the financial product under the conditions of the specific scenario. Accordingly, the smoothing function represents the (simulation) yield of the financial product as a function of the scenario parameters.

Abstract: There is disclosed a filter package comprising a housing and a cover that is adapted to enclose a sterile disposable filter wherein the package cover is penetrable at a point axially aligned with the filter and has at least one pre-formed break line along which the package cover, when subjected to appropriate force, ruptures so as to permit withdrawal of the filter by a syringe coupled thereto.

Abstract: A dispenser is disclosed that is particularly suitable for dispensing packaged items such as bandages or membrane filters. The dispenser is provided with a magazine for holding the items, with a distribution assembly for exposure and distribution of the items, an ejector operable in advance/feed and disposal modes, and with a separating assembly for separation of the item from its packaging.

Abstract: There is disclosed a vacuum filtration device for aqueous media that includes a hydrophilic tubular filter element in a cylindrical housing and at least one hydrophobic gas-permeable membrane, coupled with a gas bleed-off valve to allow the escape of air entrained in the filtration medium.

Abstract: There is disclosed a filter package comprising a housing and a cover that is adapted to enclose a sterile disposable filter wherein the package cover is penetrable at a point axially aligned with the filter and has at least one pre-formed break line along which the package cover, when subjected to appropriate force, ruptures so as to permit withdrawal of the filter by a syringe coupled thereto.